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Quorum Sensing

Quorum Sensing Book
Author : Giuseppina Tommonaro
Publisher : Academic Press
Release : 2019-04-15
ISBN : 0128149051
Language : En, Es, Fr & De

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Book Description :

Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals. Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists. Describes Quorum Sensing (QS) mechanisms from their molecular basis, to their clinical applications Spans several fields in relation to QS, including microbiology, chemistry, biochemistry and ecology Considers QS as an approach to the discovery of new antibiotics Looks at QS as a means to understand the microbial world and towards use of bacteria and their products in biotechnological applications Summarizes key results on QS mechanisms' molecular basis and fields of application

Implication of Quorum Sensing System in Biofilm Formation and Virulence

Implication of Quorum Sensing System in Biofilm Formation and Virulence Book
Author : Pallaval Veera Bramhachari
Publisher : Springer
Release : 2019-01-28
ISBN : 9811324298
Language : En, Es, Fr & De

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Book Description :

This book illustrates the importance and significance of Quorum sensing (QS), it’s critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.

Trends in Quorum Sensing and Quorum Quenching

Trends in Quorum Sensing and Quorum Quenching Book
Author : Jamuna A. Bai,V. Ravishankar Rai
Publisher : CRC Press
Release : 2020-05-25
ISBN : 9780367224288
Language : En, Es, Fr & De

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Book Description :

The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies for quorum sensing inhibition. The topics covered are multidisciplinary and wide ranging from quorum sensing phenomenon in pathogenic bacteria, food spoilers and agriculturally relevant bacteria. The potential application of quorum sensing inhibitors including small molecules, bioactives, natural compounds and quorum quenching enzymes in controlling bacterial infections, in aquaculture and biofouling are also discussed. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests, various tropical soils and oceans. Key features: Covers the fundamental aspects and the progresses and the challenges in the field and the future trend Reviews quorum sensing in gram positive and gram negative bacteria of clinical, agricultural and industrial relevance Discusses the application of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on bacterial signaling mechanism V. Ravishankar Rai earned his MSc and PhD from the University of Mysore, India. Currently, Dr. Rai is working in the Department of Studies in Microbiology, University of Mysore, India. He has been awarded fellowship of UNECSO Biotechnology Action Council, Paris (1996) to visit Murdoch University, Perth, Indo-Israel Cultural Exchange Fellowship (1998), Biotechnology Overseas fellowship, Government of India (2008), Indo-Hungarian Exchange fellowship to visit Budapest (2011) and Bilateral Exchange Fellowship by Indian National Academy of Sciences to visit Turkey (2016). He was invited by Academia Sinica, Taiwan as Visiting Fellow (2010). He received Incoming fellowship from Cardiff University, United Kingdom (2017). Recently, he was invited by Centre of Excellence for Biomedical and Biomaterials Research, Mauritius (2018). He has been awarded Bilateral Exchange Fellowship by Indian National Academy of Sciences to visit Germany (2019), Eric Ojala fund International Travel Fellowship to visit Massey University (2019) and Cambridge-Hamied Visiting Lecture Scheme (2020). Jamuna A Bai has completed her MSc and PhD in Microbiology from University of Mysore, India. She is currently working as an Assistant Professor in JSS Academy of Higher Education Research, India. She has previously worked as Research Associate in UGC sponsored University with Potential Excellence Project and ICMR Senior Research Fellow in University of Mysore, India. Her research interest includes food safety, role of quorum sensing and biofilms in food-related bacteria and developing quorum-sensing inhibitors. She is presently working on antimicrobial application of functionalized nanomaterials against pathogens.

Implication of Quorum Sensing and Biofilm Formation in Medicine Agriculture and Food Industry

Implication of Quorum Sensing and Biofilm Formation in Medicine  Agriculture and Food Industry Book
Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
Release : 2019-11-26
ISBN : 9813294094
Language : En, Es, Fr & De

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Book Description :

The book illustrates the role of quorum sensing in the food industry, agriculture, veterinary sciences, and medicine. It highlights the importance of quorum sensing in regulating diverse cellular functions in microbes, including virulence, pathogenesis, controlled-gene expression systems, and antibiotic resistance. This book also describes the role of quorum sensing in survival behavior and antibiotic resistance in bacteria. Further, it reviews the major role played by quorum sensing in food spoilage, biofilm formation, and food-related pathogenesis. It also explores the methods for the detection and quantification of quorum sensing signals. It also presents antimicrobial and anti-quorum sensing activities of medicinal plants. Finally, the book elucidates a comprehensive yet representative description of basic and applied aspects of quorum sensing inhibitors. This book serves an ideal guide for researchers to understand the implications of quorum sensing in the food industry, medicine, and agriculture.

Quorum Sensing

Quorum Sensing Book
Author : Kendra P. Rumbaugh
Publisher : Humana Press
Release : 2016-08-23
ISBN : 9781493961627
Language : En, Es, Fr & De

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Book Description :

Since its early days in the 1990s, the Quorum Sensing (QS) field has grown from a few dozen laboratories, investigating the pathways, proteins, and chemicals that facilitate signaling in bacteria, to hundreds of groups that have integrated evolutionary biology, computer science, mathematics, engineering, and metagenomics to create an ever-expanding and dynamic field. In Quorum Sensing: Methods and Protocols, expert researchers provide an in-depth set of diverse protocols that span this broad area of study. Broken into three detailed sections, the volume covers the detection, isolation, and characterization of the QS signals made by both Gram- and Gram+ bacteria, determination of the function of QS signals in vivo, and the development of QS disruption strategies. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known experimental pitfalls. Comprehensive and cutting-edge, Quorum Sensing: Methods and Protocols serves as an invaluable collection of easily accessible techniques for scientists seeking to further our knowledge about bacterial communication and its relation to humanity.

Quorum Sensing vs Quorum Quenching A Battle with No End in Sight

Quorum Sensing vs Quorum Quenching  A Battle with No End in Sight Book
Author : Vipin Chandra Kalia
Publisher : Springer
Release : 2014-09-29
ISBN : 8132219821
Language : En, Es, Fr & De

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Book Description :

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

Fundamentals of and Applications Based on Quorum Sensing and Quorum Sensing Interference

Fundamentals of  and Applications Based on  Quorum Sensing and Quorum Sensing Interference   Book
Author : Cristina García-Aljaro,Ana Otero,Tom Defoirdt
Publisher : Frontiers Media SA
Release : 2020-01-23
ISBN : 2889633810
Language : En, Es, Fr & De

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Book Description :

Background Bacteria use quorum sensing (QS) circuits to coordinate various activities (among which biofilm formation and the expression of virulence factors) based on the presence of signaling molecules. Different families of signal molecules have been identified in Gram positive and Gram negative bacteria (e.g. autoinducer peptides and acyl homoserine lactones). Similarly, different quorum sensing antagonists interfering with these system have been found in nature, promoting a new and promising field of research, quorum sensing interference. One of the most intensively studied applications of quorum sensing interference is its use as an alternative or synergycally with antibiotics to fight (antibiotic-resistant) bacterial pathogens. Many studies have been published claiming quorum sensing inhibitory activity of natural and synthetic compounds. However, after decades of research, several questions regarding the suitability of this approach to fight bacterial pathogens remain unanswered, including the risk that pathogens will develop resistance against quorum quenching. Meanwhile, the interest in quorum sensing has increased considerably, and this has broadened the fields where it can find biotechnological, environmental and industrial applications, such as anti biofouling, steering fermentations, bioremediation and wastewater treatment. Goal and scope The goal of this Research Topic is to broaden the knowledge of the phenotypes regulated by quorum sensing and the advances in quorum sensing interference. Deciphering microorganism language and the different phenotypes regulated by microbial signalling systems is a frontier for the development of new tools for the management of microorganisms to fulfil human needs with a broad application in different areas such as medicine, environmental sciences and industry.

Biotechnological Applications of Quorum Sensing Inhibitors

Biotechnological Applications of Quorum Sensing Inhibitors Book
Author : Vipin Chandra Kalia
Publisher : Springer
Release : 2018-05-30
ISBN : 9811090262
Language : En, Es, Fr & De

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Book Description :

This book discusses the practical applications of quorum sensing inhibitors for both human and plant health. Quorum sensing inhibitors that disrupt microbial biofilms can be employed to treat bacterial infections. The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors. Quorum sensing is the mechanism through which bacteria develop antibiotic resistance. Intended to provide a clearer understanding of the practical applications of quorum sensing inhibitors, the book details how the problem of antibiotic resistance can be countered through the intelligent application of quorum sensing inhibitors.

Quorum Sensing and its Biotechnological Applications

Quorum Sensing and its Biotechnological Applications Book
Author : Vipin Chandra Kalia
Publisher : Springer
Release : 2018-08-11
ISBN : 9811308489
Language : En, Es, Fr & De

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Book Description :

This book delves into the biotechnological applications of Quorum sensing (QS)- a peculiar gene-regulatory process of some microorganisms. Quorum Sensing allows a large bacterial population to work together in a coordinated manner to carry out metabolic activities, which individual bacterium cannot. The different chapters describe how, associating bioremediation process with energy generation is an economical proposal, for reducing pollution and managing biowastes. The book discusses how QS can be exploited for biotechnological applications in generating bioproducts, bioenergy, bioremediation, biosensors, health and agricultural activities. It further highlights how QS is becoming an integral part of synthetic biology for genetic circuits for producing: (i) novel products, (ii) biosensors, (iii) bioactive molecules, etc. The book is divided into different sections for a clear understanding of the applicability of QS in, the Environment, Energy, Agriculture and Health sectors.

Fundamentals of Quorum Sensing Analytical Methods and Applications in Membrane Bioreactors

Fundamentals of Quorum Sensing  Analytical Methods and Applications in Membrane Bioreactors Book
Author : Anonim
Publisher : Elsevier
Release : 2018-05-21
ISBN : 0444640657
Language : En, Es, Fr & De

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Book Description :

Fundamentals of Quorum Sensing, Analytical Methods and Applications in Membrane Bioreactors, Volume 81, describes the novelty of membrane bioreactors for the treatment of wastewater and the removal of specific contaminants that affect water quality or pose harm to humans. Topics of note in the updated release include Water Chemistry and Microbiology, Quorum Sensing as Bacterial Communication Language, the Effects of Quorum Sensing, Quorum Quenching, Membrane Bioreactors for Wastewater Treatment, Removal of Specific Contaminants, Microextraction Techniques, and the Determination of Quorum Sensing Chemicals. The contents of this updated volume will be appealing to a wide range of researchers as the authors of most chapters are experts in their respective fields with numerous published studies. Gives an overview of quorum sensing as a communication language for bacteria and quorum quenching mediated approaches to mitigate or eliminate the effects of quorum sensing Presents various sensitive determination methods where a variety of microextraction strategies is used for preconcentration of analyte(s)

Quorum Sensing

Quorum Sensing Book
Author : Saurabh Sudha Dhiman
Publisher : Unknown
Release : 2021
ISBN : 9780841298606
Language : En, Es, Fr & De

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Book Description :

New developments in researching quorum sensing Microbial growth affects industries as diverse as agriculture, engineering, and medicine, to name a few. As more precise solutions are needed for modern challenges, researchers must understand the mechanisms of microbial growth. Quorum sensing (QS) is an essential part of microbial growth, and this work contains key areas such as signal molecules; mechanisms of signal transfer, role, and type of signal receptors; quorum quenching; characterization of microbial plasmids in quorum sensing; and novel and underexplored molecules involved in QS, along with therapeutic roles of quorum sensing inhibitors. This volume is perfect for researchers working on microbiology or biotechnology.

Investigating the Role of Black Carbon in S Pneumoniae Quorum Sensing

Investigating the Role of Black Carbon in S  Pneumoniae Quorum Sensing Book
Author : Charlotte Morrissey
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Bacteria secrete and sense extracellular signals from neighboring members of a colony in a phenomenon called quorum sensing. These signals vary from species to species but allow for changes in the behavior of a colony based on changes to cell density, environment, or nutrient supply. Of particular interest to human health is the quorum sensing system of Streptococcus pneumoniae as this pathogen accounts for around one million infection-related deaths per year and is difficult to combat largely due to its ability to form biofilms. These polysaccharide coverings protect entire bacterial colonies from antimicrobial agents as well as allow them to adhere well to the nasopharynx passages of organisms, making them hard to remove. To gain a better understanding of quorum sensing in S. pneumoniae, we propose experiments to study its biofilm formation and its interactions with black carbon, a biochar shown previously to interact with the quorum sensing systems of related bacteria species. We hypothesize that inhalation of black carbon will aggravate a S. pneumoniae infection by promoting biofilm-forming quorum sensing systems making it easier for this bacteria to adhere to and remain on mammal lungs. We propose to first explore the competency and biofilm quorum sensing systems in S. pneumoniae to identify any shared signals between the two using RT-PCR and FITC-Dextran experiments. Further experiments will analyze black carbon particles’ effects on bacterial colonies grown on plates and present on the lung linings of mammals.

Quorum Sensing Involvement in T4 Bacteriophage Infection

Quorum Sensing Involvement in T4 Bacteriophage Infection Book
Author : Muhammad Kamran Taj
Publisher : Unknown
Release : 2014-09-05
ISBN : 9783656723356
Language : En, Es, Fr & De

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Book Description :

Doctoral Thesis / Dissertation from the year 2014 in the subject Biology - Micro- and Molecular Biology, grade: 1, Kunming University of Science and Technology, course: Environmental Microbiology, language: English, comment: A dissertation submitted in partial fulfillment of the requirement for the degree of doctor of environmental biology, abstract: Quorum sensing (QS) is an important way to communicate information between bacteria. Bacteria used different quorum sensing molecule for communication and these signals molecules are called autoinducer (AI). These autoinducers are produced and released by the quorum sensing bacteria to levels dominating the increasing cell-population density. The attainment of minimal threshold stimulatory concentration of an autoinducer leads to an alteration in gene expression. Both Gram-positive and Gram-negative bacteria are capable of using quorum sensing communication circuits for regulating a diverse array of physiological activities. These activities include symbiosis, competence, virulence, conjugation, antibiotic production, sporulation, motility and biofilm formation. The Gram-negative bacteria use acylated homoserine lactones as autoinducers, while Gram-positive bacteria use processed oligo-peptides to communicate. In the field of quorum sensing revealed, cell to cell communication via autoinducers both within and between bacterial species. The establishment of enormous data in this field suggests autoinducers acquiring specific responses from host organisms. Despite the difference in chemical signals, signal relay mechanisms and the target genes controlled by the bacterial quorum sensing systems, the ability to communicate with one another allows bacteria to coordinate the gene expression as well as the behavior of the entire community. This process presumably confers upon the bacteria some of the qualities of higher organisms. The evolution of quorum sensing systems in bacteria thus could have been one of the early steps i

Evidence of Quorum Sensing Activity in a Wastewater treament Environment

Evidence of Quorum Sensing Activity in a Wastewater treament Environment Book
Author : Rohit Gupta
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Evidence of Quorum Sensing Activity in a Wastewater treament Environment book written by Rohit Gupta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Natural products as potential sources of inhibitors of bacterial quorum sensing

Natural products as potential sources of inhibitors of bacterial quorum sensing Book
Author : Vijay Kothari,Haren Gosai,Shreya Raval,Vimla Chaudhary
Publisher : GRIN Verlag
Release : 2015-01-07
ISBN : 3656871205
Language : En, Es, Fr & De

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Book Description :

Scientific Study from the year 2014 in the subject Biology - Micro- and Molecular Biology, grade: A, Nirma University (Institute of Science), course: M.Sc., language: English, abstract: Objective: To investigate the effect of (i) seed extracts of Pongamia pinnata, Pyrus pyrifolia, and Manilkara hexandra, (ii) bacterial pigment prodigiosin, and (iii) three organic solvents (ethanol, methanol, and DMSO), on quorum sensing (QS) in Chromobacterium violaceum. Methods: C. violaceum was challenged with plant extracts prepared by microwave assisted extraction (MAE) method, prodigiosin, and organic solvents. Effect of these test substances on C. violaceum growth, and quorum sensing regulated pigment (violacein) production was studied by broth dilution assay. High performance liquid chromatography (HPLC) was also applied to generate chromatographic fingerprint of the active extracts. Effect of sub-MIC level of the antibiotic streptomycin on quorum sensing regulated pigment production was also studied. Results: P. pinnata seed extracts and prodigiosin were found to possess anti-QS, and M. hexandra and P. pyrifolia seed extracts to possess QS-enhancing effect in C. violaceum. DMSO was found to enhance violacein production, whereas ethanol and methanol reduced violacein production in C. violaceum. Streptomycin at sub-MIC level was able to significantly arrest QS-regulated pigment production in C. violaceum and S. marcescens. Conclusion: Prodigiosin and the seed extracts used in this study could affect quorum sensing in C. violaceum to a notable extent. Results of this study also emphasizes the importance of inclusion of appropriate solvent controls (negative controls) in bioassays designed for screening of antimicrobial and/or anti-QS compounds. Antipathogenic potential of low concentrations of streptomycin was also demonstrated.

Interactions of the Quorum Sensing Regulator TraR of Agrobacterium Tumefaciens with DNA and RNA Polymerase

Interactions of the Quorum Sensing Regulator TraR of Agrobacterium Tumefaciens with DNA and RNA Polymerase Book
Author : Catharine Elizabeth White
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

TraR of A. tumefaciens is a member of the LuxR family of transcriptional regulators, all of which respond to specific N-acylhomoserine lactones that accumulate at high population densities. TraR binds to N-3-oxooctanoyl-L-homoserine lactone (OOHL), which induces dimerization. These complexes can then bind to target binding sites (tra boxes) at TraR-dependent promoters on the Ti plasmid. Structural and biochemical studies indicate that TraR has an N-terminal OOHL binding domain connected by a flexible linker to a C-terminal DNA binding domain (CTD).

Regulation of Quorum Sensing Transcription Factor TraR and Replication of a Tumor inducing Plasmid in Agrobacterium Tumefaciens

Regulation of Quorum Sensing Transcription Factor TraR and Replication of a Tumor inducing Plasmid in Agrobacterium Tumefaciens Book
Author : Yunrong Chai
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genetic studies have shown that the activity of TraR is regulated at the post-translational level by TrIR, a native A. tumefaciens protein that resembles the N-terminal domain of TraR, and an anti-regulator of TraR. I conducted several biochemical studies and showed that TrIR inhibited TraR activity in vitro by forming inactive TrIR:TraR heterodimers.

Mathematical Modelling of Quorum Sensing in Biofilms

Mathematical Modelling of Quorum Sensing in Biofilms Book
Author : Mallory Rose Frederick
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mathematical Modelling of Quorum Sensing in Biofilms book written by Mallory Rose Frederick, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mathematical Modelling of Quorum Sensing in Biofilms

Mathematical Modelling of Quorum Sensing in Biofilms Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Quorum sensing is a cell communication mechanism used to coordinate group behaviour based on population density. A mathematical model of quorum sensing in bacterial biofilms is developed, consisting of a nonlinear diffusion reaction system describing the effects of a growing biofilm on bacterial quorum sensing behaviour. In numerical experiments, the influence of the hydrodynamic environment and nutrient conditions on biofilm growth and quorum sensing behaviour are studied, and flow-facilitated inter-colony communication and spatiotemporal quorum sensing induction patterns are observed. The model is extended to include an impact of quorum sensing on biofilm growth, through the explicit description of EPS, the protective biomass layer surrounding bacterial biofilm cells. The circumstances under which quorum sensing-regulated EPS production is a beneficial strategy for cells are identified. Biofilm colonies that use this strategy have lower cell populations than non-quorum sensing colonies, but may secure nutrients in a space-limited environment and outcompete neighbouring colonies.