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Rearrangements With Migration To Electrophilic Heteroatomic Centers

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Rearrangements with Migration to Electrophilic Heteroatomic Centers

Rearrangements with Migration to Electrophilic Heteroatomic Centers Book
Author : Sosale Chandrasekhar
Publisher : Elsevier
Release : 2022-01-15
ISBN : 9780128237434
Language : En, Es, Fr & De

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Book Description :

Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis covers the basic principles and synthetic applications of a critically important class of organic reactions that date back to the founding period of organic chemistry. These reactions are not only of historical and pedagogical interest, but also have great practical value to this day, being inevitable in any strategy concerning the introduction of nitrogen and oxygen functionality. The book is made up of three parts, dealing with the Beckmann reaction, the Hoffmann family of reactions and the Baeyer-Villiger reaction. Each part begins with a brief historical introduction followed by a mechanistic discussion. The synthetic applications are then discussed in detail, focusing on current developments and improvements. The book strikes a balance between delineation and exhaustiveness, with up-to-date refences for readers requiring in-depth coverage. Relevant industrial applications, including pharmaceutical processes, are included. This reference will be a key resource for organic synthesis researchers and students, working in academia and industry. Summarizes mechanistic background with an emphasis on synthetic applications Up to date references allow for locating original papers for experimental procedures Applications in the synthesis of complex molecules and natural products are included to judge the scope and limitations of each reaction

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Shazia Anjum,Elena Soriano,José Luis Marco-Contelles
Publisher : Elsevier Inc. Chapters
Release : 2013-06-25
ISBN : 0128084685
Language : En, Es, Fr & De

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Book Description :

Molecular rearrangements occupy center stage in the development of organic synthesis and, consequently, in the impressive achievements that have resulted in the total synthesis of many complex natural products in the last decades. The purpose of this chapter, in this volume of a book series dedicated to the Studies in Natural Product Chemistry, is to show a set of selected and organized molecular rearrangements based on a personal choice of expertise related to the synthesis of complex bioactive molecules. Our selection addresses [3,3]-sigmatropic rearrangements, which continue to provide excellent opportunities for reaching high chemical diversity, operating in efficient synthetic schemes. [3,3]-Sigmatropic rearrangements, such as the Cope and Claisen rearrangements, are among the most basic and useful transformations in synthetic organic chemistry. This is possibly due to the fact that these rearrangements are efficient methods for the synthesis of quaternary, sterically hindered chiral centers, and for the stereoselective formation of carbon–carbon and carbon–heteroatom bonds. In addition, [3,3]-sigmatropic rearrangements can be easily integrated in, and adapted to, cascade processes as a simple method to prepare complex molecules in atom-efficient reactions. Consequently, in the context of [3,3]-sigmatropic rearrangements, we focus on the transformations of propargylic esters, whose rearrangements, in different experimental conditions, have been largely exploited for the synthesis of interesting key and useful intermediates. The rearrangements can be promoted by protic acids, Lewis acids, and noble metals such as Pt, Au, or Cu salts, or complexes that have recently emerged as the most popular and potent electrophilic activators of alkynes toward a number of nucleophilic agents, under homogeneous conditions.

Modern Physical Organic Chemistry

Modern Physical Organic Chemistry Book
Author : Eric V. Anslyn,Dennis A. Dougherty
Publisher : University Science Books
Release : 2006
ISBN : 9781891389313
Language : En, Es, Fr & De

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Book Description :

Making explicit the connections between physical organic chemistry and critical fields such as organometallic chemistry, materials chemistry, bioorganic chemistry and biochemistry, this book escorts the reader into an area that has been thoroughly updated in recent times.

Polar Rearrangements

Polar Rearrangements Book
Author : Laurence M. Harwood,Lecturer in Chemistry Laurence M Harwood
Publisher : Oxford University Press, USA
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The general principles of polar rearrangements are brought together in this undergraduate chemistry text, which deals with all the major rearrangements involving electron-deficient atoms or charged intermediates. Reactions involving migration to electron-deficient carbon, nitrogen, oxygen and sulphur, and sigmatropic rearrangements involving polar species, are thus treated in a coherent and consistent manner. Clear discussions of the reaction mechanisms are followed by examples of synthetic applications providing a concise yet comprehensive account of the nature and importance of these processes.

Organic Reactions Volume 102

Organic Reactions  Volume 102 Book
Author : Anonim
Publisher : John Wiley & Sons
Release : 2020-07-08
ISBN : 1119651220
Language : En, Es, Fr & De

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Book Description :

The 102nd volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Anonim
Publisher : Elsevier
Release : 2000-07-04
ISBN : 0080493564
Language : En, Es, Fr & De

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Book Description :

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Houben Weyl Methods of Organic Chemistry Vol E 21e 4th Edition Supplement

Houben Weyl Methods of Organic Chemistry Vol  E 21e  4th Edition Supplement Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2014-05-14
ISBN : 3131822848
Language : En, Es, Fr & De

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Book Description :

Houben-Weyl is the acclaimed reference series for preparative methods in organic chemistry, in which all methods are organized accor ding to the class of compound or functional group to be synthesized. The Houben-Weyl volumes contain 146 000 product-specific experi mental procedures, 580 000 structures, and 700 000 references. The preparative significance of the methods for all classes of compou nds is critically evaluated. The series includes data from as far back as the early 1800s to 2003. // The content of this e-book was originally published in 1995.

Silver Catalysis in Organic Synthesis 2 Volume Set

Silver Catalysis in Organic Synthesis  2 Volume Set Book
Author : Chao-Jun Li,Xihe Bi
Publisher : John Wiley & Sons
Release : 2019-04-29
ISBN : 3527342818
Language : En, Es, Fr & De

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Book Description :

Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.

Target Organ Toxicity Volume I

Target Organ Toxicity  Volume I Book
Author : Gerald M. Cohen
Publisher : CRC Press
Release : 2020-01-29
ISBN : 1000722368
Language : En, Es, Fr & De

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Book Description :

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Organometallic Chemistry of the Transition Elements

Organometallic Chemistry of the Transition Elements Book
Author : Florian P. Pruchnik
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1489920765
Language : En, Es, Fr & De

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Book Description :

Organometallic chemistry belongs to the most rapidly developing area of chemistry today. This is due to the fact that research dealing with the structure of compounds and chemical bonding has been greatly intensified in recent years. Additionally, organometallic compounds have been widely utilized in catalysis, organic synthesis, electronics, etc. This book is based on my lectures concerning basic organometallic chemistry for fourth and fifth year chemistry students and on my lectures concerning advanced organometallic chemistry and homogeneous catalysis for Ph.D. graduate students. Many recent developments in the area of organometallic chemistry as weIl as homogeneous catalysis are presented. Essential research results dealing with a given class of organometallic compounds are discussed briefly. Results of physicochemical research methods of various organometallic compounds as weIl as their synthesis, properties, structures, reactivities, and applications are discussed more thoroughly. The selection of tabulated data is arbitrary because, often, it has been impossible to avoid omissions. Nevertheless, these data can be very helpful in understanding properties of organometaIlic compounds and their reactivities. All physical data are given in SI units; the interatomic distances are given in pm units in figures and tables. I am indebted to Professor S. A. Duraj for translating and editing this book. His remarks, discussions, and suggestions are greatly appreciated. I also express gratitude to Virginia E. Duraj for editing and proofreading.

Advanced Organic Chemistry

Advanced Organic Chemistry Book
Author : Bernard Miller
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This text covers the principles of mechanisms of organic reactions in a qualitative way and features a chapter on heterocyclic chemistry. End of chapter exercises feature references to current literature

Science of Synthesis Knowledge Updates 2012

Science of Synthesis Knowledge Updates 2012 Book
Author : R. Alan Aitken,Erick M. Carreira
Publisher : Georg Thieme Verlag
Release : 2014-05-14
ISBN : 3131788216
Language : En, Es, Fr & De

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Book Description :

The Science of Synthesis Editorial Board,together with the volume editors and authors, is constantly reviewing the whole field of sy nthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Fou r annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology . // Content of this volume: Acylsilanes, Asymmetric Lithiation, 1,2,3-Trithioles, Their Benzo Derivatives, Selenium and Tellurium A nalogues, 1,2,4-Triazolium Salts, Dithiadiazolium Salts and Dithiadiazolyl-Containing Compounds, 1,4-Dithiins, Pyridopyridazines, Pt eridines and Related Structures, Pteridines and Related Structures, 1,2,3-Triazines and Phosphorus Analogues, 1,2,3-Triazines and Ph osphorus Analogues, 1,2,4-Triazines, 1,3,5-Triazines and Phosphorus Analogues, Synthesis by Substitution of Hydrogen. // The content of this e-book was originally published in June 2012.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Anonim
Publisher : Newnes
Release : 2013-06-25
ISBN : 0444626328
Language : En, Es, Fr & De

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Book Description :

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable resource for natural products and medicinal chemistry

International Symposium on Bioorganic Chemistry

International Symposium on Bioorganic Chemistry Book
Author : International Symposium on Bioorganic Chemistry
Publisher : Unknown
Release : 1986
ISBN : 9780897663373
Language : En, Es, Fr & De

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Book Description :

Download International Symposium on Bioorganic Chemistry book written by International Symposium on Bioorganic Chemistry, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dynamic Stereochemistry of Chiral Compounds

Dynamic Stereochemistry of Chiral Compounds Book
Author : Christian Wolf
Publisher : Royal Society of Chemistry
Release : 2008
ISBN : 0854042466
Language : En, Es, Fr & De

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Book Description :

A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.

Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences Book
Author : Thomas Lincoln Casey,Gilbert Van Ingen,Charles Lane Poor,Edmund Otis Hovey,Ralph Winfred Tower
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annals of the New York Academy of Sciences book written by Thomas Lincoln Casey,Gilbert Van Ingen,Charles Lane Poor,Edmund Otis Hovey,Ralph Winfred Tower, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Carbon Carbon Bond Formation

Carbon Carbon   Bond Formation Book
Author : G. Pattenden
Publisher : Elsevier
Release : 1992-09-08
ISBN : 008091246X
Language : En, Es, Fr & De

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Book Description :

Volume 3 covers carbon-to-carbon single bond forming reactions involving sp3, sp2 and sp carbon centers, but only those which do not involve additions to C-X &pgr;-bonds. The volume first compares and contrasts the alkylation reactions of all types of sp3 carbon nucleophiles and also covers vinyl and alkynyl carbanions. Following on from Volume 2, a separate section covers Friedel-Crafts alkylation reactions, which is complemented by discussions of polyene cyclizations and electrophilic transannular cyclizations in synthesis. Coupling reactions leading to &agr;-bond formation, and involving all types of combinations ofsp3, sp2 and sp carbon centers are next covered, including those reactions based on pinacol, acyloin and phenol oxidative coupling reactions, and also the Kolbe reaction. Rearrangement reactions, leading to carbon-to-carbon &agr;-bond formation, are often used in a clever manner in synthesis. The volume includes all those rearrangement reactions based on intermediate carbonium ions and carbanions, and also includes the benzil-benzilic acid and the Wolff rearrangements. The volume closes with coverage of carbonylation reactions, and the use of carbene insertion reactions into the C-H bond in synthesis.

Gold Catalyzed Cycloisomerization Reactions Through Activation of Alkynes

Gold Catalyzed Cycloisomerization Reactions Through Activation of Alkynes Book
Author : Antoine Simonneau
Publisher : Springer
Release : 2014-05-21
ISBN : 3319067079
Language : En, Es, Fr & De

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Book Description :

Antoine Simonneau's thesis highlights the development of new cycloisomerization reactions through the activation of alkynes with gold complexes. First Simonneau describes 1,6-enynes and their direct conversion into allenes through 1,5-hydride or ester migration processes. The author and his team used appropriate propargylic functional groups to achieve this conversion. This study shows that O-tethered 1,6-enynes carrying a strained cycloalkane at the propargylic position could undergo a cyclopropanation/ring expansion cascade reaction. The author employed this rearrangement as the starting point in the design of a new macro cycle synthesis. The next part of the thesis focuses on the cycloisomerization of diynes involving as the first step of the process the rearrangement of one alkyne partner into an allene thanks to a gold-catalyzed 1,3-shift of a propargylic ester. The thesis discloses a new cycloisomerization pattern featuring a 1,5-carbonyl transfer, giving rise to unprecedented cross-conjugated diketones. In the final part of the research, Simmoneau investigates the gold-catalyzed cycloisomerization mechanism of 1,6-enynes and questions the intermediacy of gold acetylides. By the means of NMR and mass spectrometry analysis, theoretical treatment and solution experiments, it was possible to rule out the involvement of these species in the catalytic cycle. This thesis has led to a number of publications in high-impact journals.

Comprehensive Heterocyclic Chemistry II Six membered rings with one heteroatom and fused carbocyclic derivatives

Comprehensive Heterocyclic Chemistry II  Six membered rings with one heteroatom and fused carbocyclic derivatives Book
Author : Alan R. Katritzky,Charles Wayne Rees,Eric F. V. Scriven
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Comprehensive Heterocyclic Chemistry II Six membered rings with one heteroatom and fused carbocyclic derivatives book written by Alan R. Katritzky,Charles Wayne Rees,Eric F. V. Scriven, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Summaries of Projects Completed

Summaries of Projects Completed Book
Author : National Science Foundation (U.S.)
Publisher : Unknown
Release : 2021-12-09
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Summaries of Projects Completed book written by National Science Foundation (U.S.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.