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Polymeric Nanoparticles As A Promising Tool For Anti Cancer Therapeutics

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Polymeric Nanoparticles as a Promising Tool for Anti cancer Therapeutics

Polymeric Nanoparticles as a Promising Tool for Anti cancer Therapeutics Book
Author : Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye
Publisher : Academic Press
Release : 2019-07-08
ISBN : 0128173319
Language : En, Es, Fr & De

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Book Description :

Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Theory and Applications of Nonparenteral Nanomedicines

Theory and Applications of Nonparenteral Nanomedicines Book
Author : Prashant Kesharwani,Sebastien Taurin,Khaled Greish
Publisher : Academic Press
Release : 2020-09-12
ISBN : 0128204672
Language : En, Es, Fr & De

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Book Description :

Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications. Contains a comprehensive review of non-parenteral nanomedicines Provides analysis of non-parenteral methods of nanomedicines including regulatory implications and future applications Explores a wide range of promising approaches for non-parenteral drug delivery using the latest advancement in nanomedicine written by experts in industry and academia

Functionalized Polymers

Functionalized Polymers Book
Author : Narendra Pal Singh Chauhan
Publisher : CRC Press
Release : 2021-05-14
ISBN : 1000291170
Language : En, Es, Fr & De

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Book Description :

Functionalized polymers are macromolecules to which chemically bound functional groups are attached which can be used as catalysts, reagents, protective groups, etc. Functionalized polymers have low cost, ease of processing and attractive features for functional organic molecules. Chemical reactions for the introduction of functional groups in polymers and the conversion of functional groups in polymers depend on different properties. Such properties are of great importance for functionalization reactions for possible applications of reactive polymers. This book deals with the synthesis and design of various functional polymers, the modification of preformed polymer backbones and their various applications.

Dendrimer Based Nanotherapeutics

Dendrimer Based Nanotherapeutics Book
Author : Prashant Kesharwani
Publisher : Academic Press
Release : 2021-04-27
ISBN : 0128212519
Language : En, Es, Fr & De

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Book Description :

Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields. Discusses various routes such as oral, pulmonary, transdermal, delivery and local administration of dendrimer delivery of bioactive Explores a wide range of applications of dendrimer-based drug delivery using the latest advancements in nanomedicine Provides the most recent research on dendrimers as well as context and background, providing a useful resource for all levels of researcher

Smart Polymer Nanocomposites

Smart Polymer Nanocomposites Book
Author : Showkat Ahmad Bhawani,Anish Khan,Mohammad Jawaid
Publisher : Woodhead Publishing
Release : 2020-12-08
ISBN : 0128204354
Language : En, Es, Fr & De

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Book Description :

Smart Polymer Nanocomposites: Biomedical and Environmental Applications presents the latest information on smart polymers and their promising application in various fields, including their role in delivery systems for drugs, tissue engineering scaffolds, cell culture sports, bioseparation, and sensors or actuator systems. Features detailed information on the preparation, characterization and applications of smart functional polymer composites Covers a broad range of applications in both the biomedical and environmental engineering fields Chapters are written by authors with diverse background expertise from the faculties of chemistry, engineering and the manufacturing industry

Probiotic Research in Therapeutics

Probiotic Research in Therapeutics Book
Author : Indu Pal Kaur
Publisher : Springer Nature
Release : 2020
ISBN : 9811582149
Language : En, Es, Fr & De

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Book Description :

The volume sheds new light on role of gut dysbiosis in cancer and immunological diseases and their clinical manifestations. Contributions in the volume discuss about the gut microbiota as a therapeutic target and the role of probiotics in its management. The volume explores application of probiotics in the treatment of various cancers viz. colorectal, gastric, lung, and breast cancer and immunological diseases. The volume comprises of chapters from expert contributors organized into various important themes which include, introduction, relationship between gut microbiota and disease condition, mechanisms involved, clinical and in vivo status, conclusion and future directions. This is a highly informative and carefully presented book, providing recent and innovative insight for scholars and researchers with an interest in probiotics and its applications in cancer and immunological diseases.

Applications of Membrane Technology for Food Processing Industries

Applications of Membrane Technology for Food Processing Industries Book
Author : M. SELVAMUTHUKUMARAN
Publisher : CRC Press
Release : 2020-10-15
ISBN : 1000195279
Language : En, Es, Fr & De

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Book Description :

Membranes processing techniques are used to help separate chemical components based on molecular size under specific pressure. A great advantage of membrane processing techniques is that it is a non-thermal processing technique, which can retain enormous bioactive constituents to a greater extent. Being a less energy intensive process, this technique is widely used in several food processing industries such as in the clarification of fruit juices and wine; the concentration of milk; the preparation of whey protein concentrate; and water and waste treatment, among others. Applications of Membrane Technology for Food Processing Industries introduces membrane processing techniques, presenting principles, theory and operational conditions for achieving efficient quality product. It discusses different types of membrane processing techniques viz. reverse osmosis, nanofiltration, ultrafiltration, electro dialysis, microfiltration, pervaporation, including its applications, advantages and disadvantages. Key Features: Deals with the retention of antioxidants by using novel membrane processing techniques Includes the application of membrane processing techniques in whey processing Explains the method for degumming, dewaxing and decolorization of edible crude oils Narrates application of membrane processing techniques in waste water treatment for efficient use Readers, such as professors, scientist, research scholars, students and industrial personnel, will come to know about the current trends in use of membrane processing techniques for its application in several food processing industries. This book can be a ready reference for the food industrial industry for manufacturing of deacidified clarified fruit juices and wine by using integrated membrane technique approach. In a nutshell, this book will benefit food scientist, academicians, students and food industrial persons by providing in-depth knowledge about membrane processing of foods for quality retention and also for efficient consumer acceptability.

Conference on Drug Design and Discovery Technologies

Conference on Drug Design and Discovery Technologies Book
Author : Manikanta Murahari,Lakshmi Sundar,Soma Chaki,Vasanthanathan Poongavanam,Pritesh Bhat,Usha Y Nayak
Publisher : Royal Society of Chemistry
Release : 2019-11-20
ISBN : 1788018621
Language : En, Es, Fr & De

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Book Description :

This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.

Direct Nose to Brain Drug Delivery

Direct Nose to Brain Drug Delivery Book
Author : Chandrakantsing Pardeshi,Eliana Souto
Publisher : Academic Press
Release : 2021-06-25
ISBN : 0128225238
Language : En, Es, Fr & De

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Book Description :

Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates provides the reader with precise knowledge about the strategies and approaches for enhanced nose to brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration, includes an overview on the toxicity aspects of the various materials used to develop the direct nose to brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems, and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose to brain Discusses pharmaceutical and biomedical applications after nose to brain delivery of therapeutic pharmaceuticals and biologicals

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials Book
Author : Munmaya Mishra
Publisher : CRC Press
Release : 2017-08-16
ISBN : 1351653032
Language : En, Es, Fr & De

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Book Description :

The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Nanomaterials Evolution and Advancement towards Therapeutic Drug Delivery Part II

Nanomaterials  Evolution and Advancement towards Therapeutic Drug Delivery  Part II  Book
Author : Surendra Nimesh,Nidhi Gupta,Ramesh Chandra
Publisher : Bentham Science Publishers
Release : 2021-06-02
ISBN : 168108824X
Language : En, Es, Fr & De

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Book Description :

The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. Part II covers the following topics: · Solid lipid nanoparticles and nanostructured lipid carriers · Silica based nanomaterials · Hydrogels · Metallic nanoparticles · Computational and experimental binding interactions of drug and β-cyclodextrin · Clinical milestones in nanotherapeutics · Drug delivery systems based on poly(lactide-co-glycolide) and its copolymers The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Camptothecin and Camptothecin Producing Plants

Camptothecin and Camptothecin Producing Plants Book
Author : T. Pullaiah,P.B. Raghavendra,S. Karuppusamy,V. Raveendran,M. Anuradha
Publisher : Academic Press
Release : 2020-06-18
ISBN : 0128209275
Language : En, Es, Fr & De

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Book Description :

Camptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity and Biotechnology provides updated information on camptothecin yielding plants, chemical diversity of camptothecin, extraction and exploitation methods, biosynthesis, biotechnological production and enhancement for drug delivery, and the pharmacological properties of the drugs. The book focuses on camptothecin anticancer properties based on recent developments of biotechnology. Topics emphasize anticancer activities, biosynthesis, potent derivatives currently undergoing experimental phases, and biotechnological methods to enhance the production. This book is a valuable source for cancer researchers, oncologists, biotechnologists, pharmacologists and members of the biomedical field who are interested in camptothecin and its applicability in cancer treatment. Provides information on camptothecin producing plants and their anticancer properties for the development of new treatments Discusses new applications of camptothecin based on recent biotechnology advancements Presents comprehensive information on the pharmacology of camptothecin for leveraging new anticancer drugs developments

Natural and Synthetic Biomedical Polymers

Natural and Synthetic Biomedical Polymers Book
Author : Sangamesh Kumbar,Cato Laurencin,Meng Deng
Publisher : Newnes
Release : 2014-01-21
ISBN : 0123972906
Language : En, Es, Fr & De

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Book Description :

Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future

Nanobiomaterials in Cancer Therapy

Nanobiomaterials in Cancer Therapy Book
Author : Alexandru Grumezescu
Publisher : William Andrew
Release : 2016-03-22
ISBN : 032342886X
Language : En, Es, Fr & De

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Book Description :

Nanobiomaterials in Cancer Therapy presents the major applications of nanobiomaterials in oncology, offering an up-to-date overview of the latest research in this field. Utilizing nanobiomaterials, novel therapeutic approaches enable significant improvements in drug-loading capacity, formulation stability and drug efficiency. In this book, leading researchers from around the world share their expertise and unique insights. The book covers the fabrication methods of platforms for multimodal and combinatorial therapeutic options, along with simultaneous and real-time cancer imaging, and innovative approaches for oncology by passive or active pathways of multifunctional nanocarriers. The work also classifies and discusses engineered nanobiosystems for cancer therapy, prevention, and low cancer recurrence or relapse. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A comprehensive resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A valuable guide to recent scientific progress and the latest application methods Discusses novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology

Cancer Nanotheranostics

Cancer Nanotheranostics Book
Author : Muthupandian Saravanan
Publisher : Springer Nature
Release : 2021-10-24
ISBN : 3030762637
Language : En, Es, Fr & De

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Book Description :

Download Cancer Nanotheranostics book written by Muthupandian Saravanan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmaceutical Sciences Breakthroughs in Research and Practice

Pharmaceutical Sciences  Breakthroughs in Research and Practice Book
Author : Management Association, Information Resources
Publisher : IGI Global
Release : 2016-12-28
ISBN : 1522517634
Language : En, Es, Fr & De

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Book Description :

The delivery of optimal pharmaceutical services to patients is a pivotal concern in the healthcare field. By examining current trends and techniques in the industry, processes can be maintained and improved. Pharmaceutical Sciences: Breakthroughs in Research and Practice provides comprehensive coverage of the latest innovations and advancements for pharmaceutical applications. Focusing on emerging drug development techniques and drug delivery for improved health outcomes, this book is ideally designed for medical professionals, pharmacists, researchers, academics, and upper-level students within the growing pharmaceutical industry.

NanoBioMedicine

NanoBioMedicine Book
Author : Shailendra K. Saxena,S. M. Paul Khurana
Publisher : Springer Nature
Release : 2020-02-03
ISBN : 9813298987
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.

The Role of Computer Simulations in the Preclinical Development of Semiflexible Polymeric Anticancer Therapeutics

The Role of Computer Simulations in the Preclinical Development of Semiflexible Polymeric Anticancer Therapeutics Book
Author : Lili Xiaoping Peng
Publisher : Unknown
Release : 2010
ISBN : 9781124219271
Language : En, Es, Fr & De

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Book Description :

Poly(glutamyl-glutamate) paclitaxel (PGG-PTX) is a potential anticancer therapeutic in preclinical development. There has been increasing attention on how structural and functional properties of therapeutic nanoparticles, such as size, shape, flexibility, surface hydrophilicity, and aggregation, influence efficacy. This thesis demonstrates the application of computer simulations to elucidate these properties of PGG-PTX candidates, which would otherwise be tedious or inaccessible to achieve experimentally. Computer simulations were carried out by running molecular dynamics (MD) simulations on eighteen coarse-grained (CG) PGG-PTX models, varying in the PTX loading fraction (f/PTX = 0.18, 0.24, and 0.37) and spatial PTX arrangement (uniform : 'even' and 'random', clustered : 'clusters' and 'ends', concentrated : 'middle' and 'side') on the PGG backbone. The results show that PGG-PTX molecules with concentrated spatial PTX arrangements produce filamentous shapes and are more flexible, while PGG-PTX molecules with uniform PTX arrangements generate globular morphologies and are less flexible. The PTX loading fraction and spatial PTX arrangement have a minimal effect on the size of a PGG-PTX molecule. Intermolecular aggregation increases with increasing PTX loading fraction, while surface hydrophilicity decreases with increasing PTX loading fraction. The PGG-PTX molecules at f/PTX = 0.24 with concentrated spatial PTX distributions exhibit nonspherical shape, high flexibility, low aggregation, and high surface hydrophilicity. Since these properties have been shown to be clinically advantageous, we recommend the PGG-PTX molecules at f/PTX = 0.24 with concentrated spatial PTX distributions for experimental testing. The shape, flexibility, and surface hydrophilicity of nonpeptide RGD-targeted PGG-PTX systems varying in poly(ethylene glycol) (PEG) spacer length (500 Da, 1000 Da, and 2000 Da) and npRGD ligand density (4, 8, 12, and 16 per PGG-PTX-PEG-npRGD molecule) were also examined. Results from CG MD simulations show that the PGG-PTX-PEG1000-npRGD and PGG-PTX-PEG1000-npRGD12 molecules were the most promising candidates, given their filamentous shape, high flexibility, and high surface hydrophilicity. Overall, we introduce computer simulations as a tool for facilitating the preclinical development of polymeric drug delivery systems.

Handbook of Research on Nanoscience Nanotechnology and Advanced Materials

Handbook of Research on Nanoscience  Nanotechnology  and Advanced Materials Book
Author : Bououdina, Mohamed
Publisher : IGI Global
Release : 2014-03-31
ISBN : 1466658258
Language : En, Es, Fr & De

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Book Description :

The burgeoning field of nanotechnology has led to many recent technological innovations and discoveries. Understanding the impact of these technologies on business, science, and industry is an important first step in developing applications for a variety of settings and contexts. Handbook of Research on Nanoscience, Nanotechnology, and Advanced Materials presents a detailed analysis of current experimental and theoretical approaches surrounding nanomaterials science. With applications in fields such as biomedicine, renewable energy, and synthetic materials, the research in this book will provide experimentalists, professionals, students, and academics with an in-depth understanding of nanoscience and its impact on modern technology.

Dendrimers

Dendrimers Book
Author : Claudia Maria Simonescu
Publisher : BoD – Books on Demand
Release : 2018-04-25
ISBN : 1789230586
Language : En, Es, Fr & De

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Book Description :

Dendrimers are defined as nanoscale macromolecules having a particular architecture consisting of treelike arms or branches. They are characterized by special properties that make them promising candidates in medicine, biology, materials science, synthetic organic chemistry, biotechnology, environmental engineering, optics, electronics, catalysis, electrochemistry, photochemistry, and sensors and even for production of cosmetics and personal care products. The dendrimers research field is growing day by day, and scientists are exploring new synthesis and functionalization methods in order to improve and to determine new properties and thus new applications. The main purpose of this book is to highlight the issues regarding properties and applications of dendrimers in the field of biology, medicine, liquid crystal devices, electronics, quantum devices, and self-healing technology.