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Polymers And Nanomaterials For Gene Therapy

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Polymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy Book
Author : Ravin Narain
Publisher : Woodhead Publishing
Release : 2016-01-09
ISBN : 0081005210
Language : En, Es, Fr & De

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Book Description :

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Nanomaterials for Medical Diagnosis and Therapy

Nanomaterials for Medical Diagnosis and Therapy Book
Author : Challa S. S. R. Kumar
Publisher : John Wiley & Sons
Release : 2007-04-16
ISBN : 9783527313907
Language : En, Es, Fr & De

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Book Description :

Following an overview of nanotechnologies for diagnostic purposes, this book goes on to look at nanoparticle-based magnetic resonance, molecular and other imaging applications, as well as the potential roles of carbon nanotubes and bionanoparticles in biomedical applications. The book's main focus is on drug delivery systems based on nonporous and nanosize materials, solid lipid and polymeric nanoparticles, intelligent hydrogels, core-shell nanoparticles, and nanocapsules, rounded off by a discussion of their biomedical applications. The final part of this volume covers such biomedical strategies as gene therapy, synthetic gene-transfer vectors and targeted delivery.

Theory Techniques and Applications of Nanotechnology in Gene Silencing

Theory  Techniques and Applications of Nanotechnology in Gene Silencing Book
Author : Surendra Nimesh,Ramesh Chandra
Publisher : River Publishers
Release : 2012-02-06
ISBN : 8792329837
Language : En, Es, Fr & De

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Book Description :

Gene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence there arises a need to develop a delivery system which can protect and efficiently transport siRNA to the target cells. Nanotechnology based non-viral vectors have been proposed as a potential alternate. Various polymeric nanoparticles have been shown as suitable delivery candidates with high cellular uptake efficiencies and advantage of reduced cytotoxicity. These delivery vectors form condensed complexes with siRNA which in turn provides protection to siRNA from enzymatic degradation and further leads to enhanced tissue and cellular targeting. Nanoparticles prepared from various polymers like polyethylenimine, chitosan have been largely exploited, as they bear several advantages such as, easy manipulatibility, high stability, low cost and high payload. Though numerous publications have appeared in the literature, there was still need to get more information under one roof, as book compilation which could provide a systematic account of all the aspects of nanotechnology mediated gene silencing right from the preparation of nanoparticles to in vitro and in vivo characterization followed by various applications in vitro and in vivo models. This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted. The important topics discussed in the book include: Introduction to Nanotechnology Physicochemical Characterization of Nanoparticles In Vitro and In Vivo Characterization of Nanoparticles Concept and Barriers to Gene Silencing Nanoparticles Mediated Targeted siRNA delivery Polymers for siRNA Delivery Chitosan Polyethylenimine Poly-L-lysine Atelocollagen Protamine Dendrimers Cyclodextrin Poly (D, L-lactide-co-glycolide) Nanomaterials for siRNA delivery

Polymeric Nanomaterials in Nanotherapeutics

Polymeric Nanomaterials in Nanotherapeutics Book
Author : Anonim
Publisher : Elsevier
Release : 2018-10-26
ISBN : 0128139331
Language : En, Es, Fr & De

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Book Description :

Polymeric Nanomaterials in Nanotherapeutics describes how polymeric nanosensors and nanorobotics are used for biomedical instrumentation, surgery, diagnosis and targeted drug delivery for cancer, pharmacokinetics, monitoring of diabetes and healthcare. Key areas of coverage include drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy tissues and cells. The book demonstrates how these are applied to dental work, wound healing, cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, metabolic diseases, and more. Methods of administration discussed include oral, dental, topical and transdermal, pulmonary and nasal, ocular, vaginal, and brain drug delivery and targeting. Drug delivery topics treated in several subchapters includes materials for active targeting and cases study of polymeric nanomaterials in clinical trials. The toxicity and regulatory status of therapeutic polymeric nanomaterials are also examined. The book gives a broad perspective on the topic for researchers, postgraduate students and professionals in the biomaterials, biotechnology, and biomedical fields. Shows how the properties of polymeric nanomaterials can be used to create more efficient medical treatments/therapies Demonstrates the potential and range of applications of polymeric nanomaterials in disease prevention, diagnosis, drug development, and for improving treatment outcomes Accurately explains how nanotherapeutics can help in solving problems in the field through the latest technologies and formulations

Polymeric Gene Delivery Systems

Polymeric Gene Delivery Systems Book
Author : Yiyun Cheng
Publisher : Springer
Release : 2018-09-04
ISBN : 3319778668
Language : En, Es, Fr & De

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Book Description :

​The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Advances in Polymeric Nanomaterials for Biomedical Applications

Advances in Polymeric Nanomaterials for Biomedical Applications Book
Author : Anil Kumar Bajpai,Rajesh Kumar Saini
Publisher : Elsevier
Release : 2021-04-02
ISBN : 0128146575
Language : En, Es, Fr & De

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Book Description :

Advances in Polymeric Nanomaterials for Biomedical Applications examines advanced polymer synthetic strategies for developing novel biomaterials for use in medicine. With a strong focus on fundamentals and structure, the authors also explore their fabrication, along with their current and potential biomedical applications. The book begins with a look at the fundamentals of polymeric nanomaterials and their properties and then discusses the design of biomaterials and their applications in drug delivery. Further chapters explore important applications, such as imaging and regenerative medicine, including current challenges and future trends. This valuable resource is especially useful for materials and polymer scientists, and bioengineers wishing to broaden their knowledge of polymeric nanobiomaterials. Covers the complete spectrum of polymer nanomaterials used in biomedical applications Includes various applications, such as drug delivery, gene delivery, bio-imaging, tissue engineering and regenerative medicine, anti-microbial agents, and neuroscience Explores fundamental correlations between structures, properties and applications, as well as synthetic strategies for polymer nanomaterials

Bio Inspired Nanomaterials and Applications

Bio Inspired Nanomaterials and Applications Book
Author : Donglu Shi
Publisher : World Scientific
Release : 2014-11-18
ISBN : 9814616931
Language : En, Es, Fr & De

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Book Description :

This book intends to provide an up-to-date information in the field of nanobiomedicine. The focus of the book is on the basic concepts and recent developments in the field of nanotechnology. This book covers a broad spectrum of nanomaterials processing, structural characteristics, and related properties and will include bio-probes, medical imaging, drug delivery, and tumor diagnosis. Critical issues are addressed in a straightforward manner so those with no technical background and university students can benefit from the information. Furthermore, many novel concepts in nanomaterials are explained in light of current theories. An important aspect of the book lies on its wide coverage in practical biomedical applications. Not only are the cutting-edge technologies in modern medicine introduced, but also unique materials applications in many clinical areas. Contents:Up-Conversion Nanoparticles for Early Cancer Diagnosis (Liang Cheng, Bingbo Zhang and Zhuang Liu)Redox-Sensitive Polymeric Nanoparticles for Intracellular Drug Delivery (Huiyun Wen, Yongyong Li and Xin Zhao)Design of Biocompatible PEIs as Artificial Gene Delivery Vectors (Ting Shi, Chao Lin and Peng Zhao)Magnetic Fe3O4 Nanoparticles for Cancer Photothermal Therapy (Maoquan Chu)Nanomaterial-Based Sensors for Environmental Monitoring (Jinhu Yang)Janus Nanostructures and Their Bio-Medical Applications (Yilong Wang and Feng Wang)Nanomaterial-Involved Optical Imaging/Spectroscopy Methods for Single-Molecule Detections in Biomedicine (Yao Qin)Surface Functionalized Carbon Nanotubes for Biomedical Applications (Bingdi Chen)Intracellular siRNA Delivery by Multifunctional Nanoparticles (Kun Lu, Lei Wang, Xiaohui Tan, Yao Chen, Changhui Wang and Lifeng Qi)Chemical and Biological Sensors Based on Nanowire Transistors (Xiaohan Wu and Jia Huang) Readership: Undergraduate or graduate students, and researchers in nanomaterials, biochemistry, biomedical engineering. Key Features:It is closely clinically oriented in medical diagnosis and treatmentIt is comprehensive in both nanomaterials and biomedical applicationsIt includes many novel concepts in nanotechnology and up to dateKeywords:Nanomedicine;Nanobiomedicine;Nanobiotechnology;Nanomaterials;Bio-Probes;Medical Imaging;Drug delivery;Tumor Diagnosis

Wound Healing Tissue Repair and Regeneration in Diabetes

Wound Healing  Tissue Repair and Regeneration in Diabetes Book
Author : Debasis Bagchi,Amitava Das,Sashwati Roy
Publisher : Academic Press
Release : 2020-05
ISBN : 0128164131
Language : En, Es, Fr & De

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Book Description :

Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals.

Advances in Polymeric Nanomaterials for Biomedical Applications

Advances in Polymeric Nanomaterials for Biomedical Applications Book
Author : Anil Kumar Bajpai,Rajesh Kumar Saini
Publisher : Elsevier
Release : 2021-04-02
ISBN : 0128146575
Language : En, Es, Fr & De

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Book Description :

Advances in Polymeric Nanomaterials for Biomedical Applications examines advanced polymer synthetic strategies for developing novel biomaterials for use in medicine. With a strong focus on fundamentals and structure, the authors also explore their fabrication, along with their current and potential biomedical applications. The book begins with a look at the fundamentals of polymeric nanomaterials and their properties and then discusses the design of biomaterials and their applications in drug delivery. Further chapters explore important applications, such as imaging and regenerative medicine, including current challenges and future trends. This valuable resource is especially useful for materials and polymer scientists, and bioengineers wishing to broaden their knowledge of polymeric nanobiomaterials. Covers the complete spectrum of polymer nanomaterials used in biomedical applications Includes various applications, such as drug delivery, gene delivery, bio-imaging, tissue engineering and regenerative medicine, anti-microbial agents, and neuroscience Explores fundamental correlations between structures, properties and applications, as well as synthetic strategies for polymer nanomaterials

Advances in Nanomaterials for Drug Delivery

Advances in Nanomaterials for Drug Delivery Book
Author : Mahdi Karimi,Maryam Rad Mansouri,Navid Rabiee,Michael R Hamblin
Publisher : Morgan & Claypool Publishers
Release : 2018-12-05
ISBN : 1681742896
Language : En, Es, Fr & De

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Book Description :

Nanomedicine is a developing field, which includes different disciplines such as material science, chemistry, engineering and medicine devoted to the design, synthesis and construction of high-tech nanostructures. The ability of these structures to have their chemical and physical properties tuned by structural modification, has allowed their use in drug delivery systems, gene therapy delivery, and various types of theranostic approaches. Colloidal noble metal nanoparticles and other nanostructures have many therapeutic and diagnostic applications. The concept of drug targeting as a magic bullet has led to much research in chemical modification to design and optimize the binding to targeted receptors. It is important to understand the precise relationship between the drug and the carrier and its ability to target specific tissues, and pathogens to make an efficient drug delivery system. This book covers advances based on different drug delivery systems: polymeric and hyper branched nanomaterials, carbon-based nanomaterials, nature-inspired nanomaterials, and pathogen-based carriers.

Nanomaterials in Advanced Medicine

Nanomaterials in Advanced Medicine Book
Author : Hossein Hosseinkhani
Publisher : John Wiley & Sons
Release : 2019-08-05
ISBN : 3527345493
Language : En, Es, Fr & De

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Book Description :

A comprehensive and multidisciplinary review of the fundamental concepts and medical applications of nanomaterials development technology Nanomedicine offers a range of multi-interdisciplinary approaches and brings together the field of chemistry, pharmaceutical science, biology, and clinical medicines by focusing on design and preparation of biodegradable or non-biodegradable biomaterials for their biological, medical, and pharmaceutical applications. Nanomaterials in Advanced Medicine reviews the concepts and applications of the combination of the technology of biology and engineering that are emerging as an integral aspect of today?s advanced medicine. Nanomedicine provides the technology for imaging, cancer treatment, medical tools, bone treatment, drug delivery, diagnostic tests, drug development, angiogenesis and aims to exploit the improved and often novel physical, chemical, and biological properties of materials at the nanometer scale. Designed to provide a broad survey of the field, Nanomaterials in Advanced Medicine is divided into three main sections: Nanophysics, Nanochemistry, and Nanomedicine. Each chapter describes in detail the most current and valuable methods available and contains numerous references to the primary literature. This important book: -Offers a field guide for biologists and physicians who want to explore the fascinating world of nanotechnology -Contains a comprehensive review of the topic from a noted expert in the field -Includes an introduction to nanotechnology and explores the synthesis, structure and properties of various types of nanobiomaterials -Bridges the gap between various aspects of nanomaterials? development technology and their applications Written for pharmaceutical chemists, biotechnologists, life scientists, materials scientists, polymer chemists, and biochemists, Nanomaterials in Advanced Medicine provides a must-have guide to the fundamental concepts and current applications of nanomaterials in the medical field.

Nanoparticles in Pharmacotherapy

Nanoparticles in Pharmacotherapy Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2019-04-15
ISBN : 0128165049
Language : En, Es, Fr & De

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Book Description :

Nanoparticles in Pharmacotherapy explores the most recent findings in how nanoparticles used in pharmacotherapy, starting with their synthesis, characterization and current or potential uses. Offering he book will be a valuable resource of recent scientific progress, along with most known applications of nanoparticles on the pharmacotherapy to be used by researchers, medical doctors and academia individuals.

Polymers for Drug Delivery in Cancer Therapy

Polymers for Drug Delivery in Cancer Therapy Book
Author : Hong Zi
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polymers for Drug Delivery in Cancer Therapy book written by Hong Zi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Investigative Ophthalmology Visual Science

Investigative Ophthalmology   Visual Science Book
Author : Anonim
Publisher : Unknown
Release : 2008-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Investigative Ophthalmology Visual Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery Book
Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Release : 2014-07-25
ISBN : 9535116282
Language : En, Es, Fr & De

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Book Description :

This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Romanian Journal of Physics

Romanian Journal of Physics Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Romanian Journal of Physics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Non Viral Gene Therapy

Non Viral Gene Therapy Book
Author : Xubo Yuan
Publisher : BoD – Books on Demand
Release : 2011-11-07
ISBN : 9533075384
Language : En, Es, Fr & De

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Book Description :

This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.

Nanomaterials for Medical Applications

Nanomaterials for Medical Applications Book
Author : Zoraida Aguilar
Publisher : Newnes
Release : 2012
ISBN : 0123850894
Language : En, Es, Fr & De

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Book Description :

This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application. It presents the main types of nanomaterial used in medical application today: semiconductor nanomaterials, Magnetic nanomaterials, metal nanoparticles, Carbon nanomaterials, Hydrogel nanocomposites, Liposomes, Dendrimers, Polymer nanocomposites, and Biodegradable polymers. Structurally the work is demarcated into the six most popular areas of research: (1) biocompatibility of nanomaterials with living organisms in their various manifestations (2) nanobiosensors for clinical diagnostics, detecting biomolecules which are useful in the clinical diagnosis of genetic, metabolically acquired, induced or infectious disease (3) targeted drug delivery for nanomaterials in their various modifications (4) nanomedical devices and structures which are used in the development of implantable medical devices and structures such as nanorobots (5) nanopharmacology, as novel nanoparticles are increasingly engineered to diagnose conditions and recognize pathogens, identify ideal pharmaceutical agents to treat the condition or pathogens,fuel high-yield production of matched pharmaceuticals (potentially in vivo), locate, attach or enter target tissue, structures or pathogens; and dispense the ideal mass of matched biological compound to the target regions (6) nanotoxicology and remediation, which focuses on finished and on-going various toxicity evaluations on various nanomaterials that are used and currently being developed for medical applications Discusses the most important biomedical applications and devices of nanomaterials: drug delivery, medical imaging, gene therapy, nanorobots, biosensors and diagnostics Focuses on current commercialized techniques and applications, ensuring the work is entirely relevant to a rapidly evolving field Reviews the most recent studies on nanomaterial toxicity, thereby responding to the widescale private, policy and public interest in nanoscience

Nanotechnology for Cancer Therapy

Nanotechnology for Cancer Therapy Book
Author : Mansoor M. Amiji
Publisher : CRC Press
Release : 2006-12-19
ISBN : 1420006630
Language : En, Es, Fr & De

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Book Description :

While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo

Biotransport of Iron Oxide Magnetic Nanoparticles for Biomedical Applications

Biotransport of Iron Oxide Magnetic Nanoparticles for Biomedical Applications Book
Author : Venkatasubramaniam S. Kalambur
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biotransport of Iron Oxide Magnetic Nanoparticles for Biomedical Applications book written by Venkatasubramaniam S. Kalambur, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.