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Personalized And Stratified Therapy In Epilepsy

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Personalized and Stratified Therapy in Epilepsy

Personalized and Stratified Therapy in Epilepsy Book
Author : Sara Eyal,Dana Ekstein
Publisher : Academic Press
Release : 2020-12-15
ISBN : 9780128173466
Language : En, Es, Fr & De

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Book Description :

Personalized Treatment in Epilepsy highlights the individualized- and subgroup-based approaches in diagnosing, treating, and monitoring epilepsy. Whereas the term 'personalized medicine' is used to describe the focus on individual patients, 'stratified medicine' refers to the definition of population subgroups based on estimates of their differences in the etiology and prognosis of epilepsy, or response to treatment. The book describes the various aspects of personalized and stratified approaches in epilepsy, the potential of these approaches to improve the cost-effectiveness of epilepsy treatment, and barriers to their implementation. The book assists clinicians in rationally choosing the required diagnostic and treatment means for their patients, out of the abundance of available technologies and products. By doing so, they will provide better care, mitigating adverse events, expediting the reach of effective treatment, and reducing costs. The target audience is anyone involved in developing and delivering diagnostic means and treatment for people with epilepsy, including epileptologists, other neurologists, neurosurgeons, pharmacists, nurses, technicians, geneticists, researchers Comprehensively describes individualized and stratified treatment approaches in epilepsy Assists clinicians with rationally choosing the required diagnostic and treatment means for their patients Diagnosis, drugs, non-pharmacological treatments, and future research are all discussed in depth

Textbook of Personalized Medicine

Textbook of Personalized Medicine Book
Author : Kewal K. Jain
Publisher : Springer Nature
Release : 2020-12-05
ISBN : 3030620808
Language : En, Es, Fr & De

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Book Description :

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

Integrative Neuroscience and Personalized Medicine

Integrative Neuroscience and Personalized Medicine Book
Author : Evian Gordon,Stephen Koslow, PhD
Publisher : Oxford University Press
Release : 2011
ISBN : 0195393805
Language : En, Es, Fr & De

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Book Description :

This book takes an in depth and hard look at the current status and future direction of treatment predictive markers in Personalized Medicine for the brain from the perspectives of the researchers on the cutting edge and those involved in healthcare implementation. The contents provide a comprehensive text suitable as both a pithy introduction to and a clear summary of the "science to solutions" continuum in this developing field of Personalized Medicine and Integrative Neuroscience. The science includes both measures of genes using whole genome approaches and SNIPS as well as BRAINmarkers of direct brain function such as brain imaging, biophysical changes and objective cognitive and behavioral measurements. Personalized Medicine for Brain Disorders will soon be a reality using the comprehensive quantitative and standardized approaches to genomics, BRAINmarkers and cognitive function. Each chapter provides a review of recent relevant literature; show the solutions achieved through integrative neuroscience and applications in patient care thus providing a practical guide to the reader. The timeliness of this book's content is propitious providing bottom line information to educate practicing clinicians, health care workers and researchers, and also a pathway for undergraduate and graduates interested in further their understanding of and involvement in tailored personal solutions.

Genomic and Personalized Medicine

Genomic and Personalized Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2008-11-11
ISBN : 9780080919034
Language : En, Es, Fr & De

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Book Description :

This two-volume set — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine. Volume One Includes: Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care. Volume Two Includes: Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. Highly Commended 2013 BMA Medical Book Award for Medicine Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.

The Right Therapy for Neurological Disorders

The Right Therapy for Neurological Disorders Book
Author : E. Beghi,G. Logroscino
Publisher : Karger Medical and Scientific Publishers
Release : 2016-07-26
ISBN : 3318058653
Language : En, Es, Fr & De

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Book Description :

Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists, the articles touch on important aspects of RCTs with a clear critical approach, highlighting their limitations as well as giving recommendations for their planning and conducting to address the variable genotypic and phenotypic aspects of neurological conditions. Consideration is also given to combining the clinical impact of the study results with patients’ values and the interests of pharmaceutical companies. Neurologists involved in clinical trials will certainly benefit from this book, which should become a basic text for all neurological courses dealing with evidence-based neurology.

Astrocytes and Epilepsy

Astrocytes and Epilepsy Book
Author : Jacqueline A. Hubbard,Devin K. Binder
Publisher : Academic Press
Release : 2016-07-05
ISBN : 0128026243
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Connectomic Deep Brain Stimulation

Connectomic Deep Brain Stimulation Book
Author : Andreas Horn
Publisher : Academic Press
Release : 2021-09-10
ISBN : 0128218622
Language : En, Es, Fr & De

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Book Description :

Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation

The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder

The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder Book
Author : American Psychiatric Association
Publisher : American Psychiatric Pub
Release : 2018-01-11
ISBN : 0890426821
Language : En, Es, Fr & De

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Book Description :

The guideline focuses specifically on evidence-based pharmacological treatments for AUD in outpatient settings and includes additional information on assessment and treatment planning, which are an integral part of using pharmacotherapy to treat AUD.

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence Book
Author : Michael Mahler
Publisher : Academic Press
Release : 2021-03-12
ISBN : 032385432X
Language : En, Es, Fr & De

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Book Description :

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Essentials of Genomic and Personalized Medicine

Essentials of Genomic and Personalized Medicine Book
Author : Geoffrey S. Ginsburg,Huntington F Willard
Publisher : Academic Press
Release : 2009-10-02
ISBN : 9780080958118
Language : En, Es, Fr & De

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Book Description :

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

The Comorbidities of Epilepsy

The Comorbidities of Epilepsy Book
Author : Marco Mula
Publisher : Academic Press
Release : 2019-04-20
ISBN : 0128148780
Language : En, Es, Fr & De

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Book Description :

Epilepsy is one of most frequent neurological disorders affecting about 50 million people worldwide and 50% of them have at least another medical problem in comorbidity; sometimes this is a the cause of the epilepsy itself or it is due to shared neurobiological links between epilepsy and other medical conditions; other times it is a long-term consequence of the antiepileptic drug treatment. The Comorbidities of Epilepsy offers an up-to-date, comprehensive overview of all comorbidities of epilepsy (somatic, neurological and behavioral), by international authorities in the field of clinical epileptology, with an emphasis on epidemiology, pathophysiology, diagnosis and management. This book includes also a critical appraisal of the methodological aspects and limitations of current research on this field. Pharmacological issues in the management of comorbidities are discussed, providing information on drug dosages, side effects and interactions, in order to enable the reader to manage these patients safely. The Comorbidities of Epilepsy is aimed at all health professionals dealing with people with epilepsy including neurologists, epileptologists, psychiatrists, clinical psychologists, epilepsy specialist nurses and clinical researchers. Provides a comprehensive overview of somatic, neurological and behavioral co-morbidities of epilepsy Discusses up-to-date management of comorbidities of epilepsy Written by a group of international experts in the field

Pharmacogenomics in Precision Medicine

Pharmacogenomics in Precision Medicine Book
Author : Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publisher : Springer
Release : 2021-06-13
ISBN : 9789811538971
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Adherence to Long term Therapies

Adherence to Long term Therapies Book
Author : Organisation mondiale de la santé,World Health Organization
Publisher : World Health Organization
Release : 2003
ISBN : 9789241545990
Language : En, Es, Fr & De

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Book Description :

This report is based on an exhaustive review of the published literature on the definitions, measurements, epidemiology, economics and interventions applied to nine chronic conditions and risk factors.

Clinical Molecular Medicine

Clinical Molecular Medicine Book
Author : Dhavendra Kumar
Publisher : Academic Press
Release : 2019-11-30
ISBN : 0128094427
Language : En, Es, Fr & De

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Book Description :

Clinical Molecular Medicine: Principles and Practice presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular basis of human disease. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances. Illustrates the fundamental principles and therapeutic applications of molecular and cellular biology Offers a clinically focused account of molecular heterogeneity Includes comprehensive coverage of many different disorders, including growth and development, cardiovascular, metabolic, skin, blood, digestive, inflammatory, neuropsychiatric disorders, and many more

The Future of Pharmaceuticals

The Future of Pharmaceuticals Book
Author : Sarfaraz K. Niazi
Publisher : CRC Press
Release : 2022-03-01
ISBN : 1000458164
Language : En, Es, Fr & De

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Book Description :

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

Genomic and Personalized Medicine

Genomic and Personalized Medicine Book
Author : Geoffrey S. Ginsburg,Huntington F Willard, PhD
Publisher : Academic Press
Release : 2012-11-29
ISBN : 0123822270
Language : En, Es, Fr & De

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Book Description :

Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Textbook of Personalized Medicine

Textbook of Personalized Medicine Book
Author : Kewal K. Jain
Publisher : Humana Press
Release : 2015-03-17
ISBN : 1493925539
Language : En, Es, Fr & De

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Book Description :

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Neuroethics

Neuroethics Book
Author : Judy Illes,Sharmin Hossain
Publisher : Oxford University Press
Release : 2017
ISBN : 0198786832
Language : En, Es, Fr & De

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Book Description :

Over the last decade, there have been unparalleled advances in our understanding of brain sciences. In this volume on neuroethics, a distinguished group of contributors from a range of disciplines discuss the ethical implications of this newfound knowledge and set out the many necessary considerations for the future.

Experimental Epilepsy

Experimental Epilepsy Book
Author : Anonim
Publisher : Elsevier
Release : 1965-01-01
ISBN : 9780080861432
Language : En, Es, Fr & De

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Book Description :

Experimental Epilepsy

CPAP Adherence

CPAP Adherence Book
Author : Colin M. Shapiro,Meenakshi Gupta,Dora Zalai
Publisher : Springer Nature
Release : 2022
ISBN : 3030931463
Language : En, Es, Fr & De

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Book Description :

This book presents a broad range of perspectives on the topic of CPAP adherence. This includes theoretical underpinnings of adherence; multi-disciplinary practical approaches as well as special considerations in diverse clinical populations, age groups and cultures by authors from five continents. CPAP Adherence is a novel and highly relevant publication for sleep physicians, psychologists, dentists, respiratory therapists, sleep technicians, family physicians as well as PAP and oral appliance providers. This book will help improve patient care and quality of life.