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Principles And Applications Of Clinical Mass Spectrometry

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Principles and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry Book
Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
Publisher : Elsevier
Release : 2018-06-26
ISBN : 0128160640
Language : En, Es, Fr & De

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Book Description :

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Quantitative Biological and Clinical Mass Spectrometry

Quantitative Biological and Clinical Mass Spectrometry Book
Author : Anthony I. Mallet
Publisher : John Wiley & Sons
Release : 2018-07-23
ISBN : 1119281202
Language : En, Es, Fr & De

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Book Description :

A basic overview of mass spectrometry relevant to life and health science applications, illustrated throughout with relevant case studies This introductory text provides information and assistance to new users of mass spectrometry (MS) working in clinical or biochemical fields who are faced with implementing and designing quantitative mass spectrometric assays for a variety of classes of molecules of biological interest. It presents a detailed discussion on how to optimize measurement parameters for a candidate reference quantitative analysis, including calibration procedures, sensitivity, reproducibility, speed of assay and compliance with regulatory authorities. Quantitative Biological and Clinical Mass Spectrometry uses examples where development has not been immediately successful but where unforeseen problems have arisen and describes the strategies used to solve these. Advances in addressing the very large numbers of clinical samples that arise on routine screening programs such as those involved in inborn errors of metabolism studies are discussed. Direct mass spectrometric based analyses applicable to point of care testing (POCT) situations are also covered. The book concludes with a short section on possible novel developments, bibliography, references, and a glossary of terms. Shows how the presence of false results can be detected and understood Describes the ‘parts’ of modern instruments from sample introduction through ionization, mass analysis and detection, and the variety of techniques of tandem mass spectrometry Discusses the requirement for specificity in an assay method Fully illustrated throughout Highly relevant to all key areas of mass spectrometric analysis Quantitative Biological and Clinical Mass Spectrometry appeals to those newly exposed to the use of combined chromatography and mass spectrometry for analysis of biological material and to scientists experienced in automated clinical analysis using immunoassays or who are new to mass spectrometry.

Anesthesia Equipment

Anesthesia Equipment Book
Author : Jan Ehrenwerth,James B. Eisenkraft
Publisher : Mosby Incorporated
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Anesthesia Equipment: Principles and Applications, 2nd Edition, by Dr. Jan Ehrenwerth and Dr. James B. Eisenkraft, offers expert, highly visual, practical guidance on the full range of delivery systems and technology used in practice today. It equips you with the objective, informed answers you need to ensure optimal patient safety. "This is a comprehensive, up-to-date reference textbook covering all aspects of physics and equipment for the modern American anaesthetist. It may be helpful to those studying for American fellowship examinations but is not suited to preparation for the UK FRCA examinations." Reviewed by: I.Wrench on behalf of the British Journal of Anaesthesia, Feb 2014?

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry Book
Author : Karoly Vekey,Andreas Telekes,Akos Vertes
Publisher : Elsevier
Release : 2011-08-11
ISBN : 0080554652
Language : En, Es, Fr & De

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Book Description :

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Airway Management

Airway Management Book
Author : Leland H. Hanowell,Richard J. Waldron,Judith C. F. Hwang
Publisher : Lippincott Williams & Wilkins
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Airway Management book written by Leland H. Hanowell,Richard J. Waldron,Judith C. F. Hwang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Principles and Applications of Laboratory Instrumentation

Principles and Applications of Laboratory Instrumentation Book
Author : Sheshadri Narayanan
Publisher : Amer Society of Clinical
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Principles and Applications of Laboratory Instrumentation book written by Sheshadri Narayanan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual Review of Clinical Biochemistry

Annual Review of Clinical Biochemistry Book
Author : David M. Goldberg
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Review of Clinical Biochemistry book written by David M. Goldberg, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Direct Analysis in Real Time Mass Spectrometry

Direct Analysis in Real Time Mass Spectrometry Book
Author : Yiyang Dong
Publisher : John Wiley & Sons
Release : 2018-03-05
ISBN : 3527341846
Language : En, Es, Fr & De

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Book Description :

DART-MS is a relatively new, but very fast evolving technology. Due to its versatility, it addresses fields of crucial importance to people and community, e.g. food or agricultural, forensic, industrial, environmental, medicinal and clinical analysis.

The Bile Acids Chemistry Physiology and Metabolism

The Bile Acids  Chemistry  Physiology  and Metabolism Book
Author : K.D.R. Setchell,David Kritchevsky,Padmanabhan P. Nair
Publisher : Springer
Release : 1988-06-30
ISBN : 9780306426223
Language : En, Es, Fr & De

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Book Description :

Over a decade has elapsed since the last volume in this series was published. At that time we considered that we had comprehensively covered all aspects relating to bile acid chemistry and physiology. However, major strides have been made in our understanding of the physiology and pathophysiology of bile acids, due largely to the great advances which have taken place in analytical technology. As a result, the need to document these advances was felt acutely, and therefore this volume is devoted to methodologies in bile acid analysis and their applications. This volume includes twelve chapters written by prominent scientists in the field of bile acid research. The initial chapter discusses techniques of extraction and isolation of bile acids from biological fluids. It is followed by descriptions of physical methods of analysis and discussions of the way these techniques have been applied in the field of bile acid research. Of practical value is the inclusion of a comprehensive list of spectra obtained for refer ences by nuclear magnetic resonance spectroscopy and mass spectrometry . These chapters are followed by reviews of biological methods of immuno assay and bioluminescence. Specific applications of these techniques are then addressed in contributions relating to bile acid analysis of tissue, serum, urine, and feces. With this integrated approach we have attempted to provide a volume which represents a comprehensive review of the analytical field of bile acids, while also serving as a useful reference book for those workers involved in bile acid analysis.

Mass Spectrometry Bulletin

Mass Spectrometry Bulletin Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mass Spectrometry Bulletin book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medical Principles and Practice

Medical Principles and Practice Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medical Principles and Practice book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Current Practice of Gas Chromatography Mass Spectrometry

Current Practice of Gas Chromatography Mass Spectrometry Book
Author : Wilfried M.A. Niessen
Publisher : CRC Press
Release : 2001-04-04
ISBN : 9781420029512
Language : En, Es, Fr & De

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Book Description :

This volume details the principles and instrumentation of gas chromatography-mass spectrometry (CG-MS), and outlines industrial, environmental, pharmaceutical, clinical, toxicological, forensic and food-related applications, revealing findings from the laboratories of 40 contributing scientists around the world using GC-MS in practice. It describes upstream and downstream applications of GC-MS in the petroleum industry and identifies chlorinated compounds in the environment with quadrupole ion-trap technology and high-resolution sector instruments.

Mass Spectrometry

Mass Spectrometry Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mass Spectrometry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Use of Mass Spectrometry Technology MALDI TOF in Clinical Microbiology

The Use of Mass Spectrometry Technology  MALDI TOF  in Clinical Microbiology Book
Author : Fernando Cobo
Publisher : Academic Press
Release : 2018-08-03
ISBN : 0128144521
Language : En, Es, Fr & De

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Book Description :

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers

Mass Spectrometry Reviews

Mass Spectrometry Reviews Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Comprehensive Coordination Chemistry II Fundamentals physical methods theoretical analysis and case studies

Comprehensive Coordination Chemistry II  Fundamentals  physical methods  theoretical analysis  and case studies Book
Author : Jon A. McCleverty,Thomas J. Meyer,Alfred Beverley Philip Lever
Publisher : Pergamon
Release : 2004
ISBN : 9780080443249
Language : En, Es, Fr & De

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Book Description :

Download Comprehensive Coordination Chemistry II Fundamentals physical methods theoretical analysis and case studies book written by Jon A. McCleverty,Thomas J. Meyer,Alfred Beverley Philip Lever, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Awards Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Capnography in Clinical Practice

Capnography in Clinical Practice Book
Author : J. S. Gravenstein,David A. Paulus,Thomas J. Hayes
Publisher : Butterworth-Heinemann
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Capnography is a noninvasive technique rapidly gaining acceptance as a routine monitor of ventilation that can detect dangerous problems in gas exchange. The authors explains the basics, the technology, and the subtleties of interpretation. Annotation copyrighted by Book News, Inc., Portland, OR

The Encyclopedia of Mass Spectrometry Ten Volume Set

The Encyclopedia of Mass Spectrometry  Ten Volume Set Book
Author : Anonim
Publisher : Elsevier Science
Release : 2013-09-27
ISBN : 9780080438504
Language : En, Es, Fr & De

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Book Description :

Overview: The Encyclopedia of Mass Spectrometry The need for an encyclopedia of mass spectrometry (MS) becomes apparent when considering the subject's evolution. By 1990, MS had evolved as a discipline and as a technique for solving problems in chemistry. Along with nuclear magnetic resonance and optical spectroscopy, it was a tool for compound identification. For complex mixtures as found in environmental chemistry, flavors, energy materials, and small-molecule metabolism, gas chromatography-mass spectrometry had become the premier analytical method. Despite these advances, MS played in 1990 only a small role in polar and large-molecule analysis. Field desorption, fast atom bombardment, and Cf-252 plasma desorption gently pushed it into peptide sequencing and molecular weight determination of larger polymers. Although these ionizations had limitations, when they were coupled with tandem mass spectrometers, the future became clearer. MS now awaited the development of new ionization methods that would extend its capabilities into many different research laboratories. The inventions of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) in the late 1980s opened the door for that greater role. Even the discipline of MS could expand by embracing the chemical-physical studies of proteins and oligodeoxynucleotides in the gas phase. The broad applicability of MS to a multitude of chemical, physical, and biological problems makes it now the central tool in chemical analysis. No longer a specialist's tool, it has assumed broad applicability and availability. To permit a full and fruitful expansion in other disciplines, the Encyclopedia of Mass Spectrometry is designed to be a learning tool to newcomers who do not have the theoretical and practical background needed to take advantage of the possibilities of MS. Moreover, the field is now so broad that the specialist also needs a resource to allow exploration of its vast reaches. The encyclopedia meets that need and strives to be an entrance into the subject and to serve as its major reference work. Volume 1: Theory and Ion Chemistry Volume 1 begins with two theory chapters. The first discusses theoretical aspects of ion collisions, chemistry, and dynamics, and the second introduces ab initio calculations of ions. The latter has become a nearly indispensable tool in ion chemistry studies today. Instrumentation is essential in fundamental investigations. Chapter 3 introduces instrumentation, with an emphasis on unusual instrumentation, generally not commercially available. Ion traps, ion cyclotron resonance mass spectrometers, and time-of-flight instruments, which are important in both fundamental studies and in applications, are also covered. Chapter 4 discusses myriad means of performing spectroscopic experiments on ions. In the next chapter, various methods of measuring thermodynamic information about ions are introduced and evaluated. Collisional activation and dissociation processes, in various incarnations, are in Chapter 6. Mobility experiments are the focus of the next chapter, which covers fundamental aspects and applications of this rapidly growing technology. Various means and uses of changing charge states of ions is the topic of chapter 8. Chapters 9 and 10 introduce the ion chemistry of organic ions, positive and negative, respectively. The last three chapters (Chapter 11-13) are expositions of the ion chemistry of clusters and solvation phenomena, inorganic chemistry, and the rapidly expanding area of biochemistry. Volume 2: Biological Applications Part A The focus of Volume 2 is peptides and proteins. The organization emphasizes separation techniques, preparation protocols, and fundamentals of ionic gas-phase species of biological importance. This volume is divided into four sections: (1) experimental approaches and protocols, (2) sequence analysis, (3) other structural analyses, and (4) targeted applications. The first section encompass separation procedures (e.g., 2-D gel electrophoresis), sample preparation (e.g., desalting and enzyme digestion), and instrumentation issues (e.g., high resolving power, molecular-weight determination, protein chips, and quantification). H/D exchange, analysis of membrane proteins, and bioinformatics are included. The next section on sequencing covers high energy and low energy CAD, protein identification, fundamentals of peptide fragmentation, bottom-up and top-down strategies, chemical derivatization, and post-source decay with MALDI. A section on structure analysis includes primary structure determination and issues with studying quaternary structure, protein-protein and protein-ligand complexes, disulfide analysis, phosphopeptides and phosphoproteins, selenoproteins, nitrated proteins, metal ion binding, and oxidized proteins. Additional coverage of methods for studying the biophysics of proteins is provided in Volume 6. The last chapter, Targeted Applications, focuses on neuropeptides, clinical applications, enzyme kinetics, imaging, and single-cell analysis. Volume 3: Biological Applications Part B Over the past decades, enormous gains have been made towards the analysis of all the biomolecules in cells. Although early attention was focused on peptides and proteins, a wealth of information is arising about other major biomolecules including nucleic acids, lipids and carbohydrates. In no small way, modern ionization methods, especially electrospray and matrix-assisted laser desorption, have provided a quantum leap in the capabilities of the tools we can now deploy in answering biological questions involving structure and molecular weight of virtually every type of molecule in the cell. Volume 3 covers classes carbohydrates, nucleic acids, and lipids. In addition, special areas of application are also included, such as pharmaceuticals, natural products, isotope ratio methods for biomolecules analysis, and clinical applications. The articles are arranged under general headings for continuity and ease of access, although several of these are of interest across the various disciplines. The articles cover basics and sufficient additional detail to bring the reader up-to-date on a given subject. Some advanced topics are also covered, either in a special section of an article or in additional reading citations. Volume 4: Organic and Organometallic Compounds This volume presents a cross section of applications in organic and organometallic chemistry in two parts. Chapters 1 to 6 are devoted to the fundamentals whereas chapters 7 and 8 cover applications to organic and organometallic compounds, either available as pure compounds or present in complex mixtures. Chapter 1 describes the theory for organic mass spectrometry, building on and complementing material in Volume 1. The themes for Chapter 2 are the structures and properties of gas-phase ions of conventional, distonic, and non-covalent complexes. Chapter 3 covers methodology used in study of gas-phase ions. Chapters 4 and 5 turn to mechanisms of both unimolecular and bimolecular reactions of ions and include topics in stereochemistry and radical chemistry. Chapter 6 contains a number of articles on the formation and reactivity

World Meetings

World Meetings Book
Author : World Meetings Information Center
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download World Meetings book written by World Meetings Information Center, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.