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Physiology And Pathology Of Chloride Transporters And Channels In The Nervous System

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Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book
Author : Francisco J. Alvarez-Leefmans,Eric Delpire
Publisher : Academic Press
Release : 2009
ISBN : 9780123743732
Language : En, Es, Fr & De

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Book Description :

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book
Author : F. Javier Alvarez-Leefmans,Eric Delpire
Publisher : Academic Press
Release : 2009-08-22
ISBN : 9780080922034
Language : En, Es, Fr & De

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Book Description :

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Cell Physiology Source Book

Cell Physiology Source Book Book
Author : Nicholas Sperelakis,Nick Sperelakis
Publisher : Academic Press
Release : 2012-01-11
ISBN : 0123877385
Language : En, Es, Fr & De

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Book Description :

Cell Physiology Source Book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The 4e contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics Full color illustrations

Ion Channels and Transporters of Epithelia in Health and Disease

Ion Channels and Transporters of Epithelia in Health and Disease Book
Author : Kirk L. Hamilton,Daniel C Devor
Publisher : Springer
Release : 2015-12-14
ISBN : 1493933663
Language : En, Es, Fr & De

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Book Description :

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

Studies of Epithelial Transporters and Ion Channels

Studies of Epithelial Transporters and Ion Channels Book
Author : Kirk L. Hamilton,Daniel C. Devor
Publisher : Springer Nature
Release : 2021-03-04
ISBN : 3030554546
Language : En, Es, Fr & De

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Book Description :

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.

Cell Volume Regulation

Cell Volume Regulation Book
Author : Florian Lang
Publisher : S Karger Ag
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-05
ISBN : 0128177659
Language : En, Es, Fr & De

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Book Description :

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters

Cell Volume Regulation

Cell Volume Regulation Book
Author : Anonim
Publisher : Academic Press
Release : 2018-09-20
ISBN : 0128154578
Language : En, Es, Fr & De

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Book Description :

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on Cell Volume Regulation

Ion Transport Across Epithelial Tissues and Disease

Ion Transport Across Epithelial Tissues and Disease Book
Author : Kirk L. Hamilton,Daniel C. Devor
Publisher : Springer Nature
Release : 2020-12-12
ISBN : 3030553108
Language : En, Es, Fr & De

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Book Description :

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2011-07-05
ISBN : 0309212243
Language : En, Es, Fr & De

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Book Description :

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Optogenetics

Optogenetics Book
Author : Hiromu Yawo,Hideki Kandori,Amane Koizumi
Publisher : Springer
Release : 2015-06-05
ISBN : 4431555161
Language : En, Es, Fr & De

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Book Description :

The subject of optogenetics is comprehensively covered in this book, including physical, chemical, and biological topics of light-sensing proteins and their application in biological systems, particularly in neuroscience and medicine and the related opto-electronics. Optogenetics is a new technology that combines genetics and optics. It enables one to manipulate or measure the function of identified cells or neurons in a tissue by light with an accuracy in the range of milliseconds, even in a freely moving animal. Optogenetics has already become a powerful tool for revealing the neural mechanisms underlying behavior and analyzing various physiological phenomena. It is also expected to become useful for treating neural dysfunctions such as Parkinson disease and for the development of a brain–machine interface. This book should be read by any scientist or student performing research in any way related to optogenetics. As a milestone publication on optogenetics, this book will serve as a compass for any researcher, from beginners to experts, to explore this uncharted world.

Advanced Time Correlated Single Photon Counting Applications

Advanced Time Correlated Single Photon Counting Applications Book
Author : Wolfgang Becker
Publisher : Springer
Release : 2015-04-13
ISBN : 3319149296
Language : En, Es, Fr & De

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Book Description :

This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology, bio-chemistry, spectroscopy of live systems, live cell microscopy, clinical imaging, spectroscopy of single molecules, and other applications that require the detection of low-level light signals at single-photon sensitivity and picosecond time resolution.

Encyclopedia of the Neurological Sciences

Encyclopedia of the Neurological Sciences Book
Author : Anonim
Publisher : Academic Press
Release : 2014-04-29
ISBN : 0123851580
Language : En, Es, Fr & De

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Book Description :

The Encyclopedia of the Neurological Sciences, Second Edition develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

The Oxford Handbook of the Neurobiology of Pain

The Oxford Handbook of the Neurobiology of Pain Book
Author : Professor John N. Wood
Publisher : Oxford University Press
Release : 2020-06-17
ISBN : 0190860510
Language : En, Es, Fr & De

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Book Description :

The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of the rapidly developing field of pain research. As populations age, the number of people in pain is growing dramatically, with half the population living with pain. The opioid crisis has highlighted this problem. The present volume is thus very timely, providing expert overviews of many complex topics in pain research that are likely to be of interest not just to pain researchers, but also to pain clinicians who are seeking new therapeutic opportunities to develop analgesics. Many of the topics covered are of interest to neuroscientists, as pain is one of the most amenable sensations for mechanistic dissection. The present volume covers all aspects of the topic, from a history of pain through invertebrate model systems to the human genetics of pain and functional imaging. Chapters include the role of ion channels, the opioid system, the immune and sympathetic systems, as well as the mechanisms that transform acute to chronic pain. Migraine and the interplay between sleep and pain are also discussed. New technology in the form of transgenic animals, chemogenetics, optogenetics, and proteomic analyses are providing significant advances in our research and are covered as well. Demystifying pain through an understanding of its fundamental biology, as outlined in this volume, is the most direct route to ameliorating this vast human problem.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease Book
Author : Venkataramana K Sidhaye,Michael Koval
Publisher : Academic Press
Release : 2017-03-09
ISBN : 0128038810
Language : En, Es, Fr & De

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Book Description :

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Basic Epithelial Ion Transport Principles and Function

Basic Epithelial Ion Transport Principles and Function Book
Author : Kirk L. Hamilton,Daniel C. Devor
Publisher : Springer Nature
Release : 2020-11-26
ISBN : 3030527808
Language : En, Es, Fr & De

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Book Description :

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System Book
Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Release : 2011
ISBN : 0987073052
Language : En, Es, Fr & De

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Book Description :

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Voltage Gated Sodium Channels

Voltage Gated Sodium Channels Book
Author : Peter C. Ruben
Publisher : Springer Science & Business Media
Release : 2014-04-15
ISBN : 3642415881
Language : En, Es, Fr & De

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Book Description :

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Chloride Movements Across Cellular Membranes

Chloride Movements Across Cellular Membranes Book
Author : Anonim
Publisher : Elsevier Science
Release : 2007-01-22
ISBN : 9780444528728
Language : En, Es, Fr & De

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Book Description :

All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership. Describes the state-of-the-art in anion transport research Written by leaders in the field Presents a timely discussion of this rapidly emerging and expanding field