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Post Genomic Cardiology

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Post Genomic Cardiology

Post Genomic Cardiology Book
Author : José Marín-García
Publisher : Academic Press
Release : 2014-05-09
ISBN : 0124046428
Language : En, Es, Fr & De

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Book Description :

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Aging and the Heart

Aging and the Heart Book
Author : José Marín-García
Publisher : Springer Science & Business Media
Release : 2007-12-07
ISBN : 9780387740720
Language : En, Es, Fr & De

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Book Description :

In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.

Heart Failure

Heart Failure Book
Author : José Marín-García
Publisher : Springer Science & Business Media
Release : 2010-06-23
ISBN : 1607611473
Language : En, Es, Fr & De

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Book Description :

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

American Book Publishing Record

American Book Publishing Record Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Signaling in the Heart

Signaling in the Heart Book
Author : José Marín-García
Publisher : Springer Science & Business Media
Release : 2011-06-21
ISBN : 9781441994615
Language : En, Es, Fr & De

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Book Description :

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.

Signaling in the Heart

Signaling in the Heart Book
Author : Anonim
Publisher : Unknown
Release : 2011-10-05
ISBN : 9781441994622
Language : En, Es, Fr & De

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Book Description :

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Proteomic and Genomic Analysis of Cardiovascular Disease

Proteomic and Genomic Analysis of Cardiovascular Disease Book
Author : Jennifer E. Van Eyk,Michael J. Dunn
Publisher : Wiley-Blackwell
Release : 2003-04-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

Journal of molecular and cell cardiology

Journal of molecular and cell cardiology Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Endocrinology of the Heart in Health and Disease

Endocrinology of the Heart in Health and Disease Book
Author : Jonathan C. Schisler,Charles H Lang,Monte Willis
Publisher : Academic Press
Release : 2016-10-19
ISBN : 0128031123
Language : En, Es, Fr & De

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Book Description :

Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology

Identification of Novel Pathways for Cardiac Development and Disease Via Conditional Genetic Manipulation of Cardioblasts and Cardiomyocyte Lineages

Identification of Novel Pathways for Cardiac Development and Disease Via Conditional Genetic Manipulation of Cardioblasts and Cardiomyocyte Lineages Book
Author : Jason Tat-Kwong Lam
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Identification of Novel Pathways for Cardiac Development and Disease Via Conditional Genetic Manipulation of Cardioblasts and Cardiomyocyte Lineages book written by Jason Tat-Kwong Lam, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Matryoshka Genetics

Matryoshka Genetics Book
Author : Renate Marquis-Nicholson
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis discusses the identification of pathogenic mutations within the human genome, specifically in the context of clinical medicine. It is principally a publication-based thesis, with each of the chapters focusing on the use of a specific molecular technique or combination of techniques to address a particular clinical question, or clinical need. Indeed clinical need is the thread that binds the various chapters together. The work was predominantly carried out at LabPLUS, the tertiary referral medical laboratory attached to Auckland City Hospital. The techniques discussed range from targeted mutation analysis using amplification refractory mutation system polymerase chain reaction (ARMS-PCR), Sanger-based full gene sequencing, multi-gene panel next-generation sequencing, and deletion/duplication analysis by array comparative genomic hybridisation (aCGH). The assays are variously applied to single gene and chromosomal disorders, and in some instances several techniques are applied together in order to provide more comprehensive analysis, or to guide the use of further testing. The clinical contexts for the analyses discussed span prenatal to post-mortem diagnosis, and involve a range of clinical specialities, including cardiology, paediatric metabolic medicine, clinical genetics, neurology, psychiatry, and endocrinology. The Matryoshka, or Russian nesting doll, analogy refers primarily to the way that each assay takes a snapshot of the genome at a variable degree of resolution, depending on the type of mutation targeted – ranging from whole genome copy number analysis (the largest doll), through multi-gene sequencing panels of a range of sizes, to ARMS-PCR to detect one specific mutation in one specific gene (the smallest doll). Each chapter is able to function as a stand-alone, but together they represent the current state of diagnostic genetic testing in clinical practice. The intention is to illustrate the principle tools available, the indications for, and limitations/potential pitfalls of these tools. Of particular concern is the utility of diagnostic genetic testing within routine medical practice, and how such testing is best integrated into the clinical paradigm. An awareness of the differences between genetic testing in the research as opposed to the clinical environment is crucial, and several chapters discuss the validation process of translating assays from the research to the diagnostic laboratory. The importance of collaboration between laboratory and clinical staff in order to ensure that testing is appropriately targeted is reflected in the multi-disciplinary authorship of the publications included. Over the course of the thesis, the landscape of diagnostic genetic testing has changed markedly. Much of this change involves the introduction of techniques that blur the boundaries of more conventional analysis - whole genome assays that have a resolution approaching that of more targeted techniques. The concluding discussion focuses on the implications of these changes and how they may have an impact on genomic medicine in the future.

Transactions of the Board of Trustees

Transactions of the Board of Trustees Book
Author : University of Illinois (System). Board of Trustees
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Genome Research

Genome Research Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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The Canadian Journal of Cardiology

The Canadian Journal of Cardiology Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Index of Conference Proceedings

Index of Conference Proceedings Book
Author : British Library. Document Supply Centre
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index of Conference Proceedings book written by British Library. Document Supply Centre, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Perspectives on Patents and Patients

Perspectives on Patents and Patients Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Who is who in Lithuania

Who is who in Lithuania Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Genetics Abstracts

Genetics Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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