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Protein Physics

Protein Physics Book
Author : Alexei V. Finkelstein,Oleg Ptitsyn
Publisher : Elsevier
Release : 2016-06-22
ISBN : 0081012365
Language : En, Es, Fr & De

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Book Description :

Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

Lectures on Statistical Physics and Protein Folding

Lectures on Statistical Physics and Protein Folding Book
Author : Kerson Huang
Publisher : World Scientific
Release : 2005-05-30
ISBN : 9814481068
Language : En, Es, Fr & De

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Book Description :

' This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix. Contents:EntropyMaxwell–Boltzmann DistributionFree EnergyChemical PotentialPhase TransitionsKinetics of Phase TransitionsThe Order ParameterCorrelation FunctionStochastic ProcessesLangevin EquationThe Life ProcessSelf-AssemblyKinetics of Protein FoldingPower Laws in Protein FoldingSelf-Avoiding Walk and TurbulenceConvergent Evolution in Protein Folding Readership: Graduate students, researchers and academics interested in statistical physics and molecular biology. Keywords:Statistical Physics;Protein Folding;BiophysicsReviews:“My particularly favorite is the chapter on order parameters, explaining with simplicity and clarity this subject so frequently difficult and confusing for the beginning students … the book makes a strong attempt to place the protein folding problem where it really belongs — in the context of fundamental statistical mechanics. Whether the attempt is successful or not is a matter of a reader's opinion, but the very direction is both timely and welcome.”Professor Alexander Grosberg University of Minnesota '

The Physics of Proteins

The Physics of Proteins Book
Author : Hans Frauenfelder
Publisher : Springer Science & Business Media
Release : 2010-05-30
ISBN : 1441910441
Language : En, Es, Fr & De

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Book Description :

Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding

Explicit solvent effects on protein physics

Explicit solvent effects on protein physics Book
Author : Giovanni Salvi
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
Release : 2009
ISBN : 9783838107714
Language : En, Es, Fr & De

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Book Description :

Protein folding stands as one of the major interdisciplinary challenges of the last fifteen years, involving biology, chemistry, medicine and physics. In this book solvent effects, and the related hydrophobic effect, on proteins are investigated. Using a simple lattice model of proteins, in which the solvent is semi-explicitly taken into account, thermodynamical quantities can be investigated and the crucial role the solvent plays in protein folding can be demonstrated. Of particular relevance is our observation that a simple model, in which the potential energy is described in terms of the interactions between amino-acids only, does not correctly reproduce solvent effects. Approaches like this, in which solvent effects are treated implicitly, are commonly employed in many of more sophisticated models for protein folding dynamics. Our results are then of great importance as they suggest the treatment of the solvent in these models may need to be re-examined.

Membrane Protein Lipid Interactions Physics and Chemistry in the Bilayers

Membrane Protein     Lipid Interactions  Physics and Chemistry in the Bilayers Book
Author : Jordi H. Borrell,Òscar Domènech,Kevin M.W. Keough
Publisher : Springer
Release : 2016-04-10
ISBN : 9783319302751
Language : En, Es, Fr & De

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Book Description :

This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions. A general introduction is presented in Chapters 1 and 2. The following Chapters, 3 and 4, describe the most accepted theories on lipid-membrane protein interactions as well as the new experimental approaches, in particular, these arose from nano sciences as atomic for microscopy and single molecule force spectroscopy. The book emphasizes the relevance of physical parameters as the lateral surface pressure and the lipid curvature as actors for understanding the physicochemical properties of the biomembranes.

Protein Folding and Drug Design

Protein Folding and Drug Design Book
Author : R. A. Broglia,Luis Serrano Romero,Guido Tiana
Publisher : IOS Press
Release : 2007-01-01
ISBN : 1586037927
Language : En, Es, Fr & De

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Book Description :

"One of the great unsolved problems of science and also physics is the prediction of the three dimensional structure of a protein from its amino acid sequence: the folding problem. It may be stated that the deep connection existing between physics and protein folding is not so much, or in any case not only, through physical methods (experimental: Xrays, NMR, etc, or theoretical: statistical mechanics, spin glasses, etc), but through physical concepts. In fact, protein folding can be viewed as an emergent property not contained neither in the atoms forming the protein nor in the forces acting among them, in a similar way as superconductivity emerges as an unexpected coherent phenomenon taking place on a sea of electrons at low temperature. Already much is known about the protein folding problem, thanks, among other things, to protein engineering experiments as well as from a variety of theoretical inputs: inverse folding problem, funnellike energy landscapes (Peter Wolynes), helixcoil transitions, etc. Although quite different in appearance, the fact that the variety of models can account for much of the experimental ?ndings is likely due to the fact that they contain much of the same (right) physics. A physics which is related to the important role played by selected highly conserved, hot, amino acids which participate to the stability of independent folding units which, upon docking, give rise to a (postcritical) folding nucleus lying beyond the highest maximum of the free energy associated to the process."

Membrane Protein Lipid Interactions Physics and Chemistry in the Bilayer

Membrane Protein     Lipid Interactions  Physics and Chemistry in the Bilayer Book
Author : Jordi H. Borrell,Òscar Domènech,Kevin M.W. Keough
Publisher : Springer
Release : 2016-03-15
ISBN : 3319302779
Language : En, Es, Fr & De

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Book Description :

This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions. A general introduction is presented in Chapters 1 and 2. The following Chapters, 3 and 4, describe the most accepted theories on lipid-membrane protein interactions as well as the new experimental approaches, in particular, these arose from nano sciences as atomic for microscopy and single molecule force spectroscopy. The book emphasizes the relevance of physical parameters as the lateral surface pressure and the lipid curvature as actors for understanding the physicochemical properties of the biomembranes.

Polymer and Protein Physics

Polymer and Protein Physics Book
Author : Anonim
Publisher : Unknown
Release : 2021
ISBN : 9789151311395
Language : En, Es, Fr & De

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Book Description :

Download Polymer and Protein Physics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Proteins

Proteins Book
Author : Charles L. Brooks,Martin Karplus,B. Montgomery Pettitt
Publisher : John Wiley & Sons
Release : 2009-09-08
ISBN : 0470141816
Language : En, Es, Fr & De

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Book Description :

Presenting a wide-ranging view of current developments in protein research, the papers in this collection, each written by highly regarded experts in the field, examine various aspects of protein structure, functions, dynamics, and experimentation. Topics include dynamical simulation methods, the biological role of atom fluctuations, protein folding, influences on protein dynamics, and a variety of analytical techniques, such as X-ray diffraction, vibrational spectroscopy, photodissociation and rebinding kinetics. This is part of a series devoted to providing general information on a wide variety of topics in chemical physics in order to stimulate new research and to serve as a text for beginners in a particular area of chemical physics.

From Protein Structure to Function with Bioinformatics

From Protein Structure to Function with Bioinformatics Book
Author : Daniel John Rigden
Publisher : Springer Science & Business Media
Release : 2008-12-11
ISBN : 1402090587
Language : En, Es, Fr & De

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Book Description :

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function.

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane Book
Author : Ksenia Guseva
Publisher : Springer Science & Business Media
Release : 2011-10-01
ISBN : 9783642239885
Language : En, Es, Fr & De

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Book Description :

With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

Advances in Protein Chemistry

Advances in Protein Chemistry Book
Author : Anonim
Publisher : Academic Press
Release : 1980-01-23
ISBN : 0080582060
Language : En, Es, Fr & De

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Book Description :

Advances in Protein Chemistry

A Guide to Protein Isolation

A Guide to Protein Isolation Book
Author : C. Dennison
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 9401702691
Language : En, Es, Fr & De

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Book Description :

It is a truism of science that the more fundamental the subject, the more universally applicable it is. Neverthelens, it is important to strike a level of "fundamentalness" appropriate to the task in hand. For example, an in-depth study of the mechanics of motor cars would tell one nothing about the dynamics of traffic. Traffic exists on a different "level" - it is dependent upon the existence of motor vehicles but the physics and mathematics of traffic can be adequately addressed by considering motor vehicles as mobile "blobs", with no consideration of how they become mobile. To start a discourse on traffic with a consideration of the mechanics of motor vehicles would thus be inappropropriate. In writing this volume, I have wrestled with the question of the appropriate level at which to address the physics underlying many of the techniques used in protein isolation. I have tried to strike a level as would be used by a mechanic (with perhaps a slight leaning towards an engineer) - i.e. a practical level, offering appropriate insight but with minimal mathematics. Some people involved in biochemical research have a minimal grounding in chemistry and physics and so I have tried to keep it as simple as possible.

Varieties and Phenomenology of Electrostatic Interactions in Protein Physics

Varieties and Phenomenology of Electrostatic Interactions in Protein Physics Book
Author : Nataša Adžić (fizičarka.)
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Varieties and Phenomenology of Electrostatic Interactions in Protein Physics book written by Nataša Adžić (fizičarka.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Methods for Protein Folding

Computational Methods for Protein Folding Book
Author : Richard A. Friesner
Publisher : John Wiley & Sons
Release : 2004-04-07
ISBN : 9780471465232
Language : En, Es, Fr & De

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Book Description :

Since the first attempts to model proteins on a computer began almost thirty years ago, our understanding of protein structure and dynamics has dramatically increased. Spectroscopic measurement techniques continue to improve in resolution and sensitivity, allowing a wealth of information to be obtained with regard to the kinetics of protein folding and unfolding, and complementing the detailed structural picture of the folded state. Concurrently, algorithms, software, and computational hardware have progressed to the point where both structural and kinetic problems may be studied with a fair degree of realism. Despite these advances, many major challenges remain in understanding protein folding at both the conceptual and practical levels. Computational Methods for Protein Folding seeks to illuminate recent advances in computational modeling of protein folding in a way that will be useful to physicists, chemists, and chemical physicists. Covering a broad spectrum of computational methods and practices culled from a variety of research fields, the editors present a full range of models that, together, provide a thorough and current description of all aspects of protein folding. A valuable resource for both students and professionals in the field, the book will be of value both as a cutting-edge overview of existing information and as a catalyst for inspiring new studies. Computational Methods for Protein Folding is the 120th volume in the acclaimed series Advances in Chemical Physics, a compilation of scholarly works dedicated to the dissemination of contemporary advances in chemical physics, edited by Nobel Prize-winner Ilya Prigogine.

Physics at the Biomolecular Interface

Physics at the Biomolecular Interface Book
Author : Ariel Fernández
Publisher : Springer
Release : 2016-05-11
ISBN : 3319308521
Language : En, Es, Fr & De

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Book Description :

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.

Proceedings of 8th European Chemistry Congress 2018

Proceedings of 8th European Chemistry Congress 2018 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2022-01-21
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

June 21-23, 2018 Paris, France Key Topics : Organic Chemistry, Inorganic Chemistry, Analytical Chemistry, Green Chemistry, Physical Chemistry, Theoretical Chemistry, Environmental Chemistry, Materials Chemistry, Medicinal Chemistry, Medical Biochemistry, Biological Chemistry, Nuclear Chemistry, Petro Chemicals, Multi-disciplinary Chemistry, Chemistry Education,

Mathematical Modeling of Protein Complexes

Mathematical Modeling of Protein Complexes Book
Author : Tatiana Koshlan,Kirill Kulikov
Publisher : Springer
Release : 2018-08-24
ISBN : 3319983040
Language : En, Es, Fr & De

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Book Description :

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.

Aspects of Physical Biology

Aspects of Physical Biology Book
Author : Giancarlo Franzese,Miguel Rubi
Publisher : Springer
Release : 2008-12-02
ISBN : 3540787658
Language : En, Es, Fr & De

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Book Description :

The application to Biology of the methodologies developed in Physics is attracting an increasing interest from the scientific community. It has led to the emergence of a new interdisciplinary field, called Physical Biology, with the aim of reaching a better understanding of the biological mechanisms at molecular and cellular levels. Statistical Mechanics in particular plays an important role in the development of this new field. For this reason, the XXth session of the famous Sitges Conference on Statistical Physics was dedicated to "Physical Biology: from Molecular Interactions to Cellular Behavior". As is by now tradition, a number of lectures were subsequently selected, expanded and updated for publication as lecture notes, so as to provide both a state-of-the-art introduction and overview to a number of subjects of broader interest and to favor the interchange and cross-fertilization of ideas between biologists and physicists. The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.