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Pyrazole Based Drug Discovery

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Structure based Drug Discovery

Structure based Drug Discovery Book
Author : Harren Jhoti,Andrew R. Leach
Publisher : Springer Science & Business Media
Release : 2007-05-24
ISBN : 1402044070
Language : En, Es, Fr & De

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Book Description :

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book
Author : Bimal K. Banik
Publisher : Advances in Green Chemistry
Release : 2020-04
ISBN : 0128175923
Language : En, Es, Fr & De

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Book Description :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

Index Medicus

Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery for Leishmaniasis

Drug Discovery for Leishmaniasis Book
Author : Carmen Gil,Luis Rivas
Publisher : Royal Society of Chemistry
Release : 2017-10-26
ISBN : 1788012585
Language : En, Es, Fr & De

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Book Description :

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.

Synthesis of Withasomnine and Pyrazole Derivatives Via Intramolecular Dehydrogenative Cyclization as Well as Biological Evaluation of Withasomnine based Scaffolds1

Synthesis of Withasomnine and Pyrazole Derivatives Via Intramolecular Dehydrogenative Cyclization  as Well as Biological Evaluation of Withasomnine based Scaffolds1 Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract : Synthesis of a withasomnine-inspired library which shows anticancer reactivities and COX-2 inhibition via an intramolecular dehydrogenative cyclization process. Abstract : Fragment-based drug discovery has recently drawn great attention from both industry and academia. Fragment library design is critical to success in this field. Herein we report our facile access to pyrazole derivatives via a cascade reaction involving a double C(sp 3 )–H functionalization and dehydrogenative aromatization sequence. Based on the newly developed method, we completed the synthesis of the Indian herbal medicine, withasomnine, in only two steps. In addition, inspired by the different biological activities of withasomnine, this cascade reaction sequence enables us to quickly build up a natural product-based fragment library. The compounds in this fragment library exhibit a variety of biological activities and demonstrate high hit rates on initial biological screening against COX-2.

Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targets In Heterocyclic Systems

Targets In Heterocyclic Systems Book
Author : Orazio A. Attanasi,Domenico Spinelli
Publisher : Societa Chimica Italiana Sci
Release : 2003
ISBN : 9788886208239
Language : En, Es, Fr & De

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Book Description :

It is well known that heterocyclic derivatives represent almost half of the several million chemical species discovered to date. The importance of these compounds in many branches of chemistry ensures further investigation and attention. This series aims to stimulate creativity and innovation by including research by leading authorities. As well as highlights of interesting developments in specific areas, there are also comprehensive reviews reporting the overall state-of-the-art. Targets in Heterocyclic Systems Volume 6 will be welcomed by researchers and industrialists with an interest in the synthesis, reactivity and medicinal properties of heterorings.

Journal of Chemical Research

Journal of Chemical Research Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of Chemical Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Comprehensive Medicinal Chemistry II Vol 8

Comprehensive Medicinal Chemistry II  Vol 8 Book
Author : John B Taylor,David J Triggle
Publisher : Elsevier Science Limited
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Presents a different view of medicinal chemistry through personal accounts by eminent scientists describing their lifetime experiences in the field. Also illustrates 14 case studies of successful drug discovery and development. * valuable content available May 2009 as an individual volume * separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience * priced for individual researcher as well as library purchase

Drug Discovery Handbook

Drug Discovery Handbook Book
Author : Shayne C. Gad
Publisher : Wiley-Interscience
Release : 2005-07-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Journal of the Indian Chemical Society

Journal of the Indian Chemical Society Book
Author : Indian Chemical Society
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the Indian Chemical Society book written by Indian Chemical Society, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Wiley Encyclopedia of Chemical Biology Volume 3

Wiley Encyclopedia of Chemical Biology  Volume 3 Book
Author : Tadhg P. Begley
Publisher : Wiley
Release : 2009-02-03
ISBN : 9780470470190
Language : En, Es, Fr & De

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Book Description :

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Medicinal Chemistry and Drug Discovery Drug discovery and drug development

Medicinal Chemistry and Drug Discovery  Drug discovery and drug development Book
Author : Alfred Burger
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry and Drug Discovery Drug discovery and drug development book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmaceutical Chemistry

Pharmaceutical Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 1963
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmaceutical Chemistry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of Scientific Industrial Research

Journal of Scientific   Industrial Research Book
Author : Anonim
Publisher : Unknown
Release : 1971
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of Scientific Industrial Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Rational Molecular Design in Drug Research

Rational Molecular Design in Drug Research Book
Author : Tommy Liljefors,Flemming S. Jørgensen,Povl Krogsgaard-Larsen
Publisher : Wiley-Blackwell
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Rational Molecular Design in Drug Research book written by Tommy Liljefors,Flemming S. Jørgensen,Povl Krogsgaard-Larsen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery and Evaluation

Drug Discovery and Evaluation Book
Author : Hans G. Vogel,Wolfgang H. Vogel
Publisher : Springer
Release : 1997-04-09
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Comprehensive reference on 700 of the most frequently used assays for reliably detecting pharmacological effects of potential drugs. For practitioners and students. Includes a full-text CD-ROM.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2007-03
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.