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Principles Of Human Organs On Chips

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Principles of Tissue Engineering

Principles of Tissue Engineering Book
Author : Robert Lanza,Robert Langer,Joseph P. Vacanti
Publisher : Academic Press
Release : 2013-10-17
ISBN : 0123983703
Language : En, Es, Fr & De

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Book Description :

Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems Book
Author : Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Publisher : Elsevier
Release : 2018-09-12
ISBN : 0128136723
Language : En, Es, Fr & De

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Book Description :

Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems Book
Author : Jeffrey T. Borenstein,Vishal Tandon,Joseph L. Charest,Sarah L. Tao
Publisher : Micro and Nano Technologies
Release : 2018-06
ISBN : 9780128136713
Language : En, Es, Fr & De

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Book Description :

Microfluidic Cell Culture Systems, Second Edition, applies the design and experimental techniques used in MEMS microfabrication and microfluidics to cell culture systems. The book serves as a professional reference, providing a practical guide to the design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. It covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. This updated edition contains new material that strengthens the focus on in vitro models that are useful for drug discovery and development. New sections in this edition review liver organ models from an industry perspective, while other new material highlights the development of organ models and systems for specific applications in disease modeling and drug safety. Provides design and operation methodology for microfluidic and microfabricated biomaterials approaches to tissue engineering and cell culture systems Comprehensively covers strategies and techniques, ranging from academic first principles, to industrial scale-up approaches Offers design principles, operation techniques and background information/perspectives

Organs on chips for the pharmaceutical development process

Organs on chips for the pharmaceutical development process Book
Author : Jonas Christoffersson
Publisher : Linköping University Electronic Press
Release : 2019-01-22
ISBN : 9176853594
Language : En, Es, Fr & De

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Book Description :

Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. The aim of this thesis is to explain and discuss these cell culture devices from a design perspective and to experimentally exemplify some of the specific functions that characterize organs-on-chips. The cells in our body reside in complex environments with chemical and mechanical cues that affect their function and purpose. Such a complex environment is difficult to recreate in the laboratory and has therefore been overlooked in favor of more simple models, i.e. static twodimensional (2D) cell cultures. Numerous recent reports have shown cell culture systems that can resemble the cell’s natural habitat and enhance cell functionality and thereby potentially provide results that better reflects animal and human trials. The way these organs-on-chips improve in vitro cell culture assays is to include e.g. a three-dimensional cell architecture (3D), mechanical stimuli, gradients of oxygen or nutrients, or by combining several relevant cell types that affect each other in close proximity. The research conducted for this thesis shows how cells in 3D spheroids or in 3D hydrogels can be cultured in perfused microbioreactors. Furthermore, a pump based on electroosmosis, and a method for an objective conceptual design process, is introduced to the field of organs-on-chips.

Phase I Oncology Drug Development

Phase I Oncology Drug Development Book
Author : Timothy A. Yap,Jordi Rodon,David S. Hong
Publisher : Springer Nature
Release : 2020-09-16
ISBN : 3030476820
Language : En, Es, Fr & De

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Book Description :

This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials and beyond through the use of innovative mechanism-of-action pharmacodynamic biomarkers and pharmacokinetic studies. The reader will learn about all aspects of modern phase I trial designs, including the incorporation of precision medicine strategies, and approaches for rational patient allocation to novel anticancer therapies. Circulating biomarkers to assess mechanisms of response and resistance are changing the way we are assessing patient selection and are also covered in this book. The development of the different classes of antitumor agents are discussed, including chemotherapy, molecularly targeted agents, immunotherapies and also radiotherapy. The authors also discuss the lessons that the oncology field has learnt from the development of hematology-oncology drugs and how such strategies can be carried over into therapies for solid tumors. There is a dedicated chapter that covers the specialized statistical approaches necessary for phase I trial designs, including novel Bayesian strategies for dose escalation. This volume is designed to help clinicians better understand phase I clinical trials, but would also be of use to translational researchers (MDs and PhDs), and drug developers from academia and industry interested in cancer drug development. It could also be of use to phase I trial study coordinators, oncology nurses and advanced practice providers. Other health professionals interested in the treatment of cancer will also find this book of great value.

Essentials of Laboratory Animal Science Principles and Practices

Essentials of Laboratory Animal Science  Principles and Practices Book
Author : P. Nagarajan,Ramachandra Gudde,Ramesh Srinivasan
Publisher : Springer Nature
Release : 2021-08-24
ISBN : 981160987X
Language : En, Es, Fr & De

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Book Description :

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

Organs on chips

Organs on chips Book
Author : Yu-suke Torisawa,Yi-Chung Tung
Publisher : MDPI
Release : 2020-05-27
ISBN : 3039289179
Language : En, Es, Fr & De

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Book Description :

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.

Hayes Principles and Methods of Toxicology

Hayes  Principles and Methods of Toxicology Book
Author : A. Wallace Hayes,Claire L. Kruger
Publisher : CRC Press
Release : 2014-10-10
ISBN : 1842145371
Language : En, Es, Fr & De

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Book Description :

Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap

Organotypic Models in Drug Development

Organotypic Models in Drug Development Book
Author : Monika Schäfer-Korting
Publisher : Springer Nature
Release : 2021-09-20
ISBN : 3030700631
Language : En, Es, Fr & De

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Book Description :

Download Organotypic Models in Drug Development book written by Monika Schäfer-Korting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128098937
Language : En, Es, Fr & De

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Book Description :

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Modulation of Human Immune Parameters by Anticancer Therapies

Modulation of Human Immune Parameters by Anticancer Therapies Book
Author : Ulrich Sack,Attila Tarnok,Il-Kang Na,Frank Preijers
Publisher : Frontiers Media SA
Release : 2021-01-18
ISBN : 288966399X
Language : En, Es, Fr & De

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Book Description :

Download Modulation of Human Immune Parameters by Anticancer Therapies book written by Ulrich Sack,Attila Tarnok,Il-Kang Na,Frank Preijers, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cells

Stem Cells Book
Author : Christine L. Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers
Publisher : Academic Press
Release : 2021-01-20
ISBN : 0128226773
Language : En, Es, Fr & De

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Book Description :

Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art overview on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinical trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and iPS cells is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field. • Explains, in a straightforward, nonspecialist language, the basic biology of stem cells and their applications in modern medicine and future therapy • Provides new and expanded coverage of cloning, organoids, “synthetic embryos, and much more • Includes detailed illustrations to assist users with learning on how research is done

Robotic Systems and Autonomous Platforms

Robotic Systems and Autonomous Platforms Book
Author : Shawn M. Walsh,Michael S. Strano
Publisher : Woodhead Publishing
Release : 2018-10-11
ISBN : 0081020481
Language : En, Es, Fr & De

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Book Description :

Robotic Systems and Autonomous Platforms: Advances in Materials and Manufacturing showcases new materials and manufacturing methodologies for the enhancement of robotic and autonomous systems. Initial chapters explore how autonomous systems can enable new uses for materials, including innovations on different length scales, from nano, to macro and large systems. The means by which autonomous systems can enable new uses for manufacturing are also addressed, highlighting innovations in 3D additive manufacturing, printing of materials, novel synthesis of multifunctional materials, and robotic cooperation. Concluding themes deliver highly novel applications from the international academic, industrial and government sectors. This book will provide readers with a complete review of the cutting-edge advances in materials and manufacturing methodologies that could enhance the capabilities of robotic and autonomous systems. Presents comprehensive coverage of materials and manufacturing technologies, as well as sections on related technology, such as sensing, communications, autonomy/control and actuation Explores potential applications demonstrated by a selection of case-studies Contains contributions from leading experts in the field

Encyclopedia of Polymer Applications 3 Volume Set

Encyclopedia of Polymer Applications  3 Volume Set Book
Author : Munmaya Mishra
Publisher : CRC Press
Release : 2018-12-17
ISBN : 1351019414
Language : En, Es, Fr & De

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Book Description :

Undoubtedly the applications of polymers are rapidly evolving. Technology is continually changing and quickly advancing as polymers are needed to solve a variety of day-to-day challenges leading to improvements in quality of life. The Encyclopedia of Polymer Applications presents state-of-the-art research and development on the applications of polymers. This groundbreaking work provides important overviews to help stimulate further advancements in all areas of polymers. This comprehensive multi-volume reference includes articles contributed from a diverse and global team of renowned researchers. It offers a broad-based perspective on a multitude of topics in a variety of applications, as well as detailed research information, figures, tables, illustrations, and references. The encyclopedia provides introductions, classifications, properties, selection, types, technologies, shelf-life, recycling, testing and applications for each of the entries where applicable. It features critical content for both novices and experts including, engineers, scientists (polymer scientists, materials scientists, biomedical engineers, macromolecular chemists), researchers, and students, as well as interested readers in academia, industry, and research institutions.

Nanopharmaceuticals Principles and Applications Vol 1

Nanopharmaceuticals  Principles and Applications Vol  1 Book
Author : Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse
Publisher : Springer Nature
Release : 2020-07-14
ISBN : 3030449254
Language : En, Es, Fr & De

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Book Description :

This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ‘Computational sequence design for DNA nanostructures’ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.

Characterization and Development of Biosystems and Biomaterials

Characterization and Development of Biosystems and Biomaterials Book
Author : Andreas Öchsner,Lucas F. M. da Silva,Holm Altenbach
Publisher : Springer Science & Business Media
Release : 2012-12-16
ISBN : 3642314708
Language : En, Es, Fr & De

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Book Description :

This collection of recent activities provides researchers and scientists with the latest trends in characterization and developments of biosystems and biomaterials. Well known experts present their research in materials for drug delivery, dental implants and filling materials, biocompatible membranes, bioactive surface coatings and bio-compatible and eco-sustainable building materials. In The book covers also topics like microorganisms, the human eye, the musculoskeletal system and human body parts.

Smart Leadership Wise Leadership

Smart Leadership     Wise Leadership Book
Author : Christopher Steed
Publisher : Routledge
Release : 2017-07-14
ISBN : 131714211X
Language : En, Es, Fr & De

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Book Description :

There is a strong link between organisational culture and profit after all a happy workforce is a productive workforce. Yet a culture of inertia rather than innovation prevails in many organisations. Wise leaders, however, know how to work with the grain of human value and worth, harnessing it, so as to add shared value both for the organisation and for the good of society. So, how can astute leaders set the right conditions for creativity and cultivate non-economic goods, such as time and relationships, that make for a happy, effective workforce? The author proposes the notion of organisational culture as ’environments of value’ wherein inner value translated into external value is embedded within the triple bottom line and indeed an awareness of how an organisation is like a force field: it exercises power and leaves a footprint. This construct informs the emerging concept of Shared Value as requiring five literacies about: ¢ Shareholder value and return for risk ¢ Value for the social environment linked to respect for the natural environment ¢ Inner value of those in the enterprise, which, when unlocked, releases energies and adds value ¢ Nurture of non-quantifiable qualities that promote human flourishing ¢ Understandings of how power relations distort the way organisations operate He clearly signposts the link between promoting an environment of value within which these literacies flourish and the added value for the organisation arising from such a culture.

Endothelial Dynamics in Health and Disease

Endothelial Dynamics in Health and Disease Book
Author : Jaap Diederik Van Buul,Stephan Huveneers,Mariona Graupera,Elizabeth Anne Vincent Jones
Publisher : Frontiers Media SA
Release : 2021-01-06
ISBN : 2889663523
Language : En, Es, Fr & De

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Book Description :

Download Endothelial Dynamics in Health and Disease book written by Jaap Diederik Van Buul,Stephan Huveneers,Mariona Graupera,Elizabeth Anne Vincent Jones, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bioinspired Materials for Medical Applications

Bioinspired Materials for Medical Applications Book
Author : Lígia Rodrigues,Manuel Mota
Publisher : Woodhead Publishing
Release : 2016-09-24
ISBN : 0081007469
Language : En, Es, Fr & De

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Book Description :

Bioinspired Materials for Medical Applications examines the inspiration of natural materials and their interpretation as modern biomaterials. With a strong focus on therapeutic and diagnostic applications, the book also examines the development and manipulation of bioinspired materials in regenerative medicine. The first set of chapters is heavily focused on bioinspired solutions for the delivery of drugs and therapeutics that also offer information on the fundamentals of these materials. Chapters in part two concentrate on bioinspired materials for diagnosis applications with a wide coverage of sensor and imaging systems With a broad coverage of the applications of bioinspired biomaterials, this book is a valuable resource for biomaterials researchers, clinicians, and scientists in academia and industry, and all those who wish to broaden their knowledge in the allied field. Explores how materials designed and produced with inspiration from nature can be used to enhance man-made biomaterials and medical devices Brings together the two fields of biomaterials and bioinspired materials Written by a world-class team of research scientists, engineers, and clinicians

Designing Nanostructures at the Interface between Biomedical and Physical Systems

Designing Nanostructures at the Interface between Biomedical and Physical Systems Book
Author : The National Academies,The National Academies Keck Futures Initiative Nanoscience and Nanotechnology Planning Committee,The National Academies Keck Futures Initiative Nanoscience and Nanotechnology Steering Committee
Publisher : National Academies Press
Release : 2005-07-01
ISBN : 0309096685
Language : En, Es, Fr & De

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Book Description :

Last November, the National Academies Keck Futures Initiative held the Designing Nanostructures at the Interface Between Biomedical and Physical Systems conference at which researchers from science, engineering and medicine discussed recent developments in nanotechnology, directions for future research, and possible biomedical applications. The centerpiece of the conference was breakout sessions in which ten focus groups of researchers from different fields spent eight hours developing research plans to solve various problems in the field of nanotechnology. Among the challenges were: Building a nanosystem that can isolate, sequence and identify RNA or DNA Developing a system to detect disease in vivo Sequencing a single molecule of protein Creating a biological system that will create a local hydrogen fuel source, and Growing a biological in vivo power source. Representatives from public and private funding organizations, government, industry, and the science media also participated in the focus groups. This book provides a summary of the conference focus groups. For more information about the conference, visit Keck Futures Initiative. The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. The National Academies and the W.M. Keck Foundation believe considerable scientific progress and social benefit will be achieved by providing a counterbalance to the tendency to isolate research within academic fields. The Futures Initiative is designed to enable researchers from different disciplines to focus on new questions upon which they can base entirely new research, and to encourage better communication between scientists as well as between the scientific community and the public. Funded by a $40 million grant from the W.M. Keck Foundation, the National Academies Keck Futures Initiative is a 15-year effort to catalyze interdisciplinary inquiry and to enhance communication among researchers, funding agencies, universities, and the general public â€" with the object of stimulating interdisciplinary research at the most exciting frontiers. The Futures Initiative builds on three pillars of vital and sustained research: interdisciplinary encounters that counterbalance specialization and isolation; the identification and exploration of new research topics; and communication that bridges languages, cultures, habits of thought, and institutions. Toward these goals, the National Academies Keck Futures Initiative incorporates three core activities each year: Futures conferences, Futures grants, and National Academies Communication Awards.