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Proton Therapy Physics Second Edition

Proton Therapy Physics  Second Edition Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2018-11-19
ISBN : 1351855751
Language : En, Es, Fr & De

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Book Description :

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Proton Therapy

Proton Therapy Book
Author : Steven J. Frank,X. Ronald Zhu
Publisher : Elsevier
Release : 2020-05-07
ISBN : 9780323733496
Language : En, Es, Fr & De

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Book Description :

As proton therapy treatment centers become smaller and more cost-effective, education and training for today's multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Proton Therapy Physics

Proton Therapy Physics Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439836450
Language : En, Es, Fr & De

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Book Description :

Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

Proton Therapy and Radiosurgery

Proton Therapy and Radiosurgery Book
Author : Hans Breuer,Berend J. Smit
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662043017
Language : En, Es, Fr & De

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Book Description :

The book is divided into two parts: Part I deals with the relevant physics and planning algorithms of protons (H Breuer) and Part II with the radiobiology, radiopathology and clinical outcomes of proton therapy and a comparison of proton therapy versus photon therapy (BJ Smit). Protons can be used for radiosurgery and general radio therapy. Since proton therapy was first proposed in 1946 by Wilson, about sixteen facilities have been built globally. Only a very few of these have isocentric beam delivery systems so that proton therapy is really only now in a position to be compared directly by means of randomised clinical trials, with modern photon radiotherapy therapy sys tems, both for radiosurgery and for general fractionated radiotherapy. Three-dimensional proton planning computer systems with image fusion (image of computerised tomography (CT), magnetic resonance registration) capabilities imaging (MRI), stereotactic angiograms and perhaps positron emission tomography (PET) are essential for accurate proton therapy planning. New planning systems for spot scanning are under development. Many of the older comparisons of the advantageous dose distributions for protons were made with parallel opposing or multiple co-planar field arrangements, which are now largely obsolete. New comparative plans are necessary once more because of the very rapid progress in 3-D conformal planning with photons. New cost-benefit analy ses may be needed. Low energy (about 70 MeV) proton therapy is eminently suitable for the treatment of eye tumours and has firmly established itself as very useful in this regard.

Proton Therapy E Book

Proton Therapy E Book Book
Author : Steven J Frank,X. Ronald Zhu
Publisher : Elsevier Health Sciences
Release : 2020-05-18
ISBN : 0323733506
Language : En, Es, Fr & De

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Book Description :

As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.

Introduction to Proton Therapy

Introduction to Proton Therapy Book
Author : Robert Ferre
Publisher :
Release : 2018-02
ISBN : 9781940875941
Language : En, Es, Fr & De

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Book Description :

Concise introduction to the technology and potential of proton beam therapy to treat the vast majority of cancers.

Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility

Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility Book
Author : Matthias Würl
Publisher : Springer
Release : 2016-05-30
ISBN : 3658131683
Language : En, Es, Fr & De

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Book Description :

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

Proton Beam Therapy

Proton Beam Therapy Book
Author : Santosh Yajnik
Publisher : Springer Science & Business Media
Release : 2012-10-17
ISBN : 146145297X
Language : En, Es, Fr & De

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Book Description :

Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing the dose to surrounding tissue. The benefits of proton beam therapy in delivering a lethal hit to the target while sparing surrounding normal tissues from radiation are becoming applicable to an increasing number of patients and a growing list of conditions. In this book, the author will guide the reader through existing evidence supporting proton beam therapy for pediatric cancer, prostate cancer, lung cancer, brain tumors, spinal tumors, and several other conditions. The book will discuss which conditions are suitable for treatment with proton beam therapy, how the treatment is delivered, and the current data supporting its use.

Proton and Carbon Ion Therapy

Proton and Carbon Ion Therapy Book
Author : C-M Charlie Ma,Tony Lomax
Publisher : CRC Press
Release : 2012-10-09
ISBN : 1439816077
Language : En, Es, Fr & De

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Book Description :

Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discusses dosimetry, biology, imaging, and treatment planning basics and provides clinical guidelines on the use of proton and carbon ion therapy for the treatment of specific cancers. Suitable for anyone involved with medical physics and radiation therapy, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of proton and carbon ion therapy. It presents a thorough introduction for those new to the field while providing a helpful, up-to-date reference for readers already using the therapy in clinical settings.

Commissioning of McLaren Proton Therapy System

Commissioning of McLaren Proton Therapy System Book
Author : Biniam Tesfamicael
Publisher :
Release : 2017
ISBN :
Language : En, Es, Fr & De

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Book Description :

Introduction: McLaren Proton Therapy Center (MPTC) is equipped with a Radiance 330TM synchrotron which is capable of pencil beam delivery (70-330 MeV). The treatment rooms are equipped with a robotic couch for patient positioning and half gantry for beam delivery. The in-room imaging system is capable of acquiring planar and CBCT images while mounted from an independent x-ray gantry. Methods and Material: The ionization depth doses for 70 to 250 MeV were measured using PTW water tank and Bragg peak chambers. An IBA Lynx was used to measure the beam sigma at isocenter as well as at four different positions relative to isocenter. The IAEA TRS 398 protocol was used to calibrate the delivered dose. The dose distribution was verified using gamma index analysis. The dose calibration and dose distribution were verified by IROC Houston for a prostate phantom. The gantry mechanical isocentricity was measured using an in-house fabricated device. Isocentricity shifts are accommodated by correcting the treatment couch positions for gantry sag for various gantry angles. Results: The ranges of proton beams are verified to be within 0.5 mm of the tabulated CSDA values. The spots circularity is verified to be within 10% in X and Y axis. The positional accuracy of the spots is within 1.5% of the planned map. The gantry isocentricity is within 0.5 mm radius after couch correction.Conclusion: The gamma analysis of dose distributions had a passing rate of >95% for 2%/2mm. Independent verification by IROC has verified our beam delivery calibration and accuracy.

Proton Therapy for Head and Neck Cancer Expanding the Therapeutic Window

Proton Therapy for Head and Neck Cancer  Expanding the Therapeutic Window Book
Author : N.A
Publisher :
Release : 2017
ISBN :
Language : En, Es, Fr & De

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Book Description :

Use of proton beam therapy has expanded, with the number of proton centres rapidly increasing not only in the USA but also worldwide. The physical characteristics of the proton beam offer important advantages versus widely used photon techniques in terms of radiation precision. In head and neck cancer in particular, proton beam therapy is uniquely suited for the complex anatomy of tumours and sensitive surrounding organs. De-intensification and personalisation of treatment to limit toxicity are of renewed importance in the context of human papilloma virus-associated disease, in which young patients will be cured but bear the consequences of adverse effects for decades. Comparisons of radiation dose distributions between photon and proton techniques suggest considerable benefit in terms of toxicity sparing, but this has only recently been confirmed by substantial clinical data. In this Review, we attempt to define the role of this method in the contemporary multidisciplinary management of various types of head and neck cancer.

Proton Therapy Destroys Cancer

Proton Therapy Destroys Cancer Book
Author : Robert Ferre
Publisher :
Release : 2020
ISBN : 9781940875828
Language : En, Es, Fr & De

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Book Description :

Proton beam therapy is a controversial form of radiation that is revolutionizing cancer care. Some critics feel it needs more proof, even though 200,000 people have been treated worldwide over the past thirty years. As a cancer patient, Robert Ferré wanted to know if proton therapy would be the best treatment. The answer is a resounding yes. Now three years cancer free, he is on a mission to inform the public about this exceptional cancer treatment.Compared to surgery, x-rays, and chemotherapy, proton beam therapy gets a better result, does less damage to healthy tissue, and produces fewer side effects in almost every instance. This makes it especially valuable in areas near vital organs, such as brain, throat, breast, and lungs. In fact, 80% of all cancers can be treated with proton beam therapy. Cancers included in this book are:Base of skullBrain Breast Esophageal GastrointestinalHead and neckHodgkin's lymphomaLiverLungOpticalOropharynxPancreaticPediatricPelvic chondrosarcomaProstateRecurrentSkinSpinal cordProtons are charged particles from the nucleus of hydrogen atoms that release virtually all of their energy in the target (such as a malignant tumor) disabling the cancer's ability to reproduce. Then they stop. There is no damaging exit through the body as with x-rays, no scalpels, no chemicals. The technology is very complex, quite costly, and sometimes not covered by insurance. Your doctor probably won't recommend proton therapy, so it is necessary to find out the facts yourself. Thousands are glad they did.Robert Ferré was treated for prostate cancer with proton therapy in the fall of 2016. He was so impressed that he writes books and manages websites to help bring this valuable information to the public at large. (See www.proton-beam-therapy.com.) This book is a small investment that could have a huge impact on your life or that of a loved one. While not giving direct medical advice, this book provides information and resources that will enhance your understanding and direct you to places where you can get a second opinion.

The Physics of Three Dimensional Radiation Therapy

The Physics of Three Dimensional Radiation Therapy Book
Author : S. Webb
Publisher : CRC Press
Release : 1993-01-01
ISBN : 9781420050363
Language : En, Es, Fr & De

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Book Description :

The Physics of Three Dimensional Radiation Therapy presents a broad study of the use of three-dimensional techniques in radiation therapy. These techniques are used to specify the target volume precisely and deliver radiation with precision to minimize damage to surrounding healthy tissue. The book discusses multimodality computed tomography, complex treatment planning software, advanced collimation techniques, proton radiotherapy, megavoltage imaging, and stereotactic radiosurgery. A review of the literature, numerous questions, and many illustrations make this book suitable for teaching a course. The themes covered in this book are developed and expanded in Webb's The Physics of Conformal Radiotherapy and the two may be used together or in successive semesters for teaching purposes.

Proton Beam Radiotherapy

Proton Beam Radiotherapy Book
Author : Koji Tsuboi,Takeji Sakae,Ariungerel Gerelchuluun
Publisher : Springer Nature
Release : 2020-01-24
ISBN : 9811374546
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive, practical guide to understanding the physical and biological characteristics of proton beam radiotherapy. The application of proton beams to the treatment of solid cancers has expanded exponentially over the last decade due to their physical properties, which make it possible to administer higher doses of radiation to lesions with only a minimum dose to the surrounding healthy tissues. Accordingly, understanding the basic aspects of proton beam radiotherapy is a primary concern not only for medical physicists and radiation biologists, but also for all physicians involved in cancer treatment using proton beams. The major aspects discussed include the technique’s development background, the generation and delivery system for proton beams, physical characteristics, biological consequences, dosimetry, and future prospects in both medical physics and radiation biology in terms of effective cancer treatment. Gathering contributions from experts who provide clear and detailed information on the basics of proton beams, the book will greatly benefit not only radiological technicians, medical physicists, and physicians, but also scientists in cancer radiotherapy.

Proton and Charged Particle Radiotherapy

Proton and Charged Particle Radiotherapy Book
Author : Thomas F. De Laney,Hanne M. Kooy
Publisher : Lippincott Williams & Wilkins
Release : 2008
ISBN : 9780781765527
Language : En, Es, Fr & De

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Book Description :

This volume is the first comprehensive and practical clinical reference on proton and charged particle radiotherapy. The first half of the book explains the treatment delivery systems used, offers detailed guidance on treatment planning techniques, examines key clinical issues in proton radiotherapy, and reviews recent experience with heavier charged particle radiotherapy. The second half of the book offers "how-to" information on treatment of pediatric tumors, lymphomas, and tumors of the central nervous system, eye, skull base, cervical spine, bone and soft tissue, paranasal sinus, nasal cavity, nasopharynx, oropharynx, oral cavity, salivary glands, prostate, lung, gastrointestinal tract, female reproductive tract, and breast. More than 100 full-color illustrations complement the text.

External Beam Therapy

External Beam Therapy Book
Author : Peter Hoskin
Publisher : Oxford University Press, USA
Release : 2019-05-30
ISBN : 0198786751
Language : En, Es, Fr & De

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Book Description :

External beam therapy is the most common form of radiotherapy, delivering ionizing radiation such as high-energy x-rays, gamma rays, or electron beams directly into the location of the patient's tumour. Now in its third edition, this book is an essential, practical guide to external beam radiotherapy planning and delivery, covering the rapid technological advances made in recent years. The initial chapters give a detailed insight into the fundamentals of clinical radiotherapy. This is followed by systematic details for each tumour site commonly treated with radiotherapy, covering indications, treatment, and planning. The final chapter covers the all important aspect of quality assurance in radiotherapy delivery. This third edition has been fully updated and revised to reflect new techniques, including details of intensity modulated radiotherapy (IMRT), image guided radiotherapy (IGRT), stereotactic body radiotherapy (SBRT), and proton therapy. Written by experts in each field, External Beam Therapy is an invaluable companion to professionals and trainees in medical physics, therapeutic radiology, and clinical or radiation oncology. ABOUT THE SERIES Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in the series takes the reader through the basic principles of the use of ionizing radiation and then develops this by individual sites. This series of practical handbooks is aimed at physicians both training and practising in radiotherapy, as well as medical physics, dosimetrists, radiographers, and senior nurses.

The Project NEPTUNE Nuclear Process driven Enhancement of Proton Therapy UNraVeled

The Project NEPTUNE  Nuclear Process driven Enhancement of Proton Therapy UNraVeled  Book
Author : Giada Petringa
Publisher :
Release : 2017
ISBN :
Language : En, Es, Fr & De

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Book Description :

The project NEPTUNE (Nuclear process-driven Enhancement of Proton Therapy UNraVeled)G. Cuttone (3), S. Agosteo (1), A. Attili (7), G. A. P. Cirrone (3), V. Conte (4), R. Faccini(8), G. Forte (2), C. La Tessa (5), P. A. Lojacono (3), L. Manti (6), G. Petringa (3)(1) INFN Milano(2) Institute of Molecular Bioimaging and Physiology - National Research Council - (IBFM-CNR), Cefalu00f9, (PA), Italy(3) Laboratori Nazionali del Sud - INFN Catania(4) Laboratori Nazionali di Legnaro - INFN Legnaro(5) TIFPA-INFN Trento(6) University of Naples Federico II and INFN Napoli(7) INFN Roma3(8) INFN Roma1Recently an increase of protontherapy effectiveness for irradiations occurring in the presence of 11B atoms has been observed. A role in this effect should be played by the high-LET alpha particles mainly generated by the p(11B,u03b1)2u03b1 channel, which has a cross section of the order of 1 barn at very low incident proton energy. However, analytical calculations indicate that the number of alphas produced is too low to yield the observed biological effects.The Italian INFN institute recently funded a project called NEPTUNE (Nuclear process-driven Enhancement of Proton Therapy UNraVeled) with the main aim to study and understand this radiobiological effect.The main objectives of NEPTUNE will be the consolidation of these results, extending them to include another nuclear reaction between protons and 19F and focusing on understanding all the physical and biological mechanisms involved. A physical characterization of the radiation field will be performed with tissue-equivalent detectors of various types, all based on micro- and nanodosimetric techniques. At the same time, biological measurements will be performed for different cell lines using several endpoints. New biological approaches will be to considered to study the problem from different points of view, which could reveal mechanisms not yet considered. All experimental data will be compared with predictions from analytical and Monte Carlo models.The project is divided into four main Working Packages: WP1, modelling; WP2: imaging and quantification; WP3: microdosimetry and WP4: radiobiology. An additional group (WP5) coordinates all the foreseen experimental activities.

Prostate Cancer Meets the Proton Beam

Prostate Cancer Meets the Proton Beam Book
Author : Fuller Jones
Publisher : Lulu.com
Release : 2008-05-28
ISBN : 0615192432
Language : En, Es, Fr & De

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Book Description :

Proton Beam Therapy is an advanced cancer treatment based on the elegant physics of the proton. It is not well known, because there are currently only five hospitals in the U.S. that have the complex equipment to administer it. Protons have been used for cancer treatment in the U. S. since 1990 with success comparable to all other options, but with minimal side effects. This treatment is FDA approved and may be used for prostate and many other cancers if not metastasized. This book provides the author's experiences in dealing with the shock of cancer diagnosis, and in searching for a treatment. The book contains valuable information about becoming an informed patient. It includes a synopsis of the major treatment alternatives, and a detailed description of proton beam therapy. Robert J. Marckini, author of "You Can Beat Prostate Cancer..." says: " Prostate Cancer Meets The Proton Beam is a nuts-and-bolts journal for the prostate cancer victim, as well as his spouse and family members."

Principles and Practice of Radiation Therapy E Book

Principles and Practice of Radiation Therapy   E Book Book
Author : Charles M. Washington,Dennis T. Leaver
Publisher : Elsevier Health Sciences
Release : 2015-03-10
ISBN : 0323287816
Language : En, Es, Fr & De

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Book Description :

The only radiation therapy text written by radiation therapists, Principles and Practice of Radiation Therapy, 4th Edition helps you understand cancer management and improve clinical techniques for delivering doses of radiation. A problem-based approach makes it easy to apply principles to treatment planning and delivery. New to this edition are updates on current equipment, procedures, and treatment planning. Written by radiation therapy experts Charles Washington and Dennis Leaver, this comprehensive text will be useful throughout your radiation therapy courses and beyond. Comprehensive coverage of radiation therapy includes a clear introduction and overview plus complete information on physics, simulation, and treatment planning. Spotlights and shaded boxes identify the most important concepts. End-of-chapter questions provide a useful review. Chapter objectives, key terms, outlines, and summaries make it easier to prioritize, understand, and retain key information. Key terms are bolded and defined at first mention in the text, and included in the glossary for easy reference. UPDATED chemotherapy section, expansion of What Causes Cancer, and inclusions of additional cancer biology terms and principles provide the essential information needed for clinical success. UPDATED coverage of post-image manipulation techniques includes new material on Cone beam utilization, MR imaging, image guided therapy, and kV imaging. NEW section on radiation safety and misadministration of treatment beams addresses the most up-to-date practice requirements. Content updates also include new ASRT Practice Standards and AHA Patient Care Partnership Standards, keeping you current with practice requirements. UPDATED full-color insert is expanded to 32 pages, and displays images from newer modalities.