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Polymer Protein Conjugates

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Polymer Protein Conjugates

Polymer Protein Conjugates Book
Author : Gianfranco Pasut,Samuel Zalipsky
Publisher : Elsevier
Release : 2019-10-30
ISBN : 0444640827
Language : En, Es, Fr & De

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Book Description :

Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Polymer Therapeutics II

Polymer Therapeutics II Book
Author : Ronit Satchi-Fainaro,Ruth Duncan
Publisher : Springer Science & Business Media
Release : 2006-01-12
ISBN : 9783540292111
Language : En, Es, Fr & De

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Book Description :

With contributions by numerous experts

Encyclopedia of Polymer Science and Technology Part 2

Encyclopedia of Polymer Science and Technology  Part 2 Book
Author : Herman F. Mark
Publisher : Wiley-Interscience
Release : 2003
ISBN : 9780471287810
Language : En, Es, Fr & De

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Book Description :

This is the third Edition is a completely new version in a new century of the Encyclopedia of Polymer Science and Technology. The new edition will bring the state-of-the-art up to the 21st century, with coverage of nanotechnology, new imaging and analytical techniques, new methods of controlled polymer architecture, biomimetics, and more. New topics covered include nanotechnology, AFM, MALDI, biomimetics, and genetic methods, of increasing importance since 1990 and will also bring up-to-date coverage of traditional topics of continuing interest. This edition will publish in 3 Parts of 4 volumes each. Each Part will be an A-Z selection of the newest articles available in the online edition of this encyclopedia. A list of the titles to appear in Part I can be viewed by clicking "What's New" at www.mrw.interscience.wiley.com/epst. Titles for Parts II and III will appear there as well when available.

Nonfouling Polyampholyte Polymer Brushes with Protein Conjugation Capacity

Nonfouling Polyampholyte Polymer Brushes with Protein Conjugation Capacity Book
Author : Tapashree Tah
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The elimination of nonspecific protein adsorption is a very important challenge in many biomaterial applications. This work reports on the multi-functional properties of a mixed-charge or polyampholyte copolymer composed of positively charged [2-(acryloyloxy) ethyl] trimethyl ammonium chloride (TMA) and negatively charged 2-carboxy ethyl acrylate (CAA) monomers. TMA:CAA copolymers have previously been shown to have nonfouling properties, but the optimal conditions for nonfouling have not been determined. To accomplish this, the thickness of the polymer brush coating was varied by manipulating the surface-initiated atom transfer radical polymerization conditions. The nonspecific adsorption of fibrinogen and lysozyme was determined using a surface plasmon resonance biosensor as a function of the copolymer brush thickness. At the optimal thickness for nonfouling, nonspecific adsorption from 10% and 100% fetal bovine serum (FBS) was also determined. The results indicate that at the optimal copolymer brush thickness, TMA:CAA polyampholyte materials have ultralow fouling characteristics even upon exposure to 100% FBS (

Russian Journal of Bioorganic Chemistry

Russian Journal of Bioorganic Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Russian Journal of Bioorganic Chemistry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polymer Therapeutics II

Polymer Therapeutics II Book
Author : Valery Y. Alakhov
Publisher : Springer Science & Business Media
Release : 2006-01-12
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Physics is really important to game programmers who need to know how to add physical realism to their games. They need to take into account the laws of physics when creating a simulation or game engine, particularly in 3D computer graphics, for the purpose of making the effects appear more real to the observer or player.The game engine needs to recognize the physical properties of objects that artists create, and combine them with realistic motion. The physics ENGINE is a computer program that you work into your game that simulates Newtonian physics and predict effects under different conditions. In video games, the physics engine uses real-time physics to improve realism. This is the only book in its category to take readers through the process of building a complete game-ready physics engine from scratch. The Cyclone game engine featured in the book was written specifically for this book and has been utilized in iPhone application development and Adobe Flash projects. There is a good deal of master-class level information available, but almost nothing in any format that teaches the basics in a practical way. The second edition includes NEW and/or revised material on collision detection, 2D physics, casual game physics for Flash games, more references, a glossary, and end-of-chapter exercises. The companion website will include the full source code of the Cyclone physics engine, along with example applications that show the physics system in operation. --A truly accessible text that allows even novice programmers to create powerful physics engines for their games. --Covers particle effects, flight simulation, car pysics, crates, destructible objects, cloth and ragdolls, and more. --Supports each new concept with diagrams, code, end-of-chapter exercises and resources. --This edition includes completely NEW material on: collision detection, 2D physics, casual game physics for Flash games. --Powerful associated website offering: the full source code of the Cyclone physics engine, along with example applications that show the physics system in operation. The Cyclone engine has been used in commercial game development.

Polymer Preprints Japan

Polymer Preprints  Japan Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polymer Preprints Japan book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polymer Yearbook

Polymer Yearbook Book
Author : Richard A. Pethrick,Teiji Tsuruta,Gennady E. Zaikov
Publisher : Harwood Academic Publishers
Release : 1997-06
ISBN : 9789057021695
Language : En, Es, Fr & De

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Book Description :

This volume contains reviews on state-of-the-art Japanese research presented in the annual Spring and Autumn meetings of the Japanese Polymer Science Society. The aim of this section is to make information on the progress of Japanese Polymer Science, and on topics of current interest to polymer scientists in Japan, more easily available worldwide.

Journal of Nanoscience and Nanotechnology

Journal of Nanoscience and Nanotechnology Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of Nanoscience and Nanotechnology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

PEGylated Protein Drugs Basic Science and Clinical Applications

PEGylated Protein Drugs  Basic Science and Clinical Applications Book
Author : Francesco M. Veronese
Publisher : Springer Science & Business Media
Release : 2009-12-30
ISBN : 3764386797
Language : En, Es, Fr & De

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Book Description :

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Poly ethylene Glycol

Poly ethylene Glycol  Book
Author : J. Milton Harris,Samuel Zalipsky,American Chemical Society. Division of Polymer Chemistry,American Chemical Society Staff
Publisher : Amer Chemical Society
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume provides an interdisciplinary analysis of current biological applications of poly(ethylene glycol) (PEG). It includes a wide array of topics useful to materials scientists, organic chemists, biochemists, and bioengineers interested in drug delivery systems, pharmaceuticals and other biomaterials. The applications discussed include PEG-modified proteins, liposomes, drugs, surfaces of materials, and hydrogels. The volume also includes a review of PEG-oligonucleotides and a concise summary of the toxicology of PEG and its derivatives.

Biochemistry Moscow

Biochemistry  Moscow   Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biochemistry Moscow book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Microstructure Characterization of Polymers and Polymer protein Bioconjugates by Hyphenated Mass Spectrometry

Microstructure Characterization of Polymers and Polymer protein Bioconjugates by Hyphenated Mass Spectrometry Book
Author : Selim Gerislioglu
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Mass spectrometry (MS) has been a powerful technique for the characterization of synthetic polymers especially after the introduction of soft ionization methods such as electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). One-dimensional MS analysis provides molecular weight information by detection of the mass-to-charge (m/z) ratio of gas-phase analyte ions. However, tandem MS (MS/MS) capabilities, which involve separation and subsequent fragmentation of a selected analyte ion, are needed to obtain more detailed structural information. MS/MS can provide essential information on the backbone connectivity for synthetic polymers. For the sequence analysis of polymers having hydrocarbon backbones, multistage fragmentation (MSn) that combines different ion activation methods may be necessary. In addition to MS or MS/MS analysis, additional dimensions of separation can be achieved by online hyphenation of various dispersion techniques which allows for the investigation of more complex materials and mixtures. While online combination of liquid chromatography (LC) with MS has been the most common hyphenated technique, ion mobility (IM) spectrometry has been emerging as a much more rapid alternative method for the separation of gas-phase analyte ions based on their charge state, size, and architectural differences. These two separation techniques can be combined in a high-throughput 3D LC-IM-MS method or utilized separately depending on the sample complexity. In this dissertation, applications of MSn and hyphenated MS techniques are illustrated for the analysis of synthetic polymers and complex synthetic polymer-protein conjugates. In Chapter IV, various MSn approaches were investigated for the in-depth structural characterization of poly(N-isopropylacrylamide)s (pNIPAM). Different ion activation methods including collisionally activated dissociation (CAD) and electron transfer dissociation (ETD) provided structural information on end group and side chain functionalities. Sequential application of these ion activation methods in an MS3 fashion was necessary to obtain -C-C- bond cleavages and elucidate the backbone connectivity. In Chapter V, various hyphenated techniques that involve IM and LC were examined for the qualitative structural characterization of synthetic polymer-protein conjugates that were prepared by covalent attachment of poly(ethylene glycol) (PEG) to different proteins (PEGylation). The 3D LC-IM-MS technique was combined with in-source dissociation (ISD) for the site-specific characterization of PEGylated insulin with or without pretreatment of the sample.Finally, in Chapter VI, a methodology for occupancy analysis of PEGylated proteins was investigated on a model PEGylated myoglobin conjugate. Contrary to the qualitative approach discussed in Chapter V, the method presented in this final chapter involved a subtractive relative quantification by LC-MS which provided complete occupancy information on each possible PEG attachment site.

Polymer Science

Polymer Science Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polymer Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Papers Presented at the Meeting

Papers Presented at the     Meeting Book
Author : American Chemical Society. Division of Polymer Chemistry
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Papers Presented at the Meeting book written by American Chemical Society. Division of Polymer Chemistry, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Concise Encyclopedia of Medical and Dental Materials

Concise Encyclopedia of Medical and Dental Materials Book
Author : D. Williams,Robert W. Cahn,Michael Berliner Bever
Publisher : Pergamon
Release : 1990-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Containing over 60 articles specially written for this work or revised from the highly acclaimed Encyclopedia of Materials Science and Engineering, the Concise Encyclopedia of Medical & Dental Materials presents, in a single volume, the work of nearly 70 world experts on the current techniques and applications of materials which have been specially developed to satisfy the increasing needs of medical and dental science. Alphabetically arranged, articles cover the basic materials used including prostheses, implants, sutures and wound dressings. The biocompatibility, wear, corrosion and surface properties of the materials are also covered, as well as the mechanics of their implantation, adhesion and repair. Each article is extensively cross-referenced to other related topics and a bibliography is included referring readers to other appropriate current literature. Widely illustrated and complemented by a comprehensive three-level subject index, this is the most comprehensive and up-to-date survey of dental and medical materials available in a single volume.

Avidin biotin PEG CPA Complexes as Potential Enhanced Permeability and Retention Effect Directed Therapeutic Protein Carriers

Avidin biotin PEG CPA Complexes as Potential Enhanced Permeability and Retention Effect Directed Therapeutic Protein Carriers Book
Author : Shan Ke
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Avidin biotin PEG CPA Complexes as Potential Enhanced Permeability and Retention Effect Directed Therapeutic Protein Carriers book written by Shan Ke, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Euromat 99 Materials for Medical Engineering

Euromat 99  Materials for Medical Engineering Book
Author : Harald Stallforth,Peter A. Revell
Publisher : Wiley-VCH
Release : 2000
ISBN : 9783527301232
Language : En, Es, Fr & De

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Book Description :

The innovation of new materials for implants to achieve enhanced performance and lifetimes in the body could directly leed both to quality of life for patients and opportunities for wealth creation in associated industries. Some notable examples of major clinical applications of hard-tissue implants are in total joint replacement, spinal protheses, and dental tooth roots. Other topics addressed in this book are soft tissue implants, drug release technology, and corrosion and allergies of biomaterials.

Alkoxyamine Initiators for Nitroxide Mediated Radical Polymerization

Alkoxyamine Initiators for Nitroxide Mediated Radical Polymerization Book
Author : Jean K. Ruehl
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Alkoxyamine Initiators for Nitroxide Mediated Radical Polymerization book written by Jean K. Ruehl, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polymers for Drug Delivery in Cancer Therapy

Polymers for Drug Delivery in Cancer Therapy Book
Author : Hong Zi
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polymers for Drug Delivery in Cancer Therapy book written by Hong Zi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.