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Pharmacoepigenetics

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Pharmacoepigenetics

Pharmacoepigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-04
ISBN : 0128139404
Language : En, Es, Fr & De

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Book Description :

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Exam Prep for Pharmacoepigenetics

Exam Prep for  Pharmacoepigenetics Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-14
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exam Prep for Pharmacoepigenetics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Personalized Epigenetics

Personalized Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2015-04-28
ISBN : 0128004363
Language : En, Es, Fr & De

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Book Description :

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Pharmacogenomics

Pharmacogenomics Book
Author : Yui-Wing Francis Lam,Larisa H. Cavallari
Publisher : Academic Press
Release : 2013-02-12
ISBN : 0123983037
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy Book
Author : Steven Gray
Publisher : Academic Press
Release : 2015-07-01
ISBN : 0128002247
Language : En, Es, Fr & De

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Book Description :

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Basic and Clinical Pharmacology 12 E Inkling ENHANCED EBOOK

Basic and Clinical Pharmacology 12 E Inkling  ENHANCED EBOOK  Book
Author : Bertram G. Katzung,Susan B. Masters,Anthony J. Trevor
Publisher : McGraw Hill Professional
Release : 2012-03-22
ISBN : 007176402X
Language : En, Es, Fr & De

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Book Description :

The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine Enhanced by more than three hundred illustrations -- many in full color Organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, 12e covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors’ many years experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations, Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information. Coverage that spans every aspect of medical pharmacology: Basic principles Autonomic drugs Cardiovascular-renal drugs Drugs with important actions on smooth muscles Central nervous system drugs Drugs used to treat anemias, clotting disorders, hyperlipidemia, and inflammation and gout Endocrine drugs Chemotherapeutic and immunologic drugs Toxicology Special subjects (perinatal, geriatric, and dermatologic pharmacology) Botanical and "food supplements," and over-the-counter medications Prescribing Also in this edition: Drug Summary Tables conclude most chapters, providing a concise summary of the most important drugs General concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters Descriptions of important new drugs, including monoclonal antibodies

Pharmacogenomics An Introduction and Clinical Perspective

Pharmacogenomics An Introduction and Clinical Perspective Book
Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Publisher : McGraw Hill Professional
Release : 2012-10-12
ISBN : 0071813713
Language : En, Es, Fr & De

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Book Description :

A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus an examination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviews basic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties. FEATURES Important overview of general pharmacogenomics and pharmacogenetics concepts, including genetic variation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics Discussion of regulatory considerations in pharmacogenomics Focus on the role of health care professionals along with a review of related privacy issues, as well as broader ethical, legal, and social considerations In-depth chapters on drug metabolism and transporters Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling Up-to-date coverage of non-genetic influences on pharmacogenomics Emphasis on gene-drug interactions Numerous tables and figures Chapter-ending references Concise learning objectives at the beginning of each chapter Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Basic and Clinical Pharmacology 12 E

Basic and Clinical Pharmacology 12 E Book
Author : Bertram G. Katzung,Susan Masters,Anthony Trevor
Publisher : McGraw Hill Professional
Release : 2012-01-03
ISBN : 0071764011
Language : En, Es, Fr & De

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Book Description :

Looks at the essential conepts in the science of pharmacology and its application to clinical practice.

Basic Clinical Pharmacology Thirteenth Edition SMARTBOOKTM

Basic   Clinical Pharmacology  Thirteenth Edition  SMARTBOOKTM Book
Author : Bertram G. Katzung,Anthony J. Trevor
Publisher : McGraw Hill Professional
Release : 2014-12-22
ISBN : 0071826416
Language : En, Es, Fr & De

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Book Description :

Gain a full understanding of the basic science andclinical use of drugs with the most up-to-date andcomprehensive pharmacology text in the health sciences A Doody's Core Title for 2017! 400 ILLUSTRATIONS--MANY IN FULL COLOR Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors' many years of experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. Coverage that spans every aspect of medical pharmacology: Encompasses every aspect of medical pharmacology including botanicals and over-the-counter drugs New chapter on pharmacogenomics with important examples Emphasis is placed on discussion of druggroups and prototypes Clinically relevant, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects Full-color presentation with more than 400 illustrations Case studies introduce clinical problems in most chapters Summary tables and diagrams encapsulate important information Includes many new drugs A Generic Name/Trade Name Table appears at the end of most chapters for easy reference when writing a chart order or prescription

Basic and Clinical Pharmacology 14th Edition

Basic and Clinical Pharmacology 14th Edition Book
Author : Bertram G. Katzung
Publisher : McGraw Hill Professional
Release : 2017-11-30
ISBN : 1259641163
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine—enhanced by a new full-color illustrations A Doody’s Core Title for 2019! Organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, Fourteenth Edition covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors’ many years’ experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations (many new to this edition), Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information. • Student-acclaimed summary tables conclude each chapter • Everything students need to know about the science of pharmacology and its application to clinical practice • Strong emphasis on drug groups and prototypes • NEW! 100 new drug tables • Includes 330 full-color illustrations, case studies, and chapter-ending summary tables • Organized to reflect the syllabi of pharmacology courses • Descriptions of important new drugs

Pharmacogenomics A Primer for Clinicians

Pharmacogenomics  A Primer for Clinicians Book
Author : Jerika T. Lam,Mary A Gutierrez
Publisher : McGraw Hill Professional
Release : 2020-12-22
ISBN : 1260457117
Language : En, Es, Fr & De

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Book Description :

An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123944058
Language : En, Es, Fr & De

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Book Description :

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Handbook of Drug Screening Second Edition

Handbook of Drug Screening  Second Edition Book
Author : Ramakrishna Seethala,Litao Zhang
Publisher : CRC Press
Release : 2009-06-24
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies.

Basic and Clinical Pharmacology 15e

Basic and Clinical Pharmacology 15e Book
Author : Bertram G. Katzung,Anthony J. Trevor
Publisher : McGraw Hill Professional
Release : 2020-11-22
ISBN : 1260452328
Language : En, Es, Fr & De

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Book Description :

Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Goldfrank s Toxicologic Emergencies Eleventh Edition

Goldfrank s Toxicologic Emergencies  Eleventh Edition Book
Author : Lewis S. Nelson,Robert S. Hoffman,Mary Ann Howland,Neal A. Lewin,Lewis R. Goldfrank
Publisher : McGraw Hill Professional
Release : 2018-08-22
ISBN : 1259859592
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Goldfrank’s is the premier toxicology textbook that should be in every emergency department or poison center library. Whether you are a student, resident, or faculty, there is something here for you. If you are a toxicology fellow or poison specialist studying for your boards, this is your go-to book. I highly recommend this work... —The Journal of Emergency Medicine The best edition yet of the landmark text in medical toxicology A Doody’s Core Title for 2020! Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins. Fully referenced and supported by a cohesive organization and full-color format, Goldfrank’s begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations. The Eleventh Edition of Goldfrank’s Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis. New to this Edition: • Additional cases and “Special Considerations” chapters designed to enhance clinical decision-making and patient outcomes • New “Antidotes in Depth” provides timely, critical information on toxicologic treatment strategies • New content on toxicogenomics explores its increasingly important role in predictive toxicology • Chapter-ending bulleted summaries of key points • Updated coverage of synthetics such as “K2” • Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools

Mechanisms of Memory

Mechanisms of Memory Book
Author : J. David Sweatt
Publisher : Academic Press
Release : 2009-09-28
ISBN : 9780080959191
Language : En, Es, Fr & De

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Book Description :

This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding. More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples