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Principles Of Clinical Pharmacology

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Principles of Clinical Pharmacology

Principles of Clinical Pharmacology Book
Author : Arthur J. Atkinson, Jr.,Darrell R. Abernethy,Charles E. Daniels,Robert Dedrick,Sanford P. Markey
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080466422
Language : En, Es, Fr & De

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Book Description :

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry Expanded coverage of pharmacogenetics Expanded coverage of drug transporters and their role in interactions Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions A new chapter on drug discovery that focuses on oncologic agents Inclusion of therapeutic antibodies in chapter on biotechnology products

Atkinson s Principles of Clinical Pharmacology

Atkinson s Principles of Clinical Pharmacology Book
Author : Shiew-Mei Huang,Juan J.L. Lertora,Paolo Vicini,Arthur J. Atkinson, Jr.
Publisher : Academic Press
Release : 2021-10-16
ISBN : 0128198842
Language : En, Es, Fr & De

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Book Description :

Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK

Pharmacology in Clinical Practice

Pharmacology in Clinical Practice Book
Author : Richard Lancaster
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483192946
Language : En, Es, Fr & De

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Book Description :

Pharmacology in Clinical Practice describes basic pharmacology, clinical pharmacology, including the pharmacology of important drug groups. The author reviews the general principles of clinical pharmacology including drug actions, absorption, disposition, and excretion. Most drugs are xenobiotics—compounds foreign and harmful to human living tissues. Drugs should be properly metabolized and converted to nontoxic substance before being excreted either through spontaneous changes not mediated by enzymes or through transformation by enzyme systems. The author also discusses pharmacokinetics, including drug plasma concentration, absorption, first-pass metabolism, distribution and elimination. The author addresses pharmacogenetics that deal with possible different responses to drug intake due to factors such as age, sex, liver or renal disease, smoking, diet. The book tackles other drugs, their uses, and characteristics such as antibacterial agents, obesity drug, cytotoxic drugs or those used in chemotherapy medicine. The author explains the diagnosis of drug ingestion, clinical signs of overdose, clinical course, and prophylactic measures for users to avoid drug overdose or self-poisoning. This book is intended for medical undergraduates, pharmaceutical technicians, pharmacists, students or professors in pharmacology or general medicine.

Small Animal Clinical Pharmacology

Small Animal Clinical Pharmacology Book
Author : Jill E. Maddison,Stephen W. Page,David Church (BVSc.)
Publisher : Elsevier Health Sciences
Release : 2008
ISBN : 0702028584
Language : En, Es, Fr & De

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Book Description :

Small Animal Clinical Pharmacology is a practical, clinically-oriented pharmacology text designed to provide the veterinary student and practitioner with all the relevant information needed when designing drug treatment regimens for pets in small animal veterinary practice. Comprehensively updated and revised, the second edition of this core text covers essential new information on drugs used in the management of a range of presenting conditions including heart disease and cardiac arrhythmias. For the second edition new authors, superb new illustrations and a second colour have all been introduced. With its unique approach combining a thorough understanding of the pharmacological action of drugs with a basic understanding of the relevant physiology and pathophysiology of systems and tissues affected, Small Animal Clinical Pharmacology continues to be an indispensable book for all veterinary students and practitioners. Organised by drug class in a uniform and detailed structure which means it is easy to locate key information on dose rates, routes of administration, drug interactions and special considerations at a glance Key chapters based around treatment of disorders of particular body systems, eg cardiovascular and thyroid disorders Essential introductory chapters covering pharmacokinetics, general pharmacological principles and adverse reactions for a thorough basic grounding in the subject All authors are experienced clinicians and recognised experts in their field who bring a down to earth and practical approach to the text

Oxford Textbook of Oncology

Oxford Textbook of Oncology Book
Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publisher : Oxford University Press
Release : 2016-01-28
ISBN : 0191065110
Language : En, Es, Fr & De

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Book Description :

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Clinical Pharmacology and Therapeutics

Clinical Pharmacology and Therapeutics Book
Author : Gerard A. McKay,Matthew R. Walters,Neil D. Ritchie
Publisher : John Wiley & Sons
Release : 2022-02-07
ISBN : 1119599954
Language : En, Es, Fr & De

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Book Description :

A must-have companion for medical students and junior doctors for almost four decades, Lecture Notes: Clinical Pharmacology and Therapeutics provides concise yet thorough coverage of the principles of clinical pharmacology, the major characteristics of therapeutics, and the practical aspects of prescribing drugs to alleviate symptoms and to treat disease. Whether you are preparing for examinations or prescribing to patients, the tenth edition offers readers current and authoritative insight into the essential practical and clinical knowledge. Logically organised chapters allow for rapid location of key information, while examples of commonly encountered scenarios illustrate how and when to use drugs in clinical situations. Throughout the text, practice questions, prescribing guidelines, and self-assessment tests clarify and reinforce the principles that inform appropriate clinical decision-making. Presents an up-to-date review of drug use across all major clinical disciplines Offers a timely overview of clinical drug trials and development Provides new clinical scenarios to relate chapter content to real-life application Contains colour-coded “Key Points” and “Prescribing Points” to highlight important information Includes chapter introductions and summaries, and numerous figures, tables, and colour illustrations Lecture Notes: Clinical Pharmacology and Therapeutics, Tenth Edition, is an essential resource for medical students, junior doctors, and other prescribers looking for an up-to-date reference on pharmacological principles, prescribing, and therapeutics.

Clinical Pharmacology

Clinical Pharmacology Book
Author : Desmond Roger Laurence,P. N. Bennett,Morris Jonathan Brown
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book is about the rational scientific basis and practice of drug therapy. Doctors need to understand the psychological and medical area in which they prescribe to deliver what patients have a right to expect, ie. maximum benefit with minimum risk.

Pharmacoepidemiology

Pharmacoepidemiology Book
Author : Brian L. Strom,Stephen E. Kimmel,Sean Hennessy
Publisher : John Wiley & Sons
Release : 2019-10-18
ISBN : 1119413370
Language : En, Es, Fr & De

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Book Description :

This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.

Anesthetic Pharmacology

Anesthetic Pharmacology Book
Author : Alex S. Evers,Mervyn Maze,Evan D. Kharasch
Publisher : Cambridge University Press
Release : 2011-03-10
ISBN : 1139497022
Language : En, Es, Fr & De

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Book Description :

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Introduction to Clinical Pharmacology E Book

Introduction to Clinical Pharmacology   E Book Book
Author : Constance G Visovsky,Cheryl H Zambroski,Shirley Hosler
Publisher : Elsevier Health Sciences
Release : 2021-01-04
ISBN : 0323755364
Language : En, Es, Fr & De

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Book Description :

Emphasizing safe and effective drug administration, Introduction to Clinical Pharmacology, 10th Edition, helps you understand the principles of pharmacology and prevent medication errors. It promotes safety by showing how drugs and drug classes work, so you can understand why drugs are given, as well as the adverse effects and drug interactions that may occur. A thorough nursing process section with each drug class outlines the nurse’s role when administering drugs. The updated Get Ready for the Next Generation NCLEX® Examination! feature offers case studies with Next Generation NCLEX-format questions to help you prepare for the new licensure examination. Ideal scope of content and readability for LPN/LVN programs includes basic, need-to-know pharmacology content. Safety Alert boxes highlight important nursing considerations for safe medication administration and monitoring. Lifespan Considerations boxes for children and older adults draw attention to information that would be especially important when giving a specific drug to patients of those age groups. A focus on understanding drug classes helps students understand the actions and uses of drug classes and provides a framework for safe, effective practice as new drugs are introduced to the market. Video clips on medication administration procedures provide students with a visual reference for safe medication administration. Key terms with phonetic pronunciations and text page references help improve students’ terminology and language skills before they enter clinical practice. Essential content is highlighted throughout the text, as in all of Elsevier’s LPN Threads textbooks, with features such as Top Tips for Safety, Memory Joggers, and Lifespan Considerations boxes. NEW! Get Ready for the Next Generation NCLEX® Examination! section includes key points, review questions, and case studies with Next Generation NCLEX-format questions to prepare students for the new licensure examination. NEW! Reorganized chapters break up lengthy content and more logically present pharmacological content by body system or major disorder. UPDATED! Coverage of newly approved and updated pharmaceutical treatments and drugs prepares students for practice.

Medical Pharmacology and Therapeutics E Book

Medical Pharmacology and Therapeutics E Book Book
Author : Derek G. Waller,Tony Sampson
Publisher : Elsevier Health Sciences
Release : 2013-08-07
ISBN : 0702055034
Language : En, Es, Fr & De

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Book Description :

This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice

Principles of Pharmacology

Principles of Pharmacology Book
Author : Armen H. Tashjian,Ehrin J. Armstrong
Publisher : Lippincott Williams & Wilkins
Release : 2011-07-21
ISBN : 1451118058
Language : En, Es, Fr & De

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Book Description :

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, is a primary textbook for a first course in pharmacology. It offers an integrated mechanism-based and systems-based approach, incorporating the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition features content reflecting current research findings, more than 400 full-color illustrations, Drug Summary Tables, and increased coverage of drug metabolism and the treatment of mycobacterial infections.

Personalized Anaesthesia

Personalized Anaesthesia Book
Author : Pedro L. Gambús,Jan F. A. Hendrickx
Publisher : Cambridge University Press
Release : 2020-01-31
ISBN : 1107579252
Language : En, Es, Fr & De

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Book Description :

Presents a modern vision of anaesthesia, integrating technology and knowledge, to change how anaesthesia is taught and practised.

Pharmacology and Therapeutics

Pharmacology and Therapeutics Book
Author : Scott A. Waldman,Andre Terzic
Publisher : Saunders
Release : 2009
ISBN : 9781416060987
Language : En, Es, Fr & De

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Book Description :

Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. This multimedia resource fills a critical need for a more clinically focused, user-friendly pharmacology reference. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments.

Principles of Medical Pharmacology

Principles of Medical Pharmacology Book
Author : Harold Kalant,Walter H. E. Roschlau,Edward M. Sellers
Publisher : Oxford University Press, USA
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Principles of Medical Pharmacology covers all aspects of medical pharmacology, making it the ideal text for students in pharmacology courses in medicine, biological sciences, pharmacy, and dentistry. The book provides a solid foundation of the principles of pharmacology. Principles are explained through the use of practical examples and case studies. The text covers all aspects of medical pharmacology, including a comprehensive discussion of the clinically important features of pharmacokinetics.This new Seventh Edition has been completely revised and updated to reflect the latest research in the field. Most chapters have been extensively rewritten, with many new authors involved in the preparation of this edition.

Clinical Pharmacology During Pregnancy

Clinical Pharmacology During Pregnancy Book
Author : Donald Mattison
Publisher : Academic Press
Release : 2013
ISBN : 0123860075
Language : En, Es, Fr & De

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Book Description :

Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems, as well as essential content on dosing and efficacy. Written in a clear and practical manner, this reference provides easily accessible information and clinical guidance on how best to treat women with medications during pregnancy. Utilizes an evidence-based approach for therapeutics during pregnancy Includes a summary of specific medications by indication with up-to-date information on dosing and efficacy in pregnancy for the given indication Highlights current research in this area and provides easily accessible and vital information for clinicians Complements the companion volume, Drugs During Pregnancy and Lactation by Schaefer et al and presents a bundling opportunity to the same target audience of medical professionals Includes a companion website containing support materials for professional or continuing education courses in OB pharmacology

Principles and Practice of Pharmaceutical Medicine

Principles and Practice of Pharmaceutical Medicine Book
Author : Lionel D. Edwards,Andrew J. Fletcher,Anthony W. Fox,Peter D. Stonier
Publisher : John Wiley & Sons
Release : 2007-04-30
ISBN : 9780470093146
Language : En, Es, Fr & De

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Book Description :

The long awaited second edition of Principles and Practice of Pharmaceutical Medicine provides an invaluable guide to all areas of drug development and medical aspects of marketing. The title has been extensively revised and expanded to include the latest regulatory and scientific developments. New chapters include: European Regulations Ethics of Pharmaceutical Medicine Licensing and Due Diligence Pharmacogenomics Encompassing the entire spectrum of pharmaceutical medicine, it is the most up-to-date international guide currently available. Review of the first edition: “This book was a joy to read and a joy to review. All pharmaceutical physicians should have a copy on their bookshelves, all pharmaceutical companies should have copies in their libraries.” —BRITISH ASSOCIATION OF PHARMACEUTICAL PHYSICIANS

Introduction to Basics of Pharmacology and Toxicology

Introduction to Basics of Pharmacology and Toxicology Book
Author : Gerard Marshall Raj,Ramasamy Raveendran
Publisher : Springer Nature
Release : 2019-11-16
ISBN : 9813297794
Language : En, Es, Fr & De

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Book Description :

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Principles and Practice of Clinical Research

Principles and Practice of Clinical Research Book
Author : John I. Gallin,Frederick P Ognibene
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080489568
Language : En, Es, Fr & De

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Book Description :

The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers. *Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research *Delves into data management and addresses how to collect data and use it for discovery *Contains valuable, up-to-date information on how to obtain funding from the federal government