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Proton Therapy Physics

Proton Therapy Physics Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439836450
Language : En, Es, Fr & De

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Book Description :

Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

Proton Therapy

Proton Therapy Book
Author : Steven J. Frank,X. Ronald Zhu
Publisher : Elsevier
Release : 2020-05-07
ISBN : 9780323733496
Language : En, Es, Fr & De

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Book Description :

As proton therapy treatment centers become smaller and more cost-effective, education and training for today's multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Proton Therapy and Radiosurgery

Proton Therapy and Radiosurgery Book
Author : Hans Breuer,Berend J. Smit
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662043017
Language : En, Es, Fr & De

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Book Description :

The book is divided into two parts: Part I deals with the relevant physics and planning algorithms of protons (H Breuer) and Part II with the radiobiology, radiopathology and clinical outcomes of proton therapy and a comparison of proton therapy versus photon therapy (BJ Smit). Protons can be used for radiosurgery and general radio therapy. Since proton therapy was first proposed in 1946 by Wilson, about sixteen facilities have been built globally. Only a very few of these have isocentric beam delivery systems so that proton therapy is really only now in a position to be compared directly by means of randomised clinical trials, with modern photon radiotherapy therapy sys tems, both for radiosurgery and for general fractionated radiotherapy. Three-dimensional proton planning computer systems with image fusion (image of computerised tomography (CT), magnetic resonance registration) capabilities imaging (MRI), stereotactic angiograms and perhaps positron emission tomography (PET) are essential for accurate proton therapy planning. New planning systems for spot scanning are under development. Many of the older comparisons of the advantageous dose distributions for protons were made with parallel opposing or multiple co-planar field arrangements, which are now largely obsolete. New comparative plans are necessary once more because of the very rapid progress in 3-D conformal planning with photons. New cost-benefit analy ses may be needed. Low energy (about 70 MeV) proton therapy is eminently suitable for the treatment of eye tumours and has firmly established itself as very useful in this regard.

Proton Beam Therapy

Proton Beam Therapy Book
Author : Santosh Yajnik
Publisher : Springer Science & Business Media
Release : 2012-10-17
ISBN : 146145297X
Language : En, Es, Fr & De

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Book Description :

Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing the dose to surrounding tissue. The benefits of proton beam therapy in delivering a lethal hit to the target while sparing surrounding normal tissues from radiation are becoming applicable to an increasing number of patients and a growing list of conditions. In this book, the author will guide the reader through existing evidence supporting proton beam therapy for pediatric cancer, prostate cancer, lung cancer, brain tumors, spinal tumors, and several other conditions. The book will discuss which conditions are suitable for treatment with proton beam therapy, how the treatment is delivered, and the current data supporting its use.

Proton Therapy Physics Second Edition

Proton Therapy Physics  Second Edition Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2018-11-19
ISBN : 1351855743
Language : En, Es, Fr & De

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Book Description :

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility

Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility Book
Author : Matthias Würl
Publisher : Springer
Release : 2016-05-30
ISBN : 3658131683
Language : En, Es, Fr & De

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Book Description :

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

Proton Beam Radiotherapy

Proton Beam Radiotherapy Book
Author : Koji Tsuboi,Takeji Sakae,Ariungerel Gerelchuluun
Publisher : Springer
Release : 2020-01-14
ISBN : 9789811374531
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive, practical guide to understanding the physical and biological characteristics of proton beam radiotherapy. The application of proton beams to the treatment of solid cancers has expanded exponentially over the last decade due to their physical properties, which make it possible to administer higher doses of radiation to lesions with only a minimum dose to the surrounding healthy tissues. Accordingly, understanding the basic aspects of proton beam radiotherapy is a primary concern not only for medical physicists and radiation biologists, but also for all physicians involved in cancer treatment using proton beams. The major aspects discussed include the technique’s development background, the generation and delivery system for proton beams, physical characteristics, biological consequences, dosimetry, and future prospects in both medical physics and radiation biology in terms of effective cancer treatment. Gathering contributions from experts who provide clear and detailed information on the basics of proton beams, the book will greatly benefit not only radiological technicians, medical physicists, and physicians, but also scientists in cancer radiotherapy.

Proton Therapy E Book

Proton Therapy E Book Book
Author : Steven J Frank,X. Ronald Zhu
Publisher : Elsevier Health Sciences
Release : 2020-05-18
ISBN : 0323733506
Language : En, Es, Fr & De

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Book Description :

As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.

Proton Therapy Physics Second Edition

Proton Therapy Physics  Second Edition Book
Author : Harald Paganetti
Publisher : CRC Press
Release : 2018-11-19
ISBN : 1351855751
Language : En, Es, Fr & De

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Book Description :

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Principles and Practice of Proton Bean Therapy AAPM Monograph

Principles and Practice of Proton Bean Therapy  AAPM Monograph Book
Author : Indra J. Das,Paganetti Harald
Publisher : Unknown
Release : 2015-06-22
ISBN : 9781936366439
Language : En, Es, Fr & De

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Book Description :

Download Principles and Practice of Proton Bean Therapy AAPM Monograph book written by Indra J. Das,Paganetti Harald, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Proton and Carbon Ion Therapy

Proton and Carbon Ion Therapy Book
Author : C-M Charlie Ma,Tony Lomax
Publisher : CRC Press
Release : 2012-10-09
ISBN : 1439816077
Language : En, Es, Fr & De

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Book Description :

Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discusses dosimetry, biology, imaging, and treatment planning basics and provides clinical guidelines on the use of proton and carbon ion therapy for the treatment of specific cancers. Suitable for anyone involved with medical physics and radiation therapy, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of proton and carbon ion therapy. It presents a thorough introduction for those new to the field while providing a helpful, up-to-date reference for readers already using the therapy in clinical settings.

Proton Therapy Destroys Cancer

Proton Therapy Destroys Cancer Book
Author : Robert Ferre
Publisher : Unknown
Release : 2020
ISBN : 9781940875828
Language : En, Es, Fr & De

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Book Description :

Proton beam therapy is a controversial form of radiation that is revolutionizing cancer care. Some critics feel it needs more proof, even though 200,000 people have been treated worldwide over the past thirty years. As a cancer patient, Robert Ferré wanted to know if proton therapy would be the best treatment. The answer is a resounding yes. Now three years cancer free, he is on a mission to inform the public about this exceptional cancer treatment.Compared to surgery, x-rays, and chemotherapy, proton beam therapy gets a better result, does less damage to healthy tissue, and produces fewer side effects in almost every instance. This makes it especially valuable in areas near vital organs, such as brain, throat, breast, and lungs. In fact, 80% of all cancers can be treated with proton beam therapy. Cancers included in this book are:Base of skullBrain Breast Esophageal GastrointestinalHead and neckHodgkin's lymphomaLiverLungOpticalOropharynxPancreaticPediatricPelvic chondrosarcomaProstateRecurrentSkinSpinal cordProtons are charged particles from the nucleus of hydrogen atoms that release virtually all of their energy in the target (such as a malignant tumor) disabling the cancer's ability to reproduce. Then they stop. There is no damaging exit through the body as with x-rays, no scalpels, no chemicals. The technology is very complex, quite costly, and sometimes not covered by insurance. Your doctor probably won't recommend proton therapy, so it is necessary to find out the facts yourself. Thousands are glad they did.Robert Ferré was treated for prostate cancer with proton therapy in the fall of 2016. He was so impressed that he writes books and manages websites to help bring this valuable information to the public at large. (See www.proton-beam-therapy.com.) This book is a small investment that could have a huge impact on your life or that of a loved one. While not giving direct medical advice, this book provides information and resources that will enhance your understanding and direct you to places where you can get a second opinion.

Best Prostate Cancer Treatment

Best Prostate Cancer Treatment Book
Author : Robert Ferre
Publisher : Unknown
Release : 2018-05-15
ISBN : 9781940875965
Language : En, Es, Fr & De

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Book Description :

Any man, spouse, relative, or friend of a man facing prostate cancer should read this book. Here Robert Ferre explains in precious detail his experience receiving proton therapy for prostate cancer in 2016. So impressed was he that he wrote this (and two subsequent books) about the technology, how it works, how to pay for it, who¿s doing it, and what the future holds. This book is specifically about proton therapy and does not cover other modalities except for brief comparisons, in which protons come out the winner. Here you find far more detail about the nature and use of protons than any other non-medical book on the subject. Being in full color allows diagrams to show the intensity of the various forms of radiation. This second edition covers these and other topics:--Why your urologist never mentions proton therapy.¿--Proof that proton therapy gives the best result with the fewest side effects.¿--How proton therapy outperforms x-ray radiation such as IMRT. ¿--The author¿s personal description of receiving proton therapy treatments.¿--Recent technological advances in proton therapy not covered in older books.¿--A special program that pays 80% of the cost of proton therapy for those on Medicare.¿--How to deal with insurance companies and their resistance to proton therapy.¿--The amazing physics of proton therapy and pencil beam scanning. ¿--The superiority of pencil beam scanning for 80% of all cancers. ¿--More than 150 full-color photos and illustrations.¿--Obstacles and resistance to proton therapy. ¿--The future of proton therapy, compact equipment, lower prices, wider availability.¿--Proton therapy centers currently in operation, and those planned or under construction.Robert Ferre wrote this because of his own experience in which his doctors failed to tell him the truth about proton therapy. Cancer patients need to do their own research and become familiar with proton therapy. Then, they may need to buck their doctor¿s recommendation for surgery or x-rays and find their own way to the best proton therapy center, of which there are currently twenty-eight in the United States.

Shielding Measurements for a 230 MeV Proton Beam

Shielding Measurements for a 230 MeV Proton Beam Book
Author : Jeffrey Vincent Siebers
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Shielding Measurements for a 230 MeV Proton Beam book written by Jeffrey Vincent Siebers, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Radiation Therapy Physics

Radiation Therapy Physics Book
Author : William R. Hendee,Geoffrey S. Ibbott,Eric G. Hendee
Publisher : Wiley-Liss
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The techniques of state-of-the-art radiation therapy have evolved greatly in recent years. Treatment procedures such as conformal and intensity-modulated radiation therapy, high dose-rate and brachytherapy, and image-guided radiation therapy have become standards in radiation therapy clinics around the world. Teaching models for radiation therapy have advanced accordingly, as have the protocols for calibrating and applying radiation beams in treatment. This Third Edition of Radiation Therapy Physics provides the latest information on the technological and conceptual developments currently transforming the field. A concise guide to fundamental principles and clinical applications, the text includes reviews of the most up-to-date instrumentation as well as critical historical links. Radiation Therapy Physics, Third Edition offers: New coverage of imaging modalities in therapy planning and verification, calibration protocols, and precision radiation therapy, as well as relevant regulation and compliance issues An expanded section on computer applications in radiation therapy and electron beam therapy A new, easy-to-follow format Numerous illustrative diagrams, photographs, tables, and graphs Problems, answers, and summaries for each chapter New images obtained from high-energy x-ray beams delivered by linear accelerators Clear and concise writing style throughout With its user-friendly presentation and broad, comprehensive coverage of radiotherapy physics, Radiation Therapy Physics, Third Edition is both an accessible medical text and a handy professional reference.

Radiation Safety and Workload Determination at the Groningen Proton Therapy Center GPTC

Radiation Safety and Workload Determination at the Groningen Proton Therapy Center  GPTC  Book
Author : Marc Jan Goethem
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Purpose: The UMCG-PTCG facility opened in Jan-2018 as a two-gantry proton facility. We report on the validation of the MCNPX-MC-simulations (F.Stichelbaut [1]) based shielding design relative to measurements .Materials&Methods The beam usage was determined based on manufacturer (IBA,Belgium) provided logfiles for a mix of pediatric, intra-cranial and Head&Neck (shallow located) targets . We performed measurements and determined dose outside the treatementrooms as a function of the facility workload. Stray radiation levels were logged at pre-determined locations using a FGH-40 with an Wendi-2 neutron detector during beam-on time. The Wendi-data was correlated to beam usage data based on time-stamps. Measurements during beam-off time were used to correct for fluctuations in background radiation, as background dose rate fluctuations have the same order as the stray dose rate.Results&Discussion The log-file analysis made it possible to monitor beam usage on a day-by-day basis. Our actual beam usage increased approximately three times compared to our initial case-mix (which included deep seated targets, such as lung, prostate). In part, this increase may be explained by changes in the patient case-mix, we treat mainly shallow indications (H&N, CSA), resulting in lower energies and higher losses in the degrader/ESS. However, even at this increased yearly workload the measured radiation levels around our treatment rooms are well below the MC-predicted level of 100u00b5Sv/year.Conclusion: The MC based shielding calculation based predictions are conservative, overestimating the shielding requirements, even if the shallow targets increasing the cyclotron workload are predominantly treated.[1] F.Stichelbaut IBA, private communications.

Proton and Charged Particle Radiotherapy

Proton and Charged Particle Radiotherapy Book
Author : Thomas F. De Laney,Hanne M. Kooy
Publisher : Lippincott Williams & Wilkins
Release : 2008
ISBN : 9780781765527
Language : En, Es, Fr & De

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Book Description :

This volume is the first comprehensive and practical clinical reference on proton and charged particle radiotherapy. The first half of the book explains the treatment delivery systems used, offers detailed guidance on treatment planning techniques, examines key clinical issues in proton radiotherapy, and reviews recent experience with heavier charged particle radiotherapy. The second half of the book offers "how-to" information on treatment of pediatric tumors, lymphomas, and tumors of the central nervous system, eye, skull base, cervical spine, bone and soft tissue, paranasal sinus, nasal cavity, nasopharynx, oropharynx, oral cavity, salivary glands, prostate, lung, gastrointestinal tract, female reproductive tract, and breast. More than 100 full-color illustrations complement the text.

Applications of Accelerators in Research and Industry Proceedings of the Fifteenth International Conference

Applications of Accelerators in Research and Industry  Proceedings of the Fifteenth International Conference Book
Author : Jerome L. Duggan,I. Lon Morgan
Publisher : American Institute of Physics
Release : 1999-06-18
ISBN : 9781563968259
Language : En, Es, Fr & De

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Book Description :

The papers in this proceedings volume describe the research and applications of low energy accelerators. The research is primarily in the field of nuclear and atomic physics. The applications are: ion implantation and all of the ion beam diagnostic techniques that are currently in use with small accelerators.