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Pesticide Biotransformation And Disposition

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Pesticide Biotransformation and Disposition

Pesticide Biotransformation and Disposition Book
Author : Ernest Hodgson
Publisher : Academic Press
Release : 2012-01-01
ISBN : 0123854822
Language : En, Es, Fr & De

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Book Description :

Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations

Intentional Human Dosing Studies for EPA Regulatory Purposes

Intentional Human Dosing Studies for EPA Regulatory Purposes Book
Author : National Research Council,Policy and Global Affairs,Science, Technology, and Law Program,Committee on the Use of Third Party Toxicity Research with Human Research Participants
Publisher : National Academies Press
Release : 2004-06-04
ISBN : 0309166411
Language : En, Es, Fr & De

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Book Description :

The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Hayes Handbook of Pesticide Toxicology

Hayes  Handbook of Pesticide Toxicology Book
Author : Anonim
Publisher : Academic Press
Release : 2010-02-15
ISBN : 0080922015
Language : En, Es, Fr & De

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Book Description :

The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated 3e carries on the book’s tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.

Trends and Applications in Information Systems and Technologies

Trends and Applications in Information Systems and Technologies Book
Author : Álvaro Rocha,Hojjat Adeli,Gintautas Dzemyda,Fernando Moreira,Ana Maria Ramalho Correia
Publisher : Springer Nature
Release : 2021-03-28
ISBN : 3030726517
Language : En, Es, Fr & De

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Book Description :

This book is composed of a selection of articles from The 2021 World Conference on Information Systems and Technologies (WorldCIST'21), held online between 30 and 31 of March and 1 and 2 of April 2021 at Hangra de Heroismo, Terceira Island, Azores, Portugal. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern information systems and technologies research, together with their technological development and applications. The main topics covered are: A) Information and Knowledge Management; B) Organizational Models and Information Systems; C) Software and Systems Modeling; D) Software Systems, Architectures, Applications and Tools; E) Multimedia Systems and Applications; F) Computer Networks, Mobility and Pervasive Systems; G) Intelligent and Decision Support Systems; H) Big Data Analytics and Applications; I) Human–Computer Interaction; J) Ethics, Computers & Security; K) Health Informatics; L) Information Technologies in Education; M) Information Technologies in Radiocommunications; N) Technologies for Biomedical Applications.

Comprehensive Toxicology

Comprehensive Toxicology Book
Author : Anonim
Publisher : Elsevier
Release : 2017-12-01
ISBN : 0081006128
Language : En, Es, Fr & De

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Book Description :

Comprehensive Toxicology, Third Edition, discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Toxicology Research Projects Directory

Toxicology Research Projects Directory Book
Author : Anonim
Publisher : Unknown
Release : 1980-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Toxicology Research Projects Directory book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Recognition and Management of Pesticide Poisonings

Recognition and Management of Pesticide Poisonings Book
Author : Donald P. Morgan
Publisher : DIANE Publishing
Release : 1989-06
ISBN : 0788131761
Language : En, Es, Fr & De

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Book Description :

Designed as guidance for emergency management, this manual deals almost entirely with short-term (acute) harmful effects of pesticides. Included is information on the health hazards of pesticides currently in use, along with current consensus recommendations for management of poisonings and injuries caused by them. Formatted for quick reference by through indexing, the book addresses poisoning by insecticides, pesticides, herbicides, fungicides, rodenticides, fumigants, and other solvents, acaricides, repellents, and adjuvants. Indexed by symptoms and signs and by chemical and product names. Illustrated.

Pharmacokinetics and Toxicokinetic Considerations Vol II

Pharmacokinetics and Toxicokinetic Considerations   Vol II Book
Author : Rakesh Kumar Tekade
Publisher : Academic Press
Release : 2022-02-17
ISBN : 0323913164
Language : En, Es, Fr & De

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Book Description :

Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. Allows readers to systematically integrate up-to-date research findings into their laboratory work Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment Provides clinical applications of concepts

Bionanotechnology in Cancer

Bionanotechnology in Cancer Book
Author : D. Sakthi Kumar,Aswathy Ravindran Girija
Publisher : CRC Press
Release : 2022-10-27
ISBN : 0429750404
Language : En, Es, Fr & De

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Book Description :

The cancer research world is looking forward to bionanotechnology to find the best solutions for a complete cure from cancer, which is not possible with the current established treatment methods. The past decade of research on nano imaging and drug delivery in cancer has witnessed many interesting papers and reviews, but there has not been a concise resource that discusses all fields related to nano cancer research in diagnosis and drug delivery. This book fills this gap and presents the latest bionano research in cancer, focusing on nanodiagnostics and nanotherapy. The book is organized into two sections. The section on nanodiagnostics focuses on topics such as diagnostic methods in cancer-related therapy and use of radiolabeled nanoparticles, magnetic nanoparticles, acoustically reflective nanoparticles, X-ray computed tomography, and optical nanoprobes for diagnosis. The section on nanotherapy focuses on nanomaterials in chemotherapy, magnetic nanoparticles for hyperthermia against cancer, phototherapy, nanotechnology-mediated radiation therapy, nanoparticle-mediated small-RNA deliveries for molecular therapies, and theranostics. The book will serve as the gateway to enter the beautiful and elegant field of bionanoscience, which is considered the last hope for the fight against cancer and will be a highly useful resource for the students, researchers, teachers, and curious readers working in this field or related fields.

Environmental Health Perspectives

Environmental Health Perspectives Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Environmental Health Perspectives book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Topics on Drug Metabolism

Topics on Drug Metabolism Book
Author : James Paxton
Publisher : BoD – Books on Demand
Release : 2012-02-22
ISBN : 9535100998
Language : En, Es, Fr & De

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Book Description :

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Pesticides in the Diets of Infants and Children

Pesticides in the Diets of Infants and Children Book
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Pesticides in the Diets of Infants and Children
Publisher : National Academies Press
Release : 1993-02-01
ISBN : 0309048753
Language : En, Es, Fr & De

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Book Description :

Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.

Recognition and Management of Pesticide Poisonings 5th Ed

Recognition and Management of Pesticide Poisonings  5th Ed    Book
Author : J. Routt Reigart
Publisher : DIANE Publishing
Release : 2009-06
ISBN : 1437914527
Language : En, Es, Fr & De

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Book Description :

This 5th ed. is an update and expansion of the 1989 4th ed. This EPA manual provides health professionals with information on the health hazards of pesticides currently in use, and current consensus recommendations for management of poisonings and injuries caused by them. As with previous updates, this new ed. incorporates new pesticide products that are not necessarily widely known among health professionals. Contents: (1) General Information: Introduction; General Principles in the Management of Acute Pesticide Poisonings; Environmental and Occupational History; (2) Insecticides; (3) Herbicides; (4) Other Pesticides; (5) Index of Signs and Symptoms; Index of Pesticide Products. Charts and tables.

Toxicology Research Projects Directory

Toxicology Research Projects Directory Book
Author : Anonim
Publisher : Unknown
Release : 1977
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

An indexed directory of current research project abstracts in toxicology and related fields.

Environmental Toxicology

Environmental Toxicology Book
Author : T.W. Moon,T.P. Mommsen
Publisher : Elsevier
Release : 2005-02-19
ISBN : 9780080458731
Language : En, Es, Fr & De

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Book Description :

This sixth volume in this established series deals with the biochemical responses of fish to different environmental/ecological factors. Environmental Toxicology captures vital issues affecting the responses of fish to the chemical surroundings of their environment. Chapters included in this volume identify the systems found in fish to deal with xenobiotics, hormonal interactions initiated in the presence of these chemicals, the unique mechanisms used by fish to adjust to the present chemicals, and the new and evolving mixtures of chemicals in their environment. Also included, is a crucial review of the new methods being applied in fish systems to understand the effects of xenobiotics to fish fitness - a key theme in environmental health and critical to the future of fish populations. * Entirely new topic discussion and most recent volume in the acclaimed series * Includes chapters detailed on a cellular level * Introduces discussion of pharmaceutical effects on fish

WHO Guidelines for Indoor Air Quality

WHO Guidelines for Indoor Air Quality Book
Author : World Health Organization
Publisher : World Health Organization
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

The Toxicology of Fishes

The Toxicology of Fishes Book
Author : Richard T. Di Giulio,David E. Hinton
Publisher : CRC Press
Release : 2008-02-25
ISBN : 9780203647295
Language : En, Es, Fr & De

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Book Description :

When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on these organisms has been widely available, until now. Filling this void, The Toxicology of Fishes, written by recognized experts, covers toxic responses ranging from reduced reproduction and/or abnormal development, growth, and differentiation. General Principles — Discusses fundamental topics such as the bioavailability of chemicals present in the aquatic environment to fishes, processes governing chemical distribution within these organisms, how fish metabolize organic chemicals, and fundamental mechanisms of chemical toxicity Key Target Systems and Organismal Effects — Describes key target organ systems for chemical impacts in fish, how chemicals produce cancer in these animals, and how fishes can develop resistance to chemical toxicity Methodologies and Applications — Dovers methods for the assessment of chemical effects on fish such as toxicity tests, biomarkers, simulated ecosystems, and modeling approaches and the use of data from such studies in ecological risk assessments Case Studies — Provides examples of how the principles and approaches presented in earlier units are actually deployed in studies Illustrated by case studies of actual, large-scale field investigations, the book reviews the tools used to assess unwanted effects in laboratory model- and wild fish in detail. With 238 illustrations, 70 tables, and 50 equations, this comprehensive monograph presents detailed information on the boiavailability of chemical pollutants, their distribution, metabolism, and excretion in the host fish and mechanisms and sites of toxic responses.

Comprehensive Glossary of Terms Used in Toxicology

Comprehensive Glossary of Terms Used in Toxicology Book
Author : John Duffus,Douglas M Templeton,Michael Schwenk
Publisher : Royal Society of Chemistry
Release : 2017-07-14
ISBN : 1782621377
Language : En, Es, Fr & De

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Book Description :

This glossary addresses the need for harmonised toxicology terminology. Fully comprehensive and rigorously reviewed by IUPAC Committees, it serves as the reference glossary for students and researchers in toxicology, and those involved in chemicals legislation, regulation and risk assessment. Toxicology uses terminology from chemistry, medicine, geology, botany, zoology, ecology, and veterinary medicine, as well as some legal terms. Toxicology has become crucial to global trade in chemicals as legislation is increasingly co-ordinated around the world and is based on the classification of toxicity. Consistent terminology is crucial for effective legislation and trade in the modern world.

Pesticide Toxicology and International Regulation

Pesticide Toxicology and International Regulation Book
Author : Timothy T. Marrs,Bryan Ballantyne
Publisher : John Wiley & Sons
Release : 2004-02-13
ISBN : 9780471496441
Language : En, Es, Fr & De

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Book Description :

This book brings together key features of the toxicology and occupational hazards of pesticides and the way their use is regulated in the main trading regions of the world. There are chapters on each of the main groups of insecticides, namely organochlorines, anticholinesterases and pyrethrins and pyrethroids. The book also covers fungicides and herbicides, as well as more specialised agents such as microbial pesticides. The risks and hazards to humans are considered, both occupational and through the consumption of contaminated foodstuffs. Additionally, clinical aspects of pesticide poisoning are discussed. The possibility of harm from pesticide exposure has led to the development of national and international regulations governing the application of pesticides. The book describes the regulatory systems in three major economic areas: the North American Free Trade Area (USA, Canada and Mexico), the European Union and Japan. This book should be of interest to all individuals working on the development and application of pesticides anywhere in the world. All those involved in the manufacture, regulation and toxicology of pesticides should also benefit from reading this book.