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Perinatal Stem Cells

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Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li
Publisher : Springer
Release : 2019-04-06
ISBN : 9811327033
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Anthony Atala,Sean V. Murphy
Publisher : Springer
Release : 2014-08-28
ISBN : 149391118X
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume is one of the first books to offer the reader detailed insight into sources of perinatal stem cells, their biology, and their potential for disease treatment. It examines the research and therapeutic applications of perinatal stem cells including the treatment of renal disease, hematopoietic regeneration, cardiac disease, inflammatory disease, bone regeneration, pulmonary disease, and the treatment of spinal cord injury. Further, the book discusses current progress in the manufacturing, banking and clinical translation of perinatal stem cells. Through this book, readers will gain a thorough understanding of the current pre-clinical and clinical applications of perinatal stem cells as well as the efforts to support the transition of perinatal stem cell therapies from laboratories to clinics. Perinatal Stem Cells contains thirty-two chapters written by internationally recognized leaders in stem cell research. It is organized into four sections covering amniotic fluid stem cells, placental and placental membrane stem cells, umbilical cord stem cells, and clinical translation. This cohesive structure provides an effective framework for detailed insight into this new frontier. Edited by Dr. Anthony Atala, one of the foremost experts in the field, and his co-editor Dr. Sean V. Murphy, this volume is a definitive work for stem cell research and its future implications. It is a key resource for all stem cell researchers, clinicians, and government and industry staff working in this dynamic and exciting field.

Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
Publisher : Academic Press
Release : 2018-06-14
ISBN : 0128120630
Language : En, Es, Fr & De

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Book Description :

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Perinatal Tissue Derived Stem Cells

Perinatal Tissue Derived Stem Cells Book
Author : Babak Arjmand
Publisher : Springer
Release : 2016-12-01
ISBN : 3319464108
Language : En, Es, Fr & De

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Book Description :

This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Fetal Stem Cells in Regenerative Medicine

Fetal Stem Cells in Regenerative Medicine Book
Author : Dario O. Fauza,Mahmud Bani
Publisher : Springer
Release : 2016-05-02
ISBN : 149393483X
Language : En, Es, Fr & De

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Book Description :

This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems. Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Sean Murphy,Curtis L. Cetrulo
Publisher : Academic Press
Release : 2018-06
ISBN : 9780128120156
Language : En, Es, Fr & De

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Book Description :

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Umbilical Cord Blood Hematopoietic Stem Cells

Umbilical Cord Blood Hematopoietic Stem Cells Book
Author : Daniel Viktor Surbek
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Umbilical Cord Blood Hematopoietic Stem Cells book written by Daniel Viktor Surbek, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell Therapy for Perinatal Brain Injury

Cell Therapy for Perinatal Brain Injury Book
Author : Haruo Shintaku,Akira Oka,Makoto Nabetani
Publisher : Springer
Release : 2018-03-01
ISBN : 9811014124
Language : En, Es, Fr & De

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Book Description :

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Homing of Placental derived Mesenchymal Stem Cells After Perinatal Intracerebral Transplantation in a Rat Model

Homing of Placental derived Mesenchymal Stem Cells After Perinatal Intracerebral Transplantation in a Rat Model Book
Author : Martin Müller
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Homing of Placental derived Mesenchymal Stem Cells After Perinatal Intracerebral Transplantation in a Rat Model book written by Martin Müller, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Isolation Characterization and Therapeutic Feasibility of Human Umbilical Cord Derived Stem Cells

Isolation  Characterization and Therapeutic Feasibility of Human Umbilical Cord Derived Stem Cells Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Because of recent advances in stem cell research, cell therapies have gained increasing attention. Stem cells have shown promise to treat degenerative diseases and disorders such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and degenerative disc disease. They are also being investigated to repair and regenerate skeletal tissues and structures. Pluripotent embryonic stem cells (ESCs) have the ability to differentiate into all of 200 types of cell in human body and have greatest potential for cell therapy. However, they face ethical and moral concerns. Whereas, adult stem cells (ASCs) such as bone marrow stromal cells (MSCs), hematopoietic stem cells (HSCs) are more acceptable for cell but they display limited proliferation and differentiation potential. Furthermore, ASCs may undergo genetic changes due to aging and environmental stress. Therefore, others and we have searched for alternative sources of cells for therapeutic usage. These efforts have led to discover stem cells (SCs) from perinatal tissues such as human umbilical blood and cord (UC). Not only, the SCs isolated from perinatal sources can be isolated non-invasively but also they are more primitive than ASCs. Current methods to isolate SCs from UC yield low amounts of cells with variable proliferation potential. Since, UC is an anatomically complex organ; we hypothesized that the variation in the SCs could be due to the difference in the various niches the UC harboring the SCs. In this study, we dissected the UC into its discrete parts, cord lining (CL), Wharton's jelly (WJ) and cord placenta junction (CPJ) and isolated SCs from each of these segments using explant culture technique. The isolated cells from all three sources displayed adherent fibroblastoid morphology, and not only expressed MSCs markers, CD29, CD44, CD73, CD90, and CD105 but also pluripotency genes, OCT4, NANOG, SOX2 and KLF4. They differentiated into multiple lineages such as adipogenic, chondrogenic and osteogenic cells. However, these cells displayed variations in their clonal capacity, ability to self-renew and differentiate depending upon the source of their isolation. SCs isolated from CPJ had highest rate of proliferation and greater capacity to self-renew and differentiate as compared to the SCs derived from CT and WJ. Microarray analysis confirmed the differences in these SCs based on the findings of differentially expressed genes between CPJ-, CL- and WJ-MSCs. We also found variation in the expression of IncRNA genes. Our studies demonstrated CJP as the sources of SCs with superior properties. These cells were then used for cell therapy and toxicological studies. Cell therapy feasability studies were conducted using CPJ-SCs and their chondrogenic derivatives, chondroprogenitor cells (CPCs) and nucleus pulposus (NP) like cells (NPCs) to regenerate damaged intervertebral disc (IVD) in a rabbit model. Degeneration of IVD results due to the loss of NP and is a common cause of lower back pain. Animal studies performed by transplanting CPJ-SCs and their derivatives showed significant improvement in the histology, cellularity, extracellular matrix proteins, and water and glycosaminoglycan contents of IVDs. Furthermore, the transplanted cells survived, engrafted and displayed homing into NP in situ. In addition, IVDs receiving CPJ-SCs derivatives exhibited higher expression of NP specific human markers, SOX9, ACAN, COL2, FOXF1, and KRT19. The regulation of the regeneration process and the NP biosynthesis was determined to be via TGF[beta]1/Smad pathway. Overall, the animal study showed that NPCs were is more efficacious than the CPCs and SCs. Our results provide basis and impetus for clinical studies to treat DDD as well as other degenerative diseases and disorders. Furthermore, these cells could be used for tissue engineering, regenerative medicine and pharmaceutical applications.

Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Kyle Cetrulo,Curtis L. Cetrulo, Jr.,Rouzbeh R. Taghizadeh
Publisher : John Wiley & Sons
Release : 2013-02-04
ISBN : 1118497945
Language : En, Es, Fr & De

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Book Description :

Perinatal Stem Cells, 2nd Edition builds on the firstedition to provide an updated tutorial on perinatal stem cells,including stem cells harvested from the amniotic fluid, placenta,maternal blood supply, umbilical cord and Wharton's Jelly. As inthe first edition, coverage includes the underlying biology of eachof the sources of pregnancy related stem cells, cell culture, andpotential therapeutic uses, as well as insights on the impact ofthese stem cells from obstetricians and gynecologists,cardiologists, hematologists, tissue engineers, and cord bloodbankers. Normally discarded as medical waste, perinatal stem cells offera powerful therapeutic tool box alternative to the controversialembryonic stem cells. Since publication of the first edition, aburgeoning commerical industry has developed around various sourcesof perinatal cells, and the second edition now includes an overviewof this growing industry. With contributions from some of the top academic stem celllaboratories in the United States as well as new chapters frominternational stem cell scientists, Perinatal StemCells presents an update onthe cutting-edge research in the field whilemaintaining its signature clinical focus.

The Effects of Perinatal Hypoxia ischemia on the Stem Cells and Progenitor Cells of the SVZ subscript DL in Vivo

The Effects of Perinatal Hypoxia ischemia on the Stem Cells and Progenitor Cells of the SVZ subscript DL in Vivo Book
Author : Michael J. Romanko
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Effects of Perinatal Hypoxia ischemia on the Stem Cells and Progenitor Cells of the SVZ subscript DL in Vivo book written by Michael J. Romanko, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modelling Perinatal Stroke and Stem Cell Grafting in a Neonatal Rat

Modelling Perinatal Stroke and Stem Cell Grafting in a Neonatal Rat Book
Author : Reem Mohammed A. Basuodan
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Modelling Perinatal Stroke and Stem Cell Grafting in a Neonatal Rat book written by Reem Mohammed A. Basuodan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem cells From Potential to Promise

Stem cells  From Potential to Promise Book
Author : Khawaja H. Haider
Publisher : Springer
Release : 2021-06-28
ISBN : 9789811603006
Language : En, Es, Fr & De

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Book Description :

The book highlights the therapeutic applications of various stem cells, and introduces readers to thymus stem cells and their applications in the reconstitution of thymic structure and function. It also discusses the significant role of mesenchymal stem cells (MSCs) in the treatment of autoimmune diseases and the use of MSC-derived exosomes in cell-free therapy. Moreover, it explores the application of hematopoietic stem cells in the vasculoprotection of the ischemially injured heart. Further topics include the regenerative potential of ovarian germline stem cells and the significance of endometrial stem cells in the pathogenesis of female reproductive tract diseases. Lastly, the book addresses stem cells from perinatal tissues and their immunoregulatory and differentiation potentials, and summarizes new strategies for targeting cancer stem cells to treat tumors.

Assessment of Nycodenz Gradient on Enrichment and Culture of Perinatal Porcine Spermatogonial Stem Cells

Assessment of Nycodenz Gradient on Enrichment and Culture of Perinatal Porcine Spermatogonial Stem Cells Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The objective of this study was to assess the effectiveness of a Nycodenz gradient enrichment method to enrich a dissociated single cell suspension of porcine testicular cells for spermatogonia, and to observe the separated fractions from the gradient over a 14-day culture period for cell viability and number of spermatogonia in culture. Two germ cell specific genes, VASA and DAZL, were utilized for detection of spermatogonia using immunohistochemistry. The control group included cultures generated from the enzymatic digestion of porcine testes prior to the enrichment protocol for each replicate. The NycoDenz gradient consistently separated the isolated cell suspension into three distinct layers and a pellet, all of which were assessed for spermatogonial enrichment. Testis cells were isolated and seeded in culture on day 0. Cell viability and percent of spermatogonia was assessed on day 0, 7, and 14 of culture. Viability was determined using trypan blue exclusion assay and quantified using a hemocytometer. Spermatogonia were morphologically identified as round, plump cells with a large amount of cytoplasm. Visualization of spermatogonia was facilitated by immunostaining with DAZL and VASA polyclonal antibodies and cells exhibiting morphological characteristics in addition to bright, concentrated fluorescence were counted as spermatogonia.

The Beginnings of Perinatal Medicine

The Beginnings of Perinatal Medicine Book
Author : Erich Saling,Monika Dräger,Jens H. Stupin
Publisher : Walter de Gruyter
Release : 2014-10-13
ISBN : 9783110317909
Language : En, Es, Fr & De

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Book Description :

Perinatal medicine came into being during the middle of the 20th century, when human medicine entered the intrauterine space.This book presents in an integrative way the history of the still young speciality. The main emphasis is on the time period up to the early 70swhen the major changes e.g. Cardiotocography took place. Both scientific precursors and later developments are mentioned shortly, when appropriate. Many chapters of this book represent a unique eyewitness report by Prof. Erich Saling, the so-called "Father of Perinatal Medicine."

The Professional Responsibility Model of Perinatal Ethics

The Professional Responsibility Model of Perinatal Ethics Book
Author : Frank A. Chervenak,Laurence B. McCullough
Publisher : Walter de Gruyter
Release : 2014-07-15
ISBN : 9783110316605
Language : En, Es, Fr & De

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Book Description :

Perinatologists confront many ethical challenges in clinical care and research for which they need ethically sound, clinically practical guidance for clinical judgment and decision making with their patients.This is the first book to address these challenges in a clinically practical and comprehensive way. The unique feature of the book is its deployment of the professional responsibility model of perinatal ethics and the ethical concept of the fetus as a patient. The authors, a perinatologist and philosopher, have collaborated for more than thirty years.

Genetic and Perinatal Risk Factors for Movement Disorders

Genetic and Perinatal Risk Factors for Movement Disorders Book
Author : Melinda Barkhuizen
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Movement disorder -- Basal ganglia -- Parkinson̕ s disease -- Hunt-ington̕ s disease -- Neurogenetics -- Risk factor -- Epidemiology -- Perinatal asphyxia -- Preterm -- Stem cell therapy.