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Patient H M

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Patient H M

Patient H M  Book
Author : Luke Dittrich
Publisher : Random House
Release : 2016-08-09
ISBN : 067964380X
Language : En, Es, Fr & De

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Book Description :

“Oliver Sacks meets Stephen King”* in this propulsive, haunting journey into the life of the most studied human research subject of all time, the amnesic known as Patient H.M. For readers of The Immortal Life of Henrietta Lacks comes a story that has much to teach us about our relentless pursuit of knowledge. Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today. Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves. Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide. “An exciting, artful blend of family and medical history.”—The New York Times *Kirkus Reviews (starred review)

Permanent Present Tense

Permanent Present Tense Book
Author : Suzanne Corkin
Publisher : Hachette UK
Release : 2013-05-14
ISBN : 0465033490
Language : En, Es, Fr & De

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Book Description :

In 1953, 27-year-old Henry Gustave Molaison underwent an experimental "psychosurgical" procedure -- a targeted lobotomy -- in an effort to alleviate his debilitating epilepsy. The outcome was unexpected -- when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry's tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry's crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry -- known only by his initials H. M. until his death in 2008 -- stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain. Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

Summary and Analysis of Patient H M A Story of Memory Madness and Family Secrets

Summary and Analysis of Patient H M   A Story of Memory  Madness  and Family Secrets Book
Author : Worth Books
Publisher : Open Road Media
Release : 2017-05-16
ISBN : 1504046463
Language : En, Es, Fr & De

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Book Description :

So much to read, so little time? This brief overview of Patient H.M. tells you what you need to know—before or after you read Luke Dittrich’s book. Crafted and edited with care, Worth Books set the standard for quality and give you the tools you need to be a well-informed reader. This short summary and analysis of Patient H.M.: A Story of Memory, Madness, and Family Secrets includes: Historical context Chapter-by-chapter overviews Profiles of the main characters Detailed timeline of key events Important quotes Fascinating trivia Glossary of terms Supporting material to enhance your understanding of the original work About Patient H.M. by Luke Dittrich: Patient H.M. tells the extraordinary true story of Henry Molaison, a young man who underwent a lobotomy in 1953 in hopes of curing his epilepsy. Instead, he suffered extensive memory loss and would became the most studied patient in the history of neuroscience. Luke Dittrich, whose grandfather performed the surgery, artfully combines family history, medical science, and investigative journalism to create a suspenseful and unsettling narrative on the search to understand the most elusive of scientific research topics: the human memory. The summary and analysis in this ebook are intended to complement your reading experience and bring you closer to a great work of nonfiction.

Remembering

Remembering Book
Author : Donald G. MacKay
Publisher : Prometheus Books
Release : 2019-01-29
ISBN : 1633884082
Language : En, Es, Fr & De

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Book Description :

The psychologist who worked with a famous amnesiac patient for fifty years explains what his studies show about how memory functions and ways to keep the brain sharp. At age twenty-seven, Henry Molaison underwent brain surgery to remedy life-threatening epilepsy. This operation inadvertently destroyed his hippocampus, the engine in the brain for forming new memories. Henry--until recently, known only as Patient H.M.--suffered catastrophic memory failures for the rest of his life and he became the most studied amnesia patient in the history of the world. Dr. Donald MacKay's studies with Henry span fifty years. They reveal the profound importance of memory. Memory decline impacts everything that makes a normal human mind and brain worth having: creative expression; artistic endeavors; awareness; and the ability to plan, to comprehend, to detect and correct errors, to appreciate humor, to imagine hypothetical situations, and to perceive novelty in the world. His research also shows how to keep memories sharp at any age and how to offset the degradation that aging and infrequent use inflict on memory. Remembering summarizes other results of the revolution in scientific understanding of mind and memory that began with Henry. Importantly, it makes good on the promise that research with Henry would help others by focusing on what readers who wish to maintain the everyday functioning of memory, mind, and brain (their own or others') can learn from the still ongoing revolution that he inspired.

Patient H M

Patient H M  Book
Author : Luke Dittrich
Publisher : Random House
Release : 2016-08-11
ISBN : 1448104688
Language : En, Es, Fr & De

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Book Description :

In the summer of 1953, maverick neurosurgeon William Beecher Scoville performed a groundbreaking operation on an epileptic patient named Henry Molaison. But it was a catastrophic failure, leaving Henry unable to create long-term memories. Scoville's grandson, Luke Dittrich, takes us on an astonishing journey through the history of neuroscience, from the first brain surgeries in ancient Egypt to the New England asylum where his grandfather developed a taste for human experimentation. Dittrich's investigation confronts unsettling family secrets and reveals the dark roots of modern neuroscience, raising troubling questions that echo into the present day.

Permanent Present Tense

Permanent Present Tense Book
Author : Suzanne
Publisher : Unknown
Release : 2013
ISBN : 9781846142710
Language : En, Es, Fr & De

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Book Description :

Download Permanent Present Tense book written by Suzanne, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

2401 Objects

2401 Objects Book
Author : Analogue,,Lewis Hetherington,Hannah Barker,Liam Jarvis
Publisher : Bloomsbury Publishing
Release : 2012-06-18
ISBN : 184943381X
Language : En, Es, Fr & De

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Book Description :

2011 Fringe First Award Winner "Henry, are you awake?” Henry lives each day like the last. Exactly like the last. Every day, he tries to make sense of the world around him; the girl sitting on the lawn outside his window, the pages of a book filled with the same sentence, the 80 year old man looking at him in the mirror. In 2009 Patient H.M.’s brain is dissected live on the internet to a global audience of 400,000 people, cut into carefully preserved slices: manuscripts of tissue like the pages of a book. In 1953 Henry Molaison emerges from experimental brain surgery without any recollection of the last two years of his life or the ability to form new memories. In 1935 nine-year old Henry is knocked over by a bike, leaving him unconscious for five minutes. Following Analogue's critically acclaimed Mile End and Beachy Head and inspired by the world’s most important neuroscientific case-study, 2401 Objects tells the remarkable story of a man who could no longer remember, but who has proven impossible to forget.

Patient based Approaches to Cognitive Neuroscience

Patient based Approaches to Cognitive Neuroscience Book
Author : Todd E. Feinberg,Martha J. Farah
Publisher : MIT Press
Release : 2000
ISBN : 9780262561235
Language : En, Es, Fr & De

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Book Description :

The cognitive disorders that follow brain damage are an important source of insight into the neural bases of human thought. Although cognitive neuroscience is sometimes equated with cognitive neuroimaging, the patient-based approach to cognitive neuroscience is responsible for most of what we now know about the brain systems underlying perception, attention, memory, language, and higher-order forms of thought including consciousness. This volume brings together state-of-the-art reviews of the patient-based approach to these and other central issues in cognitive neuroscience, written by leading authorities. Part I covers the history, principles, and methods of patient-based neuroscience: lesion method, imaging, computational modeling, and anatomy. Part II covers perception and vision: sensory agnosias, disorders of body perception, attention and neglect, disorders of perception and awareness, and misidentification syndromes. Part III covers language: aphasia, language disorders in children, specific language impairments, developmental dyslexia, acquired reading disorders, and agraphia. Part IV covers memory: amnesia and semantic memory impairments. Part V covers higher cognitive functions: frontal lobes, callosal disconnection (split brain), skilled movement disorders, acalculia, dementia, delirium, and degenerative conditions including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Contributors: Michael P. Alexander, Russell M. Bauer, Kathleen Baynes, D. Frank Benson, H. Branch Coslett, Jeffrey L. Cummings, Tim Curran, Antonio R. Damasio, Hanna Damasio, Ennio De Renzi, Maureen Dennis, Mark D'Esposito, Martha J. Farah, Todd E. Feinberg, Michael S. Gazzaniga, Georg Goldenberg, Jordan Grafman, Kenneth M. Heilman, Diane M. Jacobs, Daniel I. Kaufer, Daniel Y. Kimberg, Maureen W. Lovett, Richard Mayeux, M.-Marsel Mesulam, Bruce L. Miller, Robert D. Nebes, Robert D. Rafal, Marcus E. Raichle, Timothy Rickard, David M. Roane, David J. Roeltgen, Leslie J. Gonzalez Rothi, Eleanor M. Saffran, Daniel L. Schacter, Karin Stromswold, Edward Valenstein, Robert T. Watson, Tricia Zawacki, Stuart Zola.

Neoplasma

Neoplasma Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Neoplasma book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Memory for Spacial Location and Frequency of Occurrence After Frontal Or Temporal Lobectomy in Man

Memory for Spacial Location and Frequency of Occurrence After Frontal Or Temporal Lobectomy in Man Book
Author : Mary Louise Smith
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"In Part I, recall of spatial location was studied in an incidental-learning situation, where patients with unilateral brain lesions, the amnesic patient, H. M., and normal control subjects were asked to estimate the prices of objects in an array. All patient groups could encode location normally, but patients with right temporal-lobe lesions that included extensive hippocampal removal showed abnormally rapid forgetting. For all groups, and for H. M., location-recall did not differ under automatic and under effortful encoding conditions. It is argued that these results point to the importance of hippocampal-ceocortical interactions in spatial memory. In Part II, patients with frontal-lobe lesions were shown to be impaired in judging the frequency with which words or designs occurred in a list. With words, the deficits were demonstrable for both examiner-provided and self-generated stimuli. This impairment may be attributable either to a disorderly search process or to a deficit in cognitive estimation, or both." --

Why Science Needs Art

Why Science Needs Art Book
Author : Richard Roche,Sean Commins,Francesca Farina
Publisher : Routledge
Release : 2018-04-17
ISBN : 1317337999
Language : En, Es, Fr & De

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Book Description :

Why Science Needs Art explores the complex relationship between these seemingly polarised fields. Reflecting on a time when art and science were considered inseparable and symbiotic pursuits, the book discusses how they have historically informed and influenced each other, before considering how public perception of the relationship between these disciplines has fundamentally changed. Science and art have something very important in common: they both seek to reduce something infinitely complex to something simpler. Using examples from diverse areas including microscopy, brain injury, classical art, and data visualization, the book delves into the history of the intersection of these two disciplines, before considering current tensions between the fields. The emerging field of neuroaesthetics and its attempts to scientifically understand what humans find beautiful is also explored, suggesting ways in which the relationship between art and science may return to a more co-operative state in the future. Why Science Needs Art provides an essential insight into the relationship between art and science in an appealing and relevant way. Featuring colorful examples throughout, the book will be of interest to students and researchers of neuroaesthetics and visual perception, as well as all those wanting to discover more about the complex and exciting intersection of art and science.

In the Light of Evolution

In the Light of Evolution Book
Author : National Academy of Sciences
Publisher : National Academies Press
Release : 2014-05-19
ISBN : 0309296439
Language : En, Es, Fr & De

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Book Description :

Humans possess certain unique mental traits. Self-reflection, as well as ethic and aesthetic values, is among them, constituting an essential part of what we call the human condition. The human mental machinery led our species to have a self-awareness but, at the same time, a sense of justice, willing to punish unfair actions even if the consequences of such outrages harm our own interests. Also, we appreciate searching for novelties, listening to music, viewing beautiful pictures, or living in well-designed houses. But why is this so? What is the meaning of our tendency, among other particularities, to defend and share values, to evaluate the rectitude of our actions and the beauty of our surroundings? What brain mechanisms correlate with the human capacity to maintain inner speech, or to carry out judgments of value? To what extent are they different from other primates' equivalent behaviors? In the Light of Evolution Volume VII aims to survey what has been learned about the human "mental machinery." This book is a collection of colloquium papers from the Arthur M. Sackler Colloquium "The Human Mental Machinery," which was sponsored by the National Academy of Sciences on January 11-12, 2013. The colloquium brought together leading scientists who have worked on brain and mental traits. Their 16 contributions focus the objective of better understanding human brain processes, their evolution, and their eventual shared mechanisms with other animals. The articles are grouped into three primary sections: current study of the mind-brain relationships; the primate evolutionary continuity; and the human difference: from ethics to aesthetics. This book offers fresh perspectives coming from interdisciplinary approaches that open new research fields and constitute the state of the art in some important aspects of the mind-brain relationships.

Memory in Art

Memory in Art Book
Author : Suzanne Nalbantian,Paul M. Matthews,James L. McClelland
Publisher : MIT Press
Release : 2014-01-10
ISBN : 0262317958
Language : En, Es, Fr & De

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Book Description :

The humanities can add valuable insights to the study of memory. This BIT draws on recent neuroscientific research to explore one of the great masterpieces of fifteenth-century Flemish painting, Rogier van der Weyden's Descent from the Cross. It connects memory to the direct and indirect bodily responses to a work of art.

Handbook Of Clinical And Experimental Neuropsychology

Handbook Of Clinical And Experimental Neuropsychology Book
Author : Gianfranco Denes,Luigi Pizzamiglio
Publisher : Psychology Press
Release : 2020-03-06
ISBN : 1317735021
Language : En, Es, Fr & De

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Book Description :

The domain of neuroscience has had one of the most explosive growths in recent decades: within this development there has been a remarkable and renewed interest in the study of the relations between behaviour and the central nervous system. Part of this new attention is connected with the contribution of new technologies (PET, fMRI) permitting more precise mapping of neural structures responsible for cognitive functions and the development of new theoretical models of mental activities. The diffusion of new pathologies (for example the pattern of cognitive impairment associated with AIDS) has further enlarged the field of clinical neuropsychology. Finally there has been an expanding clinical interest in the understanding and management of age-related cognitive changes. This volume is the translated and updated version of the second edition of Manuale di Neuropsicologia (Zanichelli, 1996), by the same authors, and it reflects the current status of the art. It is intended to blend clinical and theoretical aspects of neuropsychology. The first part discusses the instrumental and clinical methods of investigation in neuropsychology, together with their development. A long section is dedicated to the language and memory disorders. The impairment of non-verbal cognitve functions, such as the disorders of space orientation, of of visuo-perceptive abilities, and of the emotions and attention, are extensively discussed. The pattern of degenerative dementias is thorougly described, as e is thoroughly described, as well as a number of new topics, such as a neuropsychological approach to consciousness. Finally, perspectives for treatment of some cognitive disorders are outlined.

Learning and Memory A Comprehensive Reference

Learning and Memory  A Comprehensive Reference Book
Author : Anonim
Publisher : Academic Press
Release : 2008-04-07
ISBN : 9780123705044
Language : En, Es, Fr & De

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Book Description :

The study of Learning and Memory is a central topic in Neuroscience and Psychology. It is also a very good example of a field that has come into maturity on all levels - in the protein chemistry and molecular biology of the cellular events underlying learning and memory, the properties and functions of neuronal networks, the psychology and behavioural neuroscience of learning and memory. Many of the basic research findings are directly applicable in the treatment of diseases and aging phenomena, and have found their way into educational theory and praxis. Learning and Memory: A Comprehensive Reference is the most comprehensive source of information about learning and memory ever assembled, and the definitive reference work on the topic. In four volumes, Editor-in-Chief John H. Byrne (University of Texas), together with volume editors Howard Eichenbaum (Boston University) for Systems and Neuroscience, Randolf Menzel (Freie Universität Berlin) for Behavioral Approaches, Henry Roediger (Washington University) for Cognitive Psychology, and David Sweatt (University of Alabama, Birmingham) for Molecular Mechanisms, have put together a truly authoritative collection of overview articles in 159 chapters on over 3000 pages. Learning and Memory: A Comprehensive Reference presents an extensive, integrated summary of the present state of research in the neurobiology and psychology of learning and memory and covers an enormous range of intellectual territory. With topics ranging from the neurochemistry and neurobiology of learning at the cellular and synaptic levels, systems neurobiology, the study of remarkable capabilities in animals (such as homing), ethological and behavioristic analyses, mechanisms, psychology, and disorders of learning and memory in humans, the work broadly covers all topics in the neurobiology and psychology of learning and memory. There is no other handbook with such a comprehensive coverage and depth. The authors selected are the leading scholars for the particular topics on which they write. The most comprehensive and authoritative resource available on the topic of learning and memory and its mechanisms Representing outstanding scholarship, each chapter is written by a leader in the field and an expert in the topic area Relevant and useful for newcomers and advanced researchers alike All topics represent the most up to date research A must have set for all medical, neuroscience and psychology libraries, and of great value to neighbouring disciplines, including education Selected chapters from the on-line version can be used to great effect in teaching Full color throughout, hundreds of illustrations, four volumes, 159 chapters, 3000 pages Available in print and on-line

Encyclopedia of the Mind

Encyclopedia of the Mind Book
Author : Harold Pashler
Publisher : SAGE
Release : 2013-01-14
ISBN : 1412950570
Language : En, Es, Fr & De

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Book Description :

It’s hard to conceive of a topic of more broad and personal interest than the study of the mind. In addition to its traditional investigation by the disciplines of psychology, psychiatry, and neuroscience, the mind has also been a focus of study in the fields of philosophy, economics, anthropology, linguistics, computer science, molecular biology, education, and literature. In all these approaches, there is an almost universal fascination with how the mind works and how it affects our lives and our behavior. Studies of the mind and brain have crossed many exciting thresholds in recent years, and the study of mind now represents a thoroughly cross-disciplinary effort. Researchers from a wide range of disciplines seek answers to such questions as: What is mind? How does it operate? What is consciousness? This encyclopedia brings together scholars from the entire range of mind-related academic disciplines from across the arts and humanities, social sciences, life sciences, and computer science and engineering to explore the multidimensional nature of the human mind.

How We Remember

How We Remember Book
Author : Michael E. Hasselmo
Publisher : MIT Press
Release : 2012
ISBN : 0262016354
Language : En, Es, Fr & De

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Book Description :

Episodic memory proves essential for daily function, allowing us to remember where we parked the car, what time we walked the dog, or what a friend said earlier. In How We Remember, Michael Hasselmo draws on recent developments in neuroscience to present a new model describing the brain mechanisms for encoding and remembering such events as spatiotemporal trajectories. He reviews physiological breakthroughs on the regions implicated in episodic memory, including the discovery of grid cells, the cellular mechanisms of persistent spiking and resonant frequency, and the topographic coding of space and time. These discoveries inspire a theory for understanding the encoding and retrieval of episodic memory not just as discrete snapshots but as a dynamic replay of spatiotemporal trajectories, allowing us to "retrace our steps" to recover a memory. In the main text of the book, he presents the model in narrative form, accessible to scholars and advanced undergraduates in many fields. In the appendix, he presents the material in a more quantitative style, providing mathematical descriptions appropriate for advanced undergraduates and graduate students in neuroscience or engineering.

Patient Safety and Healthcare Improvement at a Glance

Patient Safety and Healthcare Improvement at a Glance Book
Author : Sukhmeet S. Panesar
Publisher : Unknown
Release : 2014
ISBN : 9781118361337
Language : En, Es, Fr & De

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Book Description :

Patient Safety and Healthcare Improvement at a Glance is a timely and thorough overview of healthcare quality written specifically for students and junior doctors and healthcare professionals. It bridges the gap between the practical and the theoretical to ensure the safety and wellbeing of patients. Featuring essential step-by-step guides to interpreting and managing risk, quality improvement within clinical specialties, and practice development, this highly visual textbook offers the best preparation for the increased emphasis on patient safety and quality-driven focus in today's healthcare.

The Wiley Handbook on the Aging Mind and Brain

The Wiley Handbook on the Aging Mind and Brain Book
Author : Matthew Rizzo,Steven Anderson,Bernd Fritzsch
Publisher : John Wiley & Sons
Release : 2018-04-23
ISBN : 111877177X
Language : En, Es, Fr & De

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Book Description :

A thought-provoking treatise on understanding and treating the aging mind and brain This handbook recognizes the critical issues surrounding mind and brain health by tackling overarching and pragmatic needs so as to better understand these multifaceted issues. This includes summarizing and synthesizing critical evidence, approaches, and strategies from multidisciplinary research—all of which have advanced our understanding of the neural substrates of attention, perception, memory, language, decision-making, motor behavior, social cognition, emotion, and other mental functions. Written by a plethora of health experts from around the world, The Wiley Handbook on the Aging Mind and Brain offers in-depth contributions in 7 sections: Introduction; Methods of Assessment; Brain Functions and Behavior across the Lifespan; Cognition, Behavior and Disease; Optimizing Brain Function in Health and Disease; Forensics, Competence, Legal, Ethics and Policy Issues; and Conclusion and New Directions. Geared toward improving the recognition, diagnosis, and treatment of many brain-based disorders that occur in older adults and that cause disability and death Seeks to advance the care of patients who have perceptual, cognitive, language, memory, emotional, and many other behavioral symptoms associated with these disorders Addresses principles and practice relevant to challenges posed by the US National Academy of Sciences and National Institute of Aging (NIA) Presents materials at a scientific level that is appropriate for a wide variety of providers The Wiley Handbook on the Aging Mind and Brain is an important text for neurologists, psychiatrists, psychologists, physiatrists, geriatricians, nurses, pharmacists, social workers, and other primary caregivers who care for patients in routine and specialty practices as well as students, interns, residents, and fellows.

Neuroscience of Enduring Change

Neuroscience of Enduring Change Book
Author : Richard D. Lane,Lynn Nadel
Publisher : Oxford University Press
Release : 2020-03-03
ISBN : 0190881534
Language : En, Es, Fr & De

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Book Description :

Neuroscience of Enduring Change is founded on the premise that all major psychotherapy modalities producing enduring change do so by virtue of corrective emotional experiences that alter problematic memories through the process of reconsolidation. This book is unique in linking basic science concepts to clinical research and clinical application. Experts in each area address each of the basic science and clinical topics. No other book addresses a general mechanism of change in psychotherapy in combination with the basic science underpinning it. This book is also unique in bringing the latest neuroimaging evidence and cutting-edge conceptual approaches to bear in understanding how psychological and behavioral treatment approaches bring about lasting change in the brain. Clinicians will benefit from the detailed discussion of basic mechanisms that underpin their clinical interventions and will be challenged to consider how their approach to therapy might be adjusted to optimize the opportunities for enduring change. Researchers will benefit from authoritative reviews of extant knowledge and a clear description of the research agenda going forward. The cross-fertilization between the research and clinical domains is evident throughout.