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Parkinsons Disease Therapeutics

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Parkinson s Disease

Parkinson s Disease Book
Author : Sarat Chandra Yenisetti
Publisher : BoD – Books on Demand
Release : 2018-05-30
ISBN : 1789231523
Language : En, Es, Fr & De

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Book Description :

Parkinson's disease (PD) is the second most common neurodegenerative disorder results due to loss of dopamine producing brain cells. Knowledge relating to PD condition has been known since 5000BC, however no effective therapeutic strategies are available till today. Therefore it is important for neurobiologists to work further by taking advantage of modern scientific methods and develop appropriate therapeutic strategies. Efforts in this direction are worthy as they will reduce the burden of PD among elderly, who are already burdened with age related systemic degenerative processes. This book is a humble effort in that progressive direction. It has chapters covering multiple aspects relating to etiology, pathophysiology of PD, available and futuristic therapeutics strategies. Therefore it will be of interest to common man, biomedical researchers and clinicians. This is one small step in a direction "to reduce the burden of neurological disease."

Parkinson s Disease

Parkinson s Disease Book
Author : Richard Nass,Serge Przedborski
Publisher : Academic Press
Release : 2008
ISBN : 9780123740281
Language : En, Es, Fr & De

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Book Description :

Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. * Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson's disease * Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD * Current overviews of current status of PD research and discovery from bench-to-bedside * Provides novel insights and views on where the future of PD research may lead * Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases

Parkinson s Disease Therapeutics

Parkinson   s Disease Therapeutics Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2020-01-30
ISBN : 0128198834
Language : En, Es, Fr & De

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Book Description :

Parkinson’s Disease Therapeutics: Emphasis on Nanotechnological Advances presents the latest information on the second most common neurodegenerative disorder in the elderly. Despite remarkable progress in various PD therapeutics, such as microRNAs and brain drug delivery systems, a few limitations impede their success. This book sheds light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases. Emphasizes novel therapeutics for Parkinson’s disease, including nanotechnology, natural products and antioxidants Discusses the pros and cons of recently developed therapy options for Parkinson's Focuses on the efficacy of nanotechnology in overcoming the blood-brain barrier and biomaterial design

Therapeutics of Parkinson s Disease and Other Movement Disorders

Therapeutics of Parkinson s Disease and Other Movement Disorders Book
Author : Mark Hallett,Werner Poewe
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 047071400X
Language : En, Es, Fr & De

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Book Description :

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence

Basic Clinical and Therapeutic Aspects of Alzheimer s and Parkinson s Diseases

Basic  Clinical  and Therapeutic Aspects of Alzheimer   s and Parkinson   s Diseases Book
Author : Toshiharu Nagatsu,Abraham Fisher,Mitsuo Yoshida
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468458442
Language : En, Es, Fr & De

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Book Description :

This two-volume work contains the full text of the oral and poster presentations and the general discussion at the round table discussion of the Second International Conference on Alzheimer's and Parkinson's Diseases: Basic and Therapeutic Strategies, held at the Kyoto Park Hotel in Kyoto, Japan, on November 6-10, 1989. The First Conference was held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. The record of this First Conference was published by Plenum Press in 1986 as Volume 29 in Advances in Behavioral Biology, under the title "Alzheimer's and Parkinson's Diseases: Strategies for Research and Development." We are happy that the comprehensive texts of the oral and poster presentations of the Second Conference could again be published within the framework of this series. Since the First Conference in 1985, rapid progress has been made in both basic and 'therapeutic aspects of these diseases. About 700 scientists from allover the world participated in the Second Conference, and 300 papers were presented in oral and poster sessions. Many people and organizations have helped to organize this multi disciplinary international conference and hence have contributed to the scientific quality of these two volumes. We thank the members of the organizing committee, the organizations that provided financial support, and the contributing scientists for their enthusiastic participation. These two volumes follow the same publishing philosophy as the volume derived from the First Conference. They span a broad spectrum of topics and bridge preclinical and clinical concepts related to these diseases.

Parkinson s Disease Therapeutics

Parkinson s Disease Therapeutics Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2020-01-24
ISBN : 9780128198827
Language : En, Es, Fr & De

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Book Description :

Parkinson's Disease is the second most common neurodegenerative disorder in the elderly. Vital pathological events include a decline in nigrostriatal neurons and deterioration of the neurotransmitter dopamine. Since amyloid fibrils are the key end products of several proteins implicated in neurodegenerative diseases, multiple studies emphasize their diagnosis as the mainstay of current research. Despite remarkable progress in various PD therapeutics such as microRNAs and brain drug delivery systems, a few limitations impede their success. In addition, nanotechnological therapeutics avenues employed to date for brain diseases have not been as effective strategies as they are for other diseases. This book will shed light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases. However, the efficacy of nanotechnology in overcoming the bioavailability issues associated with drugs, natural products and antioxidants, and their use in Parkinson's Disease therapy has not yet been summarized in the form of a book. Numerous unresolved major drawbacks of the existing therapeutic strategies and Nanotechnology in Parkinson's Disease treatment will be highlighted and possible future perspectives to overcome current challenges will be emphasized. Emphasizes novel therapeutics for Parkinson's disease including nanotechnology, natural products, and antioxidants Discusses the pros and cons of multiple recently developed therapy options for Parkinson's Focuses on the efficacy of nanotechnology in overcoming the blood-brain barrier and biomaterial design

Parkinson s Disease

Parkinson   s Disease Book
Author : F. Messiha
Publisher : Springer
Release : 2012-07-12
ISBN : 9781468425130
Language : En, Es, Fr & De

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Book Description :

These Proceedings are the outcome of the First Tarbox Parkinson's Disease Symposium held October 14-16, 1976, at the South Park Inn in Lubbock, Texas. The Symposium was sponsored by the Department of Pharmacology and Therapeutics and the Tarbox Parkinson's Disease In stitute of the Texas Tech University School of Medicine at Lubbock. The Tarbox Parkinson's Disease Institute was established in 1973 with funds appropriated by the State of Texas and is dedicated to re search, patient care, and educational activities related to Parkinson's disease. The Institute is named after Mr. Elmer L. Tarbox, who recently served the Lubbock area as a Representative to the Texas Legislature, and is himself a parkinsonian patient. Mr. and Mrs. Tarbox attended the Symposium as honored guests. The First Tarbox Parkinson's Disease Symposium was devoted to both basic and clinical aspects of Parkinson's disease, with an emphasis on discussion of drug therapy. This discussion focused not only on readily available drugs such as levodopa, but also on new investigational drugs such as bromocriptine. Thanks are especially due to Thelma Saunders and the office staff of the Department of Pharmacology and Therapeutics, Texas Tech Univer sity School of Medicine, for their excellent service in producing camera-ready copy for the Publisher. Thanks are also due to Fathy S. Messiha, Program Chairman, to the other committee members, and to the staff of the Office of Continuing Education and Faculty Development. The Symposium could not have succeeded without their help.

Improving Therapeutics for Parkinson s Disease

Improving Therapeutics for Parkinson s Disease Book
Author : Jennifer A. O'Malley
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The following results are from studies designed with the overall goal of elucidating means for improving therapeutics for Parkinson's disease. There is still much to be understood regarding the cellular and molecular mechanisms underlying the development of side effects to therapies for Parkinson's disease such as levodopa-induced dyskinesias. Additionally, therapeutic intervention is further complicated when one considers the role of the functionally waning host environment, especially in the context of its responsivity to therapeutic agents. The work in this thesis was designed to focus on two aspects of Parkinson's disease therapeutics, (1) improving graft efficacy by contributing additional information on how the host environment in regards to age impacts graft function in Parkinson's disease, and (2) determining whether specific morphological changes of the nigral target neurons within the striatum impact development or severity of levodopa-induced dyskinesias. The first study demonstrates that while the aging striatum can, under specific conditions, support the survival of large numbers of grafted embryonic dopamine neurons, there is limited functional benefit even with robust cell survival. This realization is an important contribution to the field as it newly suggests the aged striatum is capable of supporting grafted dopamine neurons, but the limited efficacy of these grafts demonstrates the importance of the intricate balance between grafted cells and the aged host environment. The second study demonstrate that maintaining appropriate synaptic contacts that are presumably maintained when striatal medium spiny neuron cytoarchitecture is preserved, resulting in reduced drug-induced side-effects in parkinsonian rats. Future experiments are needed to explore the specific requirements of the aging striatum for functional recovery and how to implement synaptic stability of medium spiny neurons in clinical practice to potentially decrease side-effects of dopamine replacement pharmacotherapy.

Parkinson s Disease Current and Future Therapeutics and Clinical Trials

Parkinson s Disease  Current and Future Therapeutics and Clinical Trials Book
Author : Nestor Galvez-Jimenez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox
Publisher : Cambridge University Press
Release : 2016-03-31
ISBN : 1107053862
Language : En, Es, Fr & De

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Book Description :

This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.

Handbook of Parkinson s Disease Fifth Edition

Handbook of Parkinson s Disease  Fifth Edition Book
Author : Rajesh Pahwa,Kelly E. Lyons Ph.D.
Publisher : CRC Press
Release : 2013-05-09
ISBN : 1841849081
Language : En, Es, Fr & De

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Book Description :

Highly Commended, BMA Medical Book Awards 2014 This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this volume promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies. New to this edition: • Early identification of premotor symptoms • Potential disease modification agents • Physical and occupational therapy

Towards New Therapies for Parkinson s Disease

Towards New Therapies for Parkinson s Disease Book
Author : David Finkelstein
Publisher : BoD – Books on Demand
Release : 2011-11-02
ISBN : 9533074639
Language : En, Es, Fr & De

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Book Description :

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

10 Breakthrough Therapies for Parkinson s Disease

10 Breakthrough Therapies for Parkinson s Disease Book
Author : Michael Okun
Publisher : Books4patients
Release : 2015-08-21
ISBN : 9780692497418
Language : En, Es, Fr & De

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Book Description :

Michael S. Okun, M.D. is internationally celebrated as both a neurologist and a leading researcher. He has often been referred to as, "the voice of the Parkinson's disease patient." He was honored at the White House in 2015 as a Champion of Change for Parkinson's disease. He has an international following on the National Parkinson Foundation's Ask the Doctor web-forum and he is a Professor of Neurology at the University of Florida Health Center for Movement Disorders and Neurorestoration. His many books and internet blog posts are brimming with up-to date and extremely practical information. This book is the sequel to his runaway bestseller, Parkinson's Treatment: 10 Secrets to a Happier Life, which was translated into over 20 languages. Dr. Okun is well known for infusing his readers with positivity and optimism. In his latest book he reveals the breakthroughs in Parkinson's disease that will pave the road to meaningful progress. In this book he reviews all of the recent breakthrough ideas and therapies in Parkinson's disease, and he reviews the knowledge gained which is extending far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior. He believes that patients and families with personal investments in Parkinson's disease should be informed and updated about all of these potential breakthrough therapies. This book informs, educates, and will inspire Parkinson's disease patients, family members, as well as health care professionals and scientists. As Dr. Okun points out, we will journey toward better treatments -- and one day a cure.

Encyclopedia of Parkinson s Disease

Encyclopedia of Parkinson s Disease Book
Author : Kate White
Publisher : Hayle Medical
Release : 2015-02-17
ISBN : 9781632411945
Language : En, Es, Fr & De

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Book Description :

Various therapeutic modalities and treatments of Parkinson's disease (PD) have been described in this book. This disease is caused mainly due to the death of dopaminergic neurons in the substantia nigra. Recent PD medications treat symptoms; though none decrease the rate of dopaminergic neuron degeneration. The primary problem in development of neuroprotective therapies is a restricted comprehension of the crucial molecular mechanisms that incite neurodegeneration. The discovery of PD genes has led to the hypothesis that dysfunction of the ubiquitin-proteasome pathway and misfolding of proteins are both critical to pathogenesis of the disease. Oxidative stress and mitochondrial dysfunction, earlier labeled as responsible in the neurodegeneration of this disease, may also act in part by causing the collection of misfolded proteins, along with the production of other harmful events in dopaminergic neurons. PD models based on the manipulation of PD genes should prove crucial in explaining significant characteristics of the disease, like selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process. Some important topics include theoretical model for PD, PD in drosophila, animal models of PD, etc.

Recent Advances in Parkinson s Disease Translational and clinical research

Recent Advances in Parkinson s Disease  Translational and clinical research Book
Author : Anders Björklund,M. Angela Cenci
Publisher : Elsevier Science
Release : 2010
ISBN : 9780444537508
Language : En, Es, Fr & De

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Book Description :

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Road to Recovery from Parkinsons Disease

Road to Recovery from Parkinsons Disease Book
Author : Robert Rodgers, Ph.D.
Publisher : Createspace Independent Publishing Platform
Release : 2017-05-14
ISBN : 9781546706625
Language : En, Es, Fr & De

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Book Description :

Do you have Parkinson's Disease? Are you looking for ways to feel better? Road to Recovery from Parkinson's Disease gives a comprehensive overview of the factors that cause the symptoms of Parkinson's and covers all the natural treatments that are helping thousands of people with Parkinsons become healthy and well. There is no doubt about it. Many medical specialties provide relief from the symptoms of Parkinson's Disease. Road to Recovery from Parkinson's Disease reveals the natural therapies and safe treatments that persons with Parkinson's have discovered help them steer a steady course on the road to recovery.

Peripheral Immunity in Parkinson s Disease Emerging Role and Novel Target for Therapeutics

Peripheral Immunity in Parkinson s Disease  Emerging Role and Novel Target for Therapeutics Book
Author : Cristoforo Comi,Marco Cosentino,Rodrigo Pacheco
Publisher : Frontiers Media SA
Release : 2019-12-23
ISBN : 2889632857
Language : En, Es, Fr & De

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Book Description :

Download Peripheral Immunity in Parkinson s Disease Emerging Role and Novel Target for Therapeutics book written by Cristoforo Comi,Marco Cosentino,Rodrigo Pacheco, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A History of Therapeutics in Parkinson s Disease

A History of Therapeutics in Parkinson s Disease Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A History of Therapeutics in Parkinson s Disease book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essential Oils and Parkinson s Disease

Essential Oils and Parkinson s Disease Book
Author : Robert Rodgers, PhD,Jean Oswald, RN
Publisher : Parkinsons Recovery
Release : 2014-05-22
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A wide variety of therapies have been identified by Parkinsons Recovery researcher Robert Rodgers, PhD that help people reverse symptoms of Parkinson's disease. One such method is the use of essential oils. A big advantage of this therapy is that essential oils do not require a prescription from a medical doctor. They are also soothing to the soul, mind and body. Simply put, essential oils are a natural approach that can help anyone feel a lot better. The best news of all is that they help people who experience the neurological symptoms of Parkinson's Disease. The challenge everyone faces is to figure out which essential oils should be used to address specific symptoms. There are so many essential oils (and symptoms)! The "go to" expert with answers to such questions is Aromatherapist and registered nurse Jean Oswald. Jean has a profound knowledge about which essential oils help reduce symptoms that people with Parkinson's often experience. Essential oils are a safe and inexpensive therapy that helps many persons find relief from the symptoms of Parkinsons disease. They are a potent therapy indeed.

Therapy of Parkinson s Disease

Therapy of Parkinson s Disease Book
Author : William C. Koller,George W. Paulson
Publisher : CRC PressI Llc
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This work offers a comprehensive and fully updated overview of supportive patient management strategies, highlighting therapeutic approaches other that dopaminergic agents and conventional antiparkinsonian drugs. This second edition: reviews the neuroprotective effects of selegiline on Parkinson's disease; investigates ways of enhancing the effectiveness of levodopa-based therapy; presents methods of speech therapy with well-documented short- and long-term efficacy; and more.

Clinical Studies and Therapies in Parkinson s Disease

Clinical Studies and Therapies in Parkinson s Disease Book
Author : Juan Segura-Aguilar
Publisher : Academic Press
Release : 2021-09-15
ISBN : 9780128221204
Language : En, Es, Fr & De

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Book Description :

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson's Disease, and it remains as the most common treatment despite the fact that after 4-6 years it induces severe side effects such as dyskinesia. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies in Parkinson's disease, but efforts have failed at the time of transferring these successful results to preclinical studies. Although there are several publications that warn of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow the development of the disease. Translation of Preclinical Models to Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models analyses why preclinical models based on exogenous neurotoxins have failed. To develop new pharmacological treatments for Parkinson ́s Disease, the book discusses a more physiological model directly related to metabolism of dopaminergic neurons that are lost before and after the onset of the disease. This book also reviews genetic preclinical models based on genetic mutations associated with the familial form of the disease and preclinical models based on endogenous neurotoxins. Analyses why preclinical models of Parkinson's Disease therapies based on exogenous neurotoxins have failed Proposes a more physiological model directly related to metabolism of dopaminergic neurons Reviews genetic preclinical models based on genetic mutations and preclinical models based on endogenous neurotoxins