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Phytochemicals As Lead Compounds For New Drug Discovery

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Phytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery Book
Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publisher : Elsevier
Release : 2019-09-07
ISBN : 0128178914
Language : En, Es, Fr & De

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Book Description :

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Neglected Tropical Diseases and Phytochemicals in Drug Discovery Book
Author : Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje
Publisher : Wiley
Release : 2021-08-10
ISBN : 9781119616603
Language : En, Es, Fr & De

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Book Description :

This book presents novel drug discovery updates from medicinal plants against the devastating effects of neglected tropical diseases (NTDs) on the global health care system. It is divided into six parts: part 1 presents chapters on general overview on NTDs, the recent drug discovery progress, the various druggable targets and challenges; part 2 presents chapters on protozoan infections; part 3 presents chapters on helminth infections; part 4 presents chapters on bacterial infections; and parts 5 and 6 document chapters on viral, fungal, and ectoparasitic infections.

Bioactive Phytochemicals Drug Discovery to Product Development

Bioactive Phytochemicals  Drug Discovery to Product Development Book
Author : Javed Ahmad,Javed Ahamad
Publisher : Bentham Science Publishers
Release : 2020-10-28
ISBN : 9811464464
Language : En, Es, Fr & De

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Book Description :

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Bioassay Methods in Natural Product Research and Drug Development

Bioassay Methods in Natural Product Research and Drug Development Book
Author : Lars Bohlin,Jan G. Bruhn
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401148104
Language : En, Es, Fr & De

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Book Description :

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Phytochemistry the Military and Health

Phytochemistry  the Military and Health Book
Author : Andrew G. Mtewa,Chukwuebuka Egbuna
Publisher : Elsevier
Release : 2021-03-15
ISBN : 0128232307
Language : En, Es, Fr & De

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Book Description :

Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses comes as a response to the gap that there has for so long existed between phytochemistry and survival of both service personnel and civilian communities during and after conflicts. Armed conflicts cause a lot of devastation to communities and should be avoided as much as it can be possible. The devastation is usually evident in service provisions such as Health, Education, Water, and Food among many others. Both service personnel and civilians are affected to various degrees. Facilities usually end up being physically destroyed, with no essential supplies and/or having dysfunctional systems. Going with untreated wounds, communicable and non-communicable diseases for weeks with no medical interventions due to the conflicts, disease burdens heavily weigh down on communities as well as security personnel. To make the situation even more complicated, masses of people are forced to migrate for safety and security reasons, likely going with diseases along wherever they go. In such instances, phytochemicals become handy in providing solutions from first aid, basic analgesia, antimicrobials, and the general improvement of health. Phytochemicals are known to play a major role in the day to day management of diseases and health. There has been much research into their effectiveness as community medicines and as alternatives to conventional drugs. However, the role that phytochemicals play in the military, counterterrorism, and security has been overlooked. Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses discusses the roles that phytochemicals play as friends and foes in the military, including insights aimed to help develop antidotes against phytochemicals and other chemical agents used maliciously as weapons. Filling a gap between drug discovery, security, and emergency medicine, this book describes which plants can be categorized for protection and controls, which can be helpful in times of conflicts and soon after conflicts, in military operations, and those that can be used as deterrents and as emergency medicines. Carefully designed to show the contribution that phytochemicals play in safety and security, this book is useful for researchers, regulators and anyone interested in plant chemistry. Covers the contribution that phytochemicals play in safety and security Contains insights that will help in the development of antidotes against phytochemical and other chemical weapons Categorizes plants in terms of their usefulness as well as the potential security risks they possess

Phytochemicals for Pest Control

Phytochemicals for Pest Control Book
Author : American Chemical Society,Paul Arthur Hedin,American Chemical Society. Division of Agrochemicals,International Chemical Congress of Pacific Basin Studies,American Chemical Society Staff
Publisher : Amer Chemical Society
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume identifies and describes biologically active natural products which can be used to manage a wide variety of pests, including insects, weeds, and fungi. The book presents structure-activity studies of the pest control agents and evaluates active proteins and peptides affecting insects. It also covers the identification of new plant products with unique biological properties.

Phytochemical Diversity

Phytochemical Diversity Book
Author : E. Chrystal
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

While the study of the chemicals produced by plants is arguably one of the oldest of the natural product sciences, current global concerns regarding the disappearance of biodiversity, along with the availability of methodology for systematic genetic manipulation and plant tissue culture, have rekindled industrial interest in phytochemical screening. Phytochemical Diversity gives a comprehensive overview of recent discoveries and developments of new products from plants that have potential utility in the pharmaceutical, agrochemical and cosmetic industries. It covers such areas as high throughput screening approaches for the discovery of novel phytochemicals, ethnobotanical drug discovery, comparisons of the chemical diversity available from plants and other natural sources, and adding value to phytochemicals through microbial biotransformations and synthetic approaches. It is particularly timely in its look at the ramifications of the recent UN Convention on Biological Diversity and its impact on the search for new industrial products from plants. This book provides a single source on developments in phytochemical research, with contributions from both academia to industry, and developing to developed countries, which will prove invaluable to bio-organic chemists, biotechnologists and those involved in medicinal and pharmaceutical chemistry.

Plant Natural Products for Human Health

Plant Natural Products for Human Health Book
Author : Chun-Tao Che,Hongjie Zhang
Publisher : MDPI
Release : 2019-03-21
ISBN : 3038977128
Language : En, Es, Fr & De

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Book Description :

Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs. This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Phytochemical analysis and cholesterol lowering efficiency of Averrhoa carambola Linn star fruit

Phytochemical analysis and cholesterol lowering efficiency of Averrhoa carambola Linn  star fruit   Book
Author : Prem Jose Vazhacharickal,Jiby John Mathew,Sajeshkumar N. K.,Ratheesh Mohanan,Ellamplackill Surya Santhosh
Publisher : GRIN Verlag
Release : 2017-07-10
ISBN : 3668479445
Language : En, Es, Fr & De

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Book Description :

Scientific Study from the year 2017 in the subject Agrarian Studies, grade: 1.5, Mar Augusthinose College, course: Biochemistry, language: English, abstract: Aqueous extract of the fruit pulp of Averrhoa carambola (star fruit) were evaluated for cholesterol lowering effect, in vitro, against various fatty food materials. Peoples are consuming food items made out of chicken, beef, mutton, egg and fish which contains large amount of fat. This study aims to analyze the effect of Averrhoa carambola in reducing the cholesterol level in this fat compound using water extract of the pulp. For this fatty food samples like egg yolk, pork fat, chicken fat , ghee and cod liver oil were treated with the extract and cholesterol level was estimated by Zak’s method for a period of time. Phytochemical constituents present in water extract of Averrhoa carambola Linn. pulp includes alkaloids, saponins, steroids, phlobatannins, carbohydrate, terpenoids, phenols, coumarins, flavonoids and leucoanthocyanins. The in vitro cholesterol lowering effect of Averrhoa carambola pulp extract shows a positive result on reducing chicken fat, ghee and egg yolk. But in case of cod liver oil no beneficial change was observed.

Natural Products and Drug Discovery

Natural Products and Drug Discovery Book
Author : Pinarosa Avato
Publisher : MDPI
Release : 2020-04-22
ISBN : 303928746X
Language : En, Es, Fr & De

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Book Description :

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Natural Bio active Compounds

Natural Bio active Compounds Book
Author : Mohd Sayeed Akhtar,Mallappa Kumara Swamy,Uma Rani Sinniah
Publisher : Springer Nature
Release : 2019-09-22
ISBN : 9811371547
Language : En, Es, Fr & De

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Book Description :

Bioactive compounds produced by natural sources, such as plants, microbes, endophytic fungi, etc., can potentially be applied in various fields, including agriculture, biotechnology and biomedicine. Several bioactive compounds have proved to be invaluable in mediating plant-microbe interactions, and promoting plant growth and development. Due to their numerous health-promoting properties, these compounds have been widely used as a source of medication since ancient times. However, there is an unprecedented need to meet the growing demand for natural bioactive compounds in the flavor and fragrance, food, and pharmaceutical industries. Moreover, discovering new lead molecules from natural sources is essential to overcoming the rising number of new diseases. In this regard, natural bioactive compounds hold tremendous potential for new drug discovery. Therefore, this field of research has become a vital area for researchers interested in understanding the chemistry, biosynthetic mechanisms, and pharmacological activities of these bioactive metabolites. This book describes the basics of bioactive plant compounds, their chemical properties, and their pharmacological biotechnological properties with regard to various human diseases and applications in the drug, cosmetics and herbal industries. It offers a valuable asset for all students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.

Science Culture

Science   Culture Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Science Culture book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Phytochemical and pharmacological evaluation of different fractions of Lannea grandis Engl Family Anacardiaceae

Phytochemical and pharmacological evaluation of different fractions of Lannea grandis Engl  Family  Anacardiaceae  Book
Author : Sharmin Akhter
Publisher : GRIN Verlag
Release : 2014-07-14
ISBN : 3656696713
Language : En, Es, Fr & De

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Book Description :

Master's Thesis from the year 2012 in the subject Pharmicology, , course: Pharmacy, language: English, abstract: The present research work was conducted to investigate the phytochemical and pharmacological activities of the different fractions of Lannea grandis Engl. (Family-Anacardiaceae). In phytochemical screenings with the crude extractives demonstrated the presence of alkaloids, steroids, tannins, saponins and gum. The antibacterial and antifungal activities of the crude extracts were evaluated by the disc diffusion method against 4 Gram positive and 7 Gram negative pathogenic bacteria and 7 fungi using Ciprofloxacin and Fluconazole as standards, respectively. In the screening, ethanol extract of L. grandis showed varying degrees of antibacterial activities than other two fractions with % zone of inhibition ranging from 46.09-48.42%, with strong activity against B. subtilis and S. aureus. On the other hand, the ethanol extract of plant also revealed mild to moderate antifungal activity with highest zone of inhibition of 20.5mm against B. dermatitidis. The MICs of the extracts were found to be 15.625-250μg/ml for both bacteria and fungal species used in the screening. During screening for antidiarrhoeal and antidepressant properties at dose 400mg/kg, significant (p

BIOACTIV PHYTOCHEMCLS PERSP MOD MED

BIOACTIV PHYTOCHEMCLS PERSP MOD MED Book
Author : Vijay Kumar Gupta
Publisher : Unknown
Release : 2014-01-01
ISBN : 9789351300922
Language : En, Es, Fr & De

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Book Description :

Download BIOACTIV PHYTOCHEMCLS PERSP MOD MED book written by Vijay Kumar Gupta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Natural Bio active Compounds

Natural Bio active Compounds Book
Author : Mallappa Kumara Swamy,Mohd Sayeed Akhtar
Publisher : Springer Nature
Release : 2019-09-19
ISBN : 9811372055
Language : En, Es, Fr & De

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Book Description :

Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

Sustainable Utilisation of Non timber Forest Products

Sustainable Utilisation of Non timber Forest Products Book
Author : Mohd. Yaakub Hj. Johari,Maryati Mohamed,Mary Sintoh
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Sustainable Utilisation of Non timber Forest Products book written by Mohd. Yaakub Hj. Johari,Maryati Mohamed,Mary Sintoh, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Natural Products and Drug Discovery

Natural Products and Drug Discovery Book
Author : Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Publisher : Elsevier
Release : 2018-02-16
ISBN : 0081021046
Language : En, Es, Fr & De

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Book Description :

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Intellectual Property Rights Naturally Derived Bioactive Compounds and Resource Conservation

Intellectual Property Rights  Naturally Derived Bioactive Compounds and Resource Conservation Book
Author : C. Gyllenhaal,N.R. Farnsworth,American Society of Pharmacognosy. Interim Meeting
Publisher : Elsevier Science Limited
Release : 1997-07-02
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The tropical rain forests have become an important focus in the search for new drugs from natural sources, especially from plants. This volume aims to promote a better understanding between scientists and institutions located in the developed and developing countries, in their efforts to search for new medicinal agents from the plants of these forests. The papers have been contributed by scientists and researchers from both developed and developing countries worldwide, and cover issues relevant to biodiversity prospecting activities. Such issues include rules and regulations on the collection of genetic materials for biological testing; logistical and technical challenges to be faced; sharing the benefits of discovery; patent protection for the discovery of potentially useful drug candidates; intellectual property rights; and indigenous property rights. The volume will be invaluable in achieving more fruitful collaborative efforts between scientists from different countries and different institutional affiliations, in their search for new drugs from tropical forest plants.

Endophytes

Endophytes Book
Author : Ravindra H. Patil
Publisher : Springer Nature
Release : 2021-06-20
ISBN : 981159371X
Language : En, Es, Fr & De

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Book Description :

Download Endophytes book written by Ravindra H. Patil, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Current Organic Chemistry

Current Organic Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Provides in depth reviews on current progress in the fields of asymmetric synthesis, organometallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry, and analytical methods in organic chemistry. Each issue is edited by an appointed Executive Guest Editor