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Quantitative Magnetic Resonance Imaging

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Quantitative Magnetic Resonance Imaging

Quantitative Magnetic Resonance Imaging Book
Author : Nicole Seiberlich,Vikas Gulani,Adrienne Campbell-Washburn,Steven Sourbron,Mariya Ivanova Doneva,Fernando Calamante,Houchun Harry Hu
Publisher : Academic Press
Release : 2020-11-27
ISBN : 0128170581
Language : En, Es, Fr & De

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Book Description :

Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Theory of Quantitative Magnetic Resonance Imaging

Theory of Quantitative Magnetic Resonance Imaging Book
Author : Hernán Jara
Publisher : World Scientific Publishing Company
Release : 2013-04-04
ISBN : 9814518387
Language : En, Es, Fr & De

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Book Description :

qMRI is a rapidly evolving scientific field of high current interest because it has the potential of radically changing the clinical and research practices of magnetic resonance imaging (MRI). This focuses solely on the theoretical aspects of qMRI, which are treated and analyzed at three different spatial scales, specifically: i) the quantum physics scale of individual spins; ii) the semi-classical physics scale of spin packets; and iii) the imaging scale of voxels. Topics are presented paying particular attention to theoretical unification and mathematical uniformity.

Fast Quantitative Magnetic Resonance Imaging

Fast Quantitative Magnetic Resonance Imaging Book
Author : Guido Buonincontri,Joshua Kaggie,Martin Graves
Publisher : Morgan & Claypool Publishers
Release : 2020-02-20
ISBN : 1681736950
Language : En, Es, Fr & De

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Book Description :

Among medical imaging modalities, magnetic resonance imaging (MRI) stands out for its excellent soft-tissue contrast, anatomical detail, and high sensitivity for disease detection. However, as proven by the continuous and vast effort to develop new MRI techniques, limitations and open challenges remain. The primary source of contrast in MRI images are the various relaxation parameters associated with the nuclear magnetic resonance (NMR) phenomena upon which MRI is based. Although it is possible to quantify these relaxation parameters (qMRI) they are rarely used in the clinic, and radiological interpretation of images is primarily based upon images that are relaxation time weighted. The clinical adoption of qMRI is mainly limited by the long acquisition times required to quantify each relaxation parameter as well as questions around their accuracy and reliability. More specifically, the main limitations of qMRI methods have been the difficulty in dealing with the high inter-parameter correlations and a high sensitivity to MRI system imperfections. Recently, new methods for rapid qMRI have been proposed. The multi-parametric models at the heart of these techniques have the main advantage of accounting for the correlations between the parameters of interest as well as system imperfections. This holistic view on the MR signal makes it possible to regress many individual parameters at once, potentially with a higher accuracy. Novel, accurate techniques promise a fast estimation of relevant MRI quantities, including but not limited to longitudinal (T1) and transverse (T2) relaxation times. Among these emerging methods, MR Fingerprinting (MRF), synthetic MR (syMRI or MAGIC), and T1‒T2 Shuffling are making their way into the clinical world at a very fast pace. However, the main underlying assumptions and algorithms used are sometimes different from those found in the conventional MRI literature, and can be elusive at times. In this book, we take the opportunity to study and describe the main assumptions, theoretical background, and methods that are the basis of these emerging techniques. Quantitative transient state imaging provides an incredible, transformative opportunity for MRI. There is huge potential to further extend the physics, in conjunction with the underlying physiology, toward a better theoretical description of the underlying models, their application, and evaluation to improve the assessment of disease and treatment efficacy.

Quantitative Magnetic Resonance Flow Imaging

Quantitative Magnetic Resonance Flow Imaging Book
Author : Jill Fredrickson
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Quantitative Magnetic Resonance Flow Imaging book written by Jill Fredrickson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Quantitative MRI in Cancer

Quantitative MRI in Cancer Book
Author : Thomas E. Yankeelov,David R. Pickens,Ronald R. Price
Publisher : Taylor & Francis
Release : 2011-09-13
ISBN : 1439820589
Language : En, Es, Fr & De

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Book Description :

Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications. The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study. Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

Quantitative Magnetic Resonance Imaging with Magnetic Nanoparticles

Quantitative Magnetic Resonance Imaging with Magnetic Nanoparticles Book
Author : Codi Amir Gharagouzloo
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The ability to measure structural and functional features of health and disease is limited by our current clinical imaging toolbox. For angiography, approximately 1-5 million people in the U.S. are not candidates for contrast-enhanced magnetic resonance angiography (CE-MRA) because of renal malfunction. For cancer, it is difficult to predict the extent the enhanced permeability and retention (EPR) effect will be present leading to drug accumulation in tumors. Ferumoxytol has previously been used as a surrogate to assess nanoparticle accumulation, but negative contrast suffers from poor discrimination of nanoparticle localization. For neuroimaging, MRI is a powerful technique for probing the deep brain but can only provide semi-quantitative information. Cerebral blood volume (CBV) is an important indicator of tissue health and function, however current techniques are 15-30% inaccurate, and only the relative CBV is typically measured to assess function. Currently, only nuclear medicine provides an effective means of absolute quantification of contrast agent induced signal. However, the radioisotopes involved in these procedures are hazardous, and thus the use of nuclear medicine is not warranted for repeat structural and functional imaging. Here we demonstrate a novel technique that can produce CE-MRAs using magnetic nanoparticles including the FDA approved super paramagnetic iron-oxide nanoparticle (SPION) ferumoxytol with very high Contrast to Noise Ratio (CNR) in cardiovascular, cerebral, and tumor imaging in mice and rats. First, the technique is established and shown to measure clinically relevant concentrations of ferumoxytol with high fidelity range in mice. Next, a unique feature of the methodology to produce high-contrast images of purely T1-weighted signal is employed to unambiguously delineate nanoparticle accumulation in a PC3 subcutaneous tumor model with ferumoxytol accumulation 24 hours after just one dose. From this, contrast efficiency was produced compared to standard techniques with the additional benefit that pre-contrast images are not necessitated. Finally, we show unprecedented accuracy in measuring the CBV in absolute terms throughout the whole rat brain. We create a quantitative blood volume atlas and demonstrate that absolute functional measurements of CBV can be assessed by comparing the awake, CO2-challenged and anesthetized states. The method is anchored in theory and is compatible with existing clinical SPION formulations and scanners. Thus QUTE-CE shows high potential for quantitative imaging immediately applicable to human scans.

Quantitative MRI of the Spinal Cord

Quantitative MRI of the Spinal Cord Book
Author : Julien Cohen-Adad,Claudia Wheeler-Kingshott
Publisher : Academic Press
Release : 2014-01-16
ISBN : 0123972825
Language : En, Es, Fr & De

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Book Description :

Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord. Chapters authored by international experts in the field of MRI of the spinal cord Contains “cooking recipes —examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice Ideal for clinical settings

Quantitative Magnetic Resonance Imaging and Spectroscopy of Vertebral Bone Marrow Addressing Confounding Effects in the Measurement of Fat Fraction and Apparent Diffusion Coefficient

Quantitative Magnetic Resonance Imaging and Spectroscopy of Vertebral Bone Marrow  Addressing Confounding Effects in the Measurement of Fat Fraction and Apparent Diffusion Coefficient Book
Author : Michael Dieckmeyer
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Quantitative Magnetic Resonance Imaging and Spectroscopy of Vertebral Bone Marrow Addressing Confounding Effects in the Measurement of Fat Fraction and Apparent Diffusion Coefficient book written by Michael Dieckmeyer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Quantitative Magnetic Resonance Imaging to Evaluate Patients with Liver Cirrhosis

Quantitative Magnetic Resonance Imaging to Evaluate Patients with Liver Cirrhosis Book
Author : Robert A. D. Scott
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Quantitative Magnetic Resonance Imaging to Evaluate Patients with Liver Cirrhosis book written by Robert A. D. Scott, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Quantitative Magnetic Resonance Imaging Biomarkers for Diffuse Liver Disease Technical Development and Validation

Quantitative Magnetic Resonance Imaging Biomarkers for Diffuse Liver Disease  Technical Development and Validation Book
Author : Xiaoke Wang
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder hallmarked by abnormal deposition of fat, i.e.: hepatic steatosis. NAFLD can take the form of non-alcoholic steatohepatitis (NASH) or isolated steatosis. Both forms of NAFLD can cause chronic liver injuries which leads to the progression into liver fibrosis. At the same time, NAFLD is a known risk factor of type-II diabetes and premature cardiovascular diseases. Although liver fibrosis is less common than NAFLD, it has serious complications such as liver failure. Cirrhosis as a form of advanced fibrosis is a risk factor of hepatocellular carcinoma. Effective treatments are emerging for NAFLD and liver fibrosis. Lifestyle intervention has been demonstrated to reduce hepatic steatosis and inflammation. In the case of viral hepatitis, treatment for hepatitis C virus infection often leads to the reversal of liver fibrosis (even in patients with cirrhosis). The accurate evaluation of hepatic steatosis and fibrosis using non-invasive magnetic resonance imaging (MRI) methods are needed to improve the diagnosis and treatment monitoring of patients afflicted by these conditions. Chemical shift encoded (CSE)-MRI has been established as a quantitative imaging biomarker (QIB) for hepatic steatosis. In this dissertation, the effect of non-standardized spectral model of fat was evaluated such that meaningful comparisons can be made between results obtained at different research and clinical sites. A T[subscript 1]-corrected variable flip angle (VFA) CSE-MRI was also proposed and rigorously evaluated for fat quantification in the hope of improving the precision of CSE-MRI fat quantification. Quantitative diffusion MRI using an intra-voxel incoherent motion (IVIM) model and T[subscript 2] mapping have shown promise for the evaluation of liver fibrosis. However, some additional development and validation is required for them to be recognized as QIBs. In this dissertation, a novel acetone-based diffusion phantom was proposed to provide a controlled environment for the development of quantitative diffusion MRI techniques. Further, to enable the quantification of T[subscript 2] from the water signal (parenchyma) and simultaneous quantification of R[subscript 2]*, a novel phase-based T[subscript 2] mapping technique was developed with its feasibility in the liver demonstrated.

Development and Application of Quantitative Magnetic Resonance Imaging Methods

Development and Application of Quantitative Magnetic Resonance Imaging Methods Book
Author : Melissa Schall
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Development and Application of Quantitative Magnetic Resonance Imaging Methods book written by Melissa Schall, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Parietal Lobe and Schizophrenia

The Parietal Lobe and Schizophrenia Book
Author : Robert Matthew Donnino
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Parietal Lobe and Schizophrenia book written by Robert Matthew Donnino, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Quantitative Magnetic Resonance Measurements of Porous Media

Quantitative Magnetic Resonance Measurements of Porous Media Book
Author : Sarah Vashaee
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Magnetic resonance imaging (MRI) is a powerful tool for the non-destructive measurement of fluid content and fluid behavior in porous media. The essential factor in quantitative MRI of such systems is a reliable measure of fluid quantity in the pore space. Quantitative imaging is impaired in many cases by non-uniform B1 fields in the sample space. In this thesis a novel method is described for mapping B1 inhomogeneities based on measurement of the B1 field employing centric-scan pure phase encode MRI measurements. The resultant B1 map is employed to correct B1 related non-uniformities in MR profiles, which leads to quantitative density profiling. The new B1 mapping technique is also employed to investigate B1 induced MRI artifacts by analyzing image distortions surrounding two geometrically identical metallic strips of aluminum and lead. Quantitative density profiles may be acquired in porous media with a spatially selective adiabatic inversion pulse, which is immune to B1 field non-uniformities. The pulse is applied in the presence of a slice selective magnetic field gradient to restrict the field of view to a region of interest in which the B1 field is fairly uniform. This is advantageous in axial profiling of petroleum reservoir core samples and core plugs in which the sample of interest may be much longer than the natural field of view defined by the RF probe and region of constant magnetic field gradient. The adiabatic slice selection lends itself to a spatially selective T2 distribution measurement when a CPMG pulse sequence follows the slice selection. This method is an alternative to MRI-based techniques for T2 mapping in porous media when T2 is required to be measured at only a few positions along the sample, and a resolution of 5 mm is acceptable. The above T2 distribution mapping method is compared with spin-echo SPI (SESPI) and DANTE-Z CPMG methods in terms of spatial resolution, minimum observable T2 and sensitivity. Finally, multi-slice T2 measurement employing the longitudinal Hadamard encoding technique and adiabatic inversion pulses is discussed. The method has an inherent sensitivity advantage over corresponding slice-by-slice local T2 measurements."--Pages ii-iii.

Relationship Between Quantitative MRI Biomarkers and Patient Reported Outcome Measures After Cartilage Repair Surgery A Systematic Review

Relationship Between Quantitative MRI Biomarkers and Patient Reported Outcome Measures After Cartilage Repair Surgery  A Systematic Review Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Background: Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear. Quantitative magnetic resonance imaging (qMRI) allows for a noninvasive biochemical evaluation of cartilage and may offer advantages in monitoring outcomes after cartilage repair surgery. Hypothesis: qMRI sequences will correlate with early pain and functional measures. Study Design: Systematic review; Level of evidence, 3. Methods: A PubMed search was performed with the following search terms: knee AND (cartilage repair OR cartilage restoration OR cartilage surgery) AND (delayed gadolinium-enhanced MRI OR t1-rho OR T2 mapping OR dgemric OR sodium imaging OR quantitative imaging). Studies were included if correlation data were included on quantitative imaging results and patient outcome scores. Results: Fourteen articles were included in the analysis. Eight studies showed a significant relationship between quantitative cartilage imaging and patient outcome scores, while 6 showed no relationship. T2 mapping was examined in 11 studies, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in 4 studies, sodium imaging in 2 studies, glycosaminoglycan chemical exchange saturation transfer (gagCEST) in 1 study, and diffusion-weighted imaging in 1 study. Five studies on T2 mapping showed a correlation between T2 relaxation times and clinical outcome scores. Two dGEMRIC studies found a correlation between T1 relaxation times and clinical outcome scores. Conclusion: Multiple studies on T2 mapping, dGEMRIC, and diffusion-weighted imaging showed significant correlations with patient-reported outcome measures after cartilage repair surgery, although other studies showed no significant relationship. qMRI sequences may offer a noninvasive method to monitor cartilage repair tissue in a clinically meaningful way, but further refinements in imaging protocols and clinical interpretation are necessary to improve utility.

MRI of the Knee An Issue of Magnetic Resonance Imaging Clinics of North America E Book

MRI of the Knee  An Issue of Magnetic Resonance Imaging Clinics of North America  E Book Book
Author : Kirkland W. Davis
Publisher : Elsevier Health Sciences
Release : 2014-11-13
ISBN : 0323323804
Language : En, Es, Fr & De

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Book Description :

This issue, edited by Dr. Kirkland Davis, will comprehensively review imaging of the knee. Articles will include: Magnetic Resonance Imaging of the Meniscus; MRI of Cruciate Ligaments; Magnetic Resonance Imaging of the Extensor Mechanism; Quantitative Magnetic Resonance Imaging of the Articular Cartilage of the Knee Joint; Magnetic Resonance Imaging of the Pediatric Knee; MRI of Extra-Synovial Inflammation and Impingement about the Knee; A Biomechanical Approach to Interpreting MRI of Knee Injuries; MRI Assessment of Arthritis of the Knee; MRI of the Post-Operative Meniscus; MR Imaging of Cartilage Repair Procedures; Imaging the Knee in the Setting of Metal Hardware, and more!

Quantitative MRI of the Brain

Quantitative MRI of the Brain Book
Author : Paul Tofts
Publisher : John Wiley & Sons
Release : 2005-08-19
ISBN : 0470869496
Language : En, Es, Fr & De

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Book Description :

2004 BMA Medical Book Competition Winner (Radiology category) “This is an exciting book, with a new approach to use of the MRI scanner. It bridges the gap between clinical research and general neuro-radiological practice. It is accessible to the clinical radiologist, and yet thorough in its treatment of the underlying physics and of the science of measurement. It is likely to become a classic.” British Medical Association This indispensable 'how to' manual of quantitative MR is essential for anyone who wants to use the gamut of modern quantitative methods to measure the effects of neurological disease, its progression, and its response to treatment. It contains both the methodology and clinical applications, reflecting the increasing interest in quantitative MR in studying disease and its progression. The editor is an MR scientist with an international reputation for high quality research The contributions are written jointly by MR physicists and MR clinicians, producing a practical book for both the research and medical communities A practical book for both the research and medical communities “Paul Tofts has succeeded brilliantly in capturing the essence of what needs to become the future of radiology in particular, and medicine in general – quantitative measurements of disease.” Robert I. Grossman, M.D. New York, University School of Medicine (from the Foreword)

Accelerated Acquisition of Quantitative MRI Using Parametric Redundancy

Accelerated Acquisition of Quantitative MRI Using Parametric Redundancy Book
Author : Karthik Rao Aroor
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Magnetic Resonance Imaging (MRI) is a non-invasive technique that can be utilized to obtain Quantitative T1 images of the brain. Unfortunately, the acquisition of Quantitative MRI (Q-MRI) is an extremely slow process, and this has prevented applications of Q-MRI in many clinical situations where low scan times are critical. Current approaches to speed up the acqui- sition of Q-MRI are inadequate and result in images that have artifacts. This thesis develops and validates novel compressed sensing algorithms that exploit information in spatial and para- metric dimensions for improved MRI T1 mapping. In the first project, two different sampling patterns are used to acquire MRI data at multiple Flip Angles (FAs). The two sampling patterns are the traditional stack-of-stars (SOS) and the recently introduced vastly undersampled isotropic projection (VIPR). It is shown that when used in parametric dimension regularized compressed sensing algorithms, at high accelera- tions, VIPR outperforms SOS when estimating T1 maps. The second project considers the Inversion Recovery acquisition, in which data is acquired at multiple inversion time points. Here, a novel parametric dimension compressed sensing regularizer, Total Generalized Variation (TGV) is developed, and for this data, it is shown that using TGV as a regularizer yields better T1 estimates than the current approach, which uses no regularization. TGV also outperforms the classical Total Variation (TV) regularizer by eliminating its well known staircase artifacts. In addition to continuous signals, it is also shown that TGV works well on discontinuous signals, since it does not oversmooth the discontinuities. In the third project, we develop and validate a novel technique to estimate the T1 values of all voxels in the brain simultaneously using a Total Variation (TV) regularizer, and show that this outperforms the current approach of estimating T1 values of all voxels independently. Three different approaches to perform TV based T1 estimation are proposed, and simulations are performed to determine the best one.

Diagnostic Value of Combined Serum Marker Changes and Quantitative MRI Evaluation of Cartilage Volume of Tibial Plateau in a Surgically induced Osteoarthritis Dog Model

Diagnostic Value of Combined Serum Marker Changes and Quantitative MRI Evaluation of Cartilage Volume of Tibial Plateau in a Surgically induced Osteoarthritis Dog Model Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-08
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Objective To evaluate the combined diagnostic value of two serum osteoarthritis (OA) markers and quantitative magnetic resonance imaging (MRI) evaluation of the cartilage volume of the tibial plateau in a canine model of experimental OA. Methods A total of 18 male Beagle dogs were used in this longitudinal study. OA was surgically induced via anterior cruciate ligament transection (ACLT) of the right knee in 10 dogs. The remaining eight dogs formed the sham operation control group and underwent the same procedure without ACLT. At various times after surgery, enzyme-linked immunosorbent assay was used to measure serum C-telopeptide of type II collagen (CTX-II) and type X collagen (ColX) levels. Quantitative evaluation of the tibial plateau volume was undertaken using MRI and ImageJ software. Results The serum CTX-II levels were significantly higher in the OA group at weeks 8, 12 and 16 after surgery, but not at week 4, compared with the control group. The serum ColX levels in the OA group were significantly higher than in the control group at weeks 8 and 12. The tibial plateau cartilage volumes in the OA group were significantly lower than in the control group at weeks 8 and 16. Conclusion Serum CTX-II and ColX levels combined with quantitative MRI evaluation of the tibial plateau cartilage volume in a canine model of OA demonstrated the potential to detect and monitor OA progression.