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Pharmaceutical Applications Of Dendrimers

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Pharmaceutical Applications of Dendrimers

Pharmaceutical Applications of Dendrimers Book
Author : Abhay Singh Chauhan,Hitesh Kulhari
Publisher : Elsevier
Release : 2019-11-15
ISBN : 0128145285
Language : En, Es, Fr & De

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Book Description :

Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in the imaging of diseased areas. In addition, the anti-inflammatory, antimicrobial and antiviral properties of PPI and PAMAM are also covered, along with a discussion on photosensitizers, such as rose Bengal and protoporphyrin IX that have been delivered using PAMAM and PPI dendrimers for the treatment of cancer. This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery. Explores the role of dendrimers in the design of dendritic nanoplatforms for targeted drug and gene delivery systems Discusses the potential of dendrimers in preformulation and formulation development Addresses both clinical and regulatory challenges in the development of dendrimer-based formulations

Dendrimer Based Drug Delivery Systems

Dendrimer Based Drug Delivery Systems Book
Author : Yiyun Cheng
Publisher : John Wiley & Sons
Release : 2012-05-23
ISBN : 1118275225
Language : En, Es, Fr & De

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Book Description :

The opportunities and challenges of using dendrimers to improvedrug delivery Among pharmaceutical and biomedical researchers, the use ofdendrimers in drug delivery systems has attracted increasinginterest. In particular, researchers have noted that the volume ofa dendrimer increases when it has a positive charge. If thisproperty can be applied effectively, dendrimers have enormouspotential in drug delivery systems, directly supplying medicationto targeted human organs. With contributions from an international team of pioneers andexperts in dendrimer research, this book provides a comprehensiveoverview of the latest research efforts in designing and optimizingdendrimer-based drug delivery systems. The book analyzes keyissues, demonstrating the critical connections that linkfundamental concepts, design, synthesis, analytical methodology,and biological assessment to the practical use of dendrimers indrug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects theauthors' thorough review and analysis of the current literature aswell as their own firsthand experience in the lab. Readers will notonly discover the current state of the science, but also gainvaluable insights into fruitful directions for future research.References at the end of each chapter serve as a gateway to thegrowing body of literature in the field, enabling readers toexplore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book aunique and essential guide to the opportunities, issues, andchallenges involved in fully exploiting the potential of dendrimersto improve drug delivery.

An Investigation of the Use of Dendrimer based Carrier to Cross Cellular Barrier

An Investigation of the Use of Dendrimer based Carrier to Cross Cellular Barrier Book
Author : Stephanie Teow
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Dendrimers are a novel class of highly branched polymers with a high degree of uniformity and monodispersity. As a result of the unique properties and characteristics of dendrimers, they have found a wide range of pharmaceutical applications. This study investigated the ability of polyamidoamine (PAMAM) dendrimer-based drug delivery systems to enhance the permeability of a drug that is a substrate of P-glycoprotein (P-gp) efflux transporter with low water solubility. This thesis described the syntheses, characterisations and biological evaluations of the dendrimer-based drug delivery system to overcome the cellular barriers. G3 PAMAM dendrimers were conjugated with lauryl chains via a carbamate bond. Paclitaxel, a low water solubility P-gp substrate and anti-tumour drug, was conjugated to G3 and/or lauryl-G3 PAMAM dendrimer conjugates via a glutaric anhydride linker. Unmodified G3 PAMAM dendrimer and all the dendrimer conjugates (lauryl-G3 and G3-drug conjugates) were labelled with fluorescein isothiocyanate (FITC) for quantitative detection by spectrofluorimetry in permeability studies. These conjugates were characterised using various techniques including thin layer chromatography, 1H and 13C NMR, ESI-MS and dynamic light scattering. Chemical stability studies showed that the tested dendrimer conjugate (FITC-G3L6-glu-pac) was stable at all test pHs (1.2, 7.4, and 8.5) after 48 h of incubation at 37°C. The ester bond of the conjugate was stable under several chemical conditions after 10 days of incubation. Biological evaluation of the dendrimer conjugates was initially conducted using Caco-2 cells. Lactate dehydrogenase (LDH) release assay showed that conjugation of lauryl chains and paclitaxel molecules on the surface of G3 PAMAM dendrimer significantly (p

Dendrimers for Drug Delivery

Dendrimers for Drug Delivery Book
Author : Anil K. Sharma,Raj K. Keservani
Publisher : CRC Press
Release : 2018-07-27
ISBN : 135136068X
Language : En, Es, Fr & De

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Book Description :

With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery. The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the striking features of dendrimers. It goes on to present the details of usual properties, structure, classification, and methods of synthesis, with relevant examples. The toxicity of dendrimers is also discussed. The chapter authors provide an exhaustive amount of information about dendrimers and their biomedical applications, including biocompatibility and toxicity aspects, a very useful feature. This informative volume will be valuable resource that will help readers to create products derived from dendrimers and navigate through the regulatory, manufacturing, and quality control hurdles. It will be an important resource for researchers, scientists, upper-level students, and industry professionals.

Dendrimer Based Nanotherapeutics

Dendrimer Based Nanotherapeutics Book
Author : Prashant Kesharwani
Publisher : Academic Press
Release : 2021-04-27
ISBN : 0128212519
Language : En, Es, Fr & De

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Book Description :

Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields. Discusses various routes such as oral, pulmonary, transdermal, delivery and local administration of dendrimer delivery of bioactive Explores a wide range of applications of dendrimer-based drug delivery using the latest advancements in nanomedicine Provides the most recent research on dendrimers as well as context and background, providing a useful resource for all levels of researcher

Dendrimers in Nanomedicine

Dendrimers in Nanomedicine Book
Author : Neelesh Kumar Mehra,Keerti Jain
Publisher : CRC Press
Release : 2021-03-22
ISBN : 1000333035
Language : En, Es, Fr & De

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Book Description :

Dendrimers, hyperbranched macromolecules, emerged just few decades ago but show promising potential as drug delivery nanocarriers, theranostic agents and gene vectors; in the pharmaceutical research and innovation area as well as in other healthcare applications. Although tremendous advancements have been made in dendrimer chemistry and their applications since their emergence, the synthesis, development and design of pure and safe dendrimer-based products have been a major challenge in this area. This book, edited by well-known researchers in the area of nanomaterials and drug-based drug delivery applications, exhaustively covers the nanotechnological aspects, concepts, properties, characterisation, application, biofate and regulatory aspects of dendrimers. It includes sixteen vivid chapters by renowned formulators, researchers and academicians from all over the world, highlighting their specialised areas of interest in the fields of chemistry, biology, pharmacy and nanomedicine. Features: • Highlights dendrimers’ advancements in nanomedicine in the development of safe healthcare and biotechnological products • Covers physicochemical aspects, biofate, drug delivery aspects and gene therapy using dendrimers • Covers biomedical application of dendrimers in the field of biological sciences • Gives examples of dendrimer–guest interaction chemistry Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives provides the comprehensive overview of the latest research efforts in designing, optimising, development and scale-up of dendrimer-mediated delivery systems. It analyses the key challenges of synthesis, design, molecular modelling, fundamental concepts, drug delivery aspects, analytical tools and biological fate as well as regulatory consideration to the practical use of dendrimer application. Dr. Neelesh Kumar Mehra Assistant Professor of Pharmaceutics in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He has authored more than sixty peer-reviewed publications in highly reputed international journals, as well as book chapters and contributions on two patents. Dr. Mehra has 11 years of rich research and teaching experience in the formulation and development of complex, innovative biopharmaceutical products including micro- and nanotechnologies for regulated markets. Dr. Keerti Jain Assistant Professor of Pharmaceutics in the Department of Pharmaceutics, NIPER, Raebareli, India. For more than 10 years, she has been actively engaged in formulation and development of nanomedicines. Dr. Jain has supervised masters and doctoral pharmaceutics students in their research works which have been published in high quality, good impact factor journals. She has also authored more than 60 international manuscripts in peer reviewed high impact journals. In 2019, she was awarded the prestigious ICMR-Amir Shakuntala Award.

Dendrimers in Medicine and Biotechnology

Dendrimers in Medicine and Biotechnology Book
Author : U Boas,J B Christensen,P M H Heegaard
Publisher : Royal Society of Chemistry
Release : 2007-10-31
ISBN : 1847552676
Language : En, Es, Fr & De

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Book Description :

Dendrimers are a new class of macromolecule increasingly used in the fields of synthetic organic chemistry, biology, medicine and biotechnology. Dendrimers in Medicine and Biotechnology: New Molecular Tools looks at this exciting and rapidly growing area of science. Using an interdisciplinary approach with particular emphasis on biological applications, the book discusses the relationship between the dendrimer molecular motif and its biological properties. A general introduction to the subject of dendrimers, including definitions of terms and symbols, is provided. Subsequent sections discuss topics including dendrimers in biological systems, dendrimers as drug delivery devices, dendrimers in diagnostics and dendrimer drugs. Throughout the book examples from current research are also provided. This book will appeal to a wide range of scientists, including non specialists who require an introduction to dendrimers, as well as those wishing to know more about the application of dendrimers in the field of biology and medicine.

Polysaccharides in Medicinal and Pharmaceutical Applications

Polysaccharides in Medicinal and Pharmaceutical Applications Book
Author : Valentin Popa
Publisher : Smithers Rapra
Release : 2011-06-30
ISBN : 1847354386
Language : En, Es, Fr & De

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Book Description :

Polysaccharides in Medicinal and Pharmaceutical Applications presents new and specific aspects in the field of polysaccharides and their derivatives recommended for use in medicine and pharmacy. At the same time the aspects developed in this book will be useful to designing new systems for drugs delivery, immunomodulation, and new materials based on polysaccharides isolated from different sources and their derivatives.

Dendrimers

Dendrimers Book
Author : Claudia Maria Simonescu
Publisher : BoD – Books on Demand
Release : 2018-04-25
ISBN : 1789230586
Language : En, Es, Fr & De

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Book Description :

Dendrimers are defined as nanoscale macromolecules having a particular architecture consisting of treelike arms or branches. They are characterized by special properties that make them promising candidates in medicine, biology, materials science, synthetic organic chemistry, biotechnology, environmental engineering, optics, electronics, catalysis, electrochemistry, photochemistry, and sensors and even for production of cosmetics and personal care products. The dendrimers research field is growing day by day, and scientists are exploring new synthesis and functionalization methods in order to improve and to determine new properties and thus new applications. The main purpose of this book is to highlight the issues regarding properties and applications of dendrimers in the field of biology, medicine, liquid crystal devices, electronics, quantum devices, and self-healing technology.

Dendrimers in Medical Science

Dendrimers in Medical Science Book
Author : Zahoor Ahmad Parry,Rajesh Pandey
Publisher : CRC Press
Release : 2017-05-25
ISBN : 1315341786
Language : En, Es, Fr & De

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Book Description :

This valuable new book offers a new perspective on dendrimers that bridges the gap between basic research and applied nanomedicine. It explores the ultimate effectiveness of dendrimers in theranostics, a promising field that combines therapeutics and diagnostics into single multifunctional formulations used to affect therapy or treatment of a disease state. The authors examine the potential uses of dendrimers, which have proven their capabilities in local/systemic drug delivery, physical stabilization of the drug, solubility enhancement of the poorly soluble drugs, and gene delivery.

Dendrimers and Other Dendritic Polymers

Dendrimers and Other Dendritic Polymers Book
Author : Jean M. J. Fréchet,Donald A. Tomalia
Publisher : John Wiley & Sons
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

With contributions from many of the world's leading scientists in the field of dendritic research and development, Dendrimers and Other Dendritic Polymers provides a comprehensive review of this rapidly expanding and exciting new field of polymer science. Of interest to academia and industry alike, this book covers the synthesis, characterization, unique properties, potential for novel applications and technical challenges associated with these polymers. * Detailed coverage of all known subclasses of dendritic polymers, including their properties and synthesis * Insight into the potential commercial applications of dendritic polymers, including drug delivery, cancer therapy, coatings and adhesives * Identification of the key trends and perspectives in dendrimer research * Essential reference for polymer chemists, materials scientists and plastics engineers working in academia and industry alike

Handbook of Polymers for Pharmaceutical Technologies Processing and Applications

Handbook of Polymers for Pharmaceutical Technologies  Processing and Applications Book
Author : Vijay Kumar Thakur,Manju Kumari Thakur
Publisher : John Wiley & Sons
Release : 2015-08-04
ISBN : 1119041392
Language : En, Es, Fr & De

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Book Description :

Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers

Polymeric Biomaterials

Polymeric Biomaterials Book
Author : Severian Dumitriu,Valentin I. Popa
Publisher : CRC Press
Release : 2013
ISBN : 1420094688
Language : En, Es, Fr & De

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Book Description :

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. This volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, contains 28 authoritative chapters written by experts from around the world. Contributors cover the following topics: Processing polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for use in various applications in the medical and pharmaceutical arenas Use of biomaterials to address medical issues such as pulmonary disease, cancer, heart disease, tissue damage, and bone disease Applications including a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials and the most up-to-date applications of biomaterials in medicine.

Biomedical Applications of Peptide Glyco and Glycopeptide Dendrimers and Analogous Dendrimeric Structures

Biomedical Applications of Peptide   Glyco  and Glycopeptide Dendrimers  and Analogous Dendrimeric Structures Book
Author : Jaroslav Sebestik,Milan Reinis,Jan Jezek
Publisher : Springer Science & Business Media
Release : 2012-12-13
ISBN : 3709112060
Language : En, Es, Fr & De

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Book Description :

Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.

Handbook of Polymers for Pharmaceutical Technologies Bioactive and Compatible Synthetic Hybrid Polymers

Handbook of Polymers for Pharmaceutical Technologies  Bioactive and Compatible Synthetic   Hybrid Polymers Book
Author : Vijay Kumar Thakur,Manju Kumari Thakur
Publisher : John Wiley & Sons
Release : 2015-10-20
ISBN : 1119041538
Language : En, Es, Fr & De

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Book Description :

Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers

Polymers in Regenerative Medicine

Polymers in Regenerative Medicine Book
Author : Manuel Monleon Pradas,Maria J. Vicent
Publisher : John Wiley & Sons
Release : 2015-02-02
ISBN : 1118905814
Language : En, Es, Fr & De

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Book Description :

Biomedical applications of Polymers from Scaffolds toNanostructures The ability of polymers to span wide ranges of mechanicalproperties and morph into desired shapes makes them useful for avariety of applications, including scaffolds, self-assemblingmaterials, and nanomedicines. With an interdisciplinary list ofsubjects and contributors, this book overviews the biomedicalapplications of polymers and focuses on the aspect of regenerativemedicine. Chapters also cover fundamentals, theories, and tools forscientists to apply polymers in the following ways: Matrix protein interactions with synthetic surfaces Methods and materials for cell scaffolds Complex cell-materials microenvironments in bioreactors Polymer therapeutics as nano-sized medicines for tissuerepair Functionalized mesoporous materials for controlleddelivery Nucleic acid delivery nanocarriers Concepts include macro and nano requirements for polymers aswell as future perspectives, trends, and challenges in the field.From self-assembling peptides to self-curing systems, this bookpresents the full therapeutic potential of novel polymeric systemsand topics that are in the leading edge of technology.

Multifunctional Pharmaceutical Nanocarriers

Multifunctional Pharmaceutical Nanocarriers Book
Author : Vladimir Torchilin
Publisher : Springer Science & Business Media
Release : 2008-03-21
ISBN : 0387765549
Language : En, Es, Fr & De

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Book Description :

The editors have brought together leading experts in multifunctional nanopharmaceuticals to provide cutting edge information; a critical overview of the field; and analysis of current and potential future developments to speed the subject’s rapid development.

Dendrimers in Biomedical Applications

Dendrimers in Biomedical Applications Book
Author : Barbara Klajnert,Ling Peng,Valentin Cena
Publisher : Royal Society of Chemistry
Release : 2013
ISBN : 1849736111
Language : En, Es, Fr & De

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Book Description :

Dendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agents, drug delivery systems, nucleic acid and RNA delivery vectors and to produce hybrid fibre platforms for nantechnology. Following the work of COST action TD0802, the main objective of which is to improve existing therapies and find new drugs based on dendrimers, the book will provide comprehensive coverage of dendrimer applications. Coverage includes modelling and molecular dynamic studies of dendrimers and dendrons, anionic dendrimer polymers, cationic carbosilane dendrimers and self-assembled multivalent dendrimers. Providing clear indications for future research and applications, this text will appeal to chemists, biologists and materials scientists, working in both academia and industry.

Pharmaceutical Applications of Polymers for Drug Delivery

Pharmaceutical Applications of Polymers for Drug Delivery Book
Author : David Jones
Publisher : iSmithers Rapra Publishing
Release : 2004
ISBN : 9781859574799
Language : En, Es, Fr & De

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Book Description :

Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.