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Practical Process Research and Development

Practical Process Research and Development Book
Author : Neal G. Anderson
Publisher : Academic Press
Release : 2012
ISBN : 0123865379
Language : En, Es, Fr & De

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Book Description :

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Practical Process Research and Development

Practical Process Research and Development Book
Author : Neal G. Anderson
Publisher : Elsevier
Release : 2000-06-05
ISBN : 0080514480
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

Practical Process Research and Development A guide for Organic Chemists

Practical Process Research and Development     A guide for Organic Chemists Book
Author : Neal G. Anderson
Publisher : Academic Press
Release : 2012-05-23
ISBN : 0123865387
Language : En, Es, Fr & De

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Book Description :

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

The Chemistry of Process Development in Fine Chemical and Pharmaceutical Industry

The Chemistry of Process Development in Fine Chemical and Pharmaceutical Industry Book
Author : Someswara Rao
Publisher : Wiley
Release : 2007-04-02
ISBN : 9780470319956
Language : En, Es, Fr & De

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Book Description :

This book brings together the chemical strategies used in the optimisation of organic reactions and processes, and highlights the practical and technological options available. This book offers: an encyclopedic treatment of organic chemistry from an industrial, process research and development, and manufacturing point of view plenty of examples to illustrate the scope and limitation of the strategies a comprehensive index organised by topic, reaction type, and reagent an extensive literature survey. This is an essential and comprehensive guide for experienced practitioners of chemical process research and development, fresh recruits to chemical industry R&D divisions, and academics who are interested in interacting with the chemical industry, optimising their synthetic strategies, and enriching the field of atom economy.

Pharmaceutical Process Development

Pharmaceutical Process Development Book
Author : A. John Blacker,Mike T. Williams
Publisher : Royal Society of Chemistry
Release : 2011
ISBN : 1849731462
Language : En, Es, Fr & De

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Book Description :

This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

Research for Development

Research for Development Book
Author : Sophie Laws,Caroline Harper,Nicola Jones,Rachel Marcus
Publisher : SAGE
Release : 2013-02-01
ISBN : 1446275612
Language : En, Es, Fr & De

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Book Description :

Research for Development offers a comprehensive guide to commissioning, managing and undertaking research in development work. It serves both as a practical reference manual and an indispensable learning tool. Divided into three parts, the book provides a complete overview of the research process spanning: - the uses, planning and management of research - reviewing existing evidence - learning development research skills - choosing research methods - undertaking ethical research - writing an effective research report - promoting research uptake and assessing research - monitoring and evaluation This fully revised second edition also includes a new section on how to use the internet for research. Its 16 chapters are enriched by a variety of international case studies, checklists of key points, learning exercises, helpful references to further reading and engaging illustrations. The book also includes a detailed glossary of terms. Drawing on considerable hands-on experience, Research for Development is an ideal practical companion for students of development studies and public policy, as well as practitioners in the field. Cover image © Jenny Matthews / World Vision/ PhotoVoice From PhotoVoice's See it Our Way project, Pakistan For more information visit www.photovoice.org

Practical Synthetic Organic Chemistry

Practical Synthetic Organic Chemistry Book
Author : Stéphane Caron
Publisher : John Wiley & Sons
Release : 2020-02-06
ISBN : 1119448905
Language : En, Es, Fr & De

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Book Description :

This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

Practical Guide to Research and Development Tax Incentives

Practical Guide to Research and Development Tax Incentives Book
Author : Michael D. Rashkin
Publisher : CCH
Release : 2007
ISBN : 9780808014324
Language : En, Es, Fr & De

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Book Description :

CCH's Practical Guide to Research and Development Tax Incentives--Federal, State, and Foreign by Michael Rashkin, J.D., LL.M., provides something that has been missing in professional tax literature--authoritative, comprehensive coverage of this complex and evolving topic. This newly expanded resource is practical, easy to follow, easy to understand, and is particularly effective at clarifying and demystifying this complex subject. It provides well-written, detailed guidance on claiming the federal credit for increasing research activities and the deduction for R & D expenditures. In doing so, it explains the elements of qualified research, exclusions, computational rules, and basic research payment credits. Historically, the IRS has been vigilant in denying R & D credits. This resource explains how to satisfy the IRS's requirements, document the credit, and defend against IRS challenges. It also examines research incentives offered by individual states and describes the R & D incentives available in the major economies of the world, offering helpful charts that show the key differences among the various countries.

Synthetic Liquid Fuel Research and Development Act of 1974

Synthetic Liquid Fuel Research and Development Act of 1974 Book
Author : United States. Congress. House. Committee on Science and Astronautics. Subcommittee on Science, Research, and Development
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synthetic Liquid Fuel Research and Development Act of 1974 book written by United States. Congress. House. Committee on Science and Astronautics. Subcommittee on Science, Research, and Development, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advanced Practical Process Control

Advanced Practical Process Control Book
Author : Brian Roffel,Ben Betlem
Publisher : Springer Science & Business Media
Release : 2011-06-27
ISBN : 3642182585
Language : En, Es, Fr & De

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Book Description :

An application-oriented approach to process control. The reference text systematically explains process identification, control and optimization, the three key steps needed to solve a multivariable control problem. Theory is discussed as far as it is needed to understand and solve the defined problem, while numerous examples written in MATLAB illustrate the problem-solving approach.

Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2 Book
Author : John Whittall,Peter W. Sutton
Publisher : John Wiley & Sons
Release : 2012-04-25
ISBN : 1118307860
Language : En, Es, Fr & De

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Book Description :

Biocatalysts are increasingly used by chemists engaged in finechemical synthesis within both industry and academia. Today, thereexists a huge choice of high-tech enzymes and whole cellbiocatalysts, which add enormously to the repertoire of syntheticpossibilities. Practical Methods for Biocatalysis and Biotransformations2 is a "how-to" guide that focuses on the practicalapplications of enzymes and strains of microorganisms that arereadily obtained or derived from culture collections. The sourcesof starting materials and reagents, hints, tips and safety advice(where appropriate) are given to ensure, as far as possible, thatthe procedures are reproducible. Comparisons to alternativemethodology are given and relevant references to the primaryliterature are cited. This second volume – which can be usedon its own or in combination with the first volume - concentrateson new applications and new enzyme families reported since thefirst volume. Contents include: introduction to recent developments and future needs inbiocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficientalkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation andphosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations2 is an essential collection of biocatalytic methods forchemical synthesis which will find a place on the bookshelves ofsynthetic organic chemists, pharmaceutical chemists, and processR&D chemists in industry and academia.

Pharmaceutical Process Chemistry for Synthesis

Pharmaceutical Process Chemistry for Synthesis Book
Author : Peter J. Harrington
Publisher : John Wiley & Sons
Release : 2011-02-23
ISBN : 9780470922866
Language : En, Es, Fr & De

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Book Description :

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Research Development

Research   Development Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Development book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Industrial Process Scale up

Industrial Process Scale up Book
Author : Jan Harmsen
Publisher : Elsevier
Release : 2019-05-16
ISBN : 0444642846
Language : En, Es, Fr & De

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Book Description :

Industrial Process Scale-up: A Practical Innovation Guide from Idea to Commercial Implementation, Second Edition helps industrial process innovators in research, development and commercial start-ups assess the risks of commercial-scale implementation, also providing them with practical guidelines and methods to reduce the risks to acceptable levels. In addition, the book can be used in cooperation with industrial R&D people and academic researchers to shape open innovation programs, and in education as a reference book. This updated edition has the latest literature and has been expanded with a scale-up of pharmaceutical processes and their history in both academia and the process industries. Offers easily accessible, step-by-step and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel, from research, development, demonstration and commercial implementation for any process type and branch Based on industrial experiences and practices that reduce the risks of commercial scale implementation of new processes to acceptable levels and reduce cost and time of process innovation

VANOL and VAPOL Chemistry

VANOL and VAPOL Chemistry Book
Author : Zhensheng Ding
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download VANOL and VAPOL Chemistry book written by Zhensheng Ding, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Practical Microwave Synthesis for Organic Chemists

Practical Microwave Synthesis for Organic Chemists Book
Author : C. Oliver Kappe,Doris Dallinger,Shaun S. Murphree
Publisher : John Wiley & Sons
Release : 2008-11-21
ISBN : 3527623914
Language : En, Es, Fr & De

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Book Description :

With the novice user in mind, this beginner's guide explains thebasics behind microwave technology, evaluates available instrumentsand reaction modes, and provides practical hints for everyeventuality. Includes 27 detailed protocols for often-usedreactions. From the contents: 1 Microwave Synthesis - An Introduction 2 Microwave Theory 3 Equipment Review 4 Microwave Processing Techniques 5 Starting With Microwave Chemistry 6 Experimental Protocols 6.1 General Small-Scale Sealed-Vessel Microwave Processing 6.2 Reaction Optimization 6.3 Library Generation 6.4 Reaction Scale-Up 6.5 Special Processing Techniques

Science Technology and Development

Science  Technology  and Development Book
Author : Anonim
Publisher : Unknown
Release : 1962
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Science Technology and Development book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Short History of Chemistry

A Short History of Chemistry Book
Author : James Riddick Partington
Publisher : Unknown
Release : 1951
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Short History of Chemistry book written by James Riddick Partington, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Administration of Research Development and Implementation Activities in Highway Agencies

Administration of Research  Development  and Implementation Activities in Highway Agencies Book
Author : John E. Burke,National Research Council (U.S.). Transportation Research Board
Publisher : Transportation Research Board National Research
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This synthesis will be of interest to administrators, researchers, and others concerned with the organization and operation of research and development in highway agencies. Information is presented on organizational structure, staffing, selection of research problems, management of research, and reporting and implementation of research results.

Practical Methods for Biocatalysis and Biotransformations 3

Practical Methods for Biocatalysis and Biotransformations 3 Book
Author : John Whittall
Publisher : John Wiley & Sons
Release : 2016-04-18
ISBN : 111860525X
Language : En, Es, Fr & De

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Book Description :

Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 3 will be a companion book to Practical Methods for Biocatalysis and Biotransformations (2009) and Practical Methods for Biocatalysis and Biotransformations 2 (2012). Following the successful format of the two volumes, it will be a “how-to” guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) will be given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology will be given and relevant references to the primary literature will be cited. Contents include: Biotransformation Process Technology Industrial Biooxidation Hydrolase catalysed hydrolysis/synthesis Reduction Oxidation Halogenation Transferase catalysed glycosylation, methylation, etc C-C bond formation Tandem Biocatalytic Reactions Practical Methods for Biocatalysis and Biotransformations, Volume 3 is an essential collection of validated biocatalytic methods which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.