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Perinatal And Developmental Epigenetics

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Perinatal and Developmental Epigenetics

Perinatal and Developmental Epigenetics Book
Author : Garima Singh
Publisher : Academic Press
Release : 2022-05-01
ISBN : 0128217863
Language : En, Es, Fr & De

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Book Description :

Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood. Examines disease onset stemming from epigenetic changes during the perinatal periods Features contributions from international experts in the field, including basic biology, disease research and drug discovery Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease Book
Author : Cheryl S Rosenfeld
Publisher : Academic Press
Release : 2015-10-10
ISBN : 0128016728
Language : En, Es, Fr & De

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Book Description :

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Prenatal Stress and Child Development

Prenatal Stress and Child Development Book
Author : Ashley Wazana,Eszter Székely,Tim F. Oberlander
Publisher : Springer Nature
Release : 2021-04-19
ISBN : 3030601595
Language : En, Es, Fr & De

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Book Description :

This book examines the complex impact of prenatal stress and the mechanism of its transmission on children’s development and well-being, including prenatal programming, epigenetics, infl ammatory processes, and the brain-gut microbiome. It analyzes current findings on prenatal stressors affecting pregnancy, including preconception stress, prenatal maternal depression, anxiety, and pregnancy-specific anxieties. Chapters explore how prenatal stress affects cognitive, affective, behavioral, and neurobiological development in children while pinpointing core processes of adaptation, resilience, and interventions that may reduce negative behaviors and promote optimal outcomes in children. Th is complex perspective on mechanisms by which early environmental influences interact with prenatal programming of susceptibility aims to inform clinical strategies and future research targeting prenatal stress and its cyclical impact on subsequent generations. Key areas of coverage include: The developmental effects of prenatal maternal stress on children. Epigenetic effects of prenatal stress. Intergenerational transmission of parental early life stress. The microbiome-gut-brain axis and the effects of prenatal stress on early neurodevelopment. The effect of prenatal stress on parenting. Gestational stress and resilience. Prenatal stress and children’s sleeping behavior. Prenatal, perinatal, and population-based interventions to prevent psychopathology. Prenatal Stress and Child Development is an essential resource for researchers, professors and graduate students as well as clinicians, therapists, and related professionals in infancy and early childhood development, maternal and child health, developmental psychology, pediatrics, social work, child and adolescent psychiatry, developmental neuroscience, and related behavioral and social sciences and medical disciplines. Excerpt from the foreword: “I would make the plea that in addition to anyone with an interest in child development, this book should be essential reading for researchers pursuing “pre-clinical, basic science models of neurodevelopment and brain health”.... This book provides what in my mind is the most advanced compilation of existing knowledge and state-of-the-art science in the field of prenatal psychiatry/psychology (and perhaps in the entire field of prenatal medicine). This volume can brilliantly serve to focus future directions in our understanding of the perinatal determinants of brain health.” Michael J Meaney James McGill Professor of Medicine Translational Neuroscience Programme Adjunct Professor of Paediatrics

Handbook of Prenatal and Perinatal Psychology

Handbook of Prenatal and Perinatal Psychology Book
Author : Klaus Evertz,Ludwig Janus,Rupert Linder
Publisher : Springer Nature
Release : 2020-10-27
ISBN : 3030417166
Language : En, Es, Fr & De

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Book Description :

The handbook synthesizes the comprehensive interdisciplinary research on the psychological and behavioral dimensions of life before, during, and immediately after birth. It examines how experiences during the prenatal period are associated with basic physiological and psychological imprints that last a lifetime and explores the ways in which brain networks reflect these experiences. Chapters offer findings on prenatal development, fetal programming, fetal stress, and epigenetics. In addition, chapters discuss psychotherapy for infants – before, during, and after birth – as well as prevention to promote positive health and well-being outcomes. Topics featured in this handbook include: Contemporary environmental stressors and adverse pregnancy outcomes The psychology of newborn intensive care. Art therapy and its use in treating prenatal trauma. The failures and successes of Cathartic Regression Therapy. Prenatal bonding and its positive effects on postnatal health and well-being. The role of family midwives and early prevention. The cultural meaning of prenatal psychology. The Handbook of Prenatal and Perinatal Psychology is an essential resource for researchers, clinicians and related professionals, as well as graduate students in a wide range of interrelated disciplines, including developmental psychology, pediatric and obstetrical medicine, neuroscience, infancy and early child development, obstetrics and gynecology, nursing, social work, and early childhood education.

Epigenetics the Environment and Children s Health Across Lifespans

Epigenetics  the Environment  and Children   s Health Across Lifespans Book
Author : David Hollar
Publisher : Springer
Release : 2016-02-08
ISBN : 3319253255
Language : En, Es, Fr & De

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Book Description :

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

Adaptive and Maladaptive Aspects of Developmental Stress

Adaptive and Maladaptive Aspects of Developmental Stress Book
Author : Giovanni Laviola,Simone Macrì
Publisher : Springer Science & Business Media
Release : 2013-01-31
ISBN : 1461456053
Language : En, Es, Fr & De

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Book Description :

Since the very early stages of life, we all experience some form of stress. Stressors can be mild to severe and can range from unsuccessfully longing for maternal milk in infancy, to recklessly wiggling on a motorbike to be on time to watch the NBA finals on TV, to breaking up a relationship. All those events that we call “stress” have the capability of perturbing a given state of psychological and physiological equilibrium and moving it to a different level. The transition from crawling to walking has to be considered a form of stress as much as losing a job. It is through a continuous cross-talk between environmental stressors and individual adaptations that we build our personalities and our ways to cope with daily hassles. External challenges should not necessarily be regarded as “bad”, but instead seen as constructive forces forming our ability to navigate a changing world. What is stress good for? What is stress bad for? When and why do we need to be “stressed”? Should we worry about stress? When does stress equate to “normality”? When does it turn into pathology? We hope with this book to provide some answers to these fundamental questions.

Fanaroff and Martin s Neonatal Perinatal Medicine

Fanaroff and Martin s Neonatal Perinatal Medicine Book
Author : Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publisher : Elsevier Health Sciences
Release : 2019-04-11
ISBN : 0323567096
Language : En, Es, Fr & De

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Book Description :

Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.

Fanaroff and Martin s Neonatal Perinatal Medicine E Book

Fanaroff and Martin s Neonatal Perinatal Medicine E Book Book
Author : Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publisher : Elsevier Health Sciences
Release : 2014-08-20
ISBN : 0323295371
Language : En, Es, Fr & De

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Book Description :

Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.

Developmental Origins of Health and Disease

Developmental Origins of Health and Disease Book
Author : Peter Gluckman,Mark Hanson
Publisher : Cambridge University Press
Release : 2006-04-20
ISBN : 9780521847438
Language : En, Es, Fr & De

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Book Description :

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Perinatal Growth and Nutrition

Perinatal Growth and Nutrition Book
Author : Ian J. Griffin
Publisher : CRC Press
Release : 2014-05-13
ISBN : 1466558547
Language : En, Es, Fr & De

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Book Description :

Preterm infants grow poorly after birth and very commonly develop ex utero growth restriction (EUGR). However, the risks and benefits of catch-up growth in preterm infants must be weighed, and evidence addressing this warrants examination. Perinatal Growth and Nutrition explores the reasons for EUGR and the long-term effects on developmental outcom

Developmental Human Behavioral Epigenetics

Developmental Human Behavioral Epigenetics Book
Author : Livio Provenzi,Rosario Montirosso
Publisher : Academic Press
Release : 2020-11-12
ISBN : 0128192631
Language : En, Es, Fr & De

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Book Description :

Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Examining a Developmental Approach to Childhood Obesity

Examining a Developmental Approach to Childhood Obesity Book
Author : Institute of Medicine,Food and Nutrition Board
Publisher : National Academies Press
Release : 2015-09-08
ISBN : 030937698X
Language : En, Es, Fr & De

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Book Description :

Recent scientific evidence points to the origins of childhood obesity as an outcome of the dynamic interplay of genetic, behavioral, and environmental factors throughout early development, with a compelling body of evidence suggesting that both maternal and paternal nutritional and other exposures affect a child's risk of later obesity. The burgeoning field of epigenetics has led researchers to speculate that many of the observed associations between early developmental exposures and later risk of childhood obesity are mediated, at least in part, through epigenetic mechanisms. To explore the body of evolving science that examines the nexus of biology, environment, and developmental stage on risk of childhood obesity, the Institute of Medicine and the National Research Council convened a workshop in February 2015. The workshop focused on the prenatal period, infancy, and early childhood and addressed evidence from both animal and human studies. Workshop objectives were to (1) identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related outcomes; (2) explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development; and (3) examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk. This report summarizes the information presented and discussed at the workshop.

Pregnancy Disorders and Perinatal Outcomes

Pregnancy Disorders and Perinatal Outcomes Book
Author : Cathy Vaillancourt,Julie Lafond,Maria do Carmo Ferreira,José Teixeira Freire,Ana Maria da Silveira
Publisher : Bentham Science Publishers
Release : 2012-06-08
ISBN : 1608053725
Language : En, Es, Fr & De

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Book Description :

Pregnancy Disorders and Perinatal Outcomes offers readers insights into knowledge related to maternal habits or disorders that could affect fetal development and lead to disability later in childhood and adulthood. It contains chapters on the role of plac

Parents with Mental and or Substance Use Disorders and their Children

Parents with Mental and or Substance Use Disorders and their Children Book
Author : Joanne Nicholson,Giovanni de Girolamo,Beate Schrank
Publisher : Frontiers Media SA
Release : 2020-01-17
ISBN : 2889633837
Language : En, Es, Fr & De

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Book Description :

Download Parents with Mental and or Substance Use Disorders and their Children book written by Joanne Nicholson,Giovanni de Girolamo,Beate Schrank, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fetal and Neonatal Physiology E Book

Fetal and Neonatal Physiology E Book Book
Author : Richard A. Polin,Steven H. Abman,David Rowitch,William E. Benitz
Publisher : Elsevier Health Sciences
Release : 2016-05-11
ISBN : 0323352324
Language : En, Es, Fr & De

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Book Description :

Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

Epigenetics and Psychiatric Disease

Epigenetics and Psychiatric Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2018-06-22
ISBN : 0128135662
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more. Accessible to students and researchers alike, with content that appeals to a variety of readers Written by leading authorities in their respective fields of molecular biology

Prenatal Development and Parents Lived Experiences How Early Events Shape Our Psychophysiology and Relationships Norton Series on Interpersonal Neurobiology

Prenatal Development and Parents  Lived Experiences  How Early Events Shape Our Psychophysiology and Relationships  Norton Series on Interpersonal Neurobiology  Book
Author : Ann Diamond Weinstein
Publisher : W. W. Norton & Company
Release : 2016-08-29
ISBN : 0393711072
Language : En, Es, Fr & De

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Book Description :

The influence of the preconception and prenatal period on child development and parent-child relationships. This book presents recent knowledge, research, and theory about the earliest developmental period—from conception to birth—which holds even greater consequences for the health and development of the human organism than was previously understood. Theory and research in multiple disciplines provide the foundation for the exploration of how experiences during conception and time in the womb; during and after birth; and experiences with caregivers and the family system in the early postnatal period impact an individual physically, cognitively, emotionally, and socially over their life span. Knowledge drawn from numerous fields highlights the opportunity for parents-to-be and the practitioners who care for them to intentionally support the cultivation of nurturing internal and external environments during the preconception, prenatal, and early parenting periods. Theory and research from the fields of psychology, medicine, psychophysiology, epigenetics, and traumatology, among others, suggest that doing so will support lifelong multidimensional aspects of healthy development in children and adults and may also benefit future generations.

Epigenetics and Neuroendocrinology

Epigenetics and Neuroendocrinology Book
Author : Dietmar Spengler,Elisabeth Binder
Publisher : Springer
Release : 2016-06-29
ISBN : 3319299018
Language : En, Es, Fr & De

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Book Description :

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

The Lung

The Lung Book
Author : Kent Pinkerton,Richard Harding
Publisher : Elsevier
Release : 2014-10-23
ISBN : 0128002883
Language : En, Es, Fr & De

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Book Description :

The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the “normal and “disease cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the “normal pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work. Describes the normal processes of lung development, growth and aging Considers the effects of the environmental contaminants in the air, water, soil, and diet on lung development, growth and health Describes genetic factors involved in susceptibility to lung disease Covers respiratory health risk in children

Medical Epigenetics

Medical Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2021-08-27
ISBN : 0128243260
Language : En, Es, Fr & De

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Book Description :

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine