Personalizing Asthma Management For The Clinician

Book Description :

Personalized medicine is a rapidly emerging area in health care, and asthma management lends itself particularly well to this new development. This practical resource by Dr. Stanley J. Szefler helps you navigate the many asthma medication options available to your patients, as well as providing insights into those which may be introduced within the next several years. Features a wealth of information on available asthma medications, including new immunomodulators, new responses to treatment, and new treatment strategies at all levels of asthma care. Prepares you to meet your patients’ needs regarding asthma exacerbation prevention and asthma prevention. Consolidates today’s available information and guidance in this timely area into one convenient resource.

Book Description :

Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease "phenotype" and "endotype," which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.

Book Description :

This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients’ symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff.

Book Description :

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice. Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease

Book Description :

This well-illustrated book synthesizes all aspects of allergy, asthma, and related fields such as aerobiology and immunology. Appropriate for allergy practitioners and medical students seeking the latest information on allergy and asthma, it covers aeroallergens and their source plants all over the world.The book focuses on allergies caused by pollen and environmental pollution as well as skin disorders stemming from latex allergies. It contains the latest methods of diagnosis and treatment of allergy and asthma releveant to applied clinical immunology.

Book Description :

Enormous progress in asthma research has been made in the past 50 years, including a greater understanding of its complex pathogenesis and new and more effective therapies. Consequently, the scientific literature has grown vast and can be difficult to integrate. With contributions from a distinguished panel of world-renowned authors, Clinical Asthm

Book Description :

As the series title implies each Clinician’s Desk Reference is a practical resource and a daily aid for physicians in the hospital setting and in primary care. Asthma is one of the most important chronic disorders in the developed world. Evidence from around the world shows the prevalence of asthma has increased considerably since 1975, and now affects around 7.2% of the world population (about 100 million individuals). In the UK asthma is now the most common chronic disease affecting all age groups with approximately 11% of the population being diagnosed as having asthma at some time in their lives. Understanding of the basic mechanisms involved in the pathogenesis of asthma has improved dramatically over the past 20 years. Along with this increase in basic scientific knowledge, randomized clinical trials have produced evidence to guide clinicians in how to manage patients with asthma. The book covers epidemiology, diagnosis and management, and takes a look at future developments. The authors highlight the under diagnosis of occupational asthma and emphasize the importance of effective patient education, particularly asthma action plans. There are ten clinical cases dealing with common diagnostic and management problems, frequently asked questions and appendices containing resources for patients and clinicians including useful websites, information leaflets and major references.

Book Description :

This book provides an insightful and analytical look at several aspects related to asthma. Written by experts in the field, chapters cover such topics as asthma phenotypes and current biological treatments, anaphylactic reactions in radiology procedures, asthma and COVID-19, mobile apps for both patients and providers, the function of non-coding RNAs in asthma mediated by Th2 cells, and the roles of B7 and semaphorin molecules. The book provides readers the information they need to get a clear understanding of asthma, its phenotypes, treatment biologics, COVID-19 effects, digital care frameworks, epigenetics, and costimulators/immune checkpoints.

Book Description :

Asthma, chronic pulmonary disease, is one of the major health issues in the United States. Given its chronic nature, the demand for continuous monitoring of patient's adherence to the medication care plan, assessment of their environment triggers, and management of asthma control level can be challenging in traditional clinical settings and taxing on clinical professionals. A shift from a reactive to a proactive asthma care can improve health outcomes and reduce expenses. On the technology spectrum, smart conversational systems and Internet-of-Things (IoTs) are rapidly gaining popularity in the healthcare industry. By leveraging such technological prevalence, it is feasible to design a system that is capable of monitoring asthmatic patients for a prolonged period and empowering them to manage their health better.In this thesis, we describe kBot, a knowledge-driven personalized chatbot system designed to continuously track medication adherence of pediatric asthmatic patients (age 8 to 15) and monitor relevant health and environmental data. The outcome is to help asthma patients self manage their asthma progression by generating trigger alerts and educate them with various self-management strategies. kBOT takes the form of an Android application with a frontend chat interface capable of conversing both text and voice-based conversations and a backend cloud-based server application that handles data collection, processing, and dialogue management. The domain knowledge component is pieced together from the Asthma and Allergy Foundation of America, Mayoclinic, and Verywell Health as well as our clinical collaborator. Whereas, the personalization aspect is derived from the patient's history of asthma collected from the questionnaires and day-to-day conversations. The system has been evaluated by eight asthma clinicians and eight computer science researchers for chatbot quality, technology acceptance, and system usability. kBOT achieved an overall technology acceptance score of greater than 8 on an 11-point Likert scale and a mean System Usability Score (SUS) greater than 80 from both evaluation groups.

Book Description :

Download Novel Advances in Allergy Diagnosis and Treatment book written by Simon Blank,Christiane Hilger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

Collaboratively authored by international experts and innovators, this book serves as a comprehensive introduction to flexible bronchoscopy in children, a guide to normal and abnormal bronchoscopy findings, and as the first pediatric bronchoscopy text to describe the array of innovative technologies now being utilized in advanced diagnostic and interventional bronchoscopy programs. Flexible bronchoscopy is a core clinical service provided by academic pediatric pulmonary medicine programs and a critical skill that trainees are expected to develop. The role of flexible bronchoscopy in the care of children with disorders of the respiratory tract has evolved rapidly over the past decade due to technological advances in diagnostic and therapeutic instruments. While many of these tools were designed for adult patients, pediatric pulmonologists have adapted them to meet the unique needs of children. The book is organized into three sections: the history and fundamentals of flexible bronchoscopy; the role of flexible bronchoscopy in evaluation of pediatric respiratory tract disorders; and advanced diagnostic and interventional bronchoscopy. Throughout, images and videos enhance the text and provide invaluable perspective. This is an ideal guide for practicing pediatric pulmonologists and trainees, and will also prove useful to pediatric anesthesiologists, intensivists, otolaryngologists and respiratory therapists.

Book Description :

This issue of Clinics in Chest Medicine, edited by Dr. Serpil Erzurum and Dr. Sumita Khatri, is devoted to several key areas of interest related to understanding Asthma and its treatments. Topics covered in this issue include: Epidemiology of the Asthma Epidemic in the 21st Century; Classification of Asthma; Genetics and Epigenetics of Asthma; Pro-Inflammatory Pathways in the Pathogenesis of Asthma; Dysfunction of Bronchomotor Tone Pathways in Asthmatic Airway Smooth Muscle; Systematic Approach to Asthma of Varying Severity; Comorbidities and Non-allergic Triggers in Asthma Exacerbations and Severity; Microbiome in Mechanisms of Asthma; Diet and Metabolism in the Evolution of Asthma and Obesity; The Exposome of Asthma; Life Cycle of Childhood Asthma; Asthma over the Adult Lifecourse, considering Gender and Hormonal Influences; Asthma and Corticosteroid Responses in Childhood and Adult Asthma; Immunomodulators and Biologics; Bronchial Thermoplasty; Population Health Models for Asthma; and The Future of Asthma Care: Personalized Asthma Treatment.

Book Description :

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

Book Description :

Master the role and skills of the medical-surgical nurse in Canada with the book that has it all! Lewis's Medical-Surgical Nursing in Canada: Assessment and Management of Clinical Problems, 5th Edition reflects the expertise of nurses from across Canada with evidence-informed guidelines, a focus on clinical trends, and a review of pathophysiology. Clear examples make it easy to understand every concept in nursing care — from health promotion to acute intervention to ambulatory care. An Evolve website includes new case studies to enhance your skills in clinical judgement and prepare you for the Next Generation NCLEX®, CPNRE®, and REx-PNTM. From Canadian educators Jane Tyerman and Shelley L. Cobbett, this comprehensive guide provides a solid foundation in perioperative care as well as nursing care of disorders by body system. Easy-to-understand content is written and reviewed by leading experts in the field, ensuring that information is comprehensive, current, and clinically accurate. More than 800 full-colour illustrations and photographs demonstrate disease processes and related anatomy and physiology. Focus on key areas includes the determinants of health, patient and caregiver teaching, age-related considerations, collaborative care, cultural considerations, nutrition, home care, evidence-informed practice, and patient safety. Nursing Assessment chapters focus on individual body systems and include a brief review of related anatomy and physiology, a discussion of health history and non-invasive physical assessment skills, and note common diagnostic studies, expected results, and related nursing responsibilities. Unfolding case studies in each assessment chapter help you apply important concepts and procedures to real-life patient care. UNIQUE! Levels of Care approach organizes nursing management into three levels: health promotion, acute intervention, and ambulatory and home care. Nursing Management chapters focus on the pathophysiology, clinical manifestations, laboratory and diagnostic study results, interprofessional care, and nursing management of various diseases and disorders, and are organized to follow the steps of the nursing process (assessment, nursing diagnoses, planning, implementation, and evaluation). Safety Alerts and Drug Alerts highlight important safety issues in patient care. Informatics boxes discuss the importance and use of technology with topics such as use of social media in the context of patient privacy, teaching patients to manage self-care using smartphone apps, and using Smart infusion pumps. Cultural Competence and Health Equity in Nursing Care chapter discusses culture as a determinant of health, especially in regard to Indigenous populations; health equity and health equality issues as they relate to marginalized groups in Canada; and practical suggestions for developing cultural competence in nursing care. More than 60 comprehensive nursing care plans on the Evolve website include defining characteristics, expected outcomes, specific nursing interventions with rationales, evaluation criteria, and collaborative problems.

Book Description :

Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Book Description :

This handbook gives a systematic account of the main respiratory diseases in adults, covering assessment, diagnosis and nursing management. It highlights the multiple needs of respiratory patients - not only the physical requirements but also psychosocial needs, including palliative care and end of life issues.

Book Description :

Semantic Models in IoT and eHealth Applications explores the key role of semantic web modeling in eHealth technologies, including remote monitoring, mobile health, cloud data and biomedical ontologies. The book explores different challenges and issues through the lens of various case studies of healthcare systems currently adopting these technologies. Chapters introduce the concepts of semantic interoperability within a healthcare model setting and explore how semantic representation is key to classifying, analyzing and understanding the massive amounts of biomedical data being generated by connected medical devices. Continuous health monitoring is a strong solution which can provide eHealth services to a community through the use of IoT-based devices that collect sensor data for efficient health diagnosis, monitoring and treatment. All of this collected data needs to be represented in the form of ontologies which are considered the cornerstone of the Semantic Web for knowledge sharing, information integration and information extraction. Presents comprehensive coverage of advances in the application of semantic web in the field of eHealth Explores different challenges and issues through various case studies of healthcare systems that are adopting semantic web technologies Covers applications across a range of eHealth technologies, including remote monitoring and mobile health

Book Description :

Globally, severe asthma is defined by the WHO as either (A) untreated severe asthma; (B) difficult-to-treat severe asthma; and (C) treatment-resistant severe asthma. Untreated severe asthma is a political problem: the children do not have access to the basic tools for asthma management, and when this is corrected, asthma outcomes are transformed. The problem in difficult-to-treat severe asthma is not the airway disease, but co-morbidities and behavioral factors. This is the group in which there are most asthma deaths, underscoring that severe asthma cannot be solely defined by levels of prescribed therapy. Treatment-resistant severe asthma is rare and challenging, and the problem is the airway pathology. These children require new and innovative therapies.

Book Description :

This unique new text delivers practical guidelines on diagnosing and treating patients with asthma. Drs. Castro and Kraft are extensively involved in asthma research and improved patient care, and their comprehensive coverage of key challenges in diagnosing and treating asthma makes this a must have resource. The organized full-color format ensures readability, and helps you find information quickly and easily. Offers up-to-date protocols and management guidelines to help you provide the best care for your patients. Presents chapters on special situations and special populations to help you overcome clinical challenges such as the difficult-to-control or pregnant asthma patient. Provides specialized sections on asthma education to give guidance on leading your patients to better self management by improving their adherence to treatment guidelines. Highlights material found on the Asthma Educator Certification exam in special “education boxes. Offers expert guidance on translating the new NIH EPR-3 Asthma Guidelines to hands-on patient care. Organized in a consistent chapter format that provides concise, logical coverage of essential information for easy reference. Contains special boxes that highlight clinical pearls, controversial issues, and patient education information. Uses a full-color format that makes it easy to find information quickly.

Book Description :

Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma.