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Polymer Protein Conjugates

Polymer Protein Conjugates Book
Author : Gianfranco Pasut,Samuel Zalipsky
Publisher : Elsevier
Release : 2019-10-30
ISBN : 0444640827
Language : En, Es, Fr & De

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Book Description :

Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Polymer Therapeutics II

Polymer Therapeutics II Book
Author : Ronit Satchi-Fainaro,Ruth Duncan
Publisher : Springer Science & Business Media
Release : 2006-01-12
ISBN : 9783540292111
Language : En, Es, Fr & De

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Book Description :

With contributions by numerous experts

Bio synthetic Polymer Conjugates

Bio synthetic Polymer Conjugates Book
Author : Helmut Schlaad
Publisher : Springer
Release : 2012-12-15
ISBN : 3642343503
Language : En, Es, Fr & De

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Book Description :

Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Björn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M. Eissa and Neil R. Cameron DNA-Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications, by Dawid Kedracki, Ilyès Safir, Nidhi Gour, Kien Xuan Ngo and Corinne Vebert-Nardin Synthesis of Terpene-Based Polymers, by Junpeng Zhao and Helmut Schlaad

Modulating Protein Activity Through Polymer Conjugation

Modulating Protein Activity Through Polymer Conjugation Book
Author : Caitlin Gayle Decker
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Protein therapeutics have become essential to the healthcare and pharmaceutical industries since the first recombinant proteins entered the clinic in the 1980s. Modification of proteins with polymers has traditionally been pursued as a means to improve protein stability and enhance pharmacokinetic properties. In addition to these benefits, polymer conjugation can also be utilized to control and modulate protein activity. The first polymer used for protein conjugation was poly(ethylene glycol) (PEG) in 1977. PEG is currently the only FDA-approved polymer for protein conjugation and 10 PEGylated protein drugs are currently on the market. This dissertation offers three modifications to traditional PEGylation, which allow for the modulation of protein activity. In the first example, masking and unmasking the activity of a model protein, lysozyme, was achieved by incorporating both a reducible disulfide linkage between the polymer and the protein as well as incorporating degradable cyclic ketene acetal (CKA) moieties throughout the backbone of a PEG-like polymer (Chapter 2). Specifically 5,6-benzo-2-methylene-1,3-dioxepane and poly(ethylene glycol) methyl ether methacrylate (PEGMA) were copolymerized by reversible addition-fragmentation chain transfer polymerization (RAFT) facilitated by a cysteine-reactive, pyridyl disulfide (PDS) modified chain transfer agent (CTA). Two polymers, a small (Mn GPC = 10.9 kDa) and a large (Mn GPC = 20.9 kDa) PDS-pPEGMA-co-BMDO, were synthesized with reasonable control (dispersities ( ) = 1.34 and 1.71, respectively). The polymers were then conjugated to a thiol-enriched hen egg white lysozyme by disulfide exchange. Conjugation with the 10.9 kDa polymer resulted in a conjugate, which exhibited high initial activity (63%) while the larger conjugate activity was highly attenuated (20%). Lysozyme release from both polymers by reduction of the disulfide linkage and by hydrolytic cleavage, in basic media, of the polymer backbone was visualized by gel electrophoresis. Reduction of the disulfide conjugation linkage with glutathione resulted in an increase in protein activity for both conjugates. In the next example, site-specific chemical dimerization of fibroblast growth factor 2 (FGF2) with a PEG linker, of optimized length, resulted in a FGF2 homodimer with wound healing ability at exceptionally low concentrations (Chapter 3). Homodimers of FGF2 were synthesized through site-specific conjugation to both ends of poly(ethylene glycol) (PEG). FGF2 was conjugated to 2, 6, and 20 kDa vinyl sulfone bis-functionalized PEG, as well as to a small molecule and mono-functionalized PEG controls. The optimal linker length was determined by screening FGF2 dimer-induced proliferation of human dermal fibroblasts (HDF). The inter-cyteine distance was calculated to be approximately 70 A , which is similar in length to a 2 kDa PEG. FGF2-PEG2k-FGF2 induced greater fibroblast proliferation than FGF2 alone, all other dimers, and all monoconjugates, at each concentration tested, with the greatest difference observed at low (0.1 ng/mL) concentration. FGF2-PEG2k-FGF2 further exhibited superior activity compared to FGF2 for both proliferation and migration in human umbilical vein endothelial cells, as well as improved angiogenesis in vitro. Efficacy in an in vivo wound healing model was assessed in diabetic mice. FGF2-PEG2k-FGF2 increased granulation tissue and blood vessel density in the wound bed compared to FGF2. The results suggest that this rationally designed construct may be useful in chronic wound healing. Lastly, a block copolymer capable of noncovalent and releasable conjugation to histidine-6 tagged proteins, consisting of a PEG-based block and a Ni(II) nitriolotriacetic acid (NTA)-based block was synthesized (Chapter 4). The first block was synthesized via RAFT polymerization of a NTA monomer. The resulting polymer was then utilized as a macro-CTA for the polymerization of PEGMA, resulting in a pNTAMA-b-PEGMA, containing 9 NTAMA repeats and 8 PEGMA repeats, with number average molecular weight (Mn) (GPC) = 9.9 kDa and dispersity ( ) = of 4.5. The high dispersity indicates a lack of control, and disproportionation was further confirmed by 1H-NMR. Initial studies indicated that mono-NTA-His6 interactions are not sufficient for protein conjugation, therefore extension of this work towards a multi-valent approach may prove effective in the future.

Peptide and Protein Drug Delivery

Peptide and Protein Drug Delivery Book
Author : Vincent Lee
Publisher : CRC Press
Release : 1990-11-19
ISBN : 9780824778965
Language : En, Es, Fr & De

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Book Description :

This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai

Materials for Biomedical Engineering

Materials for Biomedical Engineering Book
Author : Mohamed N. Rahaman,Roger F. Brown
Publisher : John Wiley & Sons
Release : 2021-11-09
ISBN : 1119551080
Language : En, Es, Fr & De

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Book Description :

This book provides an up-to-date textbook suitable for a one-semester (or two-quarter) course in biomaterials at the junior/senior undergraduate and introductory graduate levels. While intended primarily for students in biomedical engineering degree programs, the book will also provide an indispensable resource for an interdisciplinary audience composed of medical and dental students, researchers in the biomedical industry, and students with science and engineering backgrounds who have an interest in biomaterials. The focus of the book centers on the fundamentals to aid students to understand the materials science of biomaterials and their interaction with cells and tissues. However, it also describes conventional and emerging applications to show how these fundamentals are applied. Each chapter is replete with data in the form of tables and illustrations, and concludes with homework, review and examination problems, and a list of references for further reading. Beginning with an introductory chapter that covers general aspects related to the history, properties and applications of biomaterials, and to the biomaterials industry, the book moves on to cover the following major topics: Materials science fundamentals; Classes of materials used as biomaterials; Degradation of biomaterials in the biological environment; Biocompatibility phenomena; Applications of biomaterials in medicine and dentistry.

Thiol X Chemistries in Polymer and Materials Science

Thiol X Chemistries in Polymer and Materials Science Book
Author : Andrew B Lowe,Christopher N Bowman
Publisher : Royal Society of Chemistry
Release : 2013-08-13
ISBN : 1849736960
Language : En, Es, Fr & De

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Book Description :

Thiol-X chemistries are already well established techniques, but it is only recently that they have been exploited for the functionalization and synthesis of polymers and other materials. As such, information on these techniques is scattered across the literature and Thiol-X Chemistries in Polymer and Materials Science is the first book to compile work specifically focussing on the application of thiol-based chemistries in materials design and synthesis. The book introduces the various thiol-X chemistries currently available and applications where they have been successfully used, including examples of 'click' processes, in polymerizations, polymer synthesis, and polymer modification. Short 'how to' sections within the chapters also provide general experimental techniques to employ the various chemistries described. Written by leading experts in the field, this book is a comprehensive resource for postgraduates, academics and industrial practitioners interested in polymer and materials applications.

Synthetic Polymer protein Conjugates for Therapeutics

Synthetic Polymer protein Conjugates for Therapeutics Book
Author : Samantha B. McRae
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synthetic Polymer protein Conjugates for Therapeutics book written by Samantha B. McRae, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Functionalized Polymers

Functionalized Polymers Book
Author : Narendra Pal Singh Chauhan
Publisher : CRC Press
Release : 2021-05-14
ISBN : 1000291170
Language : En, Es, Fr & De

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Book Description :

Functionalized polymers are macromolecules to which chemically bound functional groups are attached which can be used as catalysts, reagents, protective groups, etc. Functionalized polymers have low cost, ease of processing and attractive features for functional organic molecules. Chemical reactions for the introduction of functional groups in polymers and the conversion of functional groups in polymers depend on different properties. Such properties are of great importance for functionalization reactions for possible applications of reactive polymers. This book deals with the synthesis and design of various functional polymers, the modification of preformed polymer backbones and their various applications.

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials Book
Author : Munmaya Mishra
Publisher : CRC Press
Release : 2017-08-16
ISBN : 1351653032
Language : En, Es, Fr & De

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Book Description :

The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Silicon Versus Carbon

Silicon Versus Carbon Book
Author : Yuri Magarshak,Sergey Kozyrev,Ashok K. Vaseashta
Publisher : Springer Science & Business Media
Release : 2009-05-21
ISBN : 9048125235
Language : En, Es, Fr & De

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Book Description :

Even though there is no generally accepted definition of nanotechnologies to be defined as distinct discipline there is an emerging consensus that their advent and development is a growing in importance factor of the contemporary and future technological civilization. One of these most fundamental issues we are confronted with is the compatibility with life itself. From single cell organisms to humans, carbon is a key building block of all molecular structures of life. In contrast the man created electronic industry to build on other elements, of which silicon is the most common. Both carbon and silicon create molecular chains, although different in their internal structure. All life is built from carbon-based chains. As long as the man built technological products do not directly interfere with the physiology of life the associated risks from them are relatively easy to identify. They are primarily in the environmental pollution and the possibility of upsetting the natural balance of biocoenosis, on a planetary scale. The basic life functions are still not directly subverted. We can use TV, computers, drive cars and use other technological utilities without fear of direct interference with our cellular functions. This is in particular because all these technological utilities are many orders of magnitude larger than typical scales of biological activity. Most of biological activity, from fermentative catalysis to DNA replication takes place on nanoscale. The situation is radically different when the technological goals are building nanoscale size products. All biological processes take place on nanoscale.

Biomaterials Science

Biomaterials Science Book
Author : Buddy D. Ratner
Publisher : Academic Press
Release : 2004
ISBN : 0125824637
Language : En, Es, Fr & De

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Book Description :

"... This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials." -- Publisher's description.

Smart Polymers

Smart Polymers Book
Author : Igor Galaev,Bo Mattiasson
Publisher : CRC Press
Release : 2007-07-25
ISBN : 9781439832370
Language : En, Es, Fr & De

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Book Description :

The first book to tackle the application of smart polymers in bioseparation and bioprocessing, Smart Polymers: Applications in Biotechnology and Biomedicine broke new ground in this challenging field. Completely revised, updated, and following in the footsteps of its predecessor, the second edition is poised to take its place as a premier reference in this field. This new edition considers those polymers in which a highly nonlinear response of a smart polymer to small changes in the external medium is of critical importance for the successful functioning of the system. The systems discussed are based on soluble/insoluble transition of smart polymers in aqueous solution, on conformational transitions of the macromolecules physically attached or chemically grafted to a surface and on the shrinking/swelling of covalently cross-linked networks of macromolecules, i.e. smart hydrogels. The book focuses on the theory describing the behavior of smart polymers in solution, as gels, and when grafted to surfaces. It provides solid, quantitative descriptions and reliable guidelines, reflecting the maturation of the field and the demand for the development of new smart polymer systems. The coverage highlights smart gels and especially fast responding and macroporous gels, as these gels pave the way to different applications of smart polymers in the areas ofbioseparation, drug release, and microfluidics. With contributions from leading researchers as well as extensive end-of-chapter references, this volume offers a comprehensive overview of the current state-of-the-art in the field and the potential for future developments.

Bioresponsive Polymer protein Conjugates as a Unimolecular Drug Delivery System

Bioresponsive Polymer protein Conjugates as a Unimolecular Drug Delivery System Book
Author : Helena Rosalind Petra Gilbert
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Bioresponsive Polymer protein Conjugates as a Unimolecular Drug Delivery System book written by Helena Rosalind Petra Gilbert, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Engineered Carbohydrate Based Materials for Biomedical Applications

Engineered Carbohydrate Based Materials for Biomedical Applications Book
Author : Ravin Narain
Publisher : John Wiley & Sons
Release : 2011-03-01
ISBN : 1118002245
Language : En, Es, Fr & De

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Book Description :

This book addresses the need for a comprehensive book on the design, synthesis, and characterization of synthetic carbohydrate-based polymeric materials along with their biological applications. The first two chapters cover the synthesis and self-assembly of glycopolymers and different techniques for creating these synthetic polymers. Subsequent chapters account for the preparation of block copolymers, branched glycopolymers, glycosurfaces, glycodendrimers, cationic glycopolymers, bioconjugates, glyconanoparticles and hydrogels. While these chapters comprehensively review the synthetic and characterization methods of those carbohydrate-based materials, their biological applications are discussed in detail.

Biomedical Applications of Electroactive Polymer Actuators

Biomedical Applications of Electroactive Polymer Actuators Book
Author : Federico Carpi,Elisabeth Smela
Publisher : John Wiley & Sons
Release : 2009-04-13
ISBN : 9780470744680
Language : En, Es, Fr & De

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Book Description :

Giving fundamental information on one of the most promising families of smart materials, electroactive polymers (EAP) this exciting new titles focuses on the several biomedical applications made possible by these types of materials and their related actuation technologies. Each chapter provides a description of the specific EAP material and device configuration used, material processing, device assembling and testing, along with a description of the biomedical application. Edited by well-respected academics in the field of electroactive polymers with contributions from renowned international experts, this is an excellent resource for industrial and academic research scientists, engineers, technicians and graduate students working with polymer actuators or in the fields of polymer science.

Self Assembly

Self Assembly Book
Author : Ramanathan Nagarajan
Publisher : John Wiley & Sons
Release : 2019-01-07
ISBN : 1119001366
Language : En, Es, Fr & De

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Book Description :

An introduction to the state-of-the-art of the diverse self-assembly systems Self-Assembly: From Surfactants to Nanoparticles provides an effective entry for new researchers into this exciting field while also giving the state of the art assessment of the diverse self-assembling systems for those already engaged in this research. Over the last twenty years, self-assembly has emerged as a distinct science/technology field, going well beyond the classical surfactant and block copolymer molecules, and encompassing much larger and complex molecular, biomolecular and nanoparticle systems. Within its ten chapters, each contributed by pioneers of the respective research topics, the book: Discusses the fundamental physical chemical principles that govern the formation and properties of self-assembled systems Describes important experimental techniques to characterize the properties of self-assembled systems, particularly the nature of molecular organization and structure at the nano, meso or micro scales. Provides the first exhaustive accounting of self-assembly derived from various kinds of biomolecules including peptides, DNA and proteins. Outlines methods of synthesis and functionalization of self-assembled nanoparticles and the further self-assembly of the nanoparticles into one, two or three dimensional materials. Explores numerous potential applications of self-assembled structures including nanomedicine applications of drug delivery, imaging, molecular diagnostics and theranostics, and design of materials to specification such as smart responsive materials and self-healing materials. Highlights the unifying as well as contrasting features of self-assembly, as we move from surfactant molecules to nanoparticles. Written for students and academic and industrial scientists and engineers, by pioneers of the research field, Self-Assembly: From Surfactants to Nanoparticles is a comprehensive resource on diverse self-assembly systems, that is simultaneously introductory as well as the state of the art.

Handbook of Harnessing Biomaterials in Nanomedicine

Handbook of Harnessing Biomaterials in Nanomedicine Book
Author : Dan Peer
Publisher : CRC Press
Release : 2021-01-26
ISBN : 100028428X
Language : En, Es, Fr & De

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Book Description :

Nanomedicine has emerged as a novel field in medicine integrating nano-scale technologies with materials sciences, chemistry and biology. The medical application of nanotechnology has the potential to revolutionize diagnosis and therapy and bring this new field from a notion into reality while impacting the lives of millions around the world. This second edition compiles and details the latest cutting-edge research in science and medicine from the interdisciplinary standpoint who are currently revolutionizing drug delivery techniques through the development of nanomedicines. Edited by Dan Peer, a prominent bio-nanotechnologiest, this book will attract anyone involved materials sciences, chemistry, biology and medicine that would like to design applications in the medical field of nanotechnology towards cancer therapy, inflammation, viral infection, imaging and toxicity.

Medical Nanotechnology and Nanomedicine

Medical Nanotechnology and Nanomedicine Book
Author : Harry F. Tibbals
Publisher : CRC Press
Release : 2017-12-19
ISBN : 1351834142
Language : En, Es, Fr & De

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Book Description :

Considering the fluid nature of nano breakthroughs—and the delicate balance between benefits and consequences as they apply to medicine—readers at all levels require a practical, understandable base of information about these developments to take greatest advantage of them. Medical Nanotechnology and Nanomedicine meets that need by introducing non-experts to nanomedicine and its evolving organizational infrastructure. This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects—an ideal foundation upon which to plan and make decisions. Covers the use of nanotechnology in medical applications including imaging, diagnosis and monitoring, drug delivery systems, surgery, tissue regeneration, and prosthetics Part of the Perspectives in Nanotechnology series—which contains broader coverage of the societal implications of nanotechnology—this book can be used as a standalone reference. Organized by historical perspective, current status, and future prospects, this powerful book: Explores background, definitions and terms, and recent trends and forces in nanomedicine Surveys the landscape of nanomedicine in government, academia, and the private sector Reviews projected future directions, capabilities, sustainability, and equity of nanomedicine, and choices to be made regarding its use Includes graphical illustrations, references, and keywords to reinforce concepts and aid further research In its assessment of alternative and sometimes conflicting concepts proposed for the application of nanotechnology to medicine, this book surveys major initiatives and the work of leading labs and innovators. It uses informative examples and case summaries to illustrate proven accomplishments and imagined possibilities in research and development.

Chemistry of Protein and Nucleic Acid Cross Linking and Conjugation Second Edition

Chemistry of Protein and Nucleic Acid Cross Linking and Conjugation  Second Edition Book
Author : Shan S. Wong,David M. Jameson
Publisher : CRC Press
Release : 2011-10-10
ISBN : 1420007645
Language : En, Es, Fr & De

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Book Description :

Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivity and resolution have facilitated the analysis of cross-linked products. Updated to reflect the advances of the 21st century, this book offers: An overview of the chemical principles underlying the processes of cross-linking and conjugation A thorough list of cross-linking reagents published in the literature since the first edition, covering monofunctional, homobifunctional, heterobifunctional, multifunctional, and zero-length cross-linkers Reviews of the use of these reagents in studying protein tertiary structures, geometric arrangements of subunits within complex proteins and nucleic acids, near-neighbor analysis, protein-to-protein or ligand–receptor interactions, and conformational changes of biomolecules Discusses the application of immunoconjugation for immunoassays, immunotoxins for targeted therapy, microarray technology for analysis of various biomolecules, and solid state chemistry for immobilizations