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Psychiatric Genomics

Psychiatric Genomics Book
Author : Evangelia Eirini Tsermpini,Martin Alda,George P. Patrinos
Publisher : Academic Press
Release : 2020-11-01
ISBN : 0128214007
Language : En, Es, Fr & De

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Book Description :

Although psychiatric disorders affect a large percentage of the world population, current treatment approaches and drugs administered often come with unwelcome side effects that may decrease patients’ quality of life. Psychiatric genomics is a rapidly growing field that adopts computational approaches to identify genetic factors underlying psychiatric disorders, as well as the appropriate drug and dosage plans, to enhance personalized treatment and avoid adverse reactions. Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, and offers methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, across 23 chapters, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research. Thoroughly examines genetic mechanisms underlying a broad range of psychiatric disorders Offers genomic methodologies and analytical approaches supporting new research and clinical translation, as well as personalized diagnosis and treatment models Features chapters contributions from international leaders in the field

Psychiatric Genetics

Psychiatric Genetics Book
Author : Thomas Schulze,Francis McMahon
Publisher : Oxford University Press
Release : 2018
ISBN : 0190221976
Language : En, Es, Fr & De

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Book Description :

Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

Psychiatric Genetics and Genomics

Psychiatric Genetics and Genomics Book
Author : Peter McGuffin,Michael J Owen,Irving I Gottesman
Publisher : Oxford University Press
Release : 2004-09-23
ISBN : 9780198564867
Language : En, Es, Fr & De

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Book Description :

Genetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book starts with a brief introduction to the relevant molecular and cellular biology and then moves on to cover the evidence for a genetic contribution to normal and abnormal development and to abnormal behaviour in adult life. The final section covers counselling, ethics and takes a look to the future.

Principles of Psychiatric Genetics

Principles of Psychiatric Genetics Book
Author : John I. Nurnberger, Jr,Wade Berrettini
Publisher : Cambridge University Press
Release : 2012-09-13
ISBN : 1139560379
Language : En, Es, Fr & De

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Book Description :

Disorders of behavior represent some of the most common and disabling diseases affecting humankind; however, despite their worldwide distribution, genetic influences on these illnesses are often overlooked by families and mental health professionals. Psychiatric genetics is a rapidly advancing field, elucidating the varied roles of specific genes and their interactions in brain development and dysregulation. Principles of Psychiatric Genetics includes 22 disorder-based chapters covering, amongst other conditions, schizophrenia, mood disorders, anxiety disorders, Alzheimer's disease, learning and developmental disorders, eating disorders and personality disorders. Supporting chapters focus on issues of genetic epidemiology, molecular and statistical methods, pharmacogenetics, epigenetics, gene expression studies, online genetic databases and ethical issues. Written by an international team of contributors, and fully updated with the latest results from genome-wide association studies, this comprehensive text is an indispensable reference for psychiatrists, neurologists, psychologists and anyone involved in psychiatric genetic studies.

Psychiatric Genetics

Psychiatric Genetics Book
Author : Michael Arribas-Ayllon,Andrew Bartlett,Jamie Lewis
Publisher : Routledge
Release : 2019-02-13
ISBN : 1317329627
Language : En, Es, Fr & De

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Book Description :

Psychiatric genetics has become ‘Big Biology’. This may come as a surprising development to those familiar with its controversial history. From eugenic origins and contentious twin studies to a global network of laboratories employing high-throughput genetic and genomic technologies, biological research on psychiatric disorders has become an international, multidisciplinary assemblage of massive data resources. How did psychiatric genetics achieve this scale? How is it socially and epistemically organized? And how do scientists experience this politics of scale? Psychiatric Genetics: From Hereditary Madness to Big Biology develops a sociological approach of exploring the origins of psychiatric genetics by tracing several distinct styles of scientific reasoning that coalesced at the beginning of the twentieth century. These styles of reasoning reveal, among other things, a range of practices that maintain an extraordinary stability in the face of radical criticism, internal tensions and scientific disappointments. The book draws on a variety of methods and materials to explore these claims. Combining genealogical analysis of historical literature, rhetorical analysis of scientific review articles, interviews with scientists, ethnographic observations of laboratory practices and international conferences, this book offers a comprehensive and detailed exploration of both local and global changes in the field of psychiatric genetics.

Research Advances in Genetics and Genomics

Research Advances in Genetics and Genomics Book
Author : Nancy C. Andreasen
Publisher : American Psychiatric Pub
Release : 2007-05-03
ISBN : 9781585627103
Language : En, Es, Fr & De

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Book Description :

Research Advances in Genetics and Genomics: Implications for Psychiatry introduces mental health professionals to exciting breakthroughs in endophenotypes, animal models, microarrays, and genetic mapping, as well as general strategies for identifying the genetic mechanisms of mental illnesses. Uniquely valuable both as summary and signpost, this concise volume provides a fascinating overview of recent cutting-edge developments in the application of molecular genetics, genomics, and proteomics to the study of psychiatric populations. By reading Research Advances in Genetics and Genomics, you will gain a better understanding of Psychiatric Genetics -- Reviews and assesses the major research paradigms that have emerged in the field of psychiatric genetics over the several past decades, exploring the major conceptual and philosophical issues they pose and the value of their integration. Molecular Structure of Nucleic Acids -- An overview of the double-helix discovery and provides a context for current endeavors, the original one-page April 1953 Nature paper by Watson and Crick, which sparked a revolution in the life sciences. Psychiatry in the Genomics Era -- Posits that one of the most important consequences of genomics will be the development of individualized treatments that allow a clinician to tailor therapy on the basis of the unique genotype of each patient rather than on the mean responses of groups of unrelated patients. The Genomics Revolution -- Details the implications of the genome for future medical practice, including the potential for developing methods and tools to better understand, treat, and prevent major mental disorders. The Endophenotype Concept in Psychiatry -- Explains the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics, such as schizophrenia. The Genes and Brains of Mice and Men -- Shows why a detailed assessment of brain function in mice is so important for advancing psychiatric research in humans. Humans and mice share numerous features-in fact, for an estimated 99% of human genes a mouse version may be identified-of brain organization and behavioral responses to many pharmacological agents. Microarray Technology -- Asserts that microarrays present a methodology for identifying genes or pathways for new and unique potential drug targets, determining premorbid diagnosis, predicting drug responsiveness for individual patients, and, eventually, initiating gene therapy and prevention strategies. Meticulously referenced, this volume is exceptionally useful as a starting point for understanding the impact of genetics and genomics on psychiatry, serving to introduce psychiatrists, psychologists, neurologists, and geneticists to this exciting field.

Psychiatry

Psychiatry Book
Author : Allan Tasman,Jerald Kay,Jeffrey A. Lieberman,Michael B. First,Michelle Riba
Publisher : John Wiley & Sons
Release : 2015-02-05
ISBN : 1118753364
Language : En, Es, Fr & De

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Book Description :

Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images

The American Psychiatric Publishing Textbook of Psychopharmacology

The American Psychiatric Publishing Textbook of Psychopharmacology Book
Author : Alan F. Schatzberg,Charles B. Nemeroff
Publisher : American Psychiatric Pub
Release : 2009
ISBN : 1585623091
Language : En, Es, Fr & De

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Book Description :

Now updated to keep professionals current with the latest research and trends in the field, this edition covers both basic science and clinical practice, and draws on the talents of 53 new contributors to guarantee fresh, authoritative perspectives on advances in psychiatric drug therapy.

Psychiatric Diagnosis and Management in Primary Care An Issue of Medical Clinics E Book

Psychiatric Diagnosis and Management in Primary Care  An Issue of Medical Clinics  E Book Book
Author : Genevieve Pagalilauan
Publisher : Elsevier Health Sciences
Release : 2014-08-28
ISBN : 0323323324
Language : En, Es, Fr & De

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Book Description :

This issue of the Medical Clinics of North America is devoted to Psychiatric Diagnosis and Management in Primary Care and is edited by Dr. Genevieve Pagalilauan. Articles in this issue include: Psychopharmacology; Office-based Screening of Common Psychiatric Conditions; Depression; Anxiety Disorders; Bipolar Disorder; Borderline Personality Disorder; Grief Reaction, Adjustment Disorder, Seasonal Affective Disorder; Somatiform Disorders; Addiction Disorders; Sleep disorders; Geriatric Psychiatry; Autism Spectrum Disorders in Adults; and Medical Conditions with Neuropsychiatric Manifestations.

Obsessive Compulsive and Related Disorders An Issue of Psychiatric Clinics of North America

Obsessive Compulsive and Related Disorders  An Issue of Psychiatric Clinics of North America  Book
Author : Wayne K. Goodman
Publisher : Elsevier Health Sciences
Release : 2014-08-28
ISBN : 0323323421
Language : En, Es, Fr & De

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Book Description :

Neurotransmitters in the brain are the current focus of obsessive compulsive disorders to better address the approximately 2.5 million people in the United States diagnosed with OCD. As seems the way of psychiatry practice, a disorder is viewed and treated from one perspective for a period, then a new perspective is in the forefront. Such is the case with obsessive compulsive disorders, originally treated as a behavioral problem with psychotherapy, now considered a brain circuitry disorder that can be treated with psychopharmacotherapeutics. This issue contains topics that focus on neuroscience of the brain and genetics in relation to OCD, providing the psychiatrist a comprehensive review of the current thought, approach, diagnosis, and treatment related to OCD and its related disorders. Topics include: Etiological hypotheses of OCD - molecules to circuits; Models of obsessive compulsive and related disorders; Cognitive neuroscience of OCD; Genetics of obsessive compulsive and related disorders; Tic disorders - spearate or related disorder; Pediatric acute-onset neuropsychiatric syndrome (PANS); Body dysmorphic disorder; Trichotillomania; Hoarding disorder; Pharmacotherapy; Device based interventions; Cognitive behavioral therapy for OCD.

Seminars in Psychiatric Genetics

Seminars in Psychiatric Genetics Book
Author : Peter McGuffin
Publisher :
Release : 1994
ISBN : 9780902241657
Language : En, Es, Fr & De

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Book Description :

The College Seminar Series is a collection of books aimed at helping psychiatric trainees through their clinical and academic training. They should also appeal to other mental-health professionals and more senior doctors.

Textbook of Psychiatric Epidemiology

Textbook of Psychiatric Epidemiology Book
Author : Ming T. Tsuang,Mauricio Tohen,Peter Jones
Publisher : John Wiley & Sons
Release : 2011-03-25
ISBN : 047097740X
Language : En, Es, Fr & De

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Book Description :

The new edition of this critically praised textbook continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field; particularly the application of molecular genomics and of neuroimaging. It has been revised and enhanced to capitalize on the strengths of the first and second editions while keeping it up-to-date with the field of psychiatry and epidemiology. This comprehensive publication now includes chapters on experimental epidemiology, gene-environment interactions, the use of case registries, eating disorders, suicide, childhood disorders and immigrant populations, and the epidemiology of a number of childhood disorders. As in the first and second editions, the objective is to provide a comprehensive, easy to understand overview of research methods for the non-specialist. The book is ideal for students of psychiatric epidemiology, psychiatric residents, general psychiatrists, and other mental health professionals. The book features a new editor, Peter Jones, from the University of Cambridge, who joins the successful US team of Ming Tsuang and Mauricio Tohen.

Genomics Circuits and Pathways in Clinical Neuropsychiatry

Genomics  Circuits  and Pathways in Clinical Neuropsychiatry Book
Author : Thomas Lehner,Bruce L. Miller,Matthew W. State
Publisher : Academic Press
Release : 2016-06-07
ISBN : 0128005300
Language : En, Es, Fr & De

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Book Description :

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Schizophrenia An Issue of Psychiatric Clinics E Book

Schizophrenia  An Issue of Psychiatric Clinics   E Book Book
Author : Peter F. Buckley
Publisher : Elsevier Health Sciences
Release : 2012-09-16
ISBN : 1455747491
Language : En, Es, Fr & De

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Book Description :

A major shift in approaching Schizophrenia has been witnessed among psychiatrists with the belief now that early diagnosis and intervention may have a positive influence on the outcome of schizophrenia. The search for key diagnostic clusters to enhance early diagnosis is underway as well as concerted efforts to find biomarkers of disease and disease progression. To address this, this issue of the Psychiatric Clinics of North America presents distinguished academic clinicians and neuroscientists who provide comprehensive overviews of the present state of knowledge on the epidemiology, early clinical characteristics, and diagnostic changes, proposed pathogenesis, neurobiology, and treatment requirements for this disorder. The current state of knowledge is substantial, academically credible, and scientifically based. Topics on the subject of early intervention in and diagnosis of schizophrenia include: Nosology of Schizophrenia: Defining Illness Boundaries Based upon Symptoms; Neurodevelopmental Hypothesis of Schizophrenia; Predicting Risk and the Emergence of Schizophrenia; Is Early Intervention for Psychosis Feasible and Effective?; Can Neuroimaging Be Used to Define Phenotypes and Course of Schizophrenia?; Reliable Biomarkers and Predictors of Schizophrenia and Its Treatment; From Study to Practice: Enhancing Clinical Trials Methods Toward ‘Real World’ Outcomes; Relapse Prevention in Schizophrenia; Antipsychotic Polypharmacy; Cognitive Remediation: Retraining the Brain in Schizophrenia; Peers and Peer-led Interventions; Homelessness; and The Emerging Role of Technology and Social Media in Caring for People with Schizophrenia. Each presentation in this publication includes an Overview, Implications for Practice, with Summarizations of Important Clinical and Learning Points.

Textbook in Psychiatric Epidemiology

Textbook in Psychiatric Epidemiology Book
Author : Ming T. Tsuang,Mauricio Tohen
Publisher : John Wiley & Sons
Release : 2003-04-14
ISBN : 0471461210
Language : En, Es, Fr & De

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Book Description :

The new edition of this critically praised text continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field. It has been revised and enhanced to capitalize on the strengths of the first edition while keeping it up-to-date in the field of psychiatry. This comprehensive publication now includes new chapters on child psychiatry, community studies, and perinatal studies.

Core Psychiatry E Book

Core Psychiatry E Book Book
Author : Padraig Wright,Julian Stern,Michael Phelan
Publisher : Elsevier Health Sciences
Release : 2012-01-08
ISBN : 0702048585
Language : En, Es, Fr & De

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Book Description :

A new edition of a highly successful, award winning textbook for trainee psychiatrists, covering in one volume all the subjects required for the new MRCPsych and similar exams. Written in a highly engaging manner, it will also prove invaluable to qualified psychiatrists who need to keep up-to-date with the latest developments, as well as clinical psychologists, general practitioners, psychiatric nurses and senior medical students Concise yet comprehensive, Core Psychiatry relfects the latest developments in the curriculum plus all that is new and essential in clinical practice and the sciences that underpin it. It includes new information on the new Mental Capacity Act and Mental Health Act as well as enhanced sections on psychopharmacology, old age psychiatry, child and adolescent psychiatry, forensic psychiatry and rehabilitation. The book also makes refernce to the latest NICE guidelines and includes new sections on sleep medicine and trauma psychiatry. New edition of a popular MRCPsych curriculum based text Previous edition ‘Highly Commended’ (Mental Health category) in the BMA Awards 2005 Contains useful summary boxes, lists and key points to make last minute learning easy Comprehensive and authoritative resource written by contributors to ensure complete accuracy and currency of specialist information Chapters prepared by specialists working in conjunction with trainees – content totally up-to-date and jointly written by authors who have recently been in the exam situation Contains the latest findings in sleep medicine and trauma psychiatry Expanded section on psychology – including social psychology – to reflect the latest MRCPych examination format Text updated in full to reflect the new Mental Capacity Act and Mental Health Act Relevant chapters now contain a ‘skills and competency’ section to reflect changes in MRCPsych curriculum Updating and amendments to improve coverage of old age psychiatry, child and adolescent psychiatry, forensic psychiatry and rehabilitation Contains reference to the latest NICE guidelines in boxes and tables Enhanced discussion of the use of the best current management options, both pharmacological and psychotherapeutic, the latter including CBT, DBT, EMDR and psychodynamic group, couple and family therapy.

Philosophical issues in psychiatry III

Philosophical issues in psychiatry III Book
Author : Kenneth S. Kendler,Josef Parnas
Publisher : OUP Oxford
Release : 2014-10-02
ISBN : 0191038865
Language : En, Es, Fr & De

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Book Description :

Psychiatry has long struggled with the nature of its diagnoses. The problems raised by questions about the nature of psychiatric illness are particularly fascinating because they sit at the intersection of philosophy, empirical psychiatric/psychological research, measurement theory, historical tradition and policy. In being the only medical specialty that diagnoses and treats mental illness, psychiatry has been subject to major changes in the last 150 years. This book explores the forces that have shaped these changes and especially how substantial "internal" advances in our knowledge of the nature and causes of psychiatric illness have interacted with a plethora of external forces that have impacted on the psychiatric profession. It includes contributions from philosophers of science with an interest in psychiatry, psychiatrists and psychologists with expertise in the history of their field and historians of psychiatry. Each chapter is accompanied by an introduction and a commentary. The result is a dynamic discussion about the nature of psychiatric disorders, and a book that is compelling reading for those in the field of mental health, history of science and medicine, and philosophy.

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease Book
Author : Roger N. Rosenberg
Publisher : Lippincott Williams & Wilkins
Release : 2008
ISBN : 9780781769563
Language : En, Es, Fr & De

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Book Description :

Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric diseases. More than 120 leading experts provide a fresh, new assessment of recent molecular, genetic, and genomic advances, offer new insights into disease pathogenesis, describe the newest available therapies, and explore promising areas of therapeutic development. This edition features an updated section on psychiatric disease and expanded, updated chapters on human genomics, gene therapy, and ethical issues. Six new chapters cover congenital myasthenic syndromes, hereditary spastic paraplegia, ion channel disorders, the phakomatoses, beta-galactosidase deficiency, and prion diseases. A Neurologic Gene Map describes the chromosome locus of all the genetic diseases and their gene product where known. The fully searchable online text will be available on a companion Website. (www.rosenbergneuroandpsychdisease.com)

Bipolar Disorders New Insights for the Healthcare Professional 2013 Edition

Bipolar Disorders  New Insights for the Healthcare Professional  2013 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481663488
Language : En, Es, Fr & De

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Book Description :

Bipolar Disorders: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Bipolar Disorders: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bipolar Disorders: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Treatment of Neurodevelopmental Disorders

Treatment of Neurodevelopmental Disorders Book
Author : Randi Hagerman,Robert Hendren
Publisher : Oxford University Press
Release : 2014-04-25
ISBN : 0199378886
Language : En, Es, Fr & De

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Book Description :

This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have led to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.