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Palladium Catalyzed Modification Of Nucleosides Nucleotides And Oligonucleotides

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Palladium Catalyzed Modification of Nucleosides Nucleotides and Oligonucleotides

Palladium Catalyzed Modification of Nucleosides  Nucleotides and Oligonucleotides Book
Author : Anant R. Kapdi,Debabrata Maiti,Yogesh S. Sanghvi
Publisher : Elsevier
Release : 2018-06-04
ISBN : 012811293X
Language : En, Es, Fr & De

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Book Description :

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids Book
Author : Harri Lönnberg
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2020-08-10
ISBN : 3110609290
Language : En, Es, Fr & De

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Book Description :

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Nucleic Acids Chemistry

Nucleic Acids Chemistry Book
Author : Ramon Eritja
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2021-01-18
ISBN : 3110636484
Language : En, Es, Fr & De

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Book Description :

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Anonim
Publisher : Academic Press
Release : 2020-04-24
ISBN : 0128211725
Language : En, Es, Fr & De

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Book Description :

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Alan R. Katritzky
Publisher : Academic Press
Release : 2011-01-07
ISBN : 0123854644
Language : En, Es, Fr & De

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Book Description :

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers

Palladacycles

Palladacycles Book
Author : Anant Kapdi,Debabrata Maiti
Publisher : Elsevier
Release : 2019-06-14
ISBN : 0128165162
Language : En, Es, Fr & De

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Book Description :

Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic complexes in catalysis employing azobenzene and hydrazobenzene as coordinating ligands. Its applications in processes such as selective reduction of alkenes, alkynes, or nitroalkanes are also covered. Palladacycles: Catalysis and Beyond reveals the tremendous advances that have taken place in the potential applications of palladacycles as versatile catalysts in academia and industry. It is a valuable resource for synthetic chemists, organometallic chemists, and chemical biologists. Reviews the importance and various applications of palladacycles in academic research and industry, including industrial scale applications Includes the impact of palladacycles on coupling reactions and potential applications as anticancer agents Features coverage of nano and colloidal catalysis via palladacyclic degradation

C H and C X Bond Functionalization

C H and C X Bond Functionalization Book
Author : Xavi Ribas
Publisher : Royal Society of Chemistry
Release : 2013
ISBN : 1849735700
Language : En, Es, Fr & De

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Book Description :

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron u an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation. Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry."

Modified Nucleosides

Modified Nucleosides Book
Author : Piet Herdewijn
Publisher : John Wiley & Sons
Release : 2008-09-08
ISBN : 3527623124
Language : En, Es, Fr & De

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Book Description :

Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.

Modified Nucleic Acids

Modified Nucleic Acids Book
Author : Kazuhiko Nakatani,Yitzhak Tor
Publisher : Springer
Release : 2016-04-04
ISBN : 3319271113
Language : En, Es, Fr & De

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Book Description :

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Synthesis of Therapeutic Oligonucleotides

Synthesis of Therapeutic Oligonucleotides Book
Author : Satoshi Obika,Mitsuo Sekine
Publisher : Springer
Release : 2018-12-08
ISBN : 981131912X
Language : En, Es, Fr & De

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Book Description :

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.

Official Gazette of the United States Patent and Trademark Office

Official Gazette of the United States Patent and Trademark Office Book
Author : United States. Patent and Trademark Office
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Official Gazette of the United States Patent and Trademark Office book written by United States. Patent and Trademark Office, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

DNA in Supramolecular Chemistry and Nanotechnology

DNA in Supramolecular Chemistry and Nanotechnology Book
Author : Eugen Stulz,Guido H. Clever
Publisher : John Wiley & Sons
Release : 2015-07-14
ISBN : 1118696948
Language : En, Es, Fr & De

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Book Description :

This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.

Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology Book
Author : G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
Publisher : Royal Society of Chemistry
Release : 2015-11-09
ISBN : 1782625771
Language : En, Es, Fr & De

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Book Description :

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Synthesis and Characterization of Glycosides

Synthesis and Characterization of Glycosides Book
Author : Marco Brito-Arias
Publisher : Springer
Release : 2016-06-03
ISBN : 3319323105
Language : En, Es, Fr & De

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Book Description :

This second edition is a short and comprehensive study on the best known approaches for preparing the main types of glycosides. It covers synthetic pathways of challenging glycosides known as antiviral or antineoplastic drugs, and synthetic substrates used for enzymatic detection, including those used for detection of gene markers in plant biotechnology. The author pays special attention to the structural characterization of glycosides and provides the basic tools for the structural assignment through NMR, X-Ray and mass spectra techniques. The book also covers strategies for preparation of antiviral and antineoplastic drugs included in a drug design course.

Synthesis of Therapeutic Oligonucleotides

Synthesis of Therapeutic Oligonucleotides Book
Author : Satoshi Obika,Mitsuo Sekine
Publisher : Springer
Release : 2018-12-20
ISBN : 9789811319112
Language : En, Es, Fr & De

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Book Description :

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.

Current Organic Chemistry

Current Organic Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Provides in depth reviews on current progress in the fields of asymmetric synthesis, organometallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry, and analytical methods in organic chemistry. Each issue is edited by an appointed Executive Guest Editor

Chemical Synthesis of Nucleoside Analogues

Chemical Synthesis of Nucleoside Analogues Book
Author : Pedro Merino
Publisher : John Wiley & Sons
Release : 2013-02-12
ISBN : 1118498100
Language : En, Es, Fr & De

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Book Description :

Compiles current tested and proven approaches tosynthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists fromaround the world, this book brings together and describes testedand proven approaches for the chemical synthesis of common familiesof nucleoside analogues. Readers will learn to create newnucleoside analogues with desired therapeutic properties by using avariety of methods to chemically modify natural nucleosides,including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- orheterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all themajor classes of nucleosides, including pronucleotides,C-nucleosides, carbanucleosides, and PNA monomers which have showngreat promise as starting points for the synthesis of nucleosideanalogues. The book also includes experimental procedures for keyreactions related to the synthesis of nucleoside analogues,providing a valuable tool for the preparation of a number ofdifferent compounds. Throughout the book, chemical schemes and figures help readersbetter understand the chemical structures of nucleoside analoguesand the methods used to synthesize them. Extensive references serveas a gateway to the growing body of original research studies andreviews in the field. Synthetically modified nucleosides have proven their value astherapeutic drugs, in particular as antiviral and antitumor agents.However, many of these nucleoside analogues have undesirable sideeffects. With Chemical Synthesis of Nucleoside Analogues astheir guide, researchers have a new tool for synthesizing a newgeneration of nucleoside analogues that can be used as therapeuticdrugs with fewer unwanted side effects.

The Combinatorial Index

The Combinatorial Index Book
Author : Barry A. Bunin
Publisher : Elsevier
Release : 1998-04-15
ISBN : 9780080542409
Language : En, Es, Fr & De

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Book Description :

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods Serves as a laboratory manual for bench chemists Includes a chapter on linkers to assist in choice of linking strategy Discusses strengths and limitations of the various methods Contains a structural index showing functional group transformations in solid-phase synthesis

Nucleic Acid metal Ion Interactions

Nucleic Acid metal Ion Interactions Book
Author : Nicholas V. Hud
Publisher : Royal Society of Chemistry
Release : 2009
ISBN : 0854041958
Language : En, Es, Fr & De

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Book Description :

The quest to understand how nucleic acids function at the most fundamental level requires a detailed understanding of nucleic acid-metal ion interactions, as RNA and DNA are polyanions, their structures depend strongly on their association with metal ions. While scientists have appreciated the intimate connection between metal ions and nucleic acid function for decades, the noncovalent, dynamic nature of these interactions makes their accurate, quantitative description a challenge. Over the past few years, the simultaneous development of solution-state spectroscopic techniques and achievement of high resolution X-ray crystal structures has provided tremendous insight into nucleic acid-metal ion interactions. This insight includes direct evidence for the importance of such interactions in determining nucleic acid structure over orders of magnitude in scale, from the folding pathways of large RNAs to the subtle modulation of DNA groove width. Nucleic Acid-Metal Ion Interactions provides a comprehensive review of the experimental studies that define our current understanding of the subject, with a particular emphasis on biophysical studies. The book is not merely a current review of the literature, however, as the authors also present original material and fresh perspectives. The topics covered range from crystallographic studies of transition metal coordination by single nucleotides, to the application of polyelectrolyte theory in describing the delocalized counterions that surround nucleic acids in solution. Separate chapters describe how nucleic acid-metal interactions modulate both the kinetics and thermodynamics of RNA folding, play important roles in RNA catalysis, and how these interactions are even informing the design of new therapeutics. The book is sufficiently detailed to serve as a reference for researchers active in nucleic acids biophysics or molecular biology. Additionally, chapter authors have supplied sufficient introductory and background material to make this book an accessible first resource for students and researchers who are just beginning to explore this dynamic field.

Biocatalysis in the Pharmaceutical and Biotechnology Industries

Biocatalysis in the Pharmaceutical and Biotechnology Industries Book
Author : Ramesh N. Patel
Publisher : CRC Press
Release : 2006-09-26
ISBN : 1420019376
Language : En, Es, Fr & De

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Book Description :

Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.