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Perioperative Medicine for the Junior Clinician

Perioperative Medicine for the Junior Clinician Book
Author : Joel Symons,Paul Myles,Rishi Mehra,Christine Ball
Publisher : John Wiley & Sons
Release : 2015-10-12
ISBN : 1118779169
Language : En, Es, Fr & De

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Book Description :

Perioperative Medicine for the Junior Clinician is the first easy-to-read resource, featuring a digital component, on how to manage a diverse range of patients in the perioperative period, providing up-to-date practical knowledge and advice from a broad range of medical specialists caring for surgical patients. Perioperative Medicine for the Junior Clinician provides a guide to perioperative care, covering principles and practices of care; risk assessment; laboratory investigations; medication management; specific medical conditions and complications; postoperative care and pain management. It also features bite-size videos explaining the key concepts, as well as case studies, investigations and quizzes. Ideal for final year medical students and junior clinicians, this digital and print resource will be an invaluable tool when working in this multidisciplinary, team-based specialty. Perioperative Medicine for the Junior Clinician: Is based on a sell-out course run at the Alfred Hospital and Monash University in Melbourne, Australia Is a practical resource available in a flexible and portable content Features bite-size videos which further explain concepts in the written text, and clinically relevant case studies, all found on the companion website Is structured around guidelines and protocols The video materials, case studies, self-assessment quizzes and fully explained answers can be viewed on the companion website at www.wiley.com/go/perioperativemed

Perioperative Medicine

Perioperative Medicine Book
Author : Amir K. Jaffer,Paul Grant
Publisher : Wiley-Blackwell
Release : 2012-08-28
ISBN : 9780470627518
Language : En, Es, Fr & De

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Book Description :

Provides a comprehensive evidence-based guide to the management of the growing population of patients who require perioperative care Perioperative Medicine: Medical Consultation and Co-Management is the first comprehensive reference text developed specifically for hospitalists but envisioned also to help internists, anesthesiologists, allied health professionals, fellows, residents, and medical students manage various aspects of the medical care of the surgical patient. The book features both the preoperative and postoperative medical management of the surgical patient. It focuses on systems, operations, quality of perioperative care, and preoperative assessment of the patient, all in consideration with system-specific risk and evidence-based strategies that minimize risk. It places special emphasis on care of the older hospitalized surgical patient and offers a thorough discussion of post-operative conditions and their management. Chapters cover vital topics such as: Hospitalist as a Medical Consultant Co-Management of the Surgical Patient Preoperative Evaluation Improving the Quality and Outcomes of Perioperative Care Developing, Implementing, and Operating a Preoperative Clinic Assessing and Managing Risk of Major Organ Systems Assessing and Managing Disorders for Surgery Postoperative Care and Co-Management by Surgery Type Managing Common Postoperative Conditions With the core responsibilities of perioperative care falling more and more on the shoulders of hospitalists, internists, and allied health professionals, Perioperative Medicine is a much-needed guide for managing the clinical and operational issues associated with caring for hospitalized surgical patients.

Perioperative Medicine

Perioperative Medicine Book
Author : Steven L. Cohn
Publisher : Springer Science & Business Media
Release : 2011-06-21
ISBN : 9780857294982
Language : En, Es, Fr & De

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Book Description :

Perioperative Medicine uses a concise, highly practical, bulleted format designed to ensure rapid comprehension of key concepts and reinforce the reader's understanding of complex topics in perioperative medicine. It contains authoritative, up-to-date coverage of the most essential concepts in perioperative care from preoperative risk assessment to postoperative follow-up. The Editor and his contributors use their expert insight and experience to provide an in-depth review of comorbid conditions, patient and surgery-specific risk assessment, and common postoperative complications. This new book reviews recent developments in the field, including published guidelines, and emphasizes an evidence-based, cost-effective approach designed to ensure quality, patient safety, and optimal outcomes. It is intended for use by hospitalists, general internists and subspecialists as well as anesthesiologists, surgeons, and residents in training who are caring for patients before and after surgery.

The Perioperative Medicine Consult Handbook

The Perioperative Medicine Consult Handbook Book
Author : Molly Blackley Jackson,Ronald Huang,Elizabeth Kaplan,Somnath Mookherjee
Publisher : Springer
Release : 2019-08-24
ISBN : 9783030197032
Language : En, Es, Fr & De

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Book Description :

This comprehensive third edition provides robust support to clinicians providing perioperative care for patients. Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This book offers evidence and experience-based information, advice, and guidelines on all aspects of perioperative medicine. Care around surgeries in many major clinical areas are included, including cardiology, pulmonology, gastroenterology, rheumatology, endocrinology, and so on. This new edition has been updated throughout with the latest literature, more visual content (tables and algorithms), and eleven new chapters on topics such as: chronic pain, congestive heart failure, hormone therapy and transgender patients, and postoperative hypoxemia. This new edition focuses on high value care in order to improve outcomes, including minimizing complications and readmissions. It also provides streamlined key points for caring for patients with medical diagnoses that may be especially complicated around surgery. This resource is invaluable for practicing physicians (including medical consultants, surgeons, and anesthesiologists) and other professionals who aim to optimize care of surgical patients.

Perioperative Medicine in Pediatric Anesthesia

Perioperative Medicine in Pediatric Anesthesia Book
Author : Marinella Astuto,Pablo M Ingelmo
Publisher : Springer
Release : 2015-11-09
ISBN : 331921960X
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of current practices in pediatric perioperative care. Current knowledge on vascular and nonvascular access, regional anesthesia, and noninvasive cardiovascular and respiratory monitoring is described. The prevention and treatment of postoperative pain and unsettled behavior after surgery, as well as the long-term consequences of anesthesia and surgery are discussed. Prevention of chronic postsurgical pain and the brain damage that may be associated with anesthesia and surgery are also considered. The opening section is dedicated to patient care prior to surgery and includes preoperative assessment and preparation. Care in the intraoperative period is then described, including the appropriate care when performing surgery in different locations and in various specialties, such as orthopedic surgery, neurosurgery, thoracic surgery, and abdominal and urological surgery. The subsequent section addresses perioperative care in children with special conditions, such as difficult airway, metabolic or neuromuscular diseases, or cancer. The remainder of the book is devoted to a range of further important topics and postoperative care.&nbs p;

Medical Management of the Surgical Patient

Medical Management of the Surgical Patient Book
Author : Michael F. Lubin,Thomas F. Dodson,Neil H. Winawer
Publisher : Cambridge University Press
Release : 2013-08-15
ISBN : 1107009162
Language : En, Es, Fr & De

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Book Description :

Now in its fifth edition, Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine has been fully revised and updated, and continues to provide an authoritative account of the important aspects of perioperative care for surgical patients. Including recommendations for the best appropriate treatment of patients, it provides an evidence-based approach for consulting physicians to care for patients with underlying medical conditions that will affect their surgical management. New information in the medical section includes chapters on performing the medical consult, asthma, and transplantation. The latest minimally invasive surgical techniques are included, with new chapters on thoracic aortic disease, reconstruction after cancer ablation, lung transplantation, esophagomyotomy, vasectomy, and thyroid malignancies, amongst others. With detailed descriptions of nearly 100 operations, highlighting their usual course, as well as their common complications, the book encourages learning from experience. This definitive account includes numerous contributions from leading experts at national centers of excellence. It will continue to serve as a significant reference work for internists, hospitalists, anesthesiologists, and surgeons.

Perioperative Medicine

Perioperative Medicine Book
Author : Mark F. Newman, MD,Lee A Fleisher, MD, FACC,Lee A. Fleisher,Clifford Ko,Michael (Monty) Mythen, MBBS FRCA MD
Publisher : Unknown
Release : 2021-02
ISBN : 9780323567244
Language : En, Es, Fr & De

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Book Description :

Based on the most current evidence and best practices, Perioperative Medicine: Managing for Outcome, 2nd Edition, is an easy-to-follow, authoritative guide to achieving optimal outcomes in perioperative care. Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing decision trees that define strategies to enhance the medical outcome of care. Focuses on what anesthesiologists, surgeons, and intensivists need to know in order to improve outcomes through evidence- and outcome-based approaches. Provides practical guidance on potential risks to all major organ systems, the etiology of particular organ dysfunctions, preoperative and intraoperative risk factors, and perioperative protection strategies to minimize potential complications. Features a consistent chapter format - with even more color-coded algorithms, summary tables, and boxes - that enables you to quickly explore and determine the best management approaches. Includes six all-new chapters: Perioperative Fluid Management; Delirium and POCD; Role of Palliative Care/ICU; Value-Based Care: The UK Model; CFO Perspective on Value; Hospital to Home (Perioperative Transitions of Care) Discusses timely topics such as quality improvement, pay-for-performance, preexisting disease and comorbid conditions in anesthesiology, and the team-based model of care. Features two new editors, surgeon Clifford Ko, MD, and Perioperative Summit leader, Michael (Monty) Mythen, MD. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Perioperative Medicine

Perioperative Medicine Book
Author : Joanna Chikwe,Axel Walther,Philip Jones
Publisher : Oxford Specialist Handbooks
Release : 2009
ISBN : 0199533350
Language : En, Es, Fr & De

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Book Description :

Medical handbooks rarely provide advice on what to do when your patient has to undergo surgery. Similarly surgical handbooks focus on conditions that need surgery, and the main problems caused by that surgery. In contrast, Perioperative Medicine is a concise, practical text that gives junior doctors the guidance that they need to cope with medical problems in surgical patients that might occur early in pre-assessment clinic, the night before surgery, out-of-hours or on the wards post-operatively. It is an invaluable guide to covering surgical patients, and appeals to a wide readership, including junior surgical doctors, medical doctors covering surgical acute admissions, and members of the hospital-at-night teams. It will also appeal to medical students interested in learning more about the practical management of patients, and all those who need to know how to sort out common, important and occasionally life threatening "non-surgical" conditions that frequently happen in surgical patients, such as heart attacks, strokes and asthma. This handbook is an updated version of the handbook published in 2000 in the Oxford Pocket Medicine series, entitled Peri-operative medicine - managing surgical patients with medical problems. This new edition is fully revised and is written as a guide for trainees in surgery (and its sub-disciplines) dealing with day-to-day medical problems arising in surgical patients. It covers all the fundamentals of the medical care of surgical patients, with new sections on surgical oncology, theatre etiquette, and planning lists, with most text rewritten to reflect new headings and recent guidelines.

Decision Making in Perioperative Medicine Clinical Pearls

Decision Making in Perioperative Medicine  Clinical Pearls Book
Author : Steven L. Cohn
Publisher : McGraw Hill Professional
Release : 2021-05-22
ISBN : 1260468119
Language : En, Es, Fr & De

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Book Description :

Minimize risk for every surgery-bound patient with this concise, high-yield clinical reference With new surgical advances and innovations, more older, sicker, higher-risk patients are undergoing surgery. Expertly assessing and managing patients with comorbidities who are undergoing surgical procedures is an absolutely critical task today—and Decision Making in Perioperative Medicine: Clinical Pearls will ensure that you make the right decisions through every step of the process. Which risk calculator should you use? How long should you delay surgery after percutaneous coronary intervention? Should the patient continue taking aspirin? How long before surgery should you stop a direct-acting oral anticoagulant? Decision Making in Perioperative Medicine: Clinical Pearls answers your questions when it comes to perioperative care. Filled with algorithms, tables, and clinical pearls, this practical resource is organized into three sections: Key takeaways on preoperative evaluation, testing, anesthesia, and medication management Expert guidance on evaluating the effect of comorbidities on surgical outcome and providing strategies for medical optimization to minimize risk Review of common postoperative medical complications and treatment Whether you’re a hospitalist, internist, family physician, anesthesiologist, physician assistant, or nurse practitioner, Decision Making in Perioperative Medicine: Clinical Pearls provides the evidence-based information and insights you need to make sure every surgery-bound patient receives the quality of care and management they deserve.

Perioperative Medicine E Book

Perioperative Medicine E Book Book
Author : Mark F. Newman,Lee A Fleisher,Clifford Ko,Michael (Monty) Mythen
Publisher : Elsevier Health Sciences
Release : 2021-02-16
ISBN : 0323567207
Language : En, Es, Fr & De

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Book Description :

Based on the most current evidence and best practices, Perioperative Medicine: Managing for Outcome, 2nd Edition, is an easy-to-follow, authoritative guide to achieving optimal outcomes in perioperative care. Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing decision trees that define strategies to enhance the medical outcome of care. Focuses on what anesthesiologists, surgeons, and intensivists need to know in order to improve outcomes through evidence- and outcome-based approaches. Provides practical guidance on potential risks to all major organ systems, the etiology of particular organ dysfunctions, preoperative and intraoperative risk factors, and perioperative protection strategies to minimize potential complications. Features a consistent chapter format - with even more color-coded algorithms, summary tables, and boxes – that enables you to quickly explore and determine the best management approaches. Includes six all-new chapters: Perioperative Fluid Management; Delirium and POCD; Role of Palliative Care/ICU; Value-Based Care: The UK Model; CFO Perspective on Value; Hospital to Home (Perioperative Transitions of Care) Discusses timely topics such as quality improvement, pay-for-performance, preexisting disease and comorbid conditions in anesthesiology, and the team-based model of care. Features two new editors, surgeon Clifford Ko, MD, and Perioperative Summit leader, Michael (Monty) Mythen, MD.

Perioperative Medicine

Perioperative Medicine Book
Author : Anthony Nicholls,Iain Wilson
Publisher : Oxford University Press, USA
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Many patients undergoing surgery have a chronic medical disorder unrelatedto the surgical problem. These can present major difficulties for inexperiencedsurgical house staff and junior anaesthetists working unsupervised, most of whomwill have had little or no experience in dealing with such problems.Perioperative medicine provides practical guidelines on the management of allthe common medical conditions likely to be encountered in routine surgical andanaesthetic practice. The first section addresses a range of general issues thatcan arise on surgical wards when patients with complex medical problems arebeing prepared for operation, such as obtaining informed consent. The book thenprovides simple protocols for the safe care of patients with underlying medicalproblems on surgical wards, with special focus on the risks that variousconditions pose for surgery and anaesthesia. The third part of the book looks atthe diagnosis and management of medical complications in the post-operativeperiod. References for further reading are provided throughout. This will provean essential book for junior surgeons and anaesthetists to keep by their sidesat all times.

Perioperative Medicine

Perioperative Medicine Book
Author : David R. Goldmann,Frank H. Brown,David M. Guarnieri
Publisher : McGraw-Hill
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A distinguished collaboration of internists, surgeons and anaesthesiologists present a multi-disciplinary, problem-oriented approach to the medical management of the surgical patient. The book's five-part organization allows rapid access to pertinent information regarding pre-operative, intra-operative, and post-operative issues.

Anaesthesia Intensive Care and Perioperative Medicine A Z

Anaesthesia  Intensive Care and Perioperative Medicine A Z Book
Author : Steve Yentis,Nicholas P. Hirsch,James Ip
Publisher : Elsevier
Release : 2018-05-18
ISBN : 9780702071652
Language : En, Es, Fr & De

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Book Description :

For 25 years Anaesthesia, Intensive Care and Perioperative Medicine A-Z has provided a comprehensive resource of the relevant aspects of pharmacology, physiology, anatomy, physics, statistics, medicine, surgery, general anaesthetic practice, intensive care, equipment, and the history of anaesthesia and intensive care. Originally prepared as essential reading for candidates for the Fellowship of the Royal College of Anaesthetists and similar exams, this fully updated edition will also prove as invaluable as ever for all anaesthetists and critical care physicians, as well as operating department practitioners and specialist nurses. The alphabetical arrangement with extensive cross-referencing ensures a full understanding of topics. The succinct and clear text and diagrams?make for easy quick reference. The exam preparation checklist is ordered by key topics to facilitate effective revision. The contents are easily accessible with the accompanying ebook. There has been a substantial addition of new entries as well as revision of existing ones. This acknowledges the breadth of information needed to satisfy the range of activities performed by anaesthetic, intensive care, nursing and other colleagues, and also reflects the ever-changing field in which they all work. The consolidation of the role of anaesthetists as 'perioperative physicians' is reflected in additional entries of particular relevance and also by the enhanced title of the book. The structured 'revision checklist' of entries which is particularly useful to those preparing for examinations has been further developed for this edition.

Perioperative Medicine

Perioperative Medicine Book
Author : Amir K. Jaffer,Paul Grant
Publisher : John Wiley & Sons
Release : 2012-07-25
ISBN : 1118375327
Language : En, Es, Fr & De

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Book Description :

Provides a comprehensive evidence-based guide to the management of the growing population of patients who require perioperative care Perioperative Medicine: Medical Consultation and Co-Management is the first comprehensive reference text developed specifically for hospitalists but envisioned also to help internists, anesthesiologists, allied health professionals, fellows, residents, and medical students manage various aspects of the medical care of the surgical patient. The book features both the preoperative and postoperative medical management of the surgical patient. It focuses on systems, operations, quality of perioperative care, and preoperative assessment of the patient, all in consideration with system-specific risk and evidence-based strategies that minimize risk. It places special emphasis on care of the older hospitalized surgical patient and offers a thorough discussion of post-operative conditions and their management. Chapters cover vital topics such as: Hospitalist as a Medical Consultant Co-Management of the Surgical Patient Preoperative Evaluation Improving the Quality and Outcomes of Perioperative Care Developing, Implementing, and Operating a Preoperative Clinic Assessing and Managing Risk of Major Organ Systems Assessing and Managing Disorders for Surgery Postoperative Care and Co-Management by Surgery Type Managing Common Postoperative Conditions With the core responsibilities of perioperative care falling more and more on the shoulders of hospitalists, internists, and allied health professionals, Perioperative Medicine is a much-needed guide for managing the clinical and operational issues associated with caring for hospitalized surgical patients.

The Perioperative Medicine Consult Handbook

The Perioperative Medicine Consult Handbook Book
Author : Molly Blackley Jackson,Ronald Huang,Elizabeth Kaplan,Somnath Mookherjee
Publisher : Springer Nature
Release : 2019-11-14
ISBN : 3030197042
Language : En, Es, Fr & De

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Book Description :

This comprehensive third edition provides robust support to clinicians providing perioperative care for patients. Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This book offers evidence and experience-based information, advice, and guidelines on all aspects of perioperative medicine. Care around surgeries in many major clinical areas are included, including cardiology, pulmonology, gastroenterology, rheumatology, endocrinology, and so on. This new edition has been updated throughout with the latest literature, more visual content (tables and algorithms), and eleven new chapters on topics such as: chronic pain, congestive heart failure, hormone therapy and transgender patients, and postoperative hypoxemia. This new edition focuses on high value care in order to improve outcomes, including minimizing complications and readmissions. It also provides streamlined key points for caring for patients with medical diagnoses that may be especially complicated around surgery. This resource is invaluable for practicing physicians (including medical consultants, surgeons, and anesthesiologists) and other professionals who aim to optimize care of surgical patients.

Core Topics in Perioperative Medicine

Core Topics in Perioperative Medicine Book
Author : Jonathan Hudsmith,Dan Wheeler,Arun Gupta
Publisher : Cambridge University Press
Release : 2003-01-08
ISBN : 9781841101392
Language : En, Es, Fr & De

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Book Description :

Undergraduate medical education is continuously changing to meet the requirements for the training of future medical practitioners. Over the last few years the concept of perioperative medicine has evolved, encompassing the preoperative assessment and optimisation of patients, the intraoperative and postoperative management of these patients and importantly the diagnosis and treatment of the critically ill patient. The relevance of this to undergraduate medical students is obvious. Core Topics in Perioperative Medicine provides concise, informative chapters on many aspects of perioperative medicine, allowing medical students to bridge the gap between final year clinical attachments in this specialty, and first year house officer jobs. It aims to guide the reader through the perioperative period via short, up-to-date chapters, each giving a comprehensive account of the subject and its relevance to perioperative medicine.

Perioperative Medicine

Perioperative Medicine Book
Author : Mark F. Newman,Lee A. Fleisher,Mitchell P. Fink
Publisher : Elsevier Health Sciences
Release : 2008
ISBN : 1416024565
Language : En, Es, Fr & De

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Book Description :

Recognized authorities in anesthesiology and surgical critical care present you with today's best management approaches for achieving optimal perioperative outcomes. They review the potential risks to all major organ systems by examining the incidence and significance of organ dysfunction...assessing the etiology of particular organ dysfunctions...defining the preoperative and intraoperative risk factors...and offering perioperative protection strategies to minimize potential complications. A consistent chapter format - combined with color-coded algorithms, summary tables and boxes - enable you to quickly locate specific guidance. Top evidence- and outcome-based strategies from leading world authorities enable you to avoid and manage complications. A consistent format allows you to easily and efficiently access the very latest research and clinical practice guidelines. Color-coded algorithms, as well as abundant summary tables and boxes, save you valuable time in locating the best management approaches.

Perioperative Medicine Current Controversies

Perioperative Medicine     Current Controversies Book
Author : Karen Stuart-Smith
Publisher : Springer
Release : 2016-03-08
ISBN : 3319288210
Language : En, Es, Fr & De

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Book Description :

This book addresses those aspects of anaesthetic practice in perioperative medicine which have a significant impact on both the immediate and the long-term outcome for the surgical patient. Perioperative Medicine is the natural evolution of anaesthesia from a main focus on the patient in the operating room to a responsibility for the care of the patient from the time that the decision to operate is made, through to discharge from hospital. The contributors, well-respected authors in their field, discuss the role of the perioperative medicine specialist in areas ranging from pre-operative assessment and physiological optimization via pre-habilitation, to intra-operative anaesthetic management, and post-operative care. Controversial topics discussed include fluid therapy, anaesthesia and cancer outcomes, pharmacological management of cardiac risk, and the evolution of acute to chronic pain. Developments in regional anaesthesia, quality of recovery scoring, and lung ultrasound, are described. It is hoped that the chapters contained in this book will help to define the nascent specialty that is Perioperative Medicine, and encourage further debate, research, and expansion of this vital new frontier in anaesthetic care.

The Perioperative Medicine Consult Handbook

The Perioperative Medicine Consult Handbook Book
Author : Christopher J. Wong,Nason P. Hamlin
Publisher : Springer Science & Business Media
Release : 2012-11-07
ISBN : 1461432200
Language : En, Es, Fr & De

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Book Description :

Patients with a wide range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address the needs of these patients whether pre- or post-surgery. Creating a differential diagnosis, weighing risks and benefits, providing timely treatment--these skills are equally applicable to the internist whether he or she is in an office or in a perioperative setting. The Perioperative Medicine Consult Handbook provides useful information, advice and guidelines based on a combination of clinical experience and evidence-based medicine. It covers topics in many major clinical areas (anesthesiology, cardiology, pulmonology, gastroenterology, rheumatology, endocrinology, and many others ) and puts critical surgery information at a consult physician's fingertips. This book was originally created by the Medicine Consult Service team at the University of Washington Medical Center and has already gained traction as a handy resource in the field. Now fully updated and expanded with new topics (including substance abuse and obesity), this quick reference is sure to be indispensible for residents and consult physicians alike.

Personalized Medicine in Anesthesia Pain and Perioperative Medicine

Personalized Medicine in Anesthesia  Pain and Perioperative Medicine Book
Author : Ali Dabbagh
Publisher : Springer Nature
Release : 2020-09-21
ISBN : 3030535258
Language : En, Es, Fr & De

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Book Description :

This book discusses the current and future impact of cellular and molecular medicine (CMM) on anesthesiology and perioperative medicine. It covers the topic from a translational perspective and describes the relevance of CMM to daily clinical practice. Taking a bench-to-bedside approach, chapters examine topics including perioperative acute and chronic management, perioperative organ protection, and novel pharmaceuticals. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine is aimed at anesthesiologists and pain physicians, and will also be of interest to pharmacists and those working in cellular and molecular medicine.