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Recent Advances In Ipsc Disease Modeling

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Recent Advances in iPSC Disease Modeling Volume 1

Recent Advances in iPSC Disease Modeling  Volume 1 Book
Author : ALEXANDER BIRBRAIR
Publisher : Academic Press
Release : 2020-07-16
ISBN : 0128232692
Language : En, Es, Fr & De

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Book Description :

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Recent Advances in iPSC Technology Volume 5

Recent Advances in iPSC Technology  Volume 5 Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2021-03-31
ISBN : 012822326X
Language : En, Es, Fr & De

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Book Description :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies. Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics. Covers the following topics: iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the non-coding genome, modeling of blood-brain barrier with iPSCs, mathematical modelling of iPSCs, iPSCs to study human brain evolution, self-renewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. Contributed by world-renown experts in the field

Recent Advances in iPSC Derived Cell Types

Recent Advances in iPSC Derived Cell Types Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2021-03-19
ISBN : 0128222301
Language : En, Es, Fr & De

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Book Description :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ßpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine and therapeutics. Covers the following cell types derived from iPSCs: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ?pancreatic cells, and more. Contributions from stem cell leaders around the world

Cell Biology and Translational Medicine Volume 7

Cell Biology and Translational Medicine  Volume 7 Book
Author : Kursad Turksen
Publisher : Springer Nature
Release : 2020-02-03
ISBN : 3030378454
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series.

Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells

Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells Book
Author : Valerie Sapp
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Human iPSCs derived cells provide the context to uncover novel mechanisms of development and disease in patient specific primary cells. The establishment of genome-scale functional genomics based approaches in iPSC derived cells complements recent advances in disease modeling in these cells and is well poised to highlight novel human specific, cell-autonomous mechanisms of disease. In the decade since their discovery, iPSC derived cardiomyocyte models have been developed for a range of conditions from hereditary cardiomyopathies and channelopathies to drug induced cardiotoxicity. The ability to leverage iPSC derived cells to understand disease mechanisms at genome-scale had been limited by a lack of pooled-format functional genomics screening approaches in these cells. In Chapter 2 of this dissertation I outline the optimized methods we developed for CRISPR screening in human iPS derived cells which optimize for infection with a genome-scale CRISPR library and allow screening in functional iPS derived cardiomyocytes with preserved library representation. In Chapter 3 we apply this to uncover novel mechanisms of drug induced cardiotoxicity, which is both a major impediment to new drug approval and a limiting factor in the utilization of approved drugs. We discover the transporter SLCO1A2 as a novel mediator of doxorubicin induced cardiotoxicity in cardiomyocytes, but not breast cancer cells. Through this discovery we highlight the utility of genome-scale functional genomics screening in specifically human differentiated cells of interest. In addition to their utility for modeling human disease, iPS cells have also provided a context to identify novel factors governing pluripotency maintenance and cell fate specification and have provided critical insights into the contribution of transcriptional and signaling pathways in cell fate decisions. Experiments to identify the role of signaling metabolites in cell fate specification have been limited by insufficient techniques to measure and characterize the vast majority of signaling metabolites. Recent advances in untargeted mass-spectrometry afford us the opportunity for to profile thousands of novel signaling lipids in cardiomyocyte specification. We identify a saturated dihydroxy fatty acids as a new family of pluripotency associated metabolites, which have the potential to govern stemness.

Lung Stem Cells in the Epithelium and Vasculature

Lung Stem Cells in the Epithelium and Vasculature Book
Author : Amy Firth,Jason X.-J. Yuan
Publisher : Springer
Release : 2015-05-23
ISBN : 3319162322
Language : En, Es, Fr & De

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Book Description :

This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Programmed Cells from Basic Neuroscience to Therapy

Programmed Cells from Basic Neuroscience to Therapy Book
Author : Fred H. Gage,Yves Christen
Publisher : Springer Science & Business Media
Release : 2013-05-13
ISBN : 3642366481
Language : En, Es, Fr & De

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Book Description :

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

Organs on chips

Organs on chips Book
Author : Yu-suke Torisawa,Yi-Chung Tung
Publisher : MDPI
Release : 2020-05-27
ISBN : 3039289179
Language : En, Es, Fr & De

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Book Description :

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.

Combining Induced Pluripotent Stem Cells and CRISPR Cas9 Gene Editing to Model and Characterize Rare Neurological Diseases

Combining Induced Pluripotent Stem Cells and CRISPR Cas9 Gene Editing to Model and Characterize Rare Neurological Diseases Book
Author : Scott Bell
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"The development of accurate and informative models is essential to the investigation of any disease. However, rare neurodevelopmental disorders have historically faced immense challenges developing effective models, as the scarcity of subjects and the invasive procedures required to obtain neural cells have limited the models available to researchers. However, recent advances in induced pluripotent stem cells (iPSCs) gene editing have the potential to dramatically lower the logistical barriers associated with studying rare neurological disease.This thesis will describe an improved methodology for generating iPSC based models of neurological disease, either by obtaining somatic cells from patients or using CRISPR/ Cas9 gene editing. These techniques were then validated by modelling a known disease causing mutation in the GRIN2B gene, and demonstrated that mutations in the gene caused impaired neuronal differentiation. Finally, these techniques were used to investigate mutations in a novel neurodevelopmental disease, caused by mutations in the ACTL6B gene. This work describes an improved methodology using iPSCs and gene editing to model rare neurodevelopmental disorders, validates its use in a known disease causing gene, and utilizes it to identify disease specific phenotypes in a novel neurodevelopmental disease"--

World Cancer Report 2008

World Cancer Report 2008 Book
Author : International Agency for Research on Cancer
Publisher : International Agency for Research on Cancer
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"The World Cancer Report 2008" provides a comprehensive overview of cancer for all those working in the field of health-care and research, and the general reader as well. It presents information on cancer patterns, diagnosis, causes and prevention concisely, clearly outlining the growing public health crisis. Simultaneously, there is a clear message of hope: although cancer is a great and growing devastating disease, it is largely preventable.

Pluripotent Stem Cells

Pluripotent Stem Cells Book
Author : Minoru Tomizawa
Publisher : BoD – Books on Demand
Release : 2016-07-20
ISBN : 9535124714
Language : En, Es, Fr & De

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Book Description :

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Embryonic Stem Cells

Embryonic Stem Cells Book
Author : Michael S. Kallos
Publisher : BoD – Books on Demand
Release : 2011-10-12
ISBN : 9533076321
Language : En, Es, Fr & De

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Book Description :

The ultimate clinical implementation of embryonic stem cells will require methods and protocols to turn these unspecialized cells into the fully functioning cell types found in a wide variety of tissues and organs. In order to achieve this, it is necessary to clearly understand the signals and cues that direct embryonic stem cell differentiation. This book provides a snapshot of current research on the differentiation of embryonic stem cells to a wide variety of cell types, including neural, cardiac, endothelial, osteogenic, and hepatic cells. In addition, induced pluripotent stem cells and other pluripotent stem cell sources are described. The book will serve as a valuable resource for engineers, scientists, and clinicians as well as students in a wide range of disciplines.

Connecting Sarcomere Protein Mutations to Pathogenesis in Myopathies

Connecting Sarcomere Protein Mutations to Pathogenesis in Myopathies Book
Author : Jose Renato Pinto,P. Bryant Chase
Publisher : Frontiers Media SA
Release : 2020-08-06
ISBN : 2889639215
Language : En, Es, Fr & De

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Book Description :

Download Connecting Sarcomere Protein Mutations to Pathogenesis in Myopathies book written by Jose Renato Pinto,P. Bryant Chase, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Harrison s Principles of Internal Medicine 20 E Vol 1 Vol 2 ebook

Harrison s Principles of Internal Medicine 20 E  Vol 1   Vol 2   ebook  Book
Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2018-02-06
ISBN : 1259644049
Language : En, Es, Fr & De

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Book Description :

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

Molecular Neuropharmacology A Foundation for Clinical Neuroscience Third Edition

Molecular Neuropharmacology  A Foundation for Clinical Neuroscience  Third Edition Book
Author : Eric J. Nestler,Steven E. Hyman,Robert C. Malenka
Publisher : McGraw Hill Professional
Release : 2015-03-22
ISBN : 0071827706
Language : En, Es, Fr & De

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Book Description :

GAIN A COMPLETE UNDERSTANDING OF NERVOUS SYSTEM FUNCTION AND ITS RELATIONSHIP TO HUMAN NEUROLOGIC DISORDERS Molecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others. The neuropharmacology and neural circuits that underlie complex behaviors as well as major neural disorders are also discussed as are the drugs used to treat those conditions. In the final section, the authors use the concepts presented in the first two sections to explain how irregularities in the biochemistry of neuronal interactions can lead to a wide array of clinical manifestations. FEATURES NEW chapter on neuroinflammation All chemical structure illustrations have been redrawn and improved Fully updated to reflect the latest breakthroughs and new drugs The most well-written and easily understood work on the subject More than 300 full-color illustrations!

Neurodevelopmental Disorders

Neurodevelopmental Disorders Book
Author : Emanuel DiCicco-Bloom,James H. Millonig
Publisher : Springer
Release : 2020-07-31
ISBN : 9783030454920
Language : En, Es, Fr & De

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Book Description :

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

Fitzpatrick s Dermatology Ninth Edition 2 Volume Set EBOOK

Fitzpatrick s Dermatology  Ninth Edition  2 Volume Set  EBOOK  Book
Author : Sewon Kang
Publisher : McGraw Hill Professional
Release : 2018-04-27
ISBN : 0071837833
Language : En, Es, Fr & De

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Book Description :

The gold-standard text in dermatology – completely updated for today’s practice by an all-new editorial board Encyclopedic in scope, yet skillfully edited to make it easy to read and understand, this trusted classic delivers everything clinicians need to know about skin, skin symptoms, and skin diseases. Presented in full color, Fitzpatrick’s covers all the essentials, from the basic science of skin to the day-to-day clinical issues of managing common skin disorders such as acne, skin cancer, and psoriasis. Backed by the expertise of more than 500 world-renowned contributors, and the reference of choice for clinicians, students, and educators, Fitzpatrick’s is enhanced by thousands of full-color photographs and a wealth of newly enhanced tables and diagrams. The Ninth Edition is bolstered by a new global editorial team; a reorganized table of contents; a more simple, readable, and direct writing style, the incorporation of more genetic, syndromic, and treatment information into each chapter; the addition of first, second, and third line treatment options; and improved table presentation. The reorganized table of contents reflects how disease presents rather than its cause.

Molecular Neuropharmacology A Foundation for Clinical Neuroscience Fourth Edition

Molecular Neuropharmacology  A Foundation for Clinical Neuroscience  Fourth Edition Book
Author : Eric J. Nestler,Steven E. Hyman,Robert C. Malenka
Publisher : McGraw Hill Professional
Release : 2020-09-05
ISBN : 1260456919
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The definitive guide to treating neurologic and psychiatric disorders with drugs and other approaches Fully updated with the latest research and drugs, Nestler, Hyman, & Malenka’s Molecular Neuropharmacology, Fourth Edition, is the leading guide to molecular neuroscience. Providing an in-depth look at the neuropharmacological fundamentals of the nervous system, it delivers the knowledge and insight you need to master the pathophysiology of neurologic and psychiatric disorders. Complete with tables, diagrams, and figures clearly illustrating the intricacies of neurochemistry and molecular neuroscience, this peerless guide reviews the effects of drug action (organized by drug category) to enhance your understanding of major disease mechanisms, and it explains the pathophysiology and neuropharmacology of all major neurologic and psychiatric disorders. Concise overviews of the effects of drugs and other treatment approaches are presented in a way that boosts your understanding and retention of critical concepts. Nestler, Hyman, & Malenka’s Molecular Neuropharmacology provides a deep dive into: General principles of neurophar¬macology Nervous system function Drugs that act on neuronal and glial function Major neurotrans¬mitter systems in the brain and spinal cord Atypical neurotransmitters, including peptides, growth factors, and cytokines Major brain and spinal cord systems at the molecular, cellular, and circuit levels in health and disease

Modeling the C9ORF72 Repeat Expansion Mutation Using Human Induced Pluripotent Stem Cells

Modeling the C9ORF72 Repeat Expansion Mutation Using Human Induced Pluripotent Stem Cells Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: C9ORF72 repeat expansion is the most frequent causal genetic mutation giving rise to amyotrophic lateral sclerosis (ALS) and fronto‐temporal dementia (FTD). The relatively recent discovery of the C9ORF72 repeat expansion in 2011 and the complexity of the mutation have meant that animal models that successfully recapitulate human C9ORF72 repeat expansion‐mediated disease are only now emerging. Concurrent advances in the use of patient‐derived induced pluripotent stem cells (iPSCs) to model aspects of neurological disease offers an additional approach for the study of C9ORF72 mutation. This review focuses on the opportunities of human C9ORF72 iPSC platforms to model pathological aspects of disease and how findings compare with other existing models of disease and post mortem data.

Issues in General Science and Scientific Theory and Method 2011 Edition

Issues in General Science and Scientific Theory and Method  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963479
Language : En, Es, Fr & De

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Book Description :

Issues in General Science and Scientific Theory and Method: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science and Scientific Theory and Method. The editors have built Issues in General Science and Scientific Theory and Method: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Science and Scientific Theory and Method in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Science and Scientific Theory and Method: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.