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Platelets

Platelets Book
Author : Alan D. Michelson,Marco Cattaneo,Andrew Frelinger,Peter Newman
Publisher : Academic Press
Release : 2019-03-07
ISBN : 0128134690
Language : En, Es, Fr & De

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Book Description :

Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function. Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource. Comprehensive and definitive source of state-of-the-art knowledge about platelets Integrates the entire field of platelet biology, pathophysiology, and clinical medicine Written for clinicians, pathologists and scientists by 142 world-renowned experts from 18 countries Completely revised and updated, with 11 new chapters on topics such as platelet glycobiology, the platelet transcriptome, platelet inhibitory receptors, platelet function testing in clinical research trials, therapeutic platelet-rich plasma in wound healing, and new antiplatelet drugs Full color textbook with over 250 illustrations and 15,000 references

Platelets

Platelets Book
Author : Alan D. Michelson
Publisher : Gulf Professional Publishing
Release : 2002
ISBN : 9780124939516
Language : En, Es, Fr & De

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Book Description :

2002 Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American Publishers Platelets is a comprehensive new textbook of 61 chapters and 1,100 pages (approx.) written by over 100 world leaders in the field. Platelets is a single definitive source of state-of-the-art knowledge about platelets. There has been no textbook that specifically and fully covers the entire field of platelet biology and clinical medicine. Platelets now fills this need. Platelets encompasses: platelet biology; platelet function testing; the role of platelets in disease; inherited and acquired disorders of platelet number and function; pharmacology of antiplatelet agents; pharmacology of agents to increase platelet numbers and/or function; platelet transfusion medicine; and gene therapy. The intended audience for Platelets includes hematologists, cardiologists, stroke physicians, blood bankers, pathologists, and researchers in thrombosis and hemostasis as well as students and fellows in these fields. * A single comprehensive source of state-of-the-art knowledge about platelets * Over 100 contributing authors from 13 countries * The authors of each chapter are world leaders in their fields * The definitive resource with 61 chapters, 1,100 pages (approx.), 12,000 references (approx.), 70 full color figures, 140 black and white figures, and 95 tables

Platelets and Megakaryocytes

Platelets and Megakaryocytes Book
Author : Jonathan M. Gibbins,Martyn P. Mahaut-Smith
Publisher : Springer Science & Business Media
Release : 2004
ISBN : 1592597823
Language : En, Es, Fr & De

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Book Description :

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques leading expert researchers-many responsible for seminal discoveries in the field-offer basic and advanced techniques for studying cell signaling in the regulation and function of platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts in the regulation of cell signaling, and the measurement of intracellular calcium levels. There are also techniques for the study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization. The application of many molecular and post-genomic methods to the study of platelets and megakaryocytes is also described. All protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Platelets and Megakaryocytes, Volume 1: Functional Assays describes in step-by-step detail basic and advanced techniques for analyzing platelet and megakaryocyte function. Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.

Platelets

Platelets Book
Author : Alan D. Michelson
Publisher : Elsevier
Release : 2011-08-29
ISBN : 9780080465869
Language : En, Es, Fr & De

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Book Description :

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. · First edition won Best Book in Medical Science Award from the Association of American Publishers · Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias · A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Ticlopidine Platelets and Vascular Disease

Ticlopidine  Platelets and Vascular Disease Book
Author : William K. Hass,J.Donald Easton
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461383064
Language : En, Es, Fr & De

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Book Description :

Blood platelets lack a nucleus. As a result their life span is short and they cannot reproduce themselves. Platelets share these qualities with the red blood cell. Plate lets and red blood cells, nevertheless, serve vital roles in the body. One major function of the platelet is its capacity to aggregate and thereby initiate intravas cular coagulation which often underlies such major diseases as myocardial infarc tion, cerebral infarction, and pulmonary embolism. For this reason in recent years, medical attention has been directed to drugs that inhibit platelet aggregation. Aspirin was the first drug to be proven effective in this area. Since then other drugs that share aspirin's fundamental biochemical action, inhibition of platelet cyclooxygenase, have also been studied. Very recently, ticlopidine, the first of what promises to be a new class of drugs inhibiting platelet aggregation and coagulation via an entirely different biochemical mechanism, has been exten sively studied and clinically shown to be as effective or more effective than aspirin in the prevention of ischemic cardiovascular and cerebrovascular disease.

Platelets in Thrombotic and Non Thrombotic Disorders

Platelets in Thrombotic and Non Thrombotic Disorders Book
Author : Paolo Gresele,Clive P. Page,Valentin Fuster,Jos Vermylen
Publisher : Cambridge University Press
Release : 2002-05-30
ISBN : 9780521802611
Language : En, Es, Fr & De

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Book Description :

An essential reference for biomedical scientists and clinicians in hematology, cardiology, thrombosis and related disciplines.

Platelets

Platelets Book
Author : Orhan N. Ulutin
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Platelets book written by Orhan N. Ulutin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Application of Radiolabelled Platelets

Clinical Application of Radiolabelled Platelets Book
Author : C. Kessler,M.R. Hardeman,H. Henningsen,J. Petrovici
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9400905815
Language : En, Es, Fr & De

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Book Description :

AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.

Platelets in Hematologic and Cardiovascular Disorders

Platelets in Hematologic and Cardiovascular Disorders Book
Author : Paolo Gresele,Valentin Fuster,Jose A. Lopez,Clive P. Page,Jos Vermylen
Publisher : Cambridge University Press
Release : 2007-12-13
ISBN : 1139468766
Language : En, Es, Fr & De

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Book Description :

A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

The Role of Platelets in Blood Biomaterial Interactions

The Role of Platelets in Blood Biomaterial Interactions Book
Author : E Missirlis,J-L. Wautier
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401117454
Language : En, Es, Fr & De

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Book Description :

Medicine and engineering work together towards solutions for biomedical problems. The interactions of blood elements with artificial materials (bags, tubes, artificial organs, etc.) require many disciplines for its understanding. Thus the effort presented in this book is the culmination of a genuine discussion on the problems arising in blood banks, in hospitals, in biomaterials development, in experimental hemocompatibility testing when platelets interact with biomaterials. Hematologists, chemists, biologists and engineers have tried to put their own point of view and to understand the point of view of the other disciplines. The main themes that are presented in the discussion are: Platelet collection, storage and transfusion; Hemostasis and anticoagulation; Platelet and biomaterials, extracorporeal circulation and implanted materials; Hemorheological parameters; Modulation of platelet function; Biological tests for evaluating platelet--biomaterial interactions. £/LIST£

The Non Thrombotic Role of Platelets in Health and Disease

The Non Thrombotic Role of Platelets in Health and Disease Book
Author : Steve W. Kerrigan,Niamh Moran
Publisher : BoD – Books on Demand
Release : 2015-11-18
ISBN : 9535122088
Language : En, Es, Fr & De

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Book Description :

Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Mechanisms of Stimulus Response Coupling in Platelets

Mechanisms of Stimulus   Response Coupling in Platelets Book
Author : J. Westwick,M. F. Scully,D. E. MacIntyre,V. V. Kakkar
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 1461594421
Language : En, Es, Fr & De

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Book Description :

Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.

Platelets

Platelets Book
Author : Giovanni De Gaetano,Silvio Garattini
Publisher : Raven Press (ID)
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Platelets book written by Giovanni De Gaetano,Silvio Garattini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Platelet Protocols

Platelet Protocols Book
Author : Melanie McCabe White,Lisa K. Jennings
Publisher : Elsevier
Release : 1999-04-21
ISBN : 9780080539126
Language : En, Es, Fr & De

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Book Description :

Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now. Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing. Includes: A basic introduction to platelet anatomy and physiology Testing procedures for new anti-platelet therapies Descriptions of platelet function abnormalities Therapeutic approaches to inhibition of platelet function Step-by-step methodologies with clear explanations Helpful appendixes of recipes, instructions, sources of reagents, and more

Platelets in Cardiovascular Disease

Platelets in Cardiovascular Disease Book
Author : Deepak L. Bhatt
Publisher : Imperial College Press
Release : 2008
ISBN : 1860948529
Language : En, Es, Fr & De

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Book Description :

Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine. Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease. Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful. Sample Chapter(s). Chapter 1: Platelet Biology the Role of Platelets in Hemostasis, Thrombosis and Inflammation (274 KB). Contents: Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation (R C Becker); Thromboxane Antagonists (B R Dulin & S R Steinhubl); Glycoprotein IIb/IIIa Inhibitors (S J Lehman et al.); ADP Receptor Antagonists (J Karha & C P Cannon); Monitoring Antiplatelet Therapy (P Harrison & A D Michelson); Platelet Genomics (B K Jefferson et al.); Future Strategies for the Development of Antiplatelet Drugs (R A Harrington). Readership: Physicians: cardiologists, vascular medicine specialists, hematologists; physicians in training: fellows, residents, interns; pharmacists; pharmaceutical industry: scientists, sales representatives.

Platelets Thrombosis and the Vessel Wall

Platelets  Thrombosis and the Vessel Wall Book
Author : Michael C Berndt
Publisher : CRC Press
Release : 2003-09-02
ISBN : 0203304322
Language : En, Es, Fr & De

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Book Description :

Platelets, Thrombosis and the Vessel Wall aims to highlight the key areas of platelet function in the regulation of haemostasis and thrombosis and covers areas such as platelet production, interaction of platelets with leucocytes, mechanisms of cross-talk between platelets, leukocytes, and endothelium. The two major clinical causes of thrombosis, anti-phospholipid antibodies and genetic predisposition, are also addressed.

Megakaryocytes Platelets Macrophages and Eosinophils

Megakaryocytes  Platelets  Macrophages  and Eosinophils Book
Author : J. Robin Harris
Publisher : Springer Science & Business Media
Release : 1991-01-31
ISBN : 9780306435447
Language : En, Es, Fr & De

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Book Description :

Blood Cell Biochemistry was initially conceived as part of the Plenum series Subcellular Biochemistry, from which it has developed into a separate series. The present volume is devoted primarily to contributions on megakaryocytes and platelets and, to a lesser extent, to macrophages and eosinophils. The book does not attempt a rigorous or total coverage of the particular topics; it represents the areas of current scientific activity and interest that were selected by the editor at the commencement of this project. In general, the approach has been similar to that adopted for Volume 1 of the series (Erythroid Cells); the same approach will be followed subsequently in Volume 3 (Lymphocytes and Granulocytes). This book opens with a developmentally oriented chapter by Janine Breton-Gorius on megakaryocyte maturation and platelet release in normal conditions, which serves to set the scene ultrastructurally for much of the data that follow. The biosynthesis and process­ ing of platelet glycoproteins in megakaryocytes is dealt with by Alain Duperray and his colleagues, and thereby provides an in-depth biochemical survey of the megakaryocyte. The applications and strengths of crossed immunoelectrophoresis for the study of platelet membrane proteins is then covered by Simon Karpatkin, and a detailed account of the heredity disorders of platelet function is provided by Francine Rendu and Evelyne Dupuy.

Biochemistry of Platelets

Biochemistry of Platelets Book
Author : David Phillips
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323148972
Language : En, Es, Fr & De

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Book Description :

Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.

Platelets and Prostaglandins in Cardiovascular Disease

Platelets and Prostaglandins in Cardiovascular Disease Book
Author : Jawahar Mehta,Paulette Mehta
Publisher : Wiley-Blackwell
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Platelets and Prostaglandins in Cardiovascular Disease book written by Jawahar Mehta,Paulette Mehta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Platelets and Immune Responses During Thromboinflammation

Platelets and Immune Responses During Thromboinflammation Book
Author : Mirta Schattner,Craig N. Jenne,Soledad Negrotto,Benoît Ho-Tin-Noé
Publisher : Frontiers Media SA
Release : 2020-07-09
ISBN : 2889638391
Language : En, Es, Fr & De

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Book Description :

Download Platelets and Immune Responses During Thromboinflammation book written by Mirta Schattner,Craig N. Jenne,Soledad Negrotto,Benoît Ho-Tin-Noé, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.