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Pharmacogenomics

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Pharmacogenomics

Pharmacogenomics Book
Author : Yui-Wing Francis Lam,Stuart R. Scott
Publisher : Academic Press
Release : 2018-11-27
ISBN : 0128126272
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations. With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion

Principles of Pharmacogenetics and Pharmacogenomics

Principles of Pharmacogenetics and Pharmacogenomics Book
Author : Russ B. Altman,David Flockhart,David B. Goldstein
Publisher : Cambridge University Press
Release : 2012-01-23
ISBN : 052188537X
Language : En, Es, Fr & De

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Book Description :

"This book is intended to introduce the field of phamacogenetics and pharmacogenomics to health care professionals. It brings together the latest informaiton about how human genetics impacts drug response phenotypes. It is written to enable the reader to undestand the current knowledge and challenges to the field"--Provided by publisher.

Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine Book
Author : Sandosh Padmanabhan
Publisher : Academic Press
Release : 2014-04-28
ISBN : 0123868831
Language : En, Es, Fr & De

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Book Description :

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Pharmacogenomics in Precision Medicine

Pharmacogenomics in Precision Medicine Book
Author : Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publisher : Springer Nature
Release : 2020-06-12
ISBN : 9811538956
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Pharmacogenomics

Pharmacogenomics Book
Author : Julio Licinio,Ma-Li Wong
Publisher : John Wiley & Sons
Release : 2009-07-30
ISBN : 3527616306
Language : En, Es, Fr & De

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Book Description :

This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach

Applying Pharmacogenomics in Therapeutics

Applying Pharmacogenomics in Therapeutics Book
Author : Xiaodong Feng,Hong-Guang Xie
Publisher : CRC Press
Release : 2016-01-06
ISBN : 1498782450
Language : En, Es, Fr & De

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Book Description :

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a

Pharmacogenomics

Pharmacogenomics Book
Author : Werner Kalow,Urs B. Meyer,Rachel F. Tyndale
Publisher : CRC Press
Release : 2001-05-08
ISBN : 9781420002461
Language : En, Es, Fr & De

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Book Description :

"Summarizes the history of, and available applications, techniques, and approaches to, pharmacogenomics--improving efficacy and tolerance to pharmaceutical compounds, evaluating pharmacogenomics on clinical trial design, and increasing the chances of successful clinical trials and patient outcomes. Compares pharmacogenomics to pharmacogenetics, focusing on the essential components that incorporate individual genetic variations to drug regimens resulting in different responses to therapeutics."

Concepts in Pharmacogenomics

Concepts in Pharmacogenomics Book
Author : Martin M. Zdanowicz
Publisher : ASHP
Release : 2010
ISBN : 1585282340
Language : En, Es, Fr & De

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Book Description :

The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time. If you are pharmacist, resident, or student curious about this new field, start with Concepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation. Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Pharmacogenomics

Pharmacogenomics Book
Author : Mark A. Rothstein
Publisher : John Wiley & Sons
Release : 2003-04-09
ISBN : 0471461202
Language : En, Es, Fr & De

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Book Description :

Through analyses of the complex underlying issues, thisinterdisciplinary volume frames the agenda for dealing with geneticvariation and incorporating pharmacogenomics into health care. Thethree sections of this book, Research Issues, Clinical Issues, andSocial Perspectives address key elements integral to acomprehensive discussion of this emerging field. This groundbreaking text… Examines new research strategies, methodologies, and ethicaland social considerations of pharmacogenomics Addresses practical considerations of anticipated changes ineducation, training, oversight, guidelines and protocols, andcontinuing education requirements Provides analyses of the potential enormous impact ofpharmacogenomics, such as in the standard of care and treatment,including perspectives from the fields of anthropology, law,ethics, and economics

Psychiatric Pharmacogenomics

Psychiatric Pharmacogenomics Book
Author : David A. Mrazek
Publisher : Oxford University Press
Release : 2010-05-28
ISBN : 0199710260
Language : En, Es, Fr & De

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Book Description :

Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Statistical and Computational Pharmacogenomics

Statistical and Computational Pharmacogenomics Book
Author : Rongling Wu,Min Lin
Publisher : CRC Press
Release : 2008-08-08
ISBN : 9781584888291
Language : En, Es, Fr & De

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Book Description :

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. This comprehensive volume provides key tools needed to understand and model the genetic variation for drug response and equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.

Pharmacogenomics An Introduction and Clinical Perspective

Pharmacogenomics An Introduction and Clinical Perspective Book
Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Publisher : McGraw Hill Professional
Release : 2012-10-12
ISBN : 0071813713
Language : En, Es, Fr & De

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Book Description :

A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus an examination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviews basic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties. FEATURES Important overview of general pharmacogenomics and pharmacogenetics concepts, including genetic variation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics Discussion of regulatory considerations in pharmacogenomics Focus on the role of health care professionals along with a review of related privacy issues, as well as broader ethical, legal, and social considerations In-depth chapters on drug metabolism and transporters Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling Up-to-date coverage of non-genetic influences on pharmacogenomics Emphasis on gene-drug interactions Numerous tables and figures Chapter-ending references Concise learning objectives at the beginning of each chapter Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Pharmacogenomics in Psychiatry

Pharmacogenomics in Psychiatry Book
Author : Matthias Schwab,Wolfgang P. Kaschka,Edoardo Spina
Publisher : Karger Medical and Scientific Publishers
Release : 2010-01-01
ISBN : 3805594984
Language : En, Es, Fr & De

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Book Description :

In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research. Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Pharmacogenomics

Pharmacogenomics Book
Author : Federico Innocenti
Publisher : Springer Science & Business Media
Release : 2008-02-03
ISBN : 1592599575
Language : En, Es, Fr & De

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Book Description :

Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

Pharmacogenomics

Pharmacogenomics Book
Author : Anonim
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacogenomics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacogenomics of Alcohol and Drugs of Abuse

Pharmacogenomics of Alcohol and Drugs of Abuse Book
Author : Amitava Dasgupta,Loralie J. Langman
Publisher : CRC Press
Release : 2012-04-23
ISBN : 1439856125
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics is the basis of personalized medicine, which is said to be the medicine of the future. Understanding genetic variation in drug and alcohol response is vital for professionals working in rehabilitation programs. The same principles that are applicable for therapeutic drugs are also applicable for drugs of abuse. Pharmacogenomics can supplement traditional therapeutic drug monitoring, potentially predicting correct dosage before initiation of the drug therapy. Applying these principles to testing and treatment, Pharmacogenomics of Alcohol and Drugs of Abuse discusses the role of the clinical laboratory in the practice of personalized medicine. With contributions from a range of experts, the book presents the genetic aspects of alcohol metabolism and other drugs including marijuana, cocaine, and amphetamines. In addition to basic pharmacogenomic aspects, the book addresses slate and trait markers of drugs of abuse so readers can consider setting appropriate biomarker tests in their clinical laboratory.

Pharmacogenomics and Personalized Medicine

Pharmacogenomics and Personalized Medicine Book
Author : Erika Cecchin,Gabriele Stocco
Publisher : MDPI
Release : 2021-01-20
ISBN : 3039367307
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.

Mastering Pharmacogenomics A Nurse s Handbook for Success

Mastering Pharmacogenomics  A Nurse s Handbook for Success Book
Author : Dale Halsey Lea,Dennis J. Cheek,Daniel Brazeau,Gayle Brazeau
Publisher : Sigma Theta Tau
Release : 2015-01-14
ISBN : 1938835700
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics, the study of the role of genetics in drug response, has developed into a critical new area in battling disease and improving outcomes. As our knowledge of the human genome grows, and with the advent of next-generation sequencing technologies, the role of genetic research is evolving to guide therapy and prevent many diseases and mitigate side-effects of current treatments. As a pivotal member of the healthcare team, nurses must acquire competency in pharmacogenomics to deliver optimal patient care in the 21st century. Mastering Pharmacogenomics provides nursing professionals with a foundational knowledge of human genetics and genomics that can be applied in optimizing drug therapy and patient care delivery. Coverage includes: Essential pharmacogenomics competencies for registered nurses Genomics technologies and resources Critical properties of drug response and disposition Covered specialties include obstetrics and prenatal patients, pediatrics, older adult patients, and oncology Ethics and patient careFuture developments in technology and delivery

Applying Pharmacogenomics in Therapeutics

Applying Pharmacogenomics in Therapeutics Book
Author : Xiaodong Feng,Hong-Guang Xie
Publisher : CRC Press
Release : 2016-01-06
ISBN : 1466582685
Language : En, Es, Fr & De

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Book Description :

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare—i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Pharmacogenomics in Admixed Populations

Pharmacogenomics in Admixed Populations Book
Author : Dr. G. Suarez-Kurtz
Publisher : CRC Press
Release : 2007-08-03
ISBN : 1498713793
Language : En, Es, Fr & De

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Book Description :

Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs