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Pediatric Cancer Genetics

Pediatric Cancer Genetics Book
Author : Nathaniel H. Robin,Meagan Farmer
Publisher : Elsevier Health Sciences
Release : 2017-08-22
ISBN : 0323495966
Language : En, Es, Fr & De

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Book Description :

Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today’s available information and guidance in this timely area into one convenient resource.

Pediatric Cancer Genetics

Pediatric Cancer Genetics Book
Author : Nathaniel H. Robin,Meagan Farmer
Publisher : Unknown
Release : 2017-09-28
ISBN : 9780323485555
Language : En, Es, Fr & De

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Book Description :

Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today's available information and guidance in this timely area into one convenient resource.

Pediatric Hematology and Oncology

Pediatric Hematology and Oncology Book
Author : Edward Estlin,Richard Gilbertson,Rob Wynn
Publisher : John Wiley & Sons
Release : 2011-07-20
ISBN : 1444322559
Language : En, Es, Fr & De

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Book Description :

This new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. It is specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders. This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children’s cancers and contains detailed tables, fact boxes and illustrations. The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sections are then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacology and the findings of clinical trials. For each area of science covered, key original references and reviews are highlighted to direct further reading. Diagnostic, biological, and therapeutic issues are integrated into each tumor-specific chapter, with evidence supporting the current rationales for risk stratification and the development of novel therapies. A final section then explores supportive care, palliative care, late effects considerations and psychosocial issues as relate to children’s cancer.

Handbook of Genomics and the Family

Handbook of Genomics and the Family Book
Author : Kenneth P. Tercyak
Publisher : Springer Science & Business Media
Release : 2010-08-12
ISBN : 9781441958006
Language : En, Es, Fr & De

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Book Description :

This book introduces readers to the study of how genes, singly and in combination with each other and the environment, affect health and behavior. It provides family-focused perspectives relating to genetic counseling and education.

The Hereditary Basis of Childhood Cancer

The Hereditary Basis of Childhood Cancer Book
Author : David Malkin
Publisher : Springer
Release : 2021-08-28
ISBN : 9783030744465
Language : En, Es, Fr & De

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Book Description :

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where ‘modern’ technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.

Pediatric Cancer Volume 3

Pediatric Cancer  Volume 3 Book
Author : M.A. Hayat
Publisher : Springer
Release : 2016-08-23
ISBN : 9789401779975
Language : En, Es, Fr & De

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Book Description :

Brain tumors are the most common solid tumor of childhood as well as the leading cause of cancer-related mortality in children. This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. Now it has become possible to achieve the goal of targeting new, more effective therapies to minimize the tragedy faced by children. This research features the application of molecular genetics in combating atypical teratoid/rhabdoid tumor (AT/RT), a highly aggressive embryonal CNS tumor that is among the most common malignant neoplasms in children, with a peak occurrence in infants younger than three years old. Contributors also examine the reasons for the common misdiagnosis of AT/RT tumors as other types of CNS tumors. They help resolve this issue by indicating the details of an abnormality in the genetics of AT/RT, which is unique to AT/RT type. The INII gene on chromosome 22q11 is involved in the AT/RT. The presence of this gene and the SMARCB1 is discussed. In addition to discussing these important topics, the volume includes presentations of present and future therapies. The volume also explains AT/RT’s dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. The practical knowledge of frontier-expanding research presented leads this authoritative volume to be a compelling addition to the literature.

Diagnostic and Therapeutic Advances in Pediatric Oncology

Diagnostic and Therapeutic Advances in Pediatric Oncology Book
Author : David O. Walterhouse,Susan L. Cohn
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461557674
Language : En, Es, Fr & De

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Book Description :

The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects.

Pediatric Psycho Oncology

Pediatric Psycho Oncology Book
Author : Lori S. Wiener PhD,Maryland Pao MD,Anne E. Kazak PhD,Mary Jo Kupst PhD,Andrea Farkas Patenaude PhD,Robert J. Arceci
Publisher : Oxford University Press
Release : 2015-02-04
ISBN : 0199335133
Language : En, Es, Fr & De

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Book Description :

Pediatric Psycho-Oncology is a comprehensive handbook that provides best practice models for the management of psychological, cognitive, and social outcomes of adolescents living with cancer and their families. Chapters cover a wide range of topics including psychological aspects of particular pediatric cancers and their treatments, how to talk to a child and family at critical times during the disease course, genetic testing, individual, family, educational, psychological and psychiatric interventions, and caring for international patients . Each chapter highlights the necessity of embracing an interdisciplinary approach to ensure that each child has the best options for living with cancer and, when cure is not possible, that death occurs with as much dignity as possible for the child and family. An extensive resource section is appended to provide information on written, online, video, community, national and international services and programs. This book features contributions from experts designed to help clinicians review, anticipate and respond to emotional issues that often arise in the context of treating pediatric cancer patients. Numerous cross-references and succinct tables and figures make this concise reference easy to use. Pediatric Psycho-Oncology is an ideal resource for helping pediatric oncologists and nurses recognize when it may be best to refer patients to their mental health colleagues and for those who are establishing pediatric oncology services or adding psychosocial components to existing clinics.

A Tail of Two PanCancer Projects

A Tail of Two PanCancer Projects Book
Author : Matthew Hawkins Bailey
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The implementation of next-generation genomic sequencing has exploded over the past dozen years. Large consortia, such as The Cancer Genome Atlas (TCGA); the International Cancer Genetics Consortium (ICGC); and the Pediatric Cancer Genome Projects (PCGP), made great strides in democratizing big data for the scientific community. These data sets provide a rich resource to build tools for somatic variant discovery and exploratory analysis. Public repositories hold the answer to many novel biological and clinical revelations i.e., the discovery of complex indels, splice creating mutations, alternative super enhancer binding sites, machine learning models to predict mutation impact, and cancer subtype classification and identification. At the end of 2014, seven additional cancer types and 11 different pediatric tumor cohorts were publicly available when compared to the Ding lab's first PanCancer effort [Kandoth et al., 2013]. Motivated by the possibility of novel cancer driver gene discovery, we launched a new PanCan2 effort. We assembled sequence data from 8,018 cancer cases representing a combined 30 pediatric and adult cancer types from 8 organ systems. Analysis of the resulting data corpus identified 270 cancer-associated genes, 107 of which have not been previously reported in Pan- Cancer studies. Pediatric-enriched mutant genes (e.g., IL7R, PAX5, and H3F3A) were found in tumors from the hematopoietic and central nervous systems, consistent with their roles in early development. Distinctive mutational architectures were identified for each of the 8 organ sys- tems, reflecting the tissue of origin and likely exposure to similar environmental factors. TP53 mutant vs. TP53 wild-type tumors had largely distinct patterns of co-occurring mutations, suggesting a pivotal role of TP53 in shaping the mutational network. Cis-activation of receptor tyrosine kinases at mutational, expression, and phosphorylation levels, as well as trans-activation of hormone-related transcription factors, were identified through the integration of multiple data types. In the end, this effort did not result in a publication because we did not perform uniform variant calling across all samples and relied primarily on publicly available data sets. Armed with the knowledge that reviewers would require a complete reboot of the TCGA variant calls before another PanCancer paper would be considered, Dr. Li Ding thoughtfully sub- mitted a proposal to acquire funding necessary for the recalling of all TCGA exome sequencing bams using many different calls. This effort is referred to as the Multi-center Mutation Calling in Multiple Cancers (MC3). TCGA cancer genomics data set includes over 10,000 tumor-normal exome pairs across 33 different cancer types, in total >400 TB of raw data files required re- analysis. A comprehensive encyclopedia of somatic mutation calls for the TCGA data was created to enable robust cross-tumor-type analyses. Our approach accounts for variance and batch effects introduced by the rapid advancement of DNA extraction, hybridization-capture, sequencing, and analysis methods over time. We present best practices for applying an ensemble of seven mutation-calling algorithms with scoring and artifact filtering. The data set created by this analysis includes 3.5 million somatic variants and forms the basis for PanCancer Atlas papers. The results have been made available to the research community along with the methods used to generate them. This project is the result of collaboration from a number of institutes and demonstrates how team science drives large genomics projects. Having a complete overhaul of all somatic mutations available in the TCGA, we sought to use these data for a complete TCGA PanCancer analysis. However, instead of relying wholly on in-house algorithms we also performed PanSoftware analysis spanning 26 computational tools from multiple institutions to catalog driver genes and mutations. In total, 9,423 tumor exomes (comprising all 33 of TCGA projects) we identified 299 driver genes with implications regarding their anatomical sites and cancer/cell types. Sequence- and structure-based analyses identified >3,400 putative missense driver mutations supported by multiple lines of evidence. Experimental validation confirmed 60%-85% of predicted mutations as likely drivers. We found that >300 MSI tumors are associated with high PD-1/PD-L1, and 57% of tumors analyzed harbor putative clinically actionable events. Our study represents the most comprehensive discovery of cancer genes and mutations to date and will serve as a blueprint for future biological and clinical endeavors. One of many new waves in the genomics era will be the cohesive integration of multi-omics data. At present, our current understanding of molecular processes in oncogenesis is governed by known-knowns. This is clearly illustrated in our marker paper that displays insights into cancer through the synthesis of findings from TCGA PanCancer Atlas [Ding et al., 2018]. In closing the final chapters of TCGA, we addressed three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the micro-environment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing. In quick succession, both The Cancer Genome Atlas and the International Cancer Genetics Consortium provided the cancer research community with consensus somatic mutation calls for captured exome sequencing created by the Multi-center Mutations Calling in Multiple Cancers effort (MC3) and whole genome sequence provided by the PanCancer (PCAWG). 746 of the samples underwent sequencing by MC3 and PCAWG. We found that that ~80% of possible mutations in covered exomic regions matched using the two technologies. Using a statistical model we estimated that 15-30% of the unique mutations are attributable to noise caused by variant allele fraction and clonal heterogeneity. We also observed that ~30% of the mutations uniquely identified by PCAWG could be traced to mutations made by a single caller by MC3 and are not reported in the publicly available MC3 data set. Due to the numerous modes of comparison, we built MAFit an online tool to facilitate engagement with these data. Finally, we highlight the advantages of using whole genome technologies in regions of high and low GC content and perform significantly mutated gene analysis, thus, increasing the targeted/captured exomic space by ~50% to discover additional genes that could only be found using whole genome

Cancer Genomics

Cancer Genomics Book
Author : Shahrad Rod Rassekh,Colin J.D. Ross
Publisher : Elsevier Inc. Chapters
Release : 2013-11-21
ISBN : 0128061030
Language : En, Es, Fr & De

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Book Description :

In the last 50 years, the cure rate for children with cancer has increased from 5–10% to over 80% today. However, this dramatic improvement in outcome has come at a significant cost. Approximately 40% of children suffer irreversible, life-threatening, or long-lasting toxicities that are caused by their medications during cancer treatment. Recent technological advances in genomics have opened the door to potentially identifying genetic differences between individual children that may explain their different responses to cancer therapies. The goals of the emerging field of cancer pharmacogenomics are to identify the genomic factors responsible for individual differences in drug response, specifically drug effectiveness and susceptibility to adverse drug reactions. Pharmacogenomics helps to explain why one child treated with the same medication as another child may respond well to therapy, while another patient may not respond, or worse, may develop a life-threatening adverse drug reaction. The focus of this chapter is to explore recent developments in the pharmacogenomics of pediatric cancer with a focus on serious adverse drug reactions. Specific drugs of focus include thiopurines, methotrexate, cisplatin, vincristine and anthracyclines. Several pharmacogenomic tests are currently available to provide dosing recommendations, and the number of these tests is expected to increase significantly in the future. There is a strong immediate need for international collaboration to advance this research to reduce the occurrence of severe adverse drug reactions in pediatric oncology.

Pediatric Cancer Volume 4

Pediatric Cancer  Volume 4 Book
Author : M.A. Hayat
Publisher : Springer
Release : 2016-08-23
ISBN : 9789402407266
Language : En, Es, Fr & De

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Book Description :

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors. Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing’s sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail. The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation. Discussion includes diagnosis and treatment of other pediatric tumors including adrenocortical tumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma. Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.

DNA Methylation and Pediatric Cancer

DNA Methylation and Pediatric Cancer Book
Author : 陳桂儀,Kwai-Yi Jacqueline Chan
Publisher : Open Dissertation Press
Release : 2017-01-26
ISBN : 9781361128435
Language : En, Es, Fr & De

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Book Description :

This dissertation, "DNA Methylation and Pediatric Cancer" by 陳桂儀, Kwai-yi, Jacqueline, Chan, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3197037 Subjects: DNA - Methylation Cancer - Genetic aspects Cancer in children

Recent Advances in Pediatric Cancer Predisposition Syndromes

Recent Advances in Pediatric Cancer Predisposition Syndromes Book
Author : Angela Mastronuzzi,Luigi Boccuto,Riccardo Masetti
Publisher : Frontiers Media SA
Release : 2021-05-03
ISBN : 2889667146
Language : En, Es, Fr & De

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Book Description :

We would like to acknowledge Dr. Giada Del Baldo and Dr. Mariachiara Lodi from IRCCS Bambino Gesù Children’s Hospital have acted as coordinator and have contributed to the preparation of the proposal for this Research Topic.

NCI Core Curriculum

NCI Core Curriculum Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download NCI Core Curriculum book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pediatric Cancer Volume 2

Pediatric Cancer  Volume 2 Book
Author : M.A. Hayat
Publisher : Springer Science & Business Media
Release : 2012-03-21
ISBN : 9400729561
Language : En, Es, Fr & De

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Book Description :

A general introduction to the principles of diagnosis and treatment of children with brain tumors is presented. Molecular characterization of solid tumors is also presented. Molecular pathways provide putative targets for new therapies. High resolution magic spinning NMR spectroscopy is explained, which is used to determine metabolic profiles for small pieces of intact tissue and whole cells in culture. The differences between adult and pediatric brain tumors are outlined. It is emphasized that pediatric low-grade gliomas need lower doses of antidrugs such as cisplatin/etoposide. It is explained that tumor suppressor genes and oncogenes play a crucial role in the development and progression of human malignancies, including those in children. Neurofibromatosis type-1 is a common genetic disorder with a high prevalence in CNS abnormalities including tumors in children; which is discussed in detail. Various neuroradiological imaging modalities in children with leukemia are detailed. Also are detailed results of clinical trials in pediatric brain tumors, such as medulloblastoma, ependymoma, craniopharyngioma, low-grade glioma, high-grade glioma, brainstem glioma, and germ cell tumors, using radiotherapy. Considering the clinical importance of epilepsy in the primary brain tumors in children, its symptoms, diagnosis, and treatments (surgery and antiepileptic drugs) are discussed.

Cancer

Cancer Book
Author : Michael Dean,Karobi Moitra
Publisher : Biota Publishing
Release : 2018-12-03
ISBN : 1615047956
Language : En, Es, Fr & De

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Book Description :

Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.

Developmental Genetics and Childhood Cancer

Developmental Genetics and Childhood Cancer Book
Author : American Association for Cancer Research
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Developmental Genetics and Childhood Cancer book written by American Association for Cancer Research, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pediatric Oncology Nursing

Pediatric Oncology Nursing Book
Author : Pamela S. Hinds,Lauri Linder
Publisher : Springer Nature
Release : 2020-01-23
ISBN : 3030258041
Language : En, Es, Fr & De

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Book Description :

This book presents the current state of the nursing science in topics relevant to the care of pediatric oncology patients and their families across the treatment trajectory and is framed within a precision health framework. The spectrum of topics covered is wide, including, for example, symptom management, self-care management, exercise and physical activity, family-centered care, palliative care, the role of the nurse in treatment decision making, patient and nurse resiliency, survivorship, and genetic counseling. Throughout, there is a focus on the implications of research for nursing practice, highlighting which elements of the available evidence are ready for translation into practice and which are not. In addition, careful attention is paid to the role that nursing can play in further advancing science through clinical research. The authors are leading experts from across the globe. The book will be of special interest for pediatric oncology nurses, including direct care nurses, research nurses, and nursing leaders, and will also be a stimulating source for researchers and non-oncology nurses.

The Surgery of Childhood Tumors

The Surgery of Childhood Tumors Book
Author : Robert Carachi,Jay L. Grosfeld
Publisher : Springer
Release : 2016-04-28
ISBN : 3662485907
Language : En, Es, Fr & De

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Book Description :

Beginning with the scientific basis of tumors, this book provides up-to-date information on epidemiology, cytogenetics, and molecular biology, before examining current treatments for the full range of pediatric tumors. Integration of surgery, neoadjuvant and adjuvant chemotherapy, and radiation therapy is a dominant theme. In addition, chapters on supportive care, palliative care, and the role of parents’ associations reflect the book's holistic approach. All chapters are written by world-renowned international authorities on pediatric cancer from major children's cancer groups. Excellent full-color pictures and line drawings illustrate all aspects of managing childhood tumors, including details of operative techniques neglected in many other texts. This comprehensive book, expanded and updated to encompass the very latest developments and strategies, provides a contemporary approach for pediatric, general, and urological surgeons dealing with childhood tumors.