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Precision Medicine And The Reinvention Of Human Disease

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Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease Book
Author : Jules J. Berman
Publisher : Academic Press
Release : 2018-01-26
ISBN : 0128143940
Language : En, Es, Fr & De

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Book Description :

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Evolution s Clinical Guidebook

Evolution s Clinical Guidebook Book
Author : Jules J. Berman
Publisher : Academic Press
Release : 2019-04-25
ISBN : 0128171278
Language : En, Es, Fr & De

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Book Description :

Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. Offers an innovative approach, focusing on how disease-associated pathways evolved Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine

Taxonomic Guide to Infectious Diseases

Taxonomic Guide to Infectious Diseases Book
Author : Jules J. Berman
Publisher : Academic Press
Release : 2019-05-31
ISBN : 012817577X
Language : En, Es, Fr & De

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Book Description :

Taxonomic Guide to Infectious Diseases: Understanding the Biologic Classes of Pathogenic Organisms, Second Edition tackles the complexity of clinical microbiology by assigning every infectious organism to one of 40+ taxonomic classes and providing a description of the defining traits that apply to all the organisms within each class. This edition is an updated, revised and greatly expanded guide to the classes of organisms that infect humans. This book will provide students and clinicians alike with a simplified way to understand the complex fields of clinical microbiology and parasitology. Focuses on human disease processes and includes numerous clinical tips for healthcare providers Describes the principles of classification and explains why the science of taxonomy is vital to the fields of bioinformatics and modern disease research Provides images of prototypical organisms for taxonomic classes Includes a section that lists common taxonomic pitfalls and how they can be avoided

Logic and Critical Thinking in the Biomedical Sciences

Logic and Critical Thinking in the Biomedical Sciences Book
Author : Jules J. Berman
Publisher : Academic Press
Release : 2020-07-08
ISBN : 0128213620
Language : En, Es, Fr & De

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Book Description :

All too often, individuals engaged in the biomedical sciences assume that numeric data must be left to the proper authorities (e.g., statisticians and data analysts) who are trained to apply sophisticated mathematical algorithms to sets of data. This is a terrible mistake. Individuals with keen observational skills, regardless of their mathematical training, are in the best position to draw correct inferences from their own data and to guide the subsequent implementation of robust, mathematical analyses. Volume 2 of Logic and Critical Thinking in the Biomedical Sciences provides readers with a repertoire of deductive non-mathematical methods that will help them draw useful inferences from their own data. Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. Demonstrates that a great deal can be deduced from quantitative data, without applying any statistical or mathematical analyses Provides readers with simple techniques for quickly reviewing and finding important relationships hidden within large and complex sets of data Using examples drawn from the biomedical literature, discusses common pitfalls in data interpretation and how they can be avoided

Logic and Critical Thinking in the Biomedical Sciences

Logic and Critical Thinking in the Biomedical Sciences Book
Author : Jules J. Berman
Publisher : Academic Press
Release : 2020-07-03
ISBN : 012821371X
Language : En, Es, Fr & De

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Book Description :

Science is not a collection of facts. Science is the process by which we draw inferences from facts. Volume I of Logic and Critical Thinking in the Biomedical Sciences invites readers to linger over a collection of common observations to see what inferences can be drawn, when one applies a bit of deductive logic. If we just think about what we observe, it is often possible to discover profound biomedical insights. Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. Provides a strong introduction to deductive methods that can be directly applied to the biomedical sciences Using hundreds of examples, shows how creative scientists draw important inferences from observations that are often ignored by their peers Discusses complex biological and medical concepts in a relaxed manner, intended to focus the reader’s attention on the deductive process, without dwelling excessively on details

Complex Systems in Medicine

Complex Systems in Medicine Book
Author : David C. Aron
Publisher : Springer Nature
Release : 2019-08-30
ISBN : 3030245934
Language : En, Es, Fr & De

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Book Description :

This unique title explores complex systems in clinical medicine and the subsequent implementation of that knowledge into practice. Written conversationally and as a reflection on the journey of learning about complex systems, the book explores how knowledge of these systems can be applied to four key roles in academic medicine: clinical practice, education, research, and administration. Further, this title emphasizes how gaining an understanding of complex systems can greatly help a physician deal with the many challenges found in academic medicine. Unlike other books on complexity in medicine, which tend to focus on only one aspect of the management of patients, Complex Systems in Medicine deals with the multifaceted roles of a physician. The approach in this book is uniquely qualitative rather than mathematical, and is written to make it not only of interest to physicians, trainees, and allied health providers, but also to make it more accessible to a non-medical audience. The inclusion of personal anecdotes by the author provides concrete examples of the application of knowledge of complex systems in academic medicine. A first-of-its-kind contribution to the literature, Complex Systems in Medicine: A Hedgehog’s Tale of Complexity in Clinical Practice, Research, Education, and Management is not only a novel reference for medical professionals, it is an accessible tool for the non-medical audience hoping to learn more about complex systems and their direct relevance to medicine, a field that deals with the infinite variety of humans and their ills. It illustrates the consequences of the interactive elements of patient care that make medicine both a science and an art.

Lifestyle Psychiatry

Lifestyle Psychiatry Book
Author : Douglas L. Noordsy, M.D.
Publisher : American Psychiatric Pub
Release : 2019-04-08
ISBN : 1615371664
Language : En, Es, Fr & De

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Book Description :

Exercise, a healthy diet, stress management, sound sleep: Most practitioners would agree that living well can mitigate the impact of mental disorders. Yet many are unprepared to address lifestyle factors in their care of patients. Lifestyle Psychiatry seeks to instill confidence by collating and analyzing the impressive emerging body of evidence that supports the efficacy of healthy lifestyle practices -- both as the primary intervention and in conjunction with traditional treatments such as psychopharmacology or psychotherapy -- in preventing and managing psychiatric disorders. This volume examines the impact of lifestyle interventions -- from exercise, yoga, and tai chi to mindfulness and meditation, diet and nutrition, and sleep management -- on psychiatric disorders, including depression, anxiety, posttraumatic stress disorder, schizophrenia, and addiction. Readers can readily find data to support the use of specific lifestyle interventions for a patient presenting with a specific disorder. Detailed descriptions of the mechanisms of each lifestyle intervention also prepare practitioners to educate their patients on the specific neurobiological and psychological effects of these interventions to support their recovery. With chapters that focus on developing a robust therapeutic alliance and inspiring patients to assume responsibility for their own well-being, this guide provides a framework for lasting, sustainable lifestyle changes. Additionally, the book discusses the impact of the provider's lifestyle on clinical behavior and the implications of lifestyle medicine and psychiatry for health care systems and population health, offering a broader examination of the important role this new field can play in leading a sophisticated, holistic approach to optimizing wellness.

Principles and Practice of Big Data

Principles and Practice of Big Data Book
Author : Jules J Berman
Publisher : Academic Press
Release : 2018-07-23
ISBN : 0128156104
Language : En, Es, Fr & De

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Book Description :

Principles and Practice of Big Data: Preparing, Sharing, and Analyzing Complex Information, Second Edition updates and expands on the first edition, bringing a set of techniques and algorithms that are tailored to Big Data projects. The book stresses the point that most data analyses conducted on large, complex data sets can be achieved without the use of specialized suites of software (e.g., Hadoop), and without expensive hardware (e.g., supercomputers). The core of every algorithm described in the book can be implemented in a few lines of code using just about any popular programming language (Python snippets are provided). Through the use of new multiple examples, this edition demonstrates that if we understand our data, and if we know how to ask the right questions, we can learn a great deal from large and complex data collections. The book will assist students and professionals from all scientific backgrounds who are interested in stepping outside the traditional boundaries of their chosen academic disciplines. Presents new methodologies that are widely applicable to just about any project involving large and complex datasets Offers readers informative new case studies across a range scientific and engineering disciplines Provides insights into semantics, identification, de-identification, vulnerabilities and regulatory/legal issues Utilizes a combination of pseudocode and very short snippets of Python code to show readers how they may develop their own projects without downloading or learning new software

Genomics and the Reimagining of Personalized Medicine

Genomics and the Reimagining of Personalized Medicine Book
Author : Richard Tutton
Publisher : Routledge
Release : 2016-04-15
ISBN : 1317129407
Language : En, Es, Fr & De

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Book Description :

Drawing on insights from work in medical history and sociology, this book analyzes changing meanings of personalized medicine over time, from the rise of biomedicine in the twentieth century, to the emergence of pharmacogenomics and personal genomics in the 1990s and 2000s. In the past when doctors championed personalization they did so to emphasize that patients had unique biographies and social experiences in the name of caring for their patients as individuals. However, since the middle of the twentieth century, geneticists have successfully promoted the belief that genes are implicated in why some people develop diseases and why some have adverse reactions to drugs when others do not. In doing so, they claim to offer a new way of personalizing the prediction, prevention and treatment of disease. As this book shows, the genomic reimagining of personalized medicine centres on new forms of capitalization and consumption of genetic information. While genomics promises the ultimate individualization of medicine, the author argues that personalized medicine exists in the imaginative gap between the problems and limits of current scientific practices and future prospects to individualize medical interventions. A rigorous, critical examination of the promises of genomics to transform the economics and delivery of medicine, Genomics and the Reimagining of Personalized Medicine examines the consequences of the shift towards personalization for the way we think about and act on health and disease in society. As such, it will be of interest to scholars and students of the sociology of medicine and health, science and technology studies, and health policy.

Comprehensive Systems Biomedicine

Comprehensive Systems Biomedicine Book
Author : Pietro Lio,Enrico Capobianco
Publisher : Frontiers E-books
Release : 2014-12-03
ISBN : 2889193748
Language : En, Es, Fr & De

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Book Description :

Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics” and high-content imaging are examples of advances de facto establishing the necessity of systems approaches. Hypothesis-driven models and in silico validation tools in support to all the varieties of experimental applications call for a profound revision. The focus on phases like mining and assimilating the data has substantially increased so to allow for interpretable knowledge to be inferred. Notably, to be able to tackle the newly generated data dimensionality, heterogeneity and complexity, model-free and data-driven intensive applications are increasingly shaping the computational pipelines and architectures that quant specialists set aside of the high-throughput genomics, transcriptomics, proteomics platforms. As for the societal aspects, in many advanced societies health care needs now more than in the past to address the problem of managing ageing populations and their complex morbidity patterns. In parallel, there is a growing research interest on the impact that cross-disciplinary clinical, epidemiological and quantitative modelling studies can have in relation to outcomes potentially affecting the quality of life of many people. Complex systems, including those characterizing biomedicine, are assessed in both their functionality and stability, and also relatively to the capacity of generating information from diversity, variation, and complexity. Due to the combined interactions and effects, such systems embed prediction power available for instance in both target identification or marker discovery, or more generally for conducting inference about patients’ pathological states, i.e. normal versus disease, diagnostic or prognostic analysis, and preventive assessment (e.g., risk evaluation). The ultimate goal, personalized medicine, will be achieved based on the confluence of the system’s predictive power to patient-specific profiling.

Smart Technology Applications in Business Environments

Smart Technology Applications in Business Environments Book
Author : Issa, Tomayess,Kommers, Piet,Issa, Theodora,Isaías, Pedro,Issa, Touma B.
Publisher : IGI Global
Release : 2017-03-03
ISBN : 1522524932
Language : En, Es, Fr & De

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Book Description :

Technology continues to make great strides in society by providing opportunities for advancement, inclusion, and global competency. As new systems and tools arise, novel applications are created as well. Smart Technology Applications in Business Environments is an essential reference source for the latest scholarly research on the risks and opportunities of utilizing the latest technologies in different aspects of society such as education, healthcare systems, and corporations. Featuring extensive coverage on a broad range of topics and perspectives including virtual reality, robotics, and social media, this publication is ideally designed for academicians, researchers, students, and practitioners seeking current research on the improvement and increased productivity from the implementation of smart technologies.

Contesting Aging Loss

Contesting Aging   Loss Book
Author : Janice Elizabeth Graham,Peter H. Stephenson
Publisher : University of Toronto Press
Release : 2010
ISBN : 1442600896
Language : En, Es, Fr & De

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Book Description :

"This volume invites readers to re-magine the losses of aging by listening to the views of elders themselves...Researchers, students of aging, and policy makers should find this work most enlightening." --

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Journal of Alternative and Complementary Medicine

The Journal of Alternative and Complementary Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Alternative and Complementary Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Upside of Aging

The Upside of Aging Book
Author : Paul Irving
Publisher : John Wiley & Sons
Release : 2014-04-03
ISBN : 1118691903
Language : En, Es, Fr & De

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Book Description :

The Upside of Aging: How Long Life Is Changing the World ofHealth, Work, Innovation, Policy and Purpose explores a titanicshift that will alter every aspect of human existence, from thejobs we hold to the products we buy to the medical care we receive- an aging revolution underway across America and the world. Movingbeyond the stereotypes of dependency and decline that have definedolder age, The Upside of Aging reveals the vast opportunityand potential of this aging phenomenon, despite significant policyand societal challenges that must be addressed. The book’schapter authors, all prominent thought-leaders, point to areinvention and reimagination of our older years that have criticalimplications for people of all ages. With a positive call to action, the book illuminates the upsidefor health and wellness, work and volunteerism, economic growth,innovation and education. The authors, like the baby boomgeneration itself, posit new ways of thinking about aging, aslongevity and declining birthrates put the world on track for amature population of unprecedented size and significance. Amongtopics they examine are: The emotional intelligence and qualities of the aging brainthat science is uncovering, “senior moments”notwithstanding. The new worlds of genomics, medicine and technology that arerevolutionizing health care and wellness. The aging population’s massive impact on global markets,with enormous profit potential from an explosion in products andservices geared toward mature consumers. New education paradigms to meet the needs and aspirations ofolder people, and to capitalize on their talents. The benefits that aging workers and entrepreneurs bring tocompanies, and the crucial role of older people in philanthropy andsociety. Tools and policies to facilitate financial security for longerand more purposeful lives. Infrastructure and housing changes to create livable cities forall ages, enabling “aging in place” and continuingcivic contribution from millions of older adults. The opportunities and potential for intergenerationalengagement and collaboration. The Upside of Aging defines a future that differs profoundlyfrom the retirement dreams of our parents and grandparents, onethat holds promise and power and bears the stamp of a generationthat has changed every stage of life through which it hasmoved.

Black Prometheus

Black Prometheus Book
Author : Jared Hickman
Publisher : Oxford University Press
Release : 2016-09-28
ISBN : 0190628669
Language : En, Es, Fr & De

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Book Description :

How did an ancient mythological figure who stole fire from the gods become a face of the modern, lending his name to trailblazing spaceships and radical publishing outfits alike? How did Prometheus come to represent a notion of civilizational progress through revolution--scientific, political, and spiritual--and thereby to center nothing less than a myth of modernity itself ? The answer Black Prometheus gives is that certain features of the myth--its geographical associations, iconography of bodily suffering, and function as a limit case in a long tradition of absolutist political theology--made it ripe for revival and reinvention in a historical moment in which freedom itself was racialized, in what was the Age both of Atlantic revolution and Atlantic slavery. Contained in the various incarnations of the modern Prometheus--whether in Mary Shelley's esoteric novel, Frankenstein, Denmark Vesey's real-world recruitment of slave rebels, or popular travelogues representing Muslim jihadists against the Russian empire in the Caucasus-- is a profound debate about the means and ends of liberation in our globalized world. Tracing the titan's rehabilitation and unprecedented exaltation in the eighteenth and nineteenth centuries across a range of genres and geographies turns out to provide a way to rethink the relationship between race, religion, and modernity and to interrogate the Eurocentric and secularist assumptions of our deepest intellectual traditions of critique.

The Customer Revolution in Healthcare Delivering Kinder Smarter Affordable Care for All

The Customer Revolution in Healthcare  Delivering Kinder  Smarter  Affordable Care for All Book
Author : David W Johnson
Publisher : McGraw-Hill Education
Release : 2019-08-22
ISBN : 9781260455571
Language : En, Es, Fr & De

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Book Description :

Customer-centric, market-driven solutions for fixing America’s broken healthcare system—from one of the industry’s most innovative thought leaders. Healthcare accounts for nearly a fifth of the U.S. economy. Everyone agrees that the current system is broken and in desperate need of repair. It should cost less, tackle chronic disease, and promote health. It requires a massive shift in resources from acute services to better care management, behavioral health, and primary care services. The question isn’t what to do. It’s how to do it. The revolution starts by meeting and supporting consumers’ real health needs. It’s time for American healthcare to serve the people. This is The Customer Revolution in Healthcare. Written by leading healthcare strategist and commentator David W. Johnson, this groundbreaking book is more than a wake-up call. It’s a point-by-point action plan to: • Blow up the “Healthcare Industrial Complex” • Liberate data and empower consumers with technology • Promote agile, innovative, and customer-centric “platform” companies • Reduce costs, improve service, and generate superior outcomes • Deliver personalized care with precisions and compassion • Explain and address America’s self-created opioid crisis • Provide affordable and accessible health insurance for all • Turbocharge the U.S. economy • Foster healthier communities Revolutionary healthcare empowers patients and providers alike. Competitive healthcare companies reconfigure inefficient business models to deliver appropriate, accessible, holistic, and reliable care at lower costs. Caregivers engage patients with insight and compassion informed by real-time data and analytics. Payers reward health companies that deliver great outcomes and great service at competitive prices while keeping members as healthy as possible. Investors fund innovative companies whose products and services delight customers. And consumers receive compassionate, affordable, convenient healthcare that meets their needs. Most important, The Customer Revolution in Healthcare provides a robust framework for aligning economic incentives with patient needs to deliver better outcomes at lower costs with superior customer service. The future of healthcare belongs to innovative customer-centric health companies that deliver kinder, smarter, more affordable care—to all.

Forthcoming Books

Forthcoming Books Book
Author : Rose Arny
Publisher : Unknown
Release : 2002-04
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Forthcoming Books book written by Rose Arny, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.