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Paks Rac Cdc42 P21 Activated Kinases

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PAKs RAC CDC42 p21 activated Kinases

PAKs  RAC CDC42  p21  activated Kinases Book
Author : Hiroshi Maruta
Publisher : Newnes
Release : 2013-01-23
ISBN : 0124072100
Language : En, Es, Fr & De

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Book Description :

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.

Structural and Functional Analysis of the P21 CDC42 RAC activated Kinase Pak

Structural and Functional Analysis of the P21  CDC42 RAC  activated Kinase Pak Book
Author : Claire Tse Chien Chong
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Structural and Functional Analysis of the P21 CDC42 RAC activated Kinase Pak book written by Claire Tse Chien Chong, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Interaction Between a Novel P21 Activated Kinase PAK6 and Androgen Receptor in Prostate Cancer

Interaction Between a Novel P21 Activated Kinase  PAK6  and Androgen Receptor in Prostate Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The androgen-signaling pathway is important for the growth and progression of prostate cancer. The cell cycle signaling regulated by the mitogen activated protein/extracellular-signal-regulated kinase (MAPK/ERK) have been linked to tumorigenesis and tumor progression. The p2l-activated kinases (PAKs) are members of a growing class of Rac/Cdc42-associated Ste20-like ser/thr protein kinases. Recent studies have shown that MAPK/ERK signaling can be mediated via Cdc42/Rac-stimulation of PAK activity. Recently, we demonstrated a specific interaction between a novel PAK protein, PAK6, and AR. This finding provided the first link between I PAK-mediated signaling to the steroid hormone receptor pathway. In this study, we propose to assess the biological roles of PAK6 in prostate cancer cells, and to examine the expression of PAK6 in prostate tissues. We anticipate that by completing the objectives proposed in this grant, we will obtain fresh insight into the regulatory processes of AR and PAK6 that may contribute to the development of new targets for the treatment of prostate cancer.

Cellular Signal Processing

Cellular Signal Processing Book
Author : Friedrich Marks,Ursula Klingmüller,Karin Müller-Decker
Publisher : Garland Science
Release : 2017-05-17
ISBN : 1351677225
Language : En, Es, Fr & De

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Book Description :

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Regulation of Gene Expression in the Tumor Environment

Regulation of Gene Expression in the Tumor Environment Book
Author : Menashe Bar-Eli
Publisher : Springer Science & Business Media
Release : 2008-08-25
ISBN : 1402083416
Language : En, Es, Fr & De

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Book Description :

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.

EJB Reviews 1996

EJB Reviews 1996 Book
Author : P. Christen,E. Hofmann
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642606598
Language : En, Es, Fr & De

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Book Description :

In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful, resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitely asked to be critical, selective, evaluative and interdisciplinary oriented. The reviews should encourage young scientists to think independently and creatively, and inform active investigators about the state of the art in a given field.

Cytoskeleton and Small G Proteins

Cytoskeleton and Small G Proteins Book
Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642585914
Language : En, Es, Fr & De

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Book Description :

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Handbook of Cell Signaling

Handbook of Cell Signaling Book
Author : Ralph A. Bradshaw,Edward A. Dennis
Publisher : Academic Press
Release : 2009-11-03
ISBN : 0080920918
Language : En, Es, Fr & De

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Book Description :

Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Regulators and Effectors of Small GTPases Part G Ras Family II

Regulators and Effectors of Small GTPases  Part G  Ras Family II Book
Author : Anonim
Publisher : Elsevier
Release : 2001-06-05
ISBN : 9780080522562
Language : En, Es, Fr & De

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Book Description :

The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences. This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325, 329, and 332) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in the above-mentioned aspects of cell biology at the molecular level.

The JNK Signaling Pathway

The JNK Signaling Pathway Book
Author : Anning Lin
Publisher : CRC Press
Release : 2006-02-15
ISBN : 1498713343
Language : En, Es, Fr & De

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Book Description :

Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecul

Proteomics of Spermatogenesis

Proteomics of Spermatogenesis Book
Author : G. S. Gupta
Publisher : Springer Science & Business Media
Release : 2006-07-02
ISBN : 0387276556
Language : En, Es, Fr & De

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Book Description :

Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.

The Biochemistry of Cell Signalling

The Biochemistry of Cell Signalling Book
Author : Ernst J. M. Helmreich,Department of Physiological Chemistry School of Medicine Ernst J M Helmreich
Publisher : Oxford University Press, USA
Release : 2001
ISBN : 9780198508205
Language : En, Es, Fr & De

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Book Description :

The Biochemistry of Cell Signalling is a comprehensive yet concise study of the principles of cell signalling, concentrating on the structural and mechanistic aspects.

Advances in Cancer Research

Advances in Cancer Research Book
Author : Anonim
Publisher : Academic Press
Release : 1998-02-09
ISBN : 9780080562544
Language : En, Es, Fr & De

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Book Description :

The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.

Innate Immunity of Plants Animals and Humans

Innate Immunity of Plants  Animals and Humans Book
Author : Holger Heine
Publisher : Springer Science & Business Media
Release : 2007-12-07
ISBN : 3540739300
Language : En, Es, Fr & De

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Book Description :

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.

Actin A Dynamic Framework for Multiple Plant Cell Functions

Actin  A Dynamic Framework for Multiple Plant Cell Functions Book
Author : Christopher J. Staiger,Frantisek Baluska,D. Volkmann,P. Barlow
Publisher : Springer Science & Business Media
Release : 2000-09-30
ISBN : 9780792364122
Language : En, Es, Fr & De

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Book Description :

Actin is an extremely abundant protein that comprises a dynamic polymeric network present in all eukaryotic cells, known as the actin cytoskeleton. The structure and function of the actin cytoskeleton, which is modulated by a plethora of actin-binding proteins, performs a diverse range of cellular roles. Well-documented functions for actin include: providing the molecular tracks for cytoplasmic streaming and organelle movements; formation of tethers that guide the cell plate to the division site during cytokinesis; creation of honeycomb-like arrays that enmesh and immobilize plastids in unique subcellular patterns; supporting the vesicle traffic and cytoplasmic organization essential for the directional secretory mechanism that underpins tip growth of certain cells; and coordinating the elaborate cytoplasmic responses to extra- and intracellular signals. The previous two decades have witnessed an immense accumulation of data relating to the cellular, biochemical, and molecular aspects of all these fundamental cellular processes. This prompted the editors to put together a diverse collection of topics, contributed by established international experts, related to the plant actin cytoskeleton. Because the actin cytoskeleton impinges on a multitude of processes critical for plant growth and development, as well as for responses to the environment, the book will be invaluable to any researcher, from the advanced undergraduate to the senior investigator, who is interested in these areas of plant cell biology.

Eicosanoids and Other Bioactive Lipids in Cancer Inflammation and Radiation Injury 4

Eicosanoids and Other Bioactive Lipids in Cancer  Inflammation  and Radiation Injury  4 Book
Author : Kenneth V. Honn,Lawrence J. Marnett,Santosh Nigam,Edward A. Dennis
Publisher : Springer Science & Business Media
Release : 2013-12-01
ISBN : 1461547938
Language : En, Es, Fr & De

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Book Description :

This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.

Intercellular Signaling in Development and Disease

Intercellular Signaling in Development and Disease Book
Author : Edward A. Dennis,Ralph A. Bradshaw
Publisher : Academic Press
Release : 2011-04-05
ISBN : 0123822165
Language : En, Es, Fr & De

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Book Description :

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease. Articles written and edited by experts in the field Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Chemotaxis

Chemotaxis Book
Author : Michael Eisenbach
Publisher : World Scientific Publishing Company
Release : 2004-05-24
ISBN : 1911299018
Language : En, Es, Fr & De

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Book Description :

With contribution from Joseph W Lengeler (University of Osnabrück, Germany) With contribution from Mazal Varon (Tel-Aviv University, Israel) With contribution from David Gutnick (Tel-Aviv University, Israel) With contribution from Ruedi Meili (Albert Einstein College of Medicine, USA) With contribution from Richard A Firtel (Albert Einstein College of Medicine, USA) With contribution from Jeffrey E Segall (Albert Einstein College of Medicine, USA) With contribution from Geneva M Omann (University of Michigan, Ann Arbor, USA) With contribution from Atsushi Tamada (Osaka University, Japan) With contribution from Fujio Murakami (Osaka University, Japan) How do white blood cells identify and move to fight invading microorganisms? How do metastatic cancer cells find their target organ? How are sperm cells guided to the egg to fertilize it? How do unicellular organisms find food and avoid noxious substances? By chemotaxis is the common answer to all these questions. Chemotaxis — the response of cells to chemical stimuli by directed movement — is one of the most basic and fascinating processes in nature, involved in both health and disease. This is the first and only textbook and sourcebook on chemotaxis. The authors demonstrate how basic chemotaxis is to life and how widespread it is, and presents the state of the art with respect to its molecular and physiological mechanisms. Because chemotaxis research is still in progress, the book also indicates open questions and future directions of research. In addition, potential applications to health problems are pointed out. Contents: IntroductionChemotaxis — A Basic and Universal Phenomenon Among Microorganisms and Eukaryotic CellsBacterial ChemotaxisChemotaxis as a Means of Cell-Cell Communication in BacteriaMolecular Mechanisms of Chemotaxis in AmoebaePhysiology and Molecular Mechanisms of Chemotaxis of White Blood CellsSperm ChemotaxisChemotropic Guidance of Axons in the Nervous SystemCommonality and Diversity of Chemotaxis Readership: Upper level undergraduates, graduate students, academics, researchers and clinicians in biochemistry and cell/molecular biology.

Microinjection

Microinjection Book
Author : Juan Carlos Lacal,Rosario Perona,James Feramisco
Publisher : Birkhäuser
Release : 2013-12-01
ISBN : 3034887051
Language : En, Es, Fr & De

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Book Description :

This manual describes the methodology and applications of microinjection, a powerful technique for transposing material into living cells through needle injection. Information is presented on the techniques principles, the required equipment, preparation of receiving cells and injected material, and the analysis of results. Detailed protocols for a wide range of applications in different cellular systems are included. A large part of the book is also dedicated to the Xenopus laevis oocyte system.

Signaling Networks and Cell Cycle Control

Signaling Networks and Cell Cycle Control Book
Author : J. Silvio Gutkind
Publisher : Springer Science & Business Media
Release : 2000-04-14
ISBN : 159259218X
Language : En, Es, Fr & De

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Book Description :

Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.