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Protein Biosynthesis Interference In Disease

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Protein Biosynthesis Interference in Disease

Protein Biosynthesis Interference in Disease Book
Author : Elena L. Paley
Publisher : Academic Press
Release : 2020-10-08
ISBN : 0128234865
Language : En, Es, Fr & De

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Book Description :

Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer’s and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes. Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis

Viruses and Human Disease

Viruses and Human Disease Book
Author : Ellen G. Strauss,James H. Strauss
Publisher : Elsevier
Release : 2007-09-21
ISBN : 9780080553160
Language : En, Es, Fr & De

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Book Description :

Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text

Cell and Molecular Biology

Cell and Molecular Biology Book
Author : Gerald Karp
Publisher : John Wiley & Sons
Release : 2009-10-19
ISBN : 0470483377
Language : En, Es, Fr & De

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Book Description :

Karp continues to help biologists make important connections between key concepts and experimentation. The sixth edition explores core concepts in considerable depth and presents experimental detail when it helps to explain and reinforce the concepts. The majority of discussions have been modified to reflect the latest changes in the field. The book also builds on its strong illustration program by opening each chapter with “VIP” art that serves as a visual summary for the chapter. Over 60 new micrographs and computer-derived images have been added to enhance the material. Biologists benefit from these changes as they build their skills in making the connection.

Molecules Cells and Disease

Molecules  Cells  and Disease Book
Author : J.L. VanLancker
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 146139418X
Language : En, Es, Fr & De

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Book Description :

In tracing their origin and their fate, the beginning and the end of their environment, humans have often been guided by curiosity. Such concern has helped man to discover, among other things, the structure of the universe from star to atom and the evolution of life from unicellular organism to human being. The study of disease is unique. Although it may have been in spired by the curiosity of a few, it has always been the concern of all, because preventing or curing disease has meant survival not only of individuals, but of entire nations, not only of humans, but of fellow living creatures. If greed, force, religion, and language have been major causes of wars, diseases, more than arms, have often decided the outcome of battles and thereby have woven the pattern of history. For millennia, a large fraction of the human race believed that disease expressed the wrath of God(s) against individuals or societies. Therefore, only priests or priestesses, kings, and queens were endowed with the power of healing. In the West, Hippocrates is credited for exorcising this concept of disease and for objectively describing and cataloguing them. The contributions of Greek physicians to Western medicine made possible more accurate diagnoses and prognoses.

Free Radicals in Human Health and Disease

Free Radicals in Human Health and Disease Book
Author : Vibha Rani,Umesh Chand Singh Yadav
Publisher : Springer
Release : 2014-11-14
ISBN : 8132220358
Language : En, Es, Fr & De

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Book Description :

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

RNA Interference Technology

RNA Interference Technology Book
Author : Krishnarao Appasani
Publisher : Cambridge University Press
Release : 2005-01-17
ISBN : 9781139442657
Language : En, Es, Fr & De

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Book Description :

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.

Infectious Diseases in the Female Patient

Infectious Diseases in the Female Patient Book
Author : Rudolph P. Galask,Bryan Larsen
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461248523
Language : En, Es, Fr & De

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Book Description :

In obstetrics and gynecology, as in other medical disciplines, great satisfaction comes from doing, but a greater satisfaction comes from knowing. The desire to know raises clinical practice to its highest level. This principle guided us in determining the objectives for this volume. Several standard textbooks of obstetrics and gynecology include information about infectious problems. Infectious Diseases in the Female Patient is unique in that it emphasizes primarily the basic science as pects of infections in obstetrics and gynecology. Although providing a practitioner's handbook was not our goal, the reader nevertheless will find discussions of the management of infections in the female pa tient. The continued growth of knowledge about infectious disease en countered in obstetrics and gynecology has come from many sources: bacteriology, virology, genetics, immunology, biochemistry, physiol ogy, and pharmacology. Insights from all these disciplines contribute to the conceptual framework of this volume. Many of the authors who contributed to this text are leaders in their respective areas of research and bring to the book a diversity of ex pertise and experience. Controversial issues are developed in a bal anced fashion, and, in most cases, opposing views are discussed. Since medical texts usually are read piece-meal rather than cover to cover, we have allowed some overlap between chapters. The slight degree of redundancy allows each chapter to stand on its own, so that the reader may obtain the necessary information from a single chapter.

Veterinary Microbiology and Microbial Disease

Veterinary Microbiology and Microbial Disease Book
Author : P. J. Quinn,B. K. Markey,F. C. Leonard,P. Hartigan,S. Fanning,E. S. Fitzpatrick
Publisher : John Wiley & Sons
Release : 2011-10-07
ISBN : 1118251164
Language : En, Es, Fr & De

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Book Description :

Microbiology is one of the core subjects for veterinary students,and since its first publication in 2002, Veterinary Microbiologyand Microbial Disease has become an essential text for students ofveterinary medicine. Fully revised and expanded, this new editionupdates the subject for pre-clinical and clinical veterinarystudents in a comprehensive manner. Individual sections deal withbacteriology, mycology and virology. Written by an academic teamwith many years of teaching experience, the book provides concisedescriptions of groups of microorganisms and the diseases whichthey cause. Microbial pathogens are discussed in separate chapterswhich provide information on the more important features of eachmicroorganism and its role in the pathogenesis of diseases ofanimals. The international and public health significance of thesepathogens are reviewed comprehensively. The final section isconcerned with the host and is organized according to the bodysystem affected. Tables, boxes and flow diagrams provide information in an easilyassimilated format. This edition contains new chapters on moleculardiagnostics and on infectious conditions of the skin,cardiovascular system, urinary tract and musculoskeletal system.Many new colour diagrams are incorporated into this edition andeach chapter has been updated. Key features of this edition: Twelve new chapters included Numerous new illustrations Each chapter has been updated Completely re-designed in full colour Fulfils the needs of veterinary students and academics inveterinary microbiology Companion website with figures from the book as Powerpoints forviewing or downloading by chapter: ahref="http://www.wiley.com/go/quinn/veterinarymicrobiology"www.wiley.com/go/quinn/veterinarymicrobiology/a Veterinary Microbiology and Microbial Disease remainsindispensable for all those studying and teaching this essentialcomponent of the veterinary curriculum.

Retinal Pharmacotherapy E Book

Retinal Pharmacotherapy E Book Book
Author : Quan Dong Nguyen,Eduardo Buchele Rodrigues,Michel Eid Farah,William F. Mieler
Publisher : Elsevier Health Sciences
Release : 2010-02-26
ISBN : 0702047406
Language : En, Es, Fr & De

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Book Description :

Retinal Pharmacotherapy is the first comprehensive book devoted to pharmacologic agents and their rationale and mechanisms of action in selected retinal and uveitic diseases. Drs. Quan Dong Nguyen, Eduardo Buchele Rodrigues, Michel Eid Farah, and William F. Mieler lead an international team of expert contributors to present up-to-date knowledge of new drugs on the market, the science behind the drugs, evidence of how the drugs work, and the reasons why they are effective or not. This user-friendly, all-in-one reference provides you with easy access to practical information on the effective and appropriate use of pharmacologic agents in the management of retinal diseases. Covers all new and existing retinal drugs to keep you current in this expanding area of the treatment of retinal diseases. Discusses the background behind retinal drugs and the various pathways of how they work so you can make thoroughly informed clinical decisions. Presents 400 color photographs and line drawings that illustrate disease appearance before and after treatment and clarify difficult key concepts. Features contributors from Europe, North America, South America, the Middle East, Asia, and Australia for an international approach. Identifies and emphasizes key points clearly in each chapter to improve comprehension and make finding information easier.

Gene Therapy for Renal Diseases and Transplantation

Gene Therapy for Renal Diseases and Transplantation Book
Author : Ariela Benigni,Giuseppe Remuzzi
Publisher : Karger Medical and Scientific Publishers
Release : 2008-01-01
ISBN : 3805585055
Language : En, Es, Fr & De

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Book Description :

Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. In the present book, world-renowned experts are presenting new insights into viral and non-viral systems used to effect gene delivery, one chapter being dedicated to the new field of RNA interference (RNAi). This latter method may be successfully used in renal ischemia-reperfusion injury, trauma and transplantation. In the near future, gene therapy might also prove to be a new strategy to target molecules involved in tissue damage and inflammation processes that underlie ARF. So far, gene transfer has been successfully applied in experimental glomerulonephritis and interstitial fibrosis, and studies in larger animals are keenly awaited. Also covered are issues related to transplantation, which is the therapy of choice in many end-stage organ failures. Transfer of genes whose protein products have immunomodulatory properties have proven beneficial in treating acute and chronic graft rejection, one of the problems not satisfactorily solved by current anti-rejection drugs. Gene therapy thus may become a reality in clinical transplantation once its efficacy in larger animals has been demonstrated. Last but not least, a possible benefit of targeted gene therapy in renal cancer or HIV-associated nephropathy is explored. Covering a wide spectrum of topics, this publication provides a valuable overview of current developments and issues.

Neuromuscular Diseases

Neuromuscular Diseases Book
Author : Michael Swash,Martin S. Schwartz
Publisher : Springer Science & Business Media
Release : 2013-03-14
ISBN : 1447138341
Language : En, Es, Fr & De

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Book Description :

Nine years have elapsed since the second edition of this book was published. In this time the principal advances in neuromuscular diseases have been in the application of molecular genetics to understanding the aetiology and pathogenesis of this group of disorders. As a result many previously unrecognised disorders have been charac terised. Some clinical syndromes, such as the limb girdle dystrophies, have become better defined. In many such instances the new genetic information has led to major advances in knowledge of the biology of cell structures, for example, the membrane structural and channel proteins. The clinical syndromes themselves, and their patho logical and electrophysiological characteristics, however, remain as important as ever, since they constitute the clinical problem itself and, indeed, the database from which all other concepts emerge. Knowledge of the pathogenesis, genetics, and molecular biology of neuromuscular disorders is essential both in developing and applying new therapies and preventive measures, and in formulating genetic and prognostic advice. However, this informa tion does not necessarily always define clinically useful syndromes. Myotonia, for example, is an electrophysiological finding in some syndromes in which it is un detectable by clinical examination, although the phenomenon itself was originally defined as a clinical entity. The limb girdle muscular dystrophy syndromes can be defined by severity, distribution of weakness, age of onset, sex distribution and other characteristics and many of these can be better understood by study of the under lying defect in cell structural proteins.

Pathophysiology for the Health Professions E Book

Pathophysiology for the Health Professions   E  Book Book
Author : Barbara E. Gould,Ruthanna Dyer
Publisher : Elsevier Health Sciences
Release : 2014-04-11
ISBN : 0323292402
Language : En, Es, Fr & De

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Book Description :

A concise, easy-to-understand introduction to the fundamentals, Pathophysiology for the Health Professions, 4th Edition helps you learn to identify disease processes and disorders. Authors Barbara Gould and Ruthanna Dyer continue the tradition of a text known for its readability and vivid, full-color illustrations, updated with the latest research and clinical advances. Unique Challenge, Think About, and Emergency Treatment features help in applying the material to real-life situations. No matter which area in the healthcare field you may enter, this book provides essential preparation for conditions encountered in clinical practice. Concise and readable approach includes the information students need without overwhelming them, even if they have a limited scientific background. Unique Challenge feature asks "What can go wrong with this structure or system?" as a way to help students facilitate progress by using previously learned knowledge. Unique Think About boxes help with self-evaluation, test preparation, and review. Unique Emergency Treatment boxes list basic emergency measures; these can be modified to fit specific professions, established protocols, or practice settings. Research boxes discuss new developments, problem areas of pathophysiology, and complications associated with research. Warning Signs boxes summarize conditions that may develop in patients. Diagnostic tests and treatments are included for each of the major disorders. Case studies in each chapter provide a basis for discussion or can be used as an assignment. Study questions offer a self-assessment on the material in each chapter. Ready References in the appendix provide a quick lookup for anatomic terms, conversion tables, abbreviations and acronyms, diagnostic studies and tests, and more. A companion Evolve website includes web links, learning activities, content updates, and more. New content on the causes and trends related to disease, new drugs, technology, and treatment. Coverage of obesity and its complications, including an in-depth discussion of metabolic syndrome. Multiple disorder syndromes in the aged client. DNA, genetics and the Human Genome Project with current research on protein pathways in health (proteomics) and the implications for drug treatment and disease causation. Coverage of autism. Updated content on the H1N1 virus and communicable diseases; HIV, cancer causation, and immunology; and substance abuse to reflect common practices in the use of illicit (street) drugs as well as abuse of prescription medications. Case studies revised to emphasize chronic diseases, prevention, and acute care, and to apply to a wider range of health professions. Appendices reorganized for improved reference and lookup.

Emerging Issues and Controversies in Infectious Disease

Emerging Issues and Controversies in Infectious Disease Book
Author : I.W. Fong
Publisher : Springer Science & Business Media
Release : 2009-01-01
ISBN : 038784841X
Language : En, Es, Fr & De

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Book Description :

In this edition of the Emerging Infectious Diseases of the 21st Century Series, the editor reviews the research, diagnosis, and treatment of some common infections facing researchers, clinicians and family physicians such as sinusitis, otitis media and pertussis in adults. Recent studies and surveys have shown that these conditions are often over diagnosed and treated unnecessarily with antibiotics. The approach and guidelines for diagnosis and management are reviewed in this volume. Other more complicated but less common conditions challenging internists, clinical infectious disease consultants and other specialists are also reviewed (i.e. meningitis, ventilator associated pneumonia, sepsis, hepatitis C, B, etc.).

Problems in Gastroenterology

Problems in Gastroenterology Book
Author : M. Lancaster-Smith,K.G. Williams
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401172064
Language : En, Es, Fr & De

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Book Description :

Part one of the book presents the gastrointestinal problems that commonly face the general practitioner. Emphasis is placed on analysis of clinical data and how this may provoke the most profitable lines of investigation. Many of the investigation and treatment protocols are within the scope of general practice, but hospital management is also included. It was possible to deal with common oesophageal diseases under the heading of oeso phageal problems in Part 1. In contrast, it proved impossible to discuss adequately all of the common diseases affecting other organs of the digestive system under the problem headings. For this reason, a fuller ac count of many common alimentary diseases is provided in Part two. M. L.-5. K. G. D. W. 9 Series Foreword This series of books is designed to help general practitioners. So are other books. What is unusual in this instance is their collec tive authorship; they are written by specialists working at district general hospitals. The writers derive their own experi ence from a range of cases less highly selected than those on which textbooks are traditionally based. They are also in a good position to pick out topics which they see creating difficulties for the practitioners of their district, whose personal capacities are familiar to them; and to concentrate on contexts where mistakes are most likely to occur. They are all well-accustomed to working in consultation.

Mosby s Comprehensive Review for Veterinary Technicians E Book

Mosby s Comprehensive Review for Veterinary Technicians   E Book Book
Author : Monica M. Tighe,Marg Brown
Publisher : Elsevier Health Sciences
Release : 2014-06-16
ISBN : 0323171397
Language : En, Es, Fr & De

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Book Description :

Whether you’re a new vet tech student or reviewing for the certification exam, Mosby's Comprehensive Review for Veterinary Technicians, 4th Edition is the ideal review tool to help you master critical concepts and pass the VTNE. Now in full color, this edition features a user-friendly outline format that helps break down information visually. Coverage reinforces key concepts in basic and clinical sciences, clinical applications, patient management and nutrition, anesthesia and pharmacology, medical and surgical nursing, and critical care, plus new information on pain management. To ensure the most meaningful review, the Evolve site features a study mode that includes 500 review questions and an exam mode that offers a computer-based testing environment similar to what you will encounter when taking the VTNE. Comprehensive coverage includes all areas of veterinary technology, such as: basic and clinical sciences; clinical applications; patient management, nursing and nutrition; anesthesia and pharmacology; and professional practices and issues. Comprehensive review exam at the end of the text contains 350 questions that provide you with a solid review of the vet tech curriculum and the information you need to know to pass the VTNE. User-friendly outline format is conducive to classification and grouping of material, which helps you retain the content. Coverage of dogs, cats, large animals, birds, reptiles, and laboratory animals ensures you are prepared for all aspects of the national board examination. Summarized concepts and procedures are highlighted in boxes and tables to support visual learners. Student-friendly chapter format contains a chapter outline, learning outcomes, a glossary, and review questions. Appendix of veterinary technician resources include American, Canadian, and international vet tech associations; registration of technicians; and special internet sites of interest to veterinary technicians. NEW! Chapter on pain management and updated and expanded chapter discussions provide the information needed to pass the VTNE NEW! Companion Evolve website contains a practice exam that simulates the computer-based VTNE testing environment. NEW! Full-color format features vivid color photos to support comprehension and recognition of essential concepts including histology, hematology, diagnostic microbiology and mycology, virology, urinalysis, and parasitology.