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Precision Medicine In Pediatric Health

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Precision Medicine in Pediatric Health

Precision Medicine in Pediatric Health Book
Author : Olaf Bodamer
Publisher : Academic Press
Release : 2020-05-01
ISBN : 0128170174
Language : En, Es, Fr & De

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Book Description :

Precision Medicine in Pediatric Health is an invaluable resource on state-of-the-art tools, technologies and social and ethical issues involved in fully realizing precision medicine in new pediatric research and healthcare. The book adopts a holistic approach that is grounded in key learning points and practical case studies of interest to interdisciplinary teams of researchers and clinicians working in pediatrics. Chapters provide a thorough introduction to basic principles of precision medicine, its growing role in research and clinical care, relevant technologies and digital health. From there, the book examines best practices and offers support for implementing precision medicine in research and clinical settings. Chapters are devoted to varying specialties, such as prenatal and fetal health, oncology, cardiology, neurology, rare diseases, developmental disorders, and precision therapeutics, including small molecule and gene and cell-based therapies. These sections are followed by a close look at ethical, legal and social implications of precision medicine in pediatrics, patient perspectives and next steps in research and clinical translation. Presents succinct commentary and key learning points that support the translation of precision and genomic medicine Highlights the practical use of precision medicine in the management of pediatric patients Provides a comprehensive volume that is written and edited by leading researchers, clinicians and scientists

Precision Medicine for Investigators Practitioners and Providers

Precision Medicine for Investigators  Practitioners and Providers Book
Author : Joel Faintuch,Salomao Faintuch
Publisher : Academic Press
Release : 2019-11-16
ISBN : 0128191791
Language : En, Es, Fr & De

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Book Description :

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Discovering Precision Health

Discovering Precision Health Book
Author : Lloyd Minor
Publisher : John Wiley & Sons
Release : 2020-01-23
ISBN : 1119672740
Language : En, Es, Fr & De

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Book Description :

Today we are on the brink of a much-needed transformative moment for health care. The U.S. health care system is designed to be reactive instead of preventive. The result is diagnoses that are too late and outcomes that are far worse than our level of spending should deliver. In recent years, U.S. life expectancy has been declining. Fundamental to realizing better health, and a more effective health care system, is advancing the disruptive thinking that has spawned innovation in Silicon Valley and throughout the world. That's exactly what Stanford Medicine has done by proposing a new vision for health and health care. In Discovering Precision Health, Lloyd Minor and Matthew Rees describe a holistic approach that will set health care on the right track: keep people healthy by preventing disease before it starts and personalize the treatment of individuals precisely, based on their specific profile. With descriptions of the pioneering work undertaken at Stanford Medicine, complemented by fascinating case studies of innovations from entities including the Chan Zuckerberg Biohub, GRAIL, and Impossible Foods, Minor and Rees present a dynamic vision for the future of individual health and health care. You'll see how tools from smartphone technology to genome sequencing to routine blood tests are helping avert illness and promote health. And you'll learn about the promising progress already underway in bringing greater precision to the process of predicting, preventing, and treating a range of conditions, including allergies, mental illness, preterm birth, cancer, stroke, and autism. The book highlights how biomedical advances are dramatically improving our ability to treat and cure complex diseases, while emphasizing the need to devote more attention to social, behavioral, and environmental factors that are often the primary determinants of health. The authors explore thought-provoking topics including: The unlikely role of Google Glass in treating autism How gene editing can advance precision in treating disease What medicine can learn from aviation Discovering Precision Health showcases entirely new ways of thinking about health and health care and can help empower us to lead healthier lives.

Clinical Precision Medicine

Clinical Precision Medicine Book
Author : Judy S. Crabtree
Publisher : Academic Press
Release : 2019-11-15
ISBN : 0128204028
Language : En, Es, Fr & De

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Book Description :

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Precision Medicine A Multidisciplinary Approach

Precision Medicine  A Multidisciplinary Approach Book
Author : Joel J. Heidelbaugh
Publisher : Elsevier Health Sciences
Release : 2020-12-18
ISBN : 032378948X
Language : En, Es, Fr & De

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Book Description :

The Clinics Collections titles take a multidisciplinary approach to today’s practice of medicine, selecting the most recent and relevant articles from the Clinics series and combining them into a single source of information on a focused topic. Articles are chosen from multiple Clinics to highlight the range of specialties covering major medical issues, delivering the information needed for successful interdisciplinary teamwork and effective patient care. Written from a variety of medical perspectives, these articles offer deeper insight into how each specialty cares for its patients and provide a unique entry into sharing best concepts for the entire medical team. Clinics Collections: Precision Medicine draws from Elsevier’s Clinics Review Articles database to provide today’s medical teams with practical clinical advice and insights on this timely medical model. It guides readers on how to apply current primary research findings to everyday practice, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include breast cancer, lung cancer, melanoma, arthritis, sleep medicine, and pediatric oncology. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format.

Progress and Challenges in Precision Medicine

Progress and Challenges in Precision Medicine Book
Author : Mukesh Verma,Debmalya Barh
Publisher : Academic Press
Release : 2016-12-22
ISBN : 0128095024
Language : En, Es, Fr & De

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Book Description :

Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Precision Medicine A Multidisciplinary Approach

Precision Medicine  A Multidisciplinary Approach Book
Author : Joel J. Heidelbaugh
Publisher : Elsevier
Release : 2020-05-31
ISBN : 9780323789479
Language : En, Es, Fr & De

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Book Description :

Welcome to the Clinics Collections! We have taken a multidisciplinary approach and selected the most recent and vital articles throughout all of our Clinics series and combined them into a single source on Precision Medicine. Articles are featured from multiple Clinics to highlight the range of specialties covering this major medical issue. Such information is essential to successful interdisciplinary teamwork and patient care. The articles within, written from different medical perspectives, will give deeper insight into how each specialty cares for its patients. The challenge in Precision Medicine involves specialized treatment planning with the ultimate goal of successful patient outcomes. The articles selected provide a unique entry into sharing best concepts for the entire medical team to learn and implement. Areas of focus include breast cancer, lung cancer, melanoma, arthritis, sleep medicine, and pediatric oncology. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format.

Relevance of Health Literacy to Precision Medicine

Relevance of Health Literacy to Precision Medicine Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Roundtable on Health Literacy
Publisher : National Academies Press
Release : 2016-12-04
ISBN : 0309447321
Language : En, Es, Fr & De

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Book Description :

On January 20, 2015, President Obama announced the Precision Medicine Initiative (PMI) in his State of the Union address. The PMI, by developing new approaches for detecting, measuring, and analyzing a wide range of biomedical information including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters, is intended to enable a new era of medicine in which researchers, providers, and patients work together to develop individualized care. Part of this effort included the creation of a national, large-scale research participant group, or cohort. The PMI Cohort Program is aimed at extending precision medicine to many diseases, including both rare and common diseases such as diabetes, heart disease, Alzheimer's disease, obesity, and mental illnesses such as depression, bipolar disorder, and schizophrenia, by building a national research cohort of 1 million or more U.S. participants. An important challenge to assembling the PMI Cohort will be to reach individuals who are socioeconomically disadvantaged. Individuals who are socioeconomically disadvantaged have lower health literacy; often belong to racial, ethnic, and minority communities; and are often less likely to participate in research studies and biorepositories. To explore possible strategies and messaging designs, the Roundtable on Health Literacy formed an ad hoc committee charged with planning and conducting a 1-day public workshop on the intersection of health literacy and precision medicine. The workshop participants discussed a variety of topics including an overview of precision medicine and its potential, the relevance of health literacy to the success of precision medicine efforts, and perspectives and understanding of different groups, such as health care providers, consumers, and insurers. This publication summarizes the presentations and discussions from the workshop.

Advances in Pediatrics 2019

Advances in Pediatrics  2019 Book
Author : Carol D. Berkowitz,Surendra Varma,Moira Szilagyi,Edward M. Barksdale, Jr.,Jane Carver,Leslie L. Barton
Publisher : Elsevier Health Sciences
Release : 2019-06-23
ISBN : 0323756301
Language : En, Es, Fr & De

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Book Description :

Each year, Advances in Pediatrics focuses on providing current clinical information on important topics in pediatrics. Dr. Carol Berkowitz and her editorial board, comprised of top experts in the field, have assembled authors to provide updates on the following topics: Evaluation and Management of Febrile Infants; Pediatric Emergency Medicine and Ultrasonography; The Patient-Centered Pediatric Emergency Department; Health Considerations of Refuge and Immigrant Children; Management of scoliosis; Health and Wellness for LGBTQ Youth; Sexually exploited children: recognizing and addressing; Movement disorders in children; Childhood trauma management in primary care; Feeding issues in young children; Physician Well-being and Burnout; New Molecular Methods for Diagnosing Infectious Diseases; Parental refusal: treatments, procedures and vaccines; Pediatric oncology in the ICU setting; Diaphragmatic hernia: Management and Outcomes; and Global Health and Pediatric Education: Opportunities and Challenges. Readers will come away with the clinical information that supplements their professional knowledge so they can make informed clinical decisions that improve patient outcomes.

Precision Medicine Oncology

Precision Medicine Oncology Book
Author : Lorna Rodriguez-Rodriguez
Publisher : Rutgers University Press
Release : 2019-09-13
ISBN : 0813575885
Language : En, Es, Fr & De

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Book Description :

Precision medicine is rapidly becoming the standard-of-care for the treatment of cancer patients. This is made possible, in part, by the ready availability and reasonable costs of comprehensive DNA and RNA sequencing assays. However, precision medicine is complex and incorporates entirely new types of data and treatment paradigms that are outside of the training of most oncologists in practice today. Precision Medicine Oncology: A Primer is a concise review of the fundamental principles and applications of precision medicine, intended for clinicians, particularly those working in oncology. It provides an accessible introduction to the technological advances in DNA and RNA sequencing, gives a detailed overview of approaches to the interpretation of molecular test results and their point-of-care implementation for individual patients, and describes innovative clinical trial designs in oncology as well as characteristics of the computational infrastructures through which massive quantities of data are collected, stored, and used in precision medicine oncology.

Personalizing Precision Medicine

Personalizing Precision Medicine Book
Author : Kristin Ciriello Pothier
Publisher : John Wiley & Sons
Release : 2017-10-02
ISBN : 1118792114
Language : En, Es, Fr & De

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Book Description :

The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics, therapeutics, big data, supportive care, regulation, and reimbursement and innovation in precision medicine worldwide. • Combines a unique cross section of history, current technologies, and future directions for how precision medicine has and will affect people worldwide • Reviews precision medicine around the world, including the US, China, Japan, the Middle East, India, Europe, and Latin America • Discusses a number of diseases areas – cancer, cardiovascular, neurodegenerative, infectious disease, pain, immunology, rare diseases • Includes information and quotes from over 100 interviews with key industry experts in biotech, pharma, informatics, diagnostics, health providers, advocacy groups, and more. • Includes stories illustrating current issues and future promises in precision medicine for a human touch

Omics for Personalized Medicine

Omics for Personalized Medicine Book
Author : Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Publisher : Springer Science & Business Media
Release : 2013-10-14
ISBN : 8132211847
Language : En, Es, Fr & De

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Book Description :

“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Ethics in Pediatrics

Ethics in Pediatrics Book
Author : Ian Mitchell,Juliet R. Guichon
Publisher : Springer Nature
Release : 2020-01-01
ISBN : 3030226174
Language : En, Es, Fr & De

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Book Description :

This book offers easy access to the everyday ethics problems that occur in the medical care of children. It contains practical guidance on how physicians and other healthcare practitioners may manage both straightforward and complex ethics problems. The book provides a readable and comprehensive introduction to ethics issues for beginners and is also extremely valuable to experienced practitioners.This work covers important "classical" ethical issues such as privacy, confidentiality, truth telling, and discusses the elements of the relationships that might exist between parents and healthcare providers. However, the book also provides a resource for new and emerging areas of bioethics. These include issues arising in the new population of children who are beginning to survive the neonatal and infant periods with a multitude of problems – “children with medical complexity". Finally, it also includes a section on the advantages and pitfalls of social media use.

Recent Advances in Molecular and Translational Medicine Updates in Precision Medicine

Recent Advances in Molecular and Translational Medicine  Updates in Precision Medicine Book
Author : Somchai Chutipongtanate
Publisher : Bentham Science Publishers
Release : 2021-12-13
ISBN : 9815036769
Language : En, Es, Fr & De

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Book Description :

Precision medicine is a disruptive innovation with a fast-evolving pace in the healthcare ecosystem. Precision medicine enables precise diagnosis and targeted treatment by considering individual variability in the abnormalities of causative genes and molecular drivers behind biochemical mechanisms. A vast amount of data created by advanced omics technologies is a foundation of precision medicine’s success, and the implications of the findings from these technologies can potentially improve clinical outcomes. Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine presents essential information of molecular and translational research in precision medicine, with a specific focus on pediatrics. This book provides an accessible introduction to omics technologies, gives a detailed explanation of bioinformatics workflows to interpret high-throughput omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Contributions to the book have been provided by experts in biomedical engineering and clinical practice, thus, bringing an informed perspective to the reader on each topic. The book is a valuable resource for postgraduate students, researchers, data scientists and clinicians interested in precision medicine, as well as researchers in the field of genetics and pediatrics who are interested in understanding the role of precision medicine in clinical practice.

Personalized Precision Medicine in Autism Spectrum Related Disorders

Personalized Precision Medicine in Autism Spectrum Related Disorders Book
Author : Lidia V. Gabis,Josephine Barbaro,Raz Gross
Publisher : Frontiers Media SA
Release : 2022-02-15
ISBN : 2889716775
Language : En, Es, Fr & De

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Book Description :

Download Personalized Precision Medicine in Autism Spectrum Related Disorders book written by Lidia V. Gabis,Josephine Barbaro,Raz Gross, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Toward Precision Medicine

Toward Precision Medicine Book
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Release : 2012-01-16
ISBN : 0309222222
Language : En, Es, Fr & De

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Book Description :

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Intelligence Based Medicine

Intelligence Based Medicine Book
Author : Anthony C. Chang
Publisher : Academic Press
Release : 2020-06-27
ISBN : 0128233389
Language : En, Es, Fr & De

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Book Description :

Intelligence-Based Medicine: Data Science, Artificial Intelligence, and Human Cognition in Clinical Medicine and Healthcare provides a multidisciplinary and comprehensive survey of artificial intelligence concepts and methodologies with real life applications in healthcare and medicine. Authored by a senior physician-data scientist, the book presents an intellectual and academic interface between the medical and the data science domains that is symmetric and balanced. The content consists of basic concepts of artificial intelligence and its real-life applications in a myriad of medical areas as well as medical and surgical subspecialties. It brings section summaries to emphasize key concepts delineated in each section; mini-topics authored by world-renowned experts in the respective key areas for their personal perspective; and a compendium of practical resources, such as glossary, references, best articles, and top companies. The goal of the book is to inspire clinicians to embrace the artificial intelligence methodologies as well as to educate data scientists about the medical ecosystem, in order to create a transformational paradigm for healthcare and medicine by using this emerging new technology. Covers a wide range of relevant topics from cloud computing, intelligent agents, to deep reinforcement learning and internet of everything Presents the concepts of artificial intelligence and its applications in an easy-to-understand format accessible to clinicians and data scientists Discusses how artificial intelligence can be utilized in a myriad of subspecialties and imagined of the future Delineates the necessary elements for successful implementation of artificial intelligence in medicine and healthcare

Pediatric Critical Care An Issue of Pediatric Clinics of North America E Book

Pediatric Critical Care  An Issue of Pediatric Clinics of North America  E Book Book
Author : Mary Lieh-Lai,Katherine Cashen
Publisher : Elsevier Health Sciences
Release : 2022-06-09
ISBN : 0323986765
Language : En, Es, Fr & De

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Book Description :

In this issue of Pediatric Clinics of North America, guest editors Drs. Mary Lieh-Lai and Katherine Cashen bring their considerable expertise to the topic of Pediatric Critical Care. The most common indications for admission to the PICU include respiratory disease, cardiac disease, and neurologic disorders. In this issue, top experts in the field provide current clinical knowledge about these admissions as well as other important critical care admissions, including COVID-19. Contains 13 relevant, practice-oriented topics including PICU pharmacology; COVID-19 in children; mechanical ventilation and respiratory support of critically ill children; cardiovascular critical care in children; neurocritical care in children; and more. Provides in-depth clinical reviews on pediatric critical care, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Precision Medicine in Oncology

Precision Medicine in Oncology Book
Author : Bulent Aydogan,James A. Radosevich
Publisher : John Wiley & Sons
Release : 2020-09-23
ISBN : 1119432448
Language : En, Es, Fr & De

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Book Description :

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases Book
Author : Ioana Agache,Peter Hellings
Publisher : Academic Press
Release : 2018-09-19
ISBN : 0128134720
Language : En, Es, Fr & De

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Book Description :

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice. Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease