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Principles And Applications Of Clinical Mass Spectrometry

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Principles and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry Book
Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
Publisher : Elsevier
Release : 2018-06-26
ISBN : 0128160640
Language : En, Es, Fr & De

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Book Description :

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Quantitative Biological and Clinical Mass Spectrometry

Quantitative Biological and Clinical Mass Spectrometry Book
Author : Anthony I. Mallet
Publisher : John Wiley & Sons
Release : 2018-07-23
ISBN : 1119281202
Language : En, Es, Fr & De

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Book Description :

A basic overview of mass spectrometry relevant to life and health science applications, illustrated throughout with relevant case studies This introductory text provides information and assistance to new users of mass spectrometry (MS) working in clinical or biochemical fields who are faced with implementing and designing quantitative mass spectrometric assays for a variety of classes of molecules of biological interest. It presents a detailed discussion on how to optimize measurement parameters for a candidate reference quantitative analysis, including calibration procedures, sensitivity, reproducibility, speed of assay and compliance with regulatory authorities. Quantitative Biological and Clinical Mass Spectrometry uses examples where development has not been immediately successful but where unforeseen problems have arisen and describes the strategies used to solve these. Advances in addressing the very large numbers of clinical samples that arise on routine screening programs such as those involved in inborn errors of metabolism studies are discussed. Direct mass spectrometric based analyses applicable to point of care testing (POCT) situations are also covered. The book concludes with a short section on possible novel developments, bibliography, references, and a glossary of terms. Shows how the presence of false results can be detected and understood Describes the ‘parts’ of modern instruments from sample introduction through ionization, mass analysis and detection, and the variety of techniques of tandem mass spectrometry Discusses the requirement for specificity in an assay method Fully illustrated throughout Highly relevant to all key areas of mass spectrometric analysis Quantitative Biological and Clinical Mass Spectrometry appeals to those newly exposed to the use of combined chromatography and mass spectrometry for analysis of biological material and to scientists experienced in automated clinical analysis using immunoassays or who are new to mass spectrometry.

High Resolution Mass Spectroscopy for Phytochemical Analysis

High Resolution Mass Spectroscopy for Phytochemical Analysis Book
Author : Sreeraj Gopi,Augustine Amalraj,Shintu Jude
Publisher : CRC Press
Release : 2021-09-30
ISBN : 1000353419
Language : En, Es, Fr & De

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Book Description :

This new volume provides a bird’s-eye view of the properties, utilization, and importance of high resolution mass spectrometry (HRMS) for phytochemical analysis. The book discusses the new and state-of-the-art technologies related to HRMS in phytochemical analysis for the food industry in a comprehensive manner. Phytochemical characterization of plants is important in the food and nutraceutical industries and is also necessary in the procedures followed for drug development, toxicology determination, forensic studies, origin verification, quality assurance, etc. Easy determination of active compounds and isolation as well as purification of the same from natural matrices are required, and the possibilities and advantages of HRMS pave the way for improved analysis patterns in phytochemistry. This book is unique in that its sole consideration is on the importance of HRMS in the field of phytochemical analysis. Along with an overview of basic instrumental information, the volume provides a detailed account of data processing and dereplication strategies. Technologies such as bioanalytical techniques and bioassays are considered also to provide support for the functions of the instruments used. In addition, a case study is presented to depict the complete phytochemical characterization of a matrix by HRMS. The book covers processing and computational techniques, dereplication, hyphenation, high-resolution bioassays, bioanalytical screening/purification techniques, applications of gas chromatography–high-resolution mass spectrometry, and more. Key features: Covers the fundamental instrumentation and techniques Discusses HRMS-based phytochemical research details Focuses strictly on the phytochemical considerations High-Resolution Mass Spectroscopy for Phytochemical Analysis: State-of-the-Art Applications and Techniques will be a valuable reference guide and resource for researchers, faculty and students in related fields, as well as those in the phytochemical industries.

Herbal Biomolecules in Healthcare Applications

Herbal Biomolecules in Healthcare Applications Book
Author : Subhash C. Mandal,Amit Kumar Nayak,Amal Kumar Dhara
Publisher : Academic Press
Release : 2021-10-05
ISBN : 0323900801
Language : En, Es, Fr & De

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Book Description :

Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful. Provides a study of different type of biomolecules from herbal extracts and their bioactivities as well as their application in the healthcare industry Contributions by global leaders and experts from academia, industry and regulatory agencies, who have been considered as pioneers in the application of herbal biomolecules in the diverse healthcare fields Includes updated literature review along with practical examples and research case studies

Genomics of Rare Diseases

Genomics of Rare Diseases Book
Author : Claudia Gonzaga-Jauregui,James R. Lupski
Publisher : Academic Press
Release : 2021-06-12
ISBN : 0128204362
Language : En, Es, Fr & De

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Book Description :

Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions Explores opportunities for novel therapeutics Features chapter contributions from leading researchers and clinicians

Biochemistry of Lipids Lipoproteins and Membranes

Biochemistry of Lipids  Lipoproteins and Membranes Book
Author : Neale Ridgway,Roger McLeod
Publisher : Elsevier
Release : 2021-08-19
ISBN : 0323983286
Language : En, Es, Fr & De

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Book Description :

Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences. As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis. Fully revised to cover new and emerging topics Provides an important bridge between broad-based biochemistry research and application Presents key concepts that are supported by figures and models to improve understanding Includes references from current literature in each chapter to facilitate in-depth study

Dairy Processing Advanced Research to Applications

Dairy Processing  Advanced Research to Applications Book
Author : Jagrani Minj,Aparna Sudhakaran V,Anuradha Kumari
Publisher : Springer Nature
Release : 2020-04-10
ISBN : 9811526087
Language : En, Es, Fr & De

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Book Description :

This book focuses on advanced research and technologies in dairy processing, one of the most important branches of the food industry. It addresses various topics, ranging from the basics of dairy technology to the opportunities and challenges in the industry. Following an introduction to dairy processing, the book takes readers through various aspects of dairy engineering, such as dairy-based peptides, novel milk products and bio-fortification. It also describes the essential role of microorganisms in the industry and ways to detect them, as well as the use of prebiotics, and food safety. Lastly, the book examines the challenges faced, especially in terms of maintaining quality across the supply chain. Covering all significant areas of dairy science and processing, this interesting and informative book is a valuable resource for post-graduate students, research scholars and industry experts.

Handbook of Analytical Techniques for Forensic Samples

Handbook of Analytical Techniques for Forensic Samples Book
Author : Chaudhery Mustansar Hussain,Deepak Rawtani,Gaurav Pandey,Maithri Tharmavaram
Publisher : Elsevier
Release : 2020-11-28
ISBN : 0128223014
Language : En, Es, Fr & De

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Book Description :

Handbook of Analytical Techniques for Forensic Samples: Current and Emerging Developments discusses in detail the current trends and latest analytical techniques and methods commonly employed in forensic analysis in order to ensure the proper facilitation of justice. This book is useful for readers who wish to stay updated on the latest trends in the forensic analysis of samples encountered at crime scenes. Technological advancements, such as biosensors, nanotechnology, and taggant technology have upped the level of analysis in forensic science. These emergent technologies, incorporated with existing analytical techniques, are leading to more precise, accurate, and specific examination of forensic samples. Lab-on-a-chip technology has also eased several kinds of on-site analyses done by investigating teams at different types of crime scenes. This book covers the evolution of forensic sample analysis as well as these emerging trends and new technologies. Includes an entire section of experimental exercises for self-teaching and key concept review Covers laboratory protocols used in forensic science laboratories for the analysis of various samples through different analytical techniques Condenses the many aspects of forensic analytical chemistry into a single resource with easy-to-understand language for everyone from students to practitioners

Mass Spectrometry for the Novice

Mass Spectrometry for the Novice Book
Author : John Greaves,John Roboz
Publisher : CRC Press
Release : 2013-10-16
ISBN : 1420094203
Language : En, Es, Fr & De

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Book Description :

With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers

Frontiers in Clinical Drug Research Dementia Volume 1

Frontiers in Clinical Drug Research   Dementia  Volume 1 Book
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Release : 2020-06-02
ISBN : 9811410933
Language : En, Es, Fr & De

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Book Description :

Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, - the loss of brain function associated with Alzheimer’s disease and other related medical conditions. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for dementia and related disorders. This volume includes the following reviews: - Meeting the Challenges of Falls and Hip Fractures in People with Alzheimer’s Disease - Cholesterol in Brain Health and Pathologies - Advances in the Treatment of Mild Cognitive Impairment (MCI) and Dementia - Analytical Methods in Alzheimer’s Disease Drug Discovery - Targeting Alzheimer’s Disease through Nanomedicine - Current Challenges in Alzheimer’s Disease Research - Metals Linked to Alzheimer's Disease

Sustainable Seaweed Technologies

Sustainable Seaweed Technologies Book
Author : Maria Dolores Torres,Stefan Kraan,Herminia Dominguez
Publisher : Elsevier
Release : 2020-05-20
ISBN : 0128179449
Language : En, Es, Fr & De

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Book Description :

Sustainable Seaweed Technologies: Cultivation, Biorefinery, and Applications collates key background information on efficient cultivation and biorefinery of seaweeds, combining underlying chemistry and methodology with industry experience. Beginning with a review of the opportunities for seaweed biorefinery and the varied components and properties of macroalgae, the book then reviews all the key steps needed for industrial applications, from its cultivation, collection and processing, to extraction techniques, concentration and purification. A range of important applications are then discussed, including the production of energy and novel materials from seaweed, before a set of illustrative case studies shows how these various stages work in practice. Drawing on the expert knowledge of a global team of editors and authors, this book is a practical resource for both researchers and businesses who currently work with macroalgae. Highlights the specific challenges and benefits of developing seaweed for sustainable products Presents useful case studies that demonstrate varied approaches and methodologies in practice Covers the complete seaweed chain, from cultivation to waste management

Modern Environmental Analysis Techniques for Pollutants

Modern Environmental Analysis Techniques for Pollutants Book
Author : Chaudhery Mustansar Hussain,Rustem Kecili
Publisher : Elsevier
Release : 2019-08-20
ISBN : 0128169354
Language : En, Es, Fr & De

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Book Description :

Modern Environmental Analysis Techniques for Pollutants presents established environmental analysis methods, rapidly emerging technologies, and potential future research directions. As methods of environmental analysis move toward lower impact, lower cost, miniaturization, automation, and simplicity, new methods emerge and ultimately improve the accuracy of their analytical results. This book gives in-depth, step-by-step descriptions of a variety of techniques, including methods used in sampling, field sample handling, sample preparation, quantification, and statistical evaluation. Modern Environmental Analysis Techniques for Pollutants aims to deliver a comprehensive and easy-to-read text for students and researchers in the environmental analysis arena and to provide essential information to consultants and regulators about analytical and quality control procedures helpful in their evaluation and decision-making procedures. Bridges the gap in current literature on analytical chemistry techniques and their application to environmental analysis Covers the use of nanomaterials in environmental analysis, as well as the monitoring and analysis of nanomaterials in the environment Looks to the past, present and future of environmental analysis, with chapters on historical background, established and emerging techniques and instrumentation, and predictions

Handbook on Miniaturization in Analytical Chemistry

Handbook on Miniaturization in Analytical Chemistry Book
Author : Chaudhery Mustansar Hussain
Publisher : Elsevier
Release : 2020-07-25
ISBN : 012822553X
Language : En, Es, Fr & De

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Book Description :

Handbook on Miniaturization in Analytical Chemistry: Application of Nanotechnology provides a source of authoritative fundamentals, interdisciplinary knowledge and primary literature for researchers who want to fully understand how nano-technologies work. Covering all stages of analysis, from sample preparation to separation and detection, the book discusses the design and manufacturing technology of miniaturization and includes an entire section on safety risks, ethical, legal and social issues (ELSI), the economics of nanotechnologies, and a discussion on sustainability with respect to nano- and lab-on-chip technologies. This guide for students and researchers working on applications of nanotechnology in modern systems for analysis gives readers everything they need to know to bring their current practices up-to-date. Details the impacts of miniaturization and nanotechnology Includes coverage of the current challenges for scaling up nano-miniaturization design and manufacturing technology for analysis Provides the latest reference materials, including websites of interest and details on the latest research in every chapter

Mass Spectrometry in Food Analysis

Mass Spectrometry in Food Analysis Book
Author : Leo M. L. Nollet,Robert Winkler
Publisher : CRC Press
Release : 2022-03-21
ISBN : 1000539253
Language : En, Es, Fr & De

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Book Description :

The quality and safety of food are crucial for human nutrition. However, evaluating the chemical composition of food is challenging for the analyst and requires powerful methods. Chromatography and mass spectrometry (MS) is the gold standard for analyzing complex food samples, including raw materials and intermediate and finished products. Mass Spectrometry in Food Analysis covers the MS-based analysis of different aspects of food quality, which include nutritional value, profile of macronutrients (proteins, lipids, and carbohydrates), micronutrients (vitamins), and nutraceutical active compounds. Additionally, sensory quality, flavor, food pigments, safety, and detection of pesticides, contact materials, veterinary drugs and pharmaceuticals, organic pollutants, and pathogens are covered. Key Features: Contains the basics of mass spectrometry and experimental strategies Explores determination of macro- and micronutrients Analyzes sensory and nutraceutical food quality Discusses detection of contaminants and proof of authenticity Presents emerging methods for food analysis This book contains an introductory section that explains the basics of MS and the difference between targeted and untargeted strategies for beginners. Further, it points out new analytical challenges, such as monitoring contaminants of emerging concern, and presents innovative techniques (e.g., ambient ionization MS and data mining). Also available in the Food Analysis & Properties Series: Nanoemulsions in Food Technology: Development, Characterization, and Applications, edited by Javed Ahmad and Leo M.L. Nollet (ISBN: 978-0-367-61492-8) Sequencing Technologies in Microbial Food Safety and Quality, edited by Devarajan Thangadurai, Leo M.L. Nollet, Saher Islam, and Jeyabalan Sangeetha (ISBN: 978-0-367-35118-2) Chiral Organic Pollutants: Monitoring and Characterization in Food and the Environment, edited by Edmond Sanganyado, Basil K. Munjanja, and Leo M.L. Nollet (ISBN: 978-0-367-42923-2) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO

Evolutionary Diversity as a Source for Anticancer Molecules

Evolutionary Diversity as a Source for Anticancer Molecules Book
Author : Akhileshwar Kumar Srivastava,Vinod Kumar Kannaujiya,Rajesh Kumar Singh,Divya Singh
Publisher : Academic Press
Release : 2020-09-21
ISBN : 0128216980
Language : En, Es, Fr & De

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Book Description :

Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products derived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients. This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedical field interested in understanding more about natural products with anticancer potential. Discusses the application of natural products in place of conventional drugs to minimize the side effects in cancer treatment Explains the relation between evolutionary mechanisms and climate change for production of secondary metabolites

Henry s Clinical Diagnosis and Management by Laboratory Methods E Book

Henry s Clinical Diagnosis and Management by Laboratory Methods E Book Book
Author : Richard A. McPherson,Matthew R. Pincus
Publisher : Elsevier Health Sciences
Release : 2021-06-09
ISBN : 0323755089
Language : En, Es, Fr & De

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Book Description :

For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.

Fungal Infections in Immunocompromised Hosts

Fungal Infections in Immunocompromised Hosts Book
Author : Dimitrios P. Kontoyiannis,Monica Slavin
Publisher : MDPI
Release : 2019-04-02
ISBN : 3038977160
Language : En, Es, Fr & De

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Book Description :

In this unique supplement, we have compiled several state-of-the-art topics that are based on lectures delivered by eminent mycology experts during the 37th ICHS meeting. We hope that the esteemed audience of the Journal of Fungi will enjoy and appreciate the ever-evolving and complex field of fungal infections in vulnerable hosts.

Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory Book
Author : Hari Nair,William Clarke
Publisher : Academic Press
Release : 2016-11-02
ISBN : 0128009926
Language : En, Es, Fr & De

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Book Description :

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Biomedical Science Practice

Biomedical Science Practice Book
Author : Nessar Ahmed,Hedley Glencross,Qiuyu Wang
Publisher : Oxford University Press
Release : 2016
ISBN : 0198717318
Language : En, Es, Fr & De

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Book Description :

Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science. A core text in the Fundamentals of Biomedical Science series, Biomedical Science Practice gives a comprehensive overview of the key laboratory techniques and professional skills that students need to master. The text is supported throughout with engaging clinical case studies, written to emphasize the link between theory and practice, providing a strong foundation for beginning biomedical science students.

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring Book
Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Release : 2016-07-21
ISBN : 0128020520
Language : En, Es, Fr & De

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Book Description :

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window