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Principles And Applications Of Clinical Mass Spectrometry

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Principles and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry Book
Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
Publisher : Elsevier
Release : 2018-06-26
ISBN : 0128160640
Language : En, Es, Fr & De

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Book Description :

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Clinical Biochemistry Principles Methods Applications

Clinical Biochemistry  Principles  Methods  Applications Book
Author : A. M. Lawson,H. C. Curtius,M. Roth
Publisher : Unknown
Release : 1989-01-01
ISBN : 9780899255811
Language : En, Es, Fr & De

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Book Description :

Download Clinical Biochemistry Principles Methods Applications book written by A. M. Lawson,H. C. Curtius,M. Roth, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mass Spectrometry in Drug Metabolism and Disposition

Mass Spectrometry in Drug Metabolism and Disposition Book
Author : Mike S. Lee,Mingshe Zhu
Publisher : John Wiley & Sons
Release : 2011-03-16
ISBN : 9780470934692
Language : En, Es, Fr & De

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Book Description :

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Advances in the Use of Liquid Chromatography Mass Spectrometry LC MS

Advances in the Use of Liquid Chromatography Mass Spectrometry  LC MS  Book
Author : Pierangela Palma
Publisher : Unknown
Release : 2018-01-05
ISBN : 9780444639141
Language : En, Es, Fr & De

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Book Description :

Advances in the Use of Liquid Chromatography Mass Spectrometry (LC-MS): Instrumentation Developments and Application, Volume 79, highlights the most recent LC-MS evolutions through a series of contributions by world renowned scientists that will lead the readers through the most recent innovations in the field and their possible applications. Many authoritative books on LC-MS are already present in market, describing in detail the different interfaces and their principles of operation. This book focuses more on new trends, starting with the innovations of each technique, to the most progressive challenges of LC-MS. Presents an understanding of the new advancements in LC and MS which are essential for a step forward in LC-MS applications Provides insight into the state-of-the-art in the currently available LC-MS interfaces and their principle of use Expounds on the new frontiers in LC-MS and their application potential

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry Book
Author : Karoly Vekey,Andreas Telekes,Akos Vertes
Publisher : Elsevier Science
Release : 2007-11-20
ISBN : 9780444519801
Language : En, Es, Fr & De

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Book Description :

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Toxicology Cases for the Clinical and Forensic Laboratory

Toxicology Cases for the Clinical and Forensic Laboratory Book
Author : Hema Ketha,Uttam Garg
Publisher : Academic Press
Release : 2020-06-20
ISBN : 0128163739
Language : En, Es, Fr & De

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Book Description :

Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both. Brings together expert cases encompassing analytical toxicology, clinical medicine and basic science in a consolidated format Presents unique and challenging cases in clinical laboratories contributed by experts in the field Consolidated format that make concepts in toxicology easy to learn and teach Key learning points highlighted with multiple choice questions

The Use of Mass Spectrometry Technology MALDI TOF in Clinical Microbiology

The Use of Mass Spectrometry Technology  MALDI TOF  in Clinical Microbiology Book
Author : Fernando Cobo
Publisher : Academic Press
Release : 2018-08-03
ISBN : 0128144521
Language : En, Es, Fr & De

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Book Description :

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers

Quantitative Biological and Clinical Mass Spectrometry

Quantitative Biological and Clinical Mass Spectrometry Book
Author : Anthony I. Mallet
Publisher : John Wiley & Sons
Release : 2018-07-23
ISBN : 1119281202
Language : En, Es, Fr & De

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Book Description :

A basic overview of mass spectrometry relevant to life and health science applications, illustrated throughout with relevant case studies This introductory text provides information and assistance to new users of mass spectrometry (MS) working in clinical or biochemical fields who are faced with implementing and designing quantitative mass spectrometric assays for a variety of classes of molecules of biological interest. It presents a detailed discussion on how to optimize measurement parameters for a candidate reference quantitative analysis, including calibration procedures, sensitivity, reproducibility, speed of assay and compliance with regulatory authorities. Quantitative Biological and Clinical Mass Spectrometry uses examples where development has not been immediately successful but where unforeseen problems have arisen and describes the strategies used to solve these. Advances in addressing the very large numbers of clinical samples that arise on routine screening programs such as those involved in inborn errors of metabolism studies are discussed. Direct mass spectrometric based analyses applicable to point of care testing (POCT) situations are also covered. The book concludes with a short section on possible novel developments, bibliography, references, and a glossary of terms. Shows how the presence of false results can be detected and understood Describes the ‘parts’ of modern instruments from sample introduction through ionization, mass analysis and detection, and the variety of techniques of tandem mass spectrometry Discusses the requirement for specificity in an assay method Fully illustrated throughout Highly relevant to all key areas of mass spectrometric analysis Quantitative Biological and Clinical Mass Spectrometry appeals to those newly exposed to the use of combined chromatography and mass spectrometry for analysis of biological material and to scientists experienced in automated clinical analysis using immunoassays or who are new to mass spectrometry.

Contemporary Practice in Clinical Chemistry

Contemporary Practice in Clinical Chemistry Book
Author : William Clarke,Mark Marzinke
Publisher : Academic Press
Release : 2020-06-11
ISBN : 0128158336
Language : En, Es, Fr & De

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Book Description :

Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. Includes enhanced illustration and new and revised color figures Provides improved self-assessment questions and end-of-chapter assessment questions

Genomics of Rare Diseases

Genomics of Rare Diseases Book
Author : Claudia Gonzaga-Jauregui,James R. Lupski
Publisher : Academic Press
Release : 2021-06-12
ISBN : 0128204362
Language : En, Es, Fr & De

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Book Description :

Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions Explores opportunities for novel therapeutics Features chapter contributions from leading researchers and clinicians

Mass Spectrometry for the Novice

Mass Spectrometry for the Novice Book
Author : John Greaves,John Roboz
Publisher : CRC Press
Release : 2013-10-16
ISBN : 1420094203
Language : En, Es, Fr & De

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Book Description :

With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers

Handbook of Analytical Techniques for Forensic Samples

Handbook of Analytical Techniques for Forensic Samples Book
Author : Chaudhery Mustansar Hussain,Deepak Rawtani,Gaurav Pandey,Maithri Tharmavaram
Publisher : Elsevier
Release : 2020-11-28
ISBN : 0128223014
Language : En, Es, Fr & De

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Book Description :

Handbook of Analytical Techniques for Forensic Samples: Current and Emerging Developments discusses in detail the current trends and latest analytical techniques and methods commonly employed in forensic analysis in order to ensure the proper facilitation of justice. This book is useful for readers who wish to stay updated on the latest trends in the forensic analysis of samples encountered at crime scenes. Technological advancements, such as biosensors, nanotechnology, and taggant technology have upped the level of analysis in forensic science. These emergent technologies, incorporated with existing analytical techniques, are leading to more precise, accurate, and specific examination of forensic samples. Lab-on-a-chip technology has also eased several kinds of on-site analyses done by investigating teams at different types of crime scenes. This book covers the evolution of forensic sample analysis as well as these emerging trends and new technologies. Includes an entire section of experimental exercises for self-teaching and key concept review Covers laboratory protocols used in forensic science laboratories for the analysis of various samples through different analytical techniques Condenses the many aspects of forensic analytical chemistry into a single resource with easy-to-understand language for everyone from students to practitioners

Dairy Processing Advanced Research to Applications

Dairy Processing  Advanced Research to Applications Book
Author : Jagrani Minj,Aparna Sudhakaran V,Anuradha Kumari
Publisher : Springer Nature
Release : 2020-04-10
ISBN : 9811526087
Language : En, Es, Fr & De

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Book Description :

This book focuses on advanced research and technologies in dairy processing, one of the most important branches of the food industry. It addresses various topics, ranging from the basics of dairy technology to the opportunities and challenges in the industry. Following an introduction to dairy processing, the book takes readers through various aspects of dairy engineering, such as dairy-based peptides, novel milk products and bio-fortification. It also describes the essential role of microorganisms in the industry and ways to detect them, as well as the use of prebiotics, and food safety. Lastly, the book examines the challenges faced, especially in terms of maintaining quality across the supply chain. Covering all significant areas of dairy science and processing, this interesting and informative book is a valuable resource for post-graduate students, research scholars and industry experts.

Application of IC MS and IC ICP MS in Environmental Research

Application of IC MS and IC ICP MS in Environmental Research Book
Author : Rajmund Michalski
Publisher : John Wiley & Sons
Release : 2016-06-07
ISBN : 1118862007
Language : En, Es, Fr & De

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Book Description :

Introduces the reader to the field of ion chromatography, species analysis and hyphenated methods IC-MS and IC-ICP-MS including the theory and theirs applications Covers the importance of species analysis and hyphenated methods in ion chromatography Includes practical applications of IC-MS and IC-ICP-MS in environmental analysis Details sample preparation methods for ion chromatography Discusses hyphenated methods IC-MS and IC-ICP-MS used in determining both the total element contents and its elements Details speciation analysis used in studying biochemical cycles of selected chemical compounds; determining toxicity and ecotoxicity of elements; food and pharmaceuticals quality control; and in technological process control and clinical analytics

Engineering Medicine

Engineering Medicine Book
Author : Lawrence S. Chan,William C. Tang
Publisher : CRC Press
Release : 2019-05-15
ISBN : 1351012258
Language : En, Es, Fr & De

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Book Description :

This transformative textbook, first of its kind to incorporate engineering principles into medical education and practice, will be a useful tool for physicians, medical students, biomedical engineers, biomedical engineering students, and healthcare executives. The central approach of the proposed textbook is to provide principles of engineering as applied to medicine and guide the medical students and physicians in achieving the goal of solving medical problems by engineering principles and methodologies. For the medical students and physicians, this proposed textbook will train them to “think like an engineer and act as a physician”. The textbook contains a variety of teaching techniques including class lectures, small group discussions, group projects, and individual projects, with the goals of not just helping students and professionals to understand the principles and methods of engineering, but also guiding students and professionals to develop real-life solutions. For the biomedical engineers and biomedical engineering students, this proposed textbook will give them a large framework and global perspective of how engineering principles could positively impact real-life medicine. To the healthcare executives, the goal of this book is to provide them general guidance and specific examples of applying engineering principles in implementing solution-oriented methodology to their healthcare enterprises. Overall goals of this book are to help improve the overall quality and efficiency of healthcare delivery and outcomes.

Sustainable Seaweed Technologies

Sustainable Seaweed Technologies Book
Author : Maria Dolores Torres,Stefan Kraan,Herminia Dominguez
Publisher : Elsevier
Release : 2020-05-20
ISBN : 0128179449
Language : En, Es, Fr & De

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Book Description :

Sustainable Seaweed Technologies: Cultivation, Biorefinery, and Applications collates key background information on efficient cultivation and biorefinery of seaweeds, combining underlying chemistry and methodology with industry experience. Beginning with a review of the opportunities for seaweed biorefinery and the varied components and properties of macroalgae, the book then reviews all the key steps needed for industrial applications, from its cultivation, collection and processing, to extraction techniques, concentration and purification. A range of important applications are then discussed, including the production of energy and novel materials from seaweed, before a set of illustrative case studies shows how these various stages work in practice. Drawing on the expert knowledge of a global team of editors and authors, this book is a practical resource for both researchers and businesses who currently work with macroalgae. Highlights the specific challenges and benefits of developing seaweed for sustainable products Presents useful case studies that demonstrate varied approaches and methodologies in practice Covers the complete seaweed chain, from cultivation to waste management

Modern Environmental Analysis Techniques for Pollutants

Modern Environmental Analysis Techniques for Pollutants Book
Author : Chaudhery Mustansar Hussain,Rustem Kecili
Publisher : Elsevier
Release : 2019-08-20
ISBN : 0128169354
Language : En, Es, Fr & De

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Book Description :

Modern Environmental Analysis Techniques for Pollutants presents established environmental analysis methods, rapidly emerging technologies, and potential future research directions. As methods of environmental analysis move toward lower impact, lower cost, miniaturization, automation, and simplicity, new methods emerge and ultimately improve the accuracy of their analytical results. This book gives in-depth, step-by-step descriptions of a variety of techniques, including methods used in sampling, field sample handling, sample preparation, quantification, and statistical evaluation. Modern Environmental Analysis Techniques for Pollutants aims to deliver a comprehensive and easy-to-read text for students and researchers in the environmental analysis arena and to provide essential information to consultants and regulators about analytical and quality control procedures helpful in their evaluation and decision-making procedures. Bridges the gap in current literature on analytical chemistry techniques and their application to environmental analysis Covers the use of nanomaterials in environmental analysis, as well as the monitoring and analysis of nanomaterials in the environment Looks to the past, present and future of environmental analysis, with chapters on historical background, established and emerging techniques and instrumentation, and predictions

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry Book
Author : Karoly Vekey,Andreas Telekes,Akos Vertes
Publisher : Elsevier
Release : 2011-08-11
ISBN : 0080554652
Language : En, Es, Fr & De

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Book Description :

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Handbook of GC MS

Handbook of GC MS Book
Author : Hans-Joachim Hübschmann
Publisher : John Wiley & Sons
Release : 2015-04-27
ISBN : 3527674322
Language : En, Es, Fr & De

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Book Description :

The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. For this new edition the work has been now extended to two volumes, reflecting the latest developments in the technique and related instrumentation, while also incorporating several new examples of applications in many fields. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.