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Process Systems Engineering for Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing Book
Author : Ravendra Singh,Zhihong Yuan
Publisher : Unknown
Release : 2018-03
ISBN : 9780444639639
Language : En, Es, Fr & De

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Book Description :

Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41 covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

Process Systems Engineering of Continuous Pharmaceutical Manufacturing

Process Systems Engineering of Continuous Pharmaceutical Manufacturing Book
Author : Matthew J. Abel
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

(Cont.) This reduction in equipment size translates to capital cost (CAPEX) savings for both the continuous process equipment and manufacturing facilities. The steady state operation of continuous processing also reduces the labor requirements and gives the continuous processes an operating cost (OPEX) advantage over batch processes. This research has contributed to the understanding of continuous pharmaceutical powder blending and quantified some of the benefits of continuous downstream pharmaceutical manufacturing. This work is being continued by the Novartis-MIT Center for Continuous Manufacturing whose work is providing the foundation for future industrial scale pharmaceutical continuous manufacturing systems.

Process Systems Engineering for Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing Book
Author : Ravendra Singh,Zhihong Yuan
Publisher : Elsevier
Release : 2018-03-16
ISBN : 0444639667
Language : En, Es, Fr & De

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Book Description :

Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

Process Systems Engineering Methods for the Development of Continuous Pharmaceutical Manufacturing Processes

Process Systems Engineering Methods for the Development of Continuous Pharmaceutical Manufacturing Processes Book
Author : Amanda Rogers
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The objective of this dissertation is to develop mathematical methods to assist in the development of continuous processes for the manufacture of pharmaceutical drug products. Specifically, modeling, analysis and optimization techniques will be developed in order to apply concepts from the field of process systems engineering to pharmaceutical development. These concepts, including sensitivity analysis, feasibility and flexibility analysis and optimal design under uncertainty, can contribute to the development of robust and well-understood manufacturing processes. This is consistent with the aim Quality-by-Design in the pharmaceutical process development. Throughout this dissertation, case studies related to continuous solids-based manufacturing will be used to demonstrate the role that process systems engineering can play in process development. The mathematical methods introduced in this dissertation will emphasize the use of reduced-order and surrogate models to address the unique challenges associated with modeling, analysis and optimization of solids-based processes.

13th International Symposium on Process SystemsEngineering PSE 2018 July 1 5 2018

13th International Symposium on Process SystemsEngineering     PSE 2018  July 1 5 2018 Book
Author : Mario R. Eden,Gavin Towler,Maria Ierapetritou
Publisher : Elsevier
Release : 2018-07-19
ISBN : 0444642420
Language : En, Es, Fr & De

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Book Description :

Process Systems Engineering brings together the international community of researchers and engineers interested in computing-based methods in process engineering. This conference highlights the contributions of the PSE community towards the sustainability of modern society and is based on the 13th International Symposium on Process Systems Engineering PSE 2018 event held San Diego, CA, July 1-5 2018. The book contains contributions from academia and industry, establishing the core products of PSE, defining the new and changing scope of our results, and future challenges. Plenary and keynote lectures discuss real-world challenges (globalization, energy, environment and health) and contribute to discussions on the widening scope of PSE versus the consolidation of the core topics of PSE. Highlights how the Process Systems Engineering community contributes to the sustainability of modern society Establishes the core products of Process Systems Engineering Defines the future challenges of Process Systems Engineering

10th International Symposium on Process Systems Engineering

10th International Symposium on Process Systems Engineering Book
Author : Rita Maria de Brito Alves,Cláudio Augusto Oller do Nascimento,Evaristo Chalbaud Biscaia (Jr)
Publisher : Elsevier
Release : 2009
ISBN : 0444534350
Language : En, Es, Fr & De

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Book Description :

The 10th International Symposium on Process Systems Engineering, PSE'09, will be held in Salvador-Bahia, Brazil on August 16-20, 2009. The special focus of PSE 2009 is Sustainability, Energy and Engineering. PSE 2009 is the tenth in the triennial series of international symposia on process systems engineering initiated in 1982. The meeting is brings together the worldwide PSE community of researchers and practitioners who are involved in the creation and application of computing-based methodologies for planning, design, operation, control and maintenance of chemical and petrochemical process industries. PSE'09 will look at how the PSE methods and tools can support sustainable resource systems and emerging technologies in the areas of green engineering: environmentally conscious design of industrial processes. PSE methods and tools support: - sustainable resource systems - emerging technologies in the areas of green engineering - environmentally conscious design of industrial processes

11th International Symposium on Process Systems Engineering PSE2012

11th International Symposium on Process Systems Engineering   PSE2012 Book
Author : Anonim
Publisher : Elsevier
Release : 2021-12-08
ISBN : 0444595058
Language : En, Es, Fr & De

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Book Description :

Download 11th International Symposium on Process Systems Engineering PSE2012 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering

12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering Book
Author : Anonim
Publisher : Elsevier
Release : 2015-05-28
ISBN : 0444634452
Language : En, Es, Fr & De

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Book Description :

25th European Symposium on Computer-Aided Process Engineering contains the papers presented at the 12th Process Systems Engineering (PSE) and 25th European Society of Computer Aided Process Engineering (ESCAPE) Joint Event held in Copenhagen, Denmark, 31 May - 4 June 2015. The purpose of these series is to bring together the international community of researchers and engineers who are interested in computing-based methods in process engineering. This conference highlights the contributions of the PSE/CAPE community towards the sustainability of modern society. Contributors from academia and industry establish the core products of PSE/CAPE, define the new and changing scope of our results, and future challenges. Plenary and keynote lectures discuss real-world challenges (globalization, energy, environment, and health) and contribute to discussions on the widening scope of PSE/CAPE versus the consolidation of the core topics of PSE/CAPE. Highlights how the Process Systems Engineering/Computer-Aided Process Engineering community contributes to the sustainability of modern society Presents findings and discussions from both the 12th Process Systems Engineering (PSE) and 25th European Society of Computer-Aided Process Engineering (ESCAPE) Events Establishes the core products of Process Systems Engineering/Computer Aided Process Engineering Defines the future challenges of the Process Systems Engineering/Computer Aided Process Engineering community

Model Based Tools for Pharmaceutical Manufacturing Processes

Model Based Tools for Pharmaceutical Manufacturing Processes Book
Author : Krist V. Gernaey,René Schenkendorf,Dimitrios I. Gerogiorgis,Seyed Soheil Mansouri
Publisher : MDPI
Release : 2020-03-13
ISBN : 303928424X
Language : En, Es, Fr & De

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Book Description :

The Special Issue on “Model-Based Tools for Pharmaceutical Manufacturing Processes” will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This book provides a collection of nine papers on original advances in the model-based process unit, system-level, quality-by-design under uncertainty, and decision-making applications of pharmaceutical manufacturing processes.

Continuous Manufacturing of Pharmaceuticals

Continuous Manufacturing of Pharmaceuticals Book
Author : Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publisher : John Wiley & Sons
Release : 2017-07-14
ISBN : 1119001358
Language : En, Es, Fr & De

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Book Description :

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Proceedings of the 8th International Conference on Foundations of Computer Aided Process Design

Proceedings of the 8th International Conference on Foundations of Computer Aided Process Design Book
Author : Anonim
Publisher : Elsevier
Release : 2014-07-14
ISBN : 0444634428
Language : En, Es, Fr & De

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Book Description :

This volume collects together the presentations at the Eighth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2014, an event that brings together researchers, educators, and practitioners to identify new challenges and opportunities for process and product design. The chemical industry is currently entering a new phase of rapid evolution. The availability of low-cost feedstocks from natural gas is causing renewed investment in basic chemicals in the OECD, while societal pressures for sustainability and energy security continue to be key drivers in technology development and product selection. This dynamic environment creates opportunities to launch new products and processes and to demonstrate new methodologies for innovation, synthesis and design. FOCAPD-2014 fosters constructive interaction among thought leaders from academia, industry, and government and provides a showcase for the latest research in product and process design. Focuses exclusively on the fundamentals and applications of computer-aided design for the process industries. Provides a fully archival and indexed record of the FOCAPD14 conference Aligns the FOCAPD series with the ESCAPE and PSE series

21st European Symposium on Computer Aided Process Engineering

21st European Symposium on Computer Aided Process Engineering Book
Author : E. N. Pistikopoulos,M. C. Georgiadis,A. C. Kokossis
Publisher : Elsevier
Release : 2011-05-26
ISBN : 044453895X
Language : En, Es, Fr & De

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Book Description :

The European Symposium on Computer Aided Process Engineering (ESCAPE) series presents the latest innovations and achievements of leading professionals from the industrial and academic communities. The ESCAPE series serves as a forum for engineers, scientists, researchers, managers and students to present and discuss progress being made in the area of Computer Aided Process Engineering (CAPE). European industries large and small are bringing innovations into our lives, whether in the form of new technologies to address environmental problems, new products to make our homes more comfortable and energy efficient or new therapies to improve the health and well-being of European citizens. Moreover, the European Industry needs to undertake research and technological initiatives in response to humanity's "Grand Challenges", described in the declaration of Lund, namely, Global Warming, Tightening Supplies of Energy, Water and Food, Ageing Societies, Public Health, Pandemics and Security. Thus, the Technical Theme of ESCAPE 21 will be "Process Systems Approaches for Addressing Grand Challenges in Energy, Environment, Health, Bioprocessing & Nanotechnologies".

Chemical Engineering in the Pharmaceutical Industry Active Pharmaceutical Ingredients

Chemical Engineering in the Pharmaceutical Industry  Active Pharmaceutical Ingredients Book
Author : David J. am Ende,Mary T. am Ende
Publisher : John Wiley & Sons
Release : 2019-03-28
ISBN : 1119285887
Language : En, Es, Fr & De

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Book Description :

A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: • Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety • Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying • Presents updated and expanded example calculations • Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industry focuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.

Applications of Artificial Intelligence in Process Systems Engineering

Applications of Artificial Intelligence in Process Systems Engineering Book
Author : Jingzheng Ren,Weifeng Shen,Yi Man,Lichun DOng
Publisher : Elsevier
Release : 2021-06-05
ISBN : 012821743X
Language : En, Es, Fr & De

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Book Description :

Applications of Artificial Intelligence in Process Systems Engineering offers a broad perspective on the issues related to artificial intelligence technologies and their applications in chemical and process engineering. The book comprehensively introduces the methodology and applications of AI technologies in process systems engineering, making it an indispensable reference for researchers and students. As chemical processes and systems are usually non-linear and complex, thus making it challenging to apply AI methods and technologies, this book is an ideal resource on emerging areas such as cloud computing, big data, the industrial Internet of Things and deep learning. With process systems engineering's potential to become one of the driving forces for the development of AI technologies, this book covers all the right bases. Explains the concept of machine learning, deep learning and state-of-the-art intelligent algorithms Discusses AI-based applications in process modeling and simulation, process integration and optimization, process control, and fault detection and diagnosis Gives direction to future development trends of AI technologies in chemical and process engineering

22nd European Symposium on Computer Aided Process Engineering

22nd European Symposium on Computer Aided Process Engineering Book
Author : Anonim
Publisher : Elsevier
Release : 2012-12-10
ISBN : 0444594566
Language : En, Es, Fr & De

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Book Description :

Computer aided process engineering (CAPE) plays a key design and operations role in the process industries. This conference features presentations by CAPE specialists and addresses strategic planning, supply chain issues and the increasingly important area of sustainability audits. Experts collectively highlight the need for CAPE practitioners to embrace the three components of sustainable development: environmental, social and economic progress and the role of systematic and sophisticated CAPE tools in delivering these goals. Contributions from the international community of researchers and engineers using computing-based methods in process engineering Review of the latest developments in process systems engineering Emphasis on a systems approach in tackling industrial and societal grand challenges

Specification of Drug Substances and Products

Specification of Drug Substances and Products Book
Author : Christopher M. Riley,Thomas W. Rosanske,George L. Reid
Publisher : Elsevier
Release : 2020-07-23
ISBN : 0081028253
Language : En, Es, Fr & De

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Book Description :

Specification of Drug Substances and Products: Development and Validation of Analytical Methods, Second Edition, presents a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development, validation of analytical methods, and their application in practice. This thoroughly revised second edition covers topics not covered or not substantially covered in the first edition, including method development and validation in the clinical phase, method transfer, process analytical technology, analytical life cycle management, special challenges with generic drugs, genotoxic impurities, topical products, nasal sprays and inhalation products, and biotechnology products. The book's authors have been carefully selected as former members of the ICH Expert Working Groups charged with developing the ICH guidelines, and/or subject-matter experts in the industry, academia and in government laboratories. Presents a critical assessment of the application of ICH guidelines on method validation and specification setting Written by subject-matter experts involved in the development and application of the guidelines Provides a comprehensive treatment of the analytical methodologies used in the analysis, control and specification of new drug substances and products Covers the latest statistical approaches (including analytical quality by design) in the development of specifications, method validation and shelf-life prediction

Smart Manufacturing

Smart Manufacturing Book
Author : Masoud Soroush,Michael Baldea,Thomas F. Edgar
Publisher : Elsevier
Release : 2020-08-04
ISBN : 0128203811
Language : En, Es, Fr & De

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Book Description :

Research efforts in the past decade have led to considerable advances in the concepts and methods of smart manufacturing. Smart Manufacturing: Applications and Case Studies includes information about the key applications of these new methods, as well as practitioners’ accounts of real-life applications and case studies. Written by thought leaders in the field from around the world, Smart Manufacturing: Applications and Case Studies is essential reading for graduate students, researchers, process engineers and managers. It is complemented by a companion book titled Smart Manufacturing: Concepts and Methods, which describes smart manufacturing methods in detail. Includes examples of applications of smart manufacturing in process industries Provides a thorough overview of the subject and practical examples of applications through well researched case studies Offers insights and accounts of first-hand experiences to motivate further implementations of the key concepts of smart manufacturing

23 European Symposium on Computer Aided Process Engineering

23 European Symposium on Computer Aided Process Engineering Book
Author : Anshu Gupta,Aran Giridhar,Ginataras V. Reklaitis,Venkat Venkatasubramanian
Publisher : Elsevier Inc. Chapters
Release : 2013-06-10
ISBN : 0128085827
Language : En, Es, Fr & De

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Book Description :

One of the important challenges in effective real time process management is the implementation of intelligent systems that can assist human operators in making supervisory control decisions, instead of simply sounding an alarm when process variables go out of range. Operator failures to exercise the appropriate mitigation actions often have an adverse effect on product quality, process safety, occupational health and environment. The challenges and opportunities for improvements are even greater in the pharmaceutical manufacturing domain because of the characteristic features of solid processing. An Intelligent Alarm System (IAS) is developed for monitoring of a continuous dry granulation line. The application of the framework is demonstrated through a case study on a roller compactor. The framework provides information to the operator regarding the detection and diagnosis of exceptional events along with relevant mitigation strategies, with the goal of avoiding the progression of the process to emergency shutdown.

Sterile Pharmaceutical Products

Sterile Pharmaceutical Products Book
Author : KennethE. Avis
Publisher : Routledge
Release : 2018-03-29
ISBN : 1351413872
Language : En, Es, Fr & De

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Book Description :

Sterile Pharmaceutical Products: Process Engineering Applications addresses the key concepts and applications of the sterile pharmaceutical manufacturing industry. It covers elements of the design, installation, validation, and usage of critical processes associated with sterile product manufacture. From water systems to clean-in-place systems, to sterile powder handling and robotic applications in sterile production environments, this book addresses the issues of system implementation, integration, and operations. Written by recognized experts and peer reviewed for accuracy, all chapters include references to supplemental resources and numerous illustrations.