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Quantitative Systems Pharmacology

Quantitative Systems Pharmacology Book
Author : Davide Manca
Publisher : Elsevier
Release : 2018-07-18
ISBN : 0444639675
Language : En, Es, Fr & De

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Book Description :

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology Book
Author : Tarek A. Leil,Sergey Ermakov
Publisher : Unknown
Release : 2015-09-07
ISBN : 2889196429
Language : En, Es, Fr & De

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Book Description :

In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases Book
Author : Honghui Zhou,Diane R. Mould
Publisher : Wiley
Release : 2019-03-19
ISBN : 111928919X
Language : En, Es, Fr & De

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Book Description :

Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.

Systems Pharmacology and Pharmacodynamics

Systems Pharmacology and Pharmacodynamics Book
Author : Donald E. Mager,Holly H.C. Kimko
Publisher : Springer
Release : 2016-11-29
ISBN : 3319445340
Language : En, Es, Fr & De

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Book Description :

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

Animal Biotechnology

Animal Biotechnology Book
Author : Ashish S. Verma,Anchal Singh
Publisher : Academic Press
Release : 2020-07-03
ISBN : 0128117109
Language : En, Es, Fr & De

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Book Description :

Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ethics and safety concerns, along with in-depth examples of implications for human health and prospects for the future. New chapters cover animal biotechnology as applied to various disease types and research areas, including in vitro fertilization, human embryonic stem cell research, biosensors, enteric diseases, biopharming, organ transplantation, tuberculosis, neurodegenerative disorders, and more. Highlights the latest biomedical applications of genetically modified and cloned animals, with a focus on cancer and infectious diseases Offers first-hand accounts of the use of biotechnology tools, including molecular markers, stem cells, animal cultures, tissue engineering, ADME and CAM Assay Includes case studies that illustrate safety assessment issues, ethical considerations, and intellectual property rights associated with the translation of animal biotechnology studies

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology Book
Author : Rudy J Richardson,Dale E Johnson
Publisher : Royal Society of Chemistry
Release : 2017-03-01
ISBN : 1782623736
Language : En, Es, Fr & De

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Book Description :

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Approaching Complex Diseases

Approaching Complex Diseases Book
Author : Mariano Bizzarri
Publisher : Springer Nature
Release : 2020-04-17
ISBN : 3030328570
Language : En, Es, Fr & De

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Book Description :

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Preclinical QSP Modeling in the Pharmaceutical Industry An IQ Consortium Survey Examining the Current Landscape

Preclinical QSP Modeling in the Pharmaceutical Industry  An IQ Consortium Survey Examining the Current Landscape Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract : A cross‐industry survey was conducted to assess the landscape of preclinical quantitative systems pharmacology (QSP) modeling within pharmaceutical companies. This article presents the survey results, which provide insights on the current state of preclinical QSP modeling in addition to future opportunities. Our results call attention to the need for an aligned definition and consistent terminology around QSP, yet highlight the broad applicability and benefits preclinical QSP modeling is currently delivering.

Applied Pharmacometrics

Applied Pharmacometrics Book
Author : Stephan Schmidt,Hartmut Derendorf
Publisher : Springer
Release : 2014-12-01
ISBN : 1493913042
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer’s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

Proceedings of the First International Pharmacological Meeting Abstracts

Proceedings of the First International Pharmacological Meeting  Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1962
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Proceedings of the First International Pharmacological Meeting Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Artificial Intelligence for Translational Pharmacology

Artificial Intelligence for Translational Pharmacology Book
Author : Zhi-Liang Ji,Lixia Yao,Kartick Chandra Pramanik,Zhaohui John Cai
Publisher : Frontiers Media SA
Release : 2020-07-28
ISBN : 288963888X
Language : En, Es, Fr & De

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Book Description :

Download Artificial Intelligence for Translational Pharmacology book written by Zhi-Liang Ji,Lixia Yao,Kartick Chandra Pramanik,Zhaohui John Cai, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Quantitative Methods in Human Pharmacology and Therapeutics

Quantitative Methods in Human Pharmacology and Therapeutics Book
Author : Desmond Roger Laurence
Publisher : Unknown
Release : 1959
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Quantitative Methods in Human Pharmacology and Therapeutics book written by Desmond Roger Laurence, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bibliographia Primatologica Anatomy embryology quantitative morphology physiology pharmacology psychobiology primate phylogeny miscellanea

Bibliographia Primatologica  Anatomy  embryology   quantitative morphology  physiology  pharmacology   psychobiology  primate phylogeny   miscellanea Book
Author : Theodore Cedric Ruch
Publisher : Unknown
Release : 1941
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Bibliographia Primatologica Anatomy embryology quantitative morphology physiology pharmacology psychobiology primate phylogeny miscellanea book written by Theodore Cedric Ruch, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Portonovo Conferences I on Endocrine Pharmacology Compartmental Models and Control Systems September 2 7 1974 II on Biomathematics September 27 28 1978

Portonovo Conferences  I  on Endocrine Pharmacology  Compartmental Models and Control Systems  September 2 7  1974  II  on Biomathematics  September 27 28  1978 Book
Author : Anonim
Publisher : Unknown
Release : 1979
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Portonovo Conferences I on Endocrine Pharmacology Compartmental Models and Control Systems September 2 7 1974 II on Biomathematics September 27 28 1978 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacology of the Endocrine System and Related Drugs

Pharmacology of the Endocrine System and Related Drugs Book
Author : Lars Philip Bengtsson,M. Tausk,Daniele Bovet
Publisher : Pergamon
Release : 1971
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacology of the Endocrine System and Related Drugs book written by Lars Philip Bengtsson,M. Tausk,Daniele Bovet, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Catecholamines

Catecholamines Book
Author : Earl Usdin,Arvid Carlsson,Annica Dahlström,Jörgen Engel,Alan R. Liss
Publisher : Unknown
Release : 1984
ISBN : 9780845127087
Language : En, Es, Fr & De

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Book Description :

Download Catecholamines book written by Earl Usdin,Arvid Carlsson,Annica Dahlström,Jörgen Engel,Alan R. Liss, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Improving the Use of G CSF During Chemotherapy Using Physiological Mathematical Modelling

Improving the Use of G CSF During Chemotherapy Using Physiological Mathematical Modelling Book
Author : Morgan Craig
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Dose-limitation or interruption of chemotherapeutic treatment is most often prompted by a decrease in circulating neutrophils, the most abundant white blood cell in the human body. Myelosuppression, or a reduction in absolute neutrophil counts (ANCs) by anti-cancer treatments, is precipitated by the nonspecific killing effect of chemotherapeutic drugs which have toxic effects on noncancerous cells. To mitigate this myelosuppressive effect, patients are frequently administered recombinant human granulocyte colony-stimulating factor (rhG-CSF), an exogenous form of the cytokine G-CSF, which stimulates neutrophil production and release into the blood stream. While the benefits of adjuvant treatment rhG-CSF during chemotherapy are well recognised, the protocols with which it is administered are not well defined and are frequently determined ad libitum by clinicians. To quantify and address the optimisation of the administration of rhG-CSF during chemotherapeutic treatment, we developed a physiological model of granulopoiesis which incorporates the contemporary understanding of the production of neutrophils from the hematopoietic stem cells in the bone marrow. To this physiological model, we incorporated mechanistic pharmacokinetic/pharmacodynamic (PK/PD) models of two drugs, PM00104 (Zalypsis), a chemotherapeutic drug, and rhG-CSF (filgrastim). Through exhaustive parameter estimation using first principles and no data fitting, we successfully predicted clinical data from 172 patients for an average patient undergoing the CHOP14 protocol (6 cycles of 14-day periodic chemotherapy with rhG-CSF administered on days 4-13 post-chemotherapy). We then demonstrated that delaying the administration of rhG-CSF to 6 or 7 days post-chemotherapy allowed for a reduction in the number of filgrastim administrations from ten to four or even three while maintaining or improving the neutrophil nadir. We also investigated the effects of PK variability on the model's predictions by incorporating population PK (PopPK) models of both drugs. Using five different variability scenarios and cohorts of 500 in silico patients per scenario, we established that there are no statistically significant differences between a typical patient and the population in the model's predictions with respect to three crucial clinical endpoints, namely the time to ANC nadir, the ANC nadir, and the area under the concentration-effect curve. The model's robustness to PK variability allows for the scaling up from the individual to population level. Motivated by the use of rhG-CSF in other disease-states, namely periodic pathologies like cyclical neutropenia, we next endeavoured to contextualise the model within dynamic diseases. By bringing to light that the cytokine paradigm is broken when exogenous cytokine mimetics are administered, we developed a novel physiological PK model for G-CSF incorporating both unbound and bound concentrations. The updated PK model prompted changes to the PD model since we could now track the concentrations of bound G-CSF. We showed that the mass-action equilibrium hypopthesis for bound and unbound drugs is not valid and led to overestimations of the renal clearance of G-CSF. We also successfully reproduced clinical data in a variety of settings (exogenous G-CSF alone, PM00104 alone, CHOP14 protocol) and clarified the mechanisms underlying the body's response to both drugs. Lastly, we discussed the potential of quantitative systems pharmacology in both drug development and translational medicine by using the physiological PK/PD model we developed.

Pharmacology and Therapeutics

Pharmacology and Therapeutics Book
Author : Arthur Grollman
Publisher : Unknown
Release : 1960
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacology and Therapeutics book written by Arthur Grollman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

American Men and Women of Science

American Men and Women of Science Book
Author : Anonim
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download American Men and Women of Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

U S Environmental Protection Agency Library System Book Catalog

U S  Environmental Protection Agency Library System Book Catalog Book
Author : United States. Environmental Protection Agency. Library Systems Branch
Publisher : Unknown
Release : 1970
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Includes the monographic collection of the 28 libraries comprising the Library System of the Environmental Protection Agency.