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Pragmatic Randomized Clinical Trials Using Primary Data Collection And Electronic Health Records

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Pragmatic Randomized Clinical Trials

Pragmatic Randomized Clinical Trials Book
Author : Cynthia J. Girman,Mary E. Ritchey
Publisher : Academic Press
Release : 2021-04-23
ISBN : 0128176644
Language : En, Es, Fr & De

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Book Description :

Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation, and dissemination of pragmatic randomized trials, also sometimes referred to as practical or hybrid randomized trials. While less restrictive and more generalizable than traditional randomized controlled trials, such trials have specific challenges which are addressed in this book. The book contains chapters encompassing common designs along with advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize pragmatic randomized trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed. This comprehensive resource is valuable not only for pharmacoepidemiologists, biostatisticians and clinical researchers, but also across the biomedical field for those who are interested in applying pragmatic randomized clinical trials in their research. • Addresses typical designs and challenges of pragmatic randomized clinical trials (pRCTs) • Encompasses analytic aspects of such trials • Discusses real cases on operational challenges in launching and conducting pRCTs in electronic health records

Clinical Trials

Clinical Trials Book
Author : Timothy M. Pawlik,Julie A. Sosa
Publisher : Springer Nature
Release : 2020-03-10
ISBN : 3030354881
Language : En, Es, Fr & De

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Book Description :

This extensively revised second edition is a unique and portable handbook focusing on clinical trials in surgery. It includes new educational materials addressing the rapid evolution of novel research methodologies in basic science, clinical and educational research. The underlying principles of clinical trials, trial design, the development of a study cohort, statistics, data safety, data monitoring, and trial publication for device and drug trials are also discussed. Clinical Trials provides a comprehensive resource on clinical trials in surgery and describes all the stages of a clinical trial from generating a hypothesis through to trial publication and is a valuable resource for all practicing and trainee academic surgeons.

Pharmacoepidemiology

Pharmacoepidemiology Book
Author : Brian L. Strom,Stephen E. Kimmel,Sean Hennessy
Publisher : John Wiley & Sons
Release : 2019-10-23
ISBN : 1119413427
Language : En, Es, Fr & De

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Book Description :

This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.

Prevention Practice in Primary Care

Prevention Practice in Primary Care Book
Author : Sherri Sheinfeld Gorin
Publisher : Oxford University Press
Release : 2013-11
ISBN : 0195373014
Language : En, Es, Fr & De

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Book Description :

Prevention Practice in Primary Care systematically explores state-of-the-art practical approaches to effective prevention in primary care. Guided by theory and evidence, the book reviews approaches to risk factor identification and modification for the major causes of mortality in adulthood, including cancer, stroke, and cardiovascular disease.

Clinical and Translational Science

Clinical and Translational Science Book
Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Release : 2016-11-25
ISBN : 012802111X
Language : En, Es, Fr & De

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Book Description :

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Miller s Anesthesia 2 Volume Set E Book

Miller s Anesthesia  2 Volume Set E Book Book
Author : Michael A. Gropper,Ronald D. Miller,Lars I. Eriksson,Lee A Fleisher,Jeanine P. Wiener-Kronish,Neal H Cohen,Kate Leslie
Publisher : Elsevier Health Sciences
Release : 2019-10-07
ISBN : 0323612644
Language : En, Es, Fr & De

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Book Description :

Covering everything from historical and international perspectives to basic science and current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in the field. Dr. Michael Gropper leads a team of global experts who bring you the most up-to-date information available on the technical, scientific, and clinical issues you face each day – whether you’re preparing for the boards, studying for recertification, or managing a challenging patient care situation in your practice. Includes four new chapters: Clinical Care in Extreme Environments: High Pressure, Immersion, and Hypo- and Hyperthermia; Immediate and Long-Term Complications; Clinical Research; and Interpreting the Medical Literature. Addresses timely topics such as neurotoxicity, palliation, and sleep/wake disorders. Streamlines several topics into single chapters with fresh perspectives from new authors, making the material more readable and actionable. Features the knowledge and expertise of former lead editor Dr. Ronald Miller, as well as new editor Dr. Kate Leslie of the University of Melbourne and Royal Melbourne Hospital. Provides state-of-the-art coverage of anesthetic drugs, guidelines for anesthetic practice and patient safety, new techniques, step-by-step instructions for patient management, the unique needs of pediatric patients, and much more – all highlighted by more than 1,500 full-color illustrations for enhanced visual clarity.

Real World Evidence Generation and Evaluation of Therapeutics

Real World Evidence Generation and Evaluation of Therapeutics Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Release : 2017-07-05
ISBN : 0309455650
Language : En, Es, Fr & De

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Book Description :

The volume and complexity of information about individual patients is greatly increasing with use of electronic records and personal devices. Potential effects on medical product development in the context of this wealth of real-world data could be numerous and varied, ranging from the ability to determine both large-scale and patient-specific effects of treatments to the ability to assess how therapeutics affect patients' lives through measurement of lifestyle changes. In October 2016, the National Academies of Sciences, Engineering, and Medicine held a workshop to facilitate dialogue among stakeholders about the opportunities and challenges for incorporating real-world evidence into all stages in the process for the generation and evaluation of therapeutics. Participants explored unmet stakeholder needs and opportunities to generate new kinds of evidence that meet those needs. This publication summarizes the presentations and discussions from the workshop.

Textbook of Pharmacoepidemiology

Textbook of Pharmacoepidemiology Book
Author : Brian L. Strom,Stephen E. Kimmel,Sean Hennessy
Publisher : John Wiley & Sons
Release : 2013-07-08
ISBN : 1118344847
Language : En, Es, Fr & De

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Book Description :

Textbook of Pharmacoepidemiology, Second Edition, provides an introduction to pharmacoepidemiology and the data sources, methods and applications used in clinical research, the pharmaceutical industry and regulatory agencies. Drawing upon the fifth edition of the authoritative reference, Pharmacoepidemiology, this new edition covers the key learning requirements of the discipline. The textbook provides an introduction to pharmacoepidemiology, pharmacoepidemiological data sources, special issues in methodology, special applications and future developments in the field. Updated learning features such as case studies, key points and Suggested Further Reading are included throughout the text. Textbook of Pharmacoepidemiology is a practical educational resource for upper-level undergraduates, graduate students, post-doctoral fellows in schools of public health, pharmacy and medicine, and for everyone learning and working in pharmacoepidemiology.

Landmark Papers in Psychiatry

Landmark Papers in Psychiatry Book
Author : Elizabeth Ryznar,Aderonke B. Pederson,John G. Csernansky,Mark A. Reinecke
Publisher : Oxford University Press, USA
Release : 2020-01-23
ISBN : 0198836503
Language : En, Es, Fr & De

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Book Description :

Advances in the practice of psychiatry have occurred in "fits and starts" over the last several decades. These advances are evident to anyone long affiliated with the field and are best appreciated through direct experience of living through the times. These advances can also be gleaned from historical overviews in textbooks or the recollections of one's teachers and mentors. Returning to the original papers that have ushered in these changes is rarely done for various, mostly practical, reasons. Filtering through thousands of articles in psychiatry may prove daunting, access to the manuscripts may be limited (especially for papers not available electronically), and understanding their impact requires a broader context. Moreover, with so much active research currently occurring in various branches of psychiatry, current practitioners or trainees may find their attention focused on the present, and this is reinforced by electronic search algorithms, which return articles in reverse chronological order. Not surprisingly, citations for articles in virtually all fields decline precipitously for articles over five years old. As scholars and professionals, we are losing touch with our academic heritage. Yet navigating the future of psychiatry requires a firm understanding of its past. This resource serves as a guide for anyone seeking to understand the evolution of psychiatry as a scientific discipline. It does so by summarizing over 100 landmark papers in psychiatry and placing their scientific contributions within a historical context. An introductory section sets the stage for the major theoretical constructs within the field, with chapters devoted to ontology and nosology. Subsequent sections examine major facets of the theory and practice of psychiatry, such as pathogenesis of psychiatric illness, pharmacotherapy, psychotherapy, and somatic treatments. These sections are divided logically into chapters addressing important contributions to the understanding and treatment of specific disorders. A final section explores ethical considerations within each field. This framework echoes the complexity of psychiatry, which cannot be reduced to a single set of diagnoses or subspecialty categories. Highlighting the research trajectory of psychiatry, this resource will appeal to academics, trainees, and practitioners who desire a comprehensive, easy-to-read, up-to-date collection of psychiatry's pivotal moments. By understanding the challenges, inspirations, and insights from the past, readers will be better poised to address new and ongoing challenges within the field.

Capturing Social and Behavioral Domains and Measures in Electronic Health Records

Capturing Social and Behavioral Domains and Measures in Electronic Health Records Book
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Recommended Social and Behavioral Domains and Measures for Electronic Health Records
Publisher : National Academies Press
Release : 2015-01-08
ISBN : 0309312450
Language : En, Es, Fr & De

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Book Description :

Determinants of health - like physical activity levels and living conditions - have traditionally been the concern of public health and have not been linked closely to clinical practice. However, if standardized social and behavioral data can be incorporated into patient electronic health records (EHRs), those data can provide crucial information about factors that influence health and the effectiveness of treatment. Such information is useful for diagnosis, treatment choices, policy, health care system design, and innovations to improve health outcomes and reduce health care costs. Capturing Social and Behavioral Domains and Measures in Electronic Health Records: Phase 2 identifies domains and measures that capture the social determinants of health to inform the development of recommendations for the meaningful use of EHRs. This report is the second part of a two-part study. The Phase 1 report identified 17 domains for inclusion in EHRs. This report pinpoints 12 measures related to 11 of the initial domains and considers the implications of incorporating them into all EHRs. This book includes three chapters from the Phase 1 report in addition to the new Phase 2 material. Standardized use of EHRs that include social and behavioral domains could provide better patient care, improve population health, and enable more informative research. The recommendations of Capturing Social and Behavioral Domains and Measures in Electronic Health Records: Phase 2 will provide valuable information on which to base problem identification, clinical diagnoses, patient treatment, outcomes assessment, and population health measurement.

Oxford Textbook of Global Public Health

Oxford Textbook of Global Public Health Book
Author : Roger Detels,Martin Gulliford,Quarraisha Abdool Karim,Chorh Chuan Tan
Publisher : Oxford University Press
Release : 2017-09-28
ISBN : 019881013X
Language : En, Es, Fr & De

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Book Description :

Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline.

Informed Consent and Health Literacy

Informed Consent and Health Literacy Book
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Roundtable on Health Literacy
Publisher : National Academies Press
Release : 2015-03-04
ISBN : 0309317304
Language : En, Es, Fr & De

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Book Description :

Informed consent - the process of communication between a patient or research subject and a physician or researcher that results in the explicit agreement to undergo a specific medical intervention - is an ethical concept based on the principle that all patients and research subjects should understand and agree to the potential consequences of the clinical care they receive. Regulations that govern the attainment of informed consent for treatment and research are crucial to ensuring that medical care and research are conducted in an ethical manner and with the utmost respect for individual preferences and dignity. These regulations, however, often require - or are perceived to require - that informed consent documents and related materials contain language that is beyond the comprehension level of most patients and study participants. To explore what actions can be taken to help close the gap between what is required in the informed consent process and communicating it in a health-literate and meaningful manner to individuals, the Institute of Medicine's Roundtable on Health Literacy convened a one-day public workshop featuring presentations and discussions that examine the implications of health literacy for informed consent for both research involving human subjects and treatment of patients. Topics covered in this workshop included an overview of the ethical imperative to gain informed consent from patients and research participants, a review of the current state and best practices for informed consent in research and treatment, the connection between poor informed consent processes and minority underrepresentation in research, new approaches to informed consent that reflect principles of health literacy, and the future of informed consent in the treatment and research settings. Informed Consent and Health Literacy is the summary of the presentations and discussion of the workshop.

Comparative Effectiveness and Efficacy Research and Analysis for Practice CEERAP

Comparative Effectiveness and Efficacy Research and Analysis for Practice  CEERAP  Book
Author : Francesco Chiappelli
Publisher : Springer Science & Business Media
Release : 2012-02-22
ISBN : 3642231446
Language : En, Es, Fr & De

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Book Description :

Recent trends in health care across the United States and internationally have emphasized a novel approach that consists in comparing the effectiveness and efficacy of treatment interventions with a patient-centered emphasis (i.e., evidence-based health care), while ensuring cost constraints, maximizing benefits, and minimizing risks. In this book, experts in comparative effectiveness and efficacy research and analysis for practice (CEERAP) in health care in general address a range of topical issues. The emphasis is on implications for endodontics and nursing, both of which are considered in a series of detailed chapters. Commonalities and differences among CEERAP, utility-based and logic-based analysis and decision-making, and evidence-based and patient-centered practice are defined and discussed. The book concludes by examining applications for CEERAP in developing patient-centered optimal treatment interventions for the next decade.

Post Authorization Safety Studies of Medicinal Products

Post Authorization Safety Studies of Medicinal Products Book
Author : Ayad K. Ali,Abraham G. Hartzema
Publisher : Academic Press
Release : 2018-06-27
ISBN : 0128092084
Language : En, Es, Fr & De

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Book Description :

Post-Authorization Safety Studies of Medicinal Products: The PASS Book bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid signal detection, as well as novel and advanced design and analysis approaches for causal interference from observational data. This book serves as an important reference for pharmacovigilance scientists and pharmacoepidemiologists who are searching for the appropriate study design to answer safety research questions. Readers will be able to effectively and efficiently design and interpret findings from post-authorization safety studies with the goal of improving the benefit-risk balance of a drug in order to optimize patient safety. Discusses all types of observational studies in post-marketing drug safety assessment, from spontaneous reporting systems, to pragmatic trials, with examples from real-world settings Presents various types of post-authorization safety studies Offers solutions to the common challenges in the design and conduct of these studies Highlights active surveillance programs, including common data models for rapid signal detection of drug safety issues

Process Improvement in Heart Failure An Issue of Heart Failure Clinics EBK

Process Improvement in Heart Failure  An Issue of Heart Failure Clinics EBK Book
Author : Clyde Yancy,Kannan Mutharasan
Publisher : Elsevier Health Sciences
Release : 2020-09-25
ISBN : 0323755534
Language : En, Es, Fr & De

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Book Description :

This issue of Heart Failure Clinics, guest edited by Drs. Clyde W. Yancy and R. Kannan Mutharasan, will cover Process Improvement in Heart Failure. This issue is one of four issues selected each year by our series consulting editor, Dr. Eduardo Bossone. Topics discussed in this issue will include: Approaching Process Improvement, Identifying Heart Failure Patients, Predicting High-risk Patients and High-Risk Outcomes in Heart Failure, Selecting the Correct Target for Improvement in Heart Failure Care and Improving Adherence, Empowering Patients Living with Heart Failure with Social Media and Technology, Transitioning Heart Failure Patients to Outpatient Care, Innovating Outpatient Processes of Care and Anticipating Complex Care Algorithms, Addressing Co-morbidities in Heart Failure, Systematizing Heart Failure Population Health, Defragmenting Heart Failure Care, and Adapting to the Payment Landscape.

Encyclopedia of Pharmacy Practice and Clinical Pharmacy

Encyclopedia of Pharmacy Practice and Clinical Pharmacy Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-28
ISBN : 0128127368
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Pharmacy Practice and Clinical Pharmacy covers definitions, concepts, methods, theories and applications of clinical pharmacy and pharmacy practice. It highlights why and how this field has a significant impact on healthcare. The work brings baseline knowledge, along with the latest, most cutting-edge research. In addition, new treatments, algorithms, standard treatment guidelines, and pharmacotherapies regarding diseases and disorders are also covered. The book's main focus lies on the pharmacy practice side, covering pharmacy practice research, pharmacovigilance, pharmacoeconomics, social and administrative pharmacy, public health pharmacy, pharmaceutical systems research, the future of pharmacy, and new interventional models of pharmaceutical care. By providing concise expositions on a broad range of topics, this book is an excellent resource for those seeking information beyond their specific areas of expertise. This outstanding reference is essential for anyone involved in the study of pharmacy practice. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the field Meticulously organized, with articles split into three clear sections, it is the ideal resource for students, researchers and professionals to find relevant information Contains concise and accessible chapters that are ideal as an authoritative introduction for non-specialists and readers from the undergraduate level upwards Includes multimedia options, such as hyperlinked references and further readings, cross-references and videos

Green Computing and Predictive Analytics for Healthcare

Green Computing and Predictive Analytics for Healthcare Book
Author : Sourav Banerjee,Chinmay Chakraborty,Kousik Dasgupta
Publisher : CRC Press
Release : 2020-12-10
ISBN : 1000223949
Language : En, Es, Fr & De

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Book Description :

Green Computing and Predictive Analytics for Healthcare excavates the rudimentary concepts of Green Computing, Big Data and the Internet of Things along with the latest research development in the domain of healthcare. It also covers various applications and case studies in the field of computer science with state-of-the-art tools and technologies. The rapid growth of the population is a challenging issue in maintaining and monitoring various experiences of quality of service in healthcare. The coherent usage of these limited resources in connection with optimum energy consumption has been becoming more important. The major healthcare nodes are gradually becoming Internet of Things-enabled, and sensors, work data and the involvement of networking are creating smart campuses and smart houses. The book includes chapters on the Internet of Things and Big Data technologies. Features: Biomedical data monitoring under the Internet of Things Environment data sensing and analyzing Big data analytics and clustering Machine learning techniques for sudden cardiac death prediction Robust brain tissue segmentation Energy-efficient and green Internet of Things for healthcare applications Blockchain technology for the healthcare Internet of Things Advanced healthcare for domestic medical tourism system Edge computing for data analytics This book on Green Computing and Predictive Analytics for Healthcare aims to promote and facilitate the exchange of research knowledge and findings across different disciplines on the design and investigation of healthcare data analytics. It can also be used as a textbook for a master’s course in biomedical engineering. This book will also present new methods for medical data evaluation and the diagnosis of different diseases to improve quality-of-life in general and for better integration of Internet of Things into society. Dr. Sourav Banerjee is an Assistant Professor at the Department of Computer Science and Engineering of Kalyani Government Engineering College, Kalyani, West Bengal, India. His research interests include Big Data, Cloud Computing, Distributed Computing and Mobile Communications. Dr. Chinmay Chakraborty is an Assistant Professor at the Department of Electronics and Communication Engineering, Birla Institute of Technology, Mesra, India. His main research interests include the Internet of Medical Things, WBAN, Wireless Networks, Telemedicine, m-Health/e-Health and Medical Imaging. Dr. Kousik Dasgupta is an Assistant Professor at the Department of Computer Science and Engineering, Kalyani Government Engineering College, India. His research interests include Computer Vision, AI/ML, Cloud Computing, Big Data and Security.

Hypertension in High Risk African Americans

Hypertension in High Risk African Americans Book
Author : Keith C. Ferdinand
Publisher : Springer
Release : 2015-01-02
ISBN : 1493920103
Language : En, Es, Fr & De

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Book Description :

This volume discusses the many ways to prevent, identify and control hypertension in African Americans, a common and potent risk factor for virtually all forms of cardiovascular-renal diseases. Comprehensive chapters address modifiable risk factors, such as lifestyle changes, especially sodium restriction, and appropriate combination pharmacotherapy. Emerging devices and evidence-based approaches that may also enhance effective blood pressure control and decrease the disparate cardiovascular disease risks, including MI, stroke, HF, and cardiorenal metabolic syndrome and diabetes are also discussed in detail. Written by a wide-range of experts in the field, Hypertension in High Risk African Americans: Current Concepts, Evidence-based Therapeutics and Future Considerations is a valuable resource for clinicians, researchers, health administrators and public health policy leaders to better understand the best practices and unique aspects of risk assessment and treatment of hypertension and co-morbid conditions in African Americans.

Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology

Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology Book
Author : Carol Brayne,Professor of Public Health Medicine and Director of the Cambridge University Department of Public Health Carol Brayne,Director National Institute for Stroke and Applied Neuroscience (Nisan) Valery Feigin,Valery Feigin,Lenore Launer,Giancarlo Logroscino
Publisher : Oxford University Press, USA
Release : 2020-11-02
ISBN : 019874949X
Language : En, Es, Fr & De

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Book Description :

The Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology focuses on the overlaps between neuro-epidemiological disorders. Harmonising cohort studies to determine causes related to rarer disorders, this key work is an invaluable reference to current neuro-epidemiological methods.

Pharmacogenomics

Pharmacogenomics Book
Author : Yui-Wing Francis Lam,Stuart R. Scott
Publisher : Academic Press
Release : 2018-11-27
ISBN : 0128126272
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations. With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion