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Proton Therapy E Book

Proton Therapy E Book Book
Author : Steven J Frank,X. Ronald Zhu
Publisher : Elsevier Health Sciences
Release : 2020-05-18
ISBN : 0323733506
Language : En, Es, Fr & De

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Book Description :

As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.

Proton Therapy Physics Second Edition

Proton Therapy Physics  Second Edition Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2018-11-19
ISBN : 1351855743
Language : En, Es, Fr & De

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Book Description :

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Principles and Practice of Proton Bean Therapy AAPM Monograph

Principles and Practice of Proton Bean Therapy  AAPM Monograph Book
Author : Indra J. Das,Paganetti Harald
Publisher : Unknown
Release : 2015-06-22
ISBN : 9781936366439
Language : En, Es, Fr & De

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Book Description :

Download Principles and Practice of Proton Bean Therapy AAPM Monograph book written by Indra J. Das,Paganetti Harald, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Proton Therapy Physics

Proton Therapy Physics Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439836450
Language : En, Es, Fr & De

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Book Description :

Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

Proton and Carbon Ion Therapy

Proton and Carbon Ion Therapy Book
Author : C-M Charlie Ma,Tony Lomax
Publisher : CRC Press
Release : 2012-10-09
ISBN : 1439816085
Language : En, Es, Fr & De

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Book Description :

Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discusses dosimetry, biology, imaging, and treatment planning basics and provides clinical guidelines on the use of proton and carbon ion therapy for the treatment of specific cancers. Suitable for anyone involved with medical physics and radiation therapy, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of proton and carbon ion therapy. It presents a thorough introduction for those new to the field while providing a helpful, up-to-date reference for readers already using the therapy in clinical settings.

Proton Therapy and Radiosurgery

Proton Therapy and Radiosurgery Book
Author : Hans Breuer,Berend J. Smit
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662043017
Language : En, Es, Fr & De

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Book Description :

The book is divided into two parts: Part I deals with the relevant physics and planning algorithms of protons (H Breuer) and Part II with the radiobiology, radiopathology and clinical outcomes of proton therapy and a comparison of proton therapy versus photon therapy (BJ Smit). Protons can be used for radiosurgery and general radio therapy. Since proton therapy was first proposed in 1946 by Wilson, about sixteen facilities have been built globally. Only a very few of these have isocentric beam delivery systems so that proton therapy is really only now in a position to be compared directly by means of randomised clinical trials, with modern photon radiotherapy therapy sys tems, both for radiosurgery and for general fractionated radiotherapy. Three-dimensional proton planning computer systems with image fusion (image of computerised tomography (CT), magnetic resonance registration) capabilities imaging (MRI), stereotactic angiograms and perhaps positron emission tomography (PET) are essential for accurate proton therapy planning. New planning systems for spot scanning are under development. Many of the older comparisons of the advantageous dose distributions for protons were made with parallel opposing or multiple co-planar field arrangements, which are now largely obsolete. New comparative plans are necessary once more because of the very rapid progress in 3-D conformal planning with photons. New cost-benefit analy ses may be needed. Low energy (about 70 MeV) proton therapy is eminently suitable for the treatment of eye tumours and has firmly established itself as very useful in this regard.

Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility

Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility Book
Author : Matthias Würl
Publisher : Springer
Release : 2016-05-30
ISBN : 3658131683
Language : En, Es, Fr & De

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Book Description :

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

Proton Beam Therapy

Proton Beam Therapy Book
Author : Santosh Yajnik
Publisher : Springer Science & Business Media
Release : 2012-10-17
ISBN : 146145297X
Language : En, Es, Fr & De

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Book Description :

Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing the dose to surrounding tissue. The benefits of proton beam therapy in delivering a lethal hit to the target while sparing surrounding normal tissues from radiation are becoming applicable to an increasing number of patients and a growing list of conditions. In this book, the author will guide the reader through existing evidence supporting proton beam therapy for pediatric cancer, prostate cancer, lung cancer, brain tumors, spinal tumors, and several other conditions. The book will discuss which conditions are suitable for treatment with proton beam therapy, how the treatment is delivered, and the current data supporting its use.

Proton Therapy Destroys Cancer

Proton Therapy Destroys Cancer Book
Author : Robert Ferre
Publisher : Unknown
Release : 2020
ISBN : 9781940875828
Language : En, Es, Fr & De

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Book Description :

Proton beam therapy is a controversial form of radiation that is revolutionizing cancer care. Some critics feel it needs more proof, even though 200,000 people have been treated worldwide over the past thirty years. As a cancer patient, Robert Ferré wanted to know if proton therapy would be the best treatment. The answer is a resounding yes. Now three years cancer free, he is on a mission to inform the public about this exceptional cancer treatment.Compared to surgery, x-rays, and chemotherapy, proton beam therapy gets a better result, does less damage to healthy tissue, and produces fewer side effects in almost every instance. This makes it especially valuable in areas near vital organs, such as brain, throat, breast, and lungs. In fact, 80% of all cancers can be treated with proton beam therapy. Cancers included in this book are:Base of skullBrain Breast Esophageal GastrointestinalHead and neckHodgkin's lymphomaLiverLungOpticalOropharynxPancreaticPediatricPelvic chondrosarcomaProstateRecurrentSkinSpinal cordProtons are charged particles from the nucleus of hydrogen atoms that release virtually all of their energy in the target (such as a malignant tumor) disabling the cancer's ability to reproduce. Then they stop. There is no damaging exit through the body as with x-rays, no scalpels, no chemicals. The technology is very complex, quite costly, and sometimes not covered by insurance. Your doctor probably won't recommend proton therapy, so it is necessary to find out the facts yourself. Thousands are glad they did.Robert Ferré was treated for prostate cancer with proton therapy in the fall of 2016. He was so impressed that he writes books and manages websites to help bring this valuable information to the public at large. (See www.proton-beam-therapy.com.) This book is a small investment that could have a huge impact on your life or that of a loved one. While not giving direct medical advice, this book provides information and resources that will enhance your understanding and direct you to places where you can get a second opinion.

Proton Therapy

Proton Therapy Book
Author : Steven J. Frank,X. Ronald Zhu
Publisher : Elsevier
Release : 2020-05-07
ISBN : 9780323733496
Language : En, Es, Fr & De

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Book Description :

As proton therapy treatment centers become smaller and more cost-effective, education and training for today's multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Best Prostate Cancer Treatment

Best Prostate Cancer Treatment Book
Author : Robert Ferre
Publisher : Unknown
Release : 2018-05-15
ISBN : 9781940875965
Language : En, Es, Fr & De

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Book Description :

Any man, spouse, relative, or friend of a man facing prostate cancer should read this book. Here Robert Ferre explains in precious detail his experience receiving proton therapy for prostate cancer in 2016. So impressed was he that he wrote this (and two subsequent books) about the technology, how it works, how to pay for it, who¿s doing it, and what the future holds. This book is specifically about proton therapy and does not cover other modalities except for brief comparisons, in which protons come out the winner. Here you find far more detail about the nature and use of protons than any other non-medical book on the subject. Being in full color allows diagrams to show the intensity of the various forms of radiation. This second edition covers these and other topics:--Why your urologist never mentions proton therapy.¿--Proof that proton therapy gives the best result with the fewest side effects.¿--How proton therapy outperforms x-ray radiation such as IMRT. ¿--The author¿s personal description of receiving proton therapy treatments.¿--Recent technological advances in proton therapy not covered in older books.¿--A special program that pays 80% of the cost of proton therapy for those on Medicare.¿--How to deal with insurance companies and their resistance to proton therapy.¿--The amazing physics of proton therapy and pencil beam scanning. ¿--The superiority of pencil beam scanning for 80% of all cancers. ¿--More than 150 full-color photos and illustrations.¿--Obstacles and resistance to proton therapy. ¿--The future of proton therapy, compact equipment, lower prices, wider availability.¿--Proton therapy centers currently in operation, and those planned or under construction.Robert Ferre wrote this because of his own experience in which his doctors failed to tell him the truth about proton therapy. Cancer patients need to do their own research and become familiar with proton therapy. Then, they may need to buck their doctor¿s recommendation for surgery or x-rays and find their own way to the best proton therapy center, of which there are currently twenty-eight in the United States.

OPTima Optimising Proton Therapy Through Imaging

OPTima  Optimising Proton Therapy Through Imaging Book
Author : Michela Esposito
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Several research groups worldwide have worked in the past years towards the introduction of a new imaging modality u2013 proton Computed Tomography (pCT) into the Proton Beam Therapy (PBT) clinical workflow, with the aim of directly measuring a patientu2019s tissue stopping power and reduce uncertainties in treatment margins. Among others, the PRaVDA collaboration developed the first fully solid-state imaging system for pCT and showed a reduction in relative stopping power uncertainties down to 1.6% for a number of tissue substitute materials [Esposito et al., Phys. Med., 58, 2018].Building on the PRaVDA experience, a new UK-based collaboration named OPTIma was formed in 2018 to take forward the concept of a solid-state proton imaging system along the route to clinical use. The OPTIma system, currently under design, will be hosted in the Christie PBT Research Room using state-of-the-art spot-scanning delivery, providing a national facility for tissue stopping power calibration and evaluation of pCT in developing optimum and personalised treatment plans. Key aspects of the project include adapting detector technology and reconstruction algorithm to spot-scanning delivery systems, decreasing relative stopping power uncertainty to 1%, combining stopping power imaging with other aspects of the physics of proton interaction (i.e. scattering, straggling and attenuation powers) and integrating pCT with other existing imaging modalities in the clinical workflow.

Proton and Charged Particle Radiotherapy

Proton and Charged Particle Radiotherapy Book
Author : Thomas F. De Laney,Hanne M. Kooy
Publisher : Lippincott Williams & Wilkins
Release : 2008
ISBN : 9780781765527
Language : En, Es, Fr & De

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Book Description :

This volume is the first comprehensive and practical clinical reference on proton and charged particle radiotherapy. The first half of the book explains the treatment delivery systems used, offers detailed guidance on treatment planning techniques, examines key clinical issues in proton radiotherapy, and reviews recent experience with heavier charged particle radiotherapy. The second half of the book offers "how-to" information on treatment of pediatric tumors, lymphomas, and tumors of the central nervous system, eye, skull base, cervical spine, bone and soft tissue, paranasal sinus, nasal cavity, nasopharynx, oropharynx, oral cavity, salivary glands, prostate, lung, gastrointestinal tract, female reproductive tract, and breast. More than 100 full-color illustrations complement the text.

Prostate Cancer Conquered with Proton Therapy

Prostate Cancer Conquered with Proton Therapy Book
Author : Robert Ferre
Publisher : Unknown
Release : 2020
ISBN : 9781940875026
Language : En, Es, Fr & De

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Book Description :

When it comes to prostate cancer, men (and the women who love them) must do their own research to discover the best treatment. Too many jump directly into surgery without knowing their range of options. Author Robert Ferré has been down that road (PSA of 16.0, seven of twelve cores 40-100% malignant, Gleason score of 4+3=7). After extensive inquiry, he chose proton therapy for his treatment. The daily fifteen-minute treatment killed the cancer while causing a minimum of side effects. Now three years on, Robert is in robust health and cancer-free.Critics claim proton therapy is unproven even though more than 200,000 people have been treated worldwide over the past thirty years. The technology is more than sixty years old, although recent improvements have really ignited its potential. Studies show success rates as high as 98% for prostate cancer. This revolutionary treatment of the future is available today. Because the technology is complex and expensive, some insurance companies resist coverage. There are, however, ways to deal with that. Your urologist is most likely to recommend surgery. Before agreeing, check out your other options. Too many men are later sorry they rushed into something. This book is the most complete and up-to-date presentation available on the market today. In this book you will find: ? Why your urologist never mentioned proton therapy. ? ? Why protons give the best result with the fewest side effects.? ? How proton therapy outperforms x-rays and surgery. ? ? The author's personal description of receiving proton therapy.? ? Recent technological advances not covered in older books.? ? A program in which Medicare pays 80% of the cost.? ? How to deal with recalcitrant insurance companies.? ? The amazing physics of pencil beam scanning (PBS).? ? The superiority of proton therapy for other cancers (brain, neck, breast). ? ? Some 150 photos and illustrations for clarification.? ? The future: compact equipment, lower prices, wider availability.? ? A current list of proton therapy centers in the United States. ? ? Links to informative websites such as www.ProtonTherapyBook.com.

Ion Beam Therapy

Ion Beam Therapy Book
Author : Ute Linz
Publisher : Springer Science & Business Media
Release : 2011-12-09
ISBN : 3642214142
Language : En, Es, Fr & De

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Book Description :

The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public and for patients who might want to learn about this treatment option.

Commissioning of Shanghai Advance Proton Therapy

Commissioning of Shanghai Advance Proton Therapy Book
Author : deming li
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Shanghai advance proton therapy (SAPT) is a dedicate facility for cancer treatment. The commissioning of the accelerator started at the end of April 2017, and the proton beam has been already transported to the treatment room. This paper shows the commissioning results of synchrotron and transport line.

Proton Therapy Physics Second Edition

Proton Therapy Physics  Second Edition Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2018-11-19
ISBN : 1351855751
Language : En, Es, Fr & De

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Book Description :

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Radiation Safety and Workload Determination at the Groningen Proton Therapy Center GPTC

Radiation Safety and Workload Determination at the Groningen Proton Therapy Center  GPTC  Book
Author : Marc Jan Goethem
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Purpose: The UMCG-PTCG facility opened in Jan-2018 as a two-gantry proton facility. We report on the validation of the MCNPX-MC-simulations (F.Stichelbaut [1]) based shielding design relative to measurements .Materials&Methods The beam usage was determined based on manufacturer (IBA,Belgium) provided logfiles for a mix of pediatric, intra-cranial and Head&Neck (shallow located) targets . We performed measurements and determined dose outside the treatementrooms as a function of the facility workload. Stray radiation levels were logged at pre-determined locations using a FGH-40 with an Wendi-2 neutron detector during beam-on time. The Wendi-data was correlated to beam usage data based on time-stamps. Measurements during beam-off time were used to correct for fluctuations in background radiation, as background dose rate fluctuations have the same order as the stray dose rate.Results&Discussion The log-file analysis made it possible to monitor beam usage on a day-by-day basis. Our actual beam usage increased approximately three times compared to our initial case-mix (which included deep seated targets, such as lung, prostate). In part, this increase may be explained by changes in the patient case-mix, we treat mainly shallow indications (H&N, CSA), resulting in lower energies and higher losses in the degrader/ESS. However, even at this increased yearly workload the measured radiation levels around our treatment rooms are well below the MC-predicted level of 100u00b5Sv/year.Conclusion: The MC based shielding calculation based predictions are conservative, overestimating the shielding requirements, even if the shallow targets increasing the cyclotron workload are predominantly treated.[1] F.Stichelbaut IBA, private communications.

Development of Dose Verification Detectors Towards Improving Proton Therapy Outcomes

Development of Dose Verification Detectors Towards Improving Proton Therapy Outcomes Book
Author : Jason M. Holmes
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The challenge of radiation therapy is to maximize the dose to the tumor while simultaneously minimizing the dose elsewhere. Proton therapy is well suited to this challenge due to the way protons slow down in matter. As the proton slows down, the rate of energy loss per unit path length continuously increases leading to a sharp dose near the end of range. Unlike conventional radiation therapy, protons stop inside the patient, sparing tissue beyond the tumor. Proton therapy should be superior to existing modalities; however, because protons stop inside the patient, there is uncertainty in the range. "Range uncertainty" causes doctors to take a conservative approach in treatment planning, counteracting the advantages offered by proton therapy. Range uncertainty prevents proton therapy from reaching its full potential. A new method of delivering protons, pencil-beam scanning (PBS), has become the new standard for treatment over the past few years. PBS utilizes magnets to raster scan a thin proton beam across the tumor at discrete locations and using many discrete pulses of typically 10 ms duration each. The depth is controlled by changing the beam energy. The discretization in time of the proton delivery allows for new methods of dose verification, however few devices have been developed which can meet the bandwidth demands of PBS. In this work, two devices have been developed to perform dose verification and monitoring with an emphasis placed on fast response times. Measurements were performed at the Mayo Clinic. One detector addresses range uncertainty by measuring prompt gamma-rays emitted during treatment. The range detector presented in this work is able to measure the proton range in-vivo to within 1.1 mm at depths up to 11 cm in less than 500 ms and up to 7.5 cm in less than 200 ms. A beam fluence detector presented in this work is able to measure the position and shape of each beam spot. It is hoped that this work may lead to a further maturation of detection techniques in proton therapy, helping the treatment to reach its full potential to improve the outcomes in patients.

Surviving Cancer with Proton Therapy

Surviving Cancer with Proton Therapy Book
Author : York Phillips
Publisher : Unknown
Release : 2012-05-01
ISBN : 9780615645360
Language : En, Es, Fr & De

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Book Description :

This book is presented as non-fiction and serves as a guide to research options for treatment of prostate cancer and other localized cancers, including pediatric cancers. It also serves as a guide for those who travel to South Korea for treatment. Finally, it serves as a guide for understanding the many challenges facing cancer patients and their families. In order to present a composite story based on the experiences of several real patients who have been treated for prostate and other localized cancers, the storyline uses both fictional and real characters. This is the account of a man who discovers he has prostate cancer, investigates his choices for treatment, chooses proton beam therapy (PBT), and goes to Seoul, South Korea to be treated at the National Cancer Center. Side stories deal with men who did not actively seek treatment in time, along with the happy story of proton beam therapy being used to treat pediatric cancer.