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Polycomb Group Proteins

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Polycomb Group Proteins

Polycomb Group Proteins Book
Author : Vincenzo Pirrotta
Publisher : Academic Press
Release : 2017-01-01
ISBN : 0128098228
Language : En, Es, Fr & De

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Book Description :

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

Polycomb Group Proteins

Polycomb Group Proteins Book
Author : Chiara Lanzuolo,Beatrice Bodega
Publisher : Humana Press
Release : 2016-09-14
ISBN : 9781493963782
Language : En, Es, Fr & De

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Book Description :

This volume presents the most recent technologies used in the Polycomb Group Proteins (PcG) field. Chapters detail state-of-the-art methods, creating a unique and comprehensive reference source for investigating Polycomb function in the nucleus. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Polycomb Group Proteins: Method and Protocols aims to ensure successful results in the further study of this vital field.

Polycomb Group Proteins Methods and Protocols

Polycomb Group Proteins  Methods and Protocols Book
Author : Chiara Lanzuolo,Beatrice Bodega
Publisher : Methods in Molecular Biology
Release : 2018-10-07
ISBN : 9781493981816
Language : En, Es, Fr & De

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Book Description :

Download Polycomb Group Proteins Methods and Protocols book written by Chiara Lanzuolo,Beatrice Bodega, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polycomb Group Proteins and Homeotic Gene Silencing in Drosophila

Polycomb Group Proteins and Homeotic Gene Silencing in Drosophila Book
Author : Aditya Kumar Sengupta
Publisher : Unknown
Release : 2003
ISBN : 9783898255738
Language : En, Es, Fr & De

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Book Description :

Download Polycomb Group Proteins and Homeotic Gene Silencing in Drosophila book written by Aditya Kumar Sengupta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polycomb Group Proteins in the Freshwater Polyp Hydra

Polycomb Group Proteins in the Freshwater Polyp Hydra Book
Author : Sonja Matt
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polycomb Group Proteins in the Freshwater Polyp Hydra book written by Sonja Matt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Identification and characterization of polycomb group proteins

Identification and characterization of polycomb group proteins Book
Author : Thihan Nyun,Reed College (Portland, Or.). Established Interdisciplinary Committee of Biochemistry and Molecular Biology
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Identification and characterization of polycomb group proteins book written by Thihan Nyun,Reed College (Portland, Or.). Established Interdisciplinary Committee of Biochemistry and Molecular Biology, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polycomb Group Proteins

Polycomb Group Proteins Book
Author : Vincenzo Pirrotta
Publisher : Academic Press
Release : 2017-01-05
ISBN : 9780128097373
Language : En, Es, Fr & De

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Book Description :

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

Function of Polycomb Group Proteins During Seed Development

Function of Polycomb Group Proteins During Seed Development Book
Author : Aleksandra Erilova
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Function of Polycomb Group Proteins During Seed Development book written by Aleksandra Erilova, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Roles of P300 BMP Signalling and Polycomb Group Proteins in the Transcriptional Regulation of the Inhibitor of Differentiation 1 and 2 Genes

Roles of P300  BMP Signalling and Polycomb Group Proteins in the Transcriptional Regulation of the Inhibitor of Differentiation 1 and 2 Genes Book
Author : Ralph Kretzschmar
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Roles of P300 BMP Signalling and Polycomb Group Proteins in the Transcriptional Regulation of the Inhibitor of Differentiation 1 and 2 Genes book written by Ralph Kretzschmar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of Polycomb Group Proteins Throughout Development

The Role of Polycomb Group Proteins Throughout Development Book
Author : Petronella Maria Stoop
Publisher : Unknown
Release : 2009
ISBN : 9789075575200
Language : En, Es, Fr & De

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Book Description :

Download The Role of Polycomb Group Proteins Throughout Development book written by Petronella Maria Stoop, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genome wide Intergenic Repression by Polycomb Group Proteins

Genome wide Intergenic Repression by Polycomb Group Proteins Book
Author : Hungoo Lee
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Polycomb group (PcG) proteins have been studied as epigenetic regulators of diverse developmental regulatory genes in various organisms. PcG proteins form two major complexes: the Polycomb repressive complex 2 (PRC2) which includes Enhancer of zeste (E(Z)) that methylates the lysine 27 residue of histone H3 (H3K27) and the Polycomb repressive complex 1 (PRC1) which preferentially binds to tri-methylated H3K27 (H3K27me3). Recent genome-wide analysis revealed that the PcG proteins stably bind to hundreds of genomic loci with strong H3K27me3 enrichment. Unlike the focused enrichment of H3K27me3, di-methylation of H3K27 (H3 K27me2) is found on more than half of all nucleosomal H3, raising the interesting possibility that H3K27me2 might have a potential repressive role across the genome. To address the possibility, we generated an E(z) temperature sensitive mutant cell line and examined the effects of E(Z) inactivation. Upon E(Z) inactivation, we observed a strong transcriptional increase from the H3K27me2-enriched intergenic regions along with significant increases of H3K27ac and H3K4me1. The intergenic de-repression was dependent on two dUTX-containing H3K27 de-methylase complexes that are associated with the increased active marks. Genome-wide analysis revealed that these effects are prevailing all over the genome, suggesting an antagonistic relationship between PRC2 and the dUTX complexes for regulating chromatin states genome-wide. In addition, PRC1 involvement in the intergenic repression was indicated by increased intergenic transcription by knock-downs or a mutation of PRC1 components. Moreover, a significant level of H2Aub1, a repressive mark produced by PRC1, was found in silent intergenic regions. These results extend the roles of PcG proteins by showing that PcG complexes not only function as master regulators of several hundred developmental regulators but also set a high inhibitory threshold to suppress the pervasive intergenic transcription all over the genome.

Identification and Characterization of Human Polycomb group Proteins

Identification and Characterization of Human Polycomb group Proteins Book
Author : David Pierre Elisabeth Satijn
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Identification and Characterization of Human Polycomb group Proteins book written by David Pierre Elisabeth Satijn, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Transcriptional Repression by Polycomb group Proteins

Transcriptional Repression by Polycomb group Proteins Book
Author : Ian F.G.. King
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Transcriptional Repression by Polycomb group Proteins book written by Ian F.G.. King, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polycomb Group Proteins Recruitment During Mouse Development

Polycomb Group Proteins Recruitment During Mouse Development Book
Author : Ligia Tavares
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polycomb Group Proteins Recruitment During Mouse Development book written by Ligia Tavares, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mechanism of Transcriptional Silencing by the Polycomb Group Proteins Extra Sex Combs and Enhancer of Zeste

Mechanism of Transcriptional Silencing by the Polycomb Group Proteins  Extra Sex Combs and Enhancer of Zeste Book
Author : Takehito Furuyama
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mechanism of Transcriptional Silencing by the Polycomb Group Proteins Extra Sex Combs and Enhancer of Zeste book written by Takehito Furuyama, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of Polycomb Group Proteins in Hox Gene Regulation and Chromatin Organization

The Role of Polycomb Group Proteins in   Hox   Gene Regulation and Chromatin Organization Book
Author : Claudia Gentile
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Proper embryonic development requires the function of the Hox gene family, which encode transcription factors essential for patterning the developing embryo along its main body axis. Most remarkably, the Hox genes are expressed in a spatially- and temporally- collinear fashion, corresponding to their relative positions along the chromosome. As such, mechanisms for Hox gene activation have been largely studied as the deregulation of Hox genes leads to severe developmental malformations. Our lab uses the developing limb as a model system to study Hox gene regulation. Previous work in our lab as well as others has contributed to understanding mechanisms of Hox gene activation through the identification of numerous enhancer elements which are located outside of the HoxA and HoxD clusters, within the large regulatory landscapes that flank the clusters. However, mechanisms for Hox gene silencing still remain largely elusive. Studies have demonstrated the important role for the Polycomb Group (PcG) protein complexes in the transcriptional repression of the Hox genes during development. Therefore, the aim of my thesis was to study the functional role of the PcG proteins in HoxA gene regulation during limb development. We first studied the functional role of the PcG proteins in organizing the chromatin architecture at and around the HoxA cluster. ChIP-seq experiments to map the binding of the Polycomb Repressive Complexes 1 and 2 (PRC1 and PRC2) in the proximal and distal limb bud at embryonic day 12.5 (E12.5) revealed that PcG occupancy correlated with the dynamic expression of the HoxA genes in the proximal and distal limb. Moreover, to study the functional link between PcG occupancy and chromatin organization we performed 5C (Chromosome Conformation Capture Carbon Copy), which allows for the detection of long-range spatial interactions between two genomic loci of interest. Our 5C analyses revealed that PcG bound loci physically interact in the 3D-environment, and that these contacts are lost upon PRC2 inactivation. In addition, we show that the differences in chromatin architecture which distinguish the proximal from distal limb were abrogated upon loss of PRC2 function. The resulting changes in chromatin architecture demonstrate that PRC2 is required to prevent certain enhancer-promoter interactions in the proximal limb in order to maintain Hoxa13 gene repression, whereas unexpectedly, we also find that PRC2 function is required to favor other enhancer-promoter contacts needed for HoxA gene activation by modulating the chromatin organization via PcG-mediated long-range contacts. Next, we assessed the genome-wide binding dynamics of PRC1 and PRC2 during limb development and demonstrated the requirement of PRC2 for transcriptional regulation. Our analyses revealed that PRC1 and PRC2 target genes involved in developmental processes and that the inactivation of PRC2 results in an up-regulation of these target genes. Strikingly, our analyses also reveal that PRC1 occupancy is unaffected by PRC2 inactivation, which reveals that a complex functional relationship between PRC1 and PRC2 exists during development. Finally, we show that while PRC2 inactivation does not globally affect proximal and distal limb identity, PRC2 is necessary to maintain the proper Hox transcriptional programs in the proximal and distal limb. Altogether this work emphasizes the important role of PcG proteins in regulating Hox gene expression during limb development. Importantly, we identified the contribution of PcG proteins in modulating the chromatin architecture at the HoxA cluster to promote gene activation and silencing. Moreover, we uncovered a dynamic relationship between PRC1 and PRC2 occupancy on a genome-wide scale, which correlates to transcriptional regulation during limb development. Overall, this work provides insights into the complex relationship between gene activation and repression during development processes"--

Mechanistic Studies of Polycomb Group Proteins

Mechanistic Studies of Polycomb Group Proteins Book
Author : Stanley M. Lo
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mechanistic Studies of Polycomb Group Proteins book written by Stanley M. Lo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dual Function of Polycomb Group Proteins in T Helper CD4 Cells

Dual Function of Polycomb Group Proteins in T Helper  CD4   Cells Book
Author : Reut Hod-Dvorai,Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel. Fakultah li-rfu'ah
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dual Function of Polycomb Group Proteins in T Helper CD4 Cells book written by Reut Hod-Dvorai,Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel. Fakultah li-rfu'ah, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.