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Oxidative Stress

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Oxidative Stress and Antioxidant Protection

Oxidative Stress and Antioxidant Protection Book
Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Release : 2016-01-14
ISBN : 111883237X
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Brain Aging

Brain Aging Book
Author : David R. Riddle
Publisher : CRC Press
Release : 2007-04-19
ISBN : 9781420005523
Language : En, Es, Fr & De

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Book Description :

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Oxidative Stress

Oxidative Stress Book
Author : Helmut Sies
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483289117
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress is intended as an in-depth account of knowledge and problems in the field of oxygen-related damage in biological systems. The topics range from an assessment of molecular events in in vitro model systems to complex problems in clinical medicine. Organized into two parts with a total of 18 chapters, this book begins with an introduction to oxidative stress, elucidating specific topics on reactive oxygen species, detoxification system, and nature of oxidative damage. The first part focuses on models used with cells and tissues in the study of oxidative stress, whereas the second part describes the processes elicited by oxidative stress.

Aging Research in Yeast

Aging Research in Yeast Book
Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Publisher : Springer Science & Business Media
Release : 2011-11-19
ISBN : 9789400725614
Language : En, Es, Fr & De

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Book Description :

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Cellular Oxidative Stress

Cellular Oxidative Stress Book
Author : Silvia Dossena,Angela Marino
Publisher : MDPI
Release : 2021-09-06
ISBN : 3036516441
Language : En, Es, Fr & De

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Book Description :

This book collects 17 original research papers and 9 reviews that are part of the Special Issue “Cellular Oxidative Stress”, published in the journal Antioxidants. Oxidative stress on a cellular level affects the function of tissues and organs and may eventually lead to disease. Therefore, a precise understanding of how oxidative stress develops and can be counteracted is of utmost importance. The scope of the book is to emphasize the latest findings on the cellular targets of oxidative stress and the potential beneficial effect of antioxidants on human health.

Oxidative Stress and Biomaterials

Oxidative Stress and Biomaterials Book
Author : Thomas Dziubla,D Allan Butterfield
Publisher : Academic Press
Release : 2016-05-31
ISBN : 0128032707
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Oxidative Stress Exercise and Aging

Oxidative Stress  Exercise and Aging Book
Author : Helaine M Alessio,Ann E Hagerman
Publisher : World Scientific
Release : 2006-03-27
ISBN : 178326005X
Language : En, Es, Fr & De

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Book Description :

This book brings together some of the leading researchers in the actively investigated field of oxidative stress, an area of study which is of importance to human health and disease. It examines oxidative stress in a variety of models, at rest and after exercise, in young and old. Key concepts of oxidative stress, exercise and aging are presented in clear and easy-to-understand terms. Oxidative stress in different types of exercises — isometric, isotonic and sports — is explained in detail, with several chapters focusing on acute and chronic adaptations of skeletal muscles following both aerobic and non-aerobic exercises. The book includes current knowledge of the underlying mechanisms influencing health and disease processes associated with oxidative stress. Contents:Chemistry of Reactive Oxygen Species and Antioxidants (D C Close & A E Hagerman)Oxidative Stress in Plants and Animals (D C Close & A E Hagerman)The Exercise Continuum (R L Wiley)Oxidative Stress and Muscle Size, Type, and Action (H M Alessio)Oxidative Stress Across the Exercise Continuum (H M Alessio)Oxidative Stress and Antioxidant Defense: Effects of Aging and Exercise (L L Ji)Muscle, Oxidative Stress and Aging (J S Moylan et al.)Aging, Exercise, Antioxidants, and Cardioprotection (J Quindry & S Powers)Genetic Expressions: Oxidative Stress, Exercise, and Aging (N B Schweitzer & H M Alessio) Readership: Academics, researchers, upper undergraduate and graduate students in biochemistry, biological chemistry, physiology, gerontology, and cell & molecular biology; companies that develop and market products for sports, health, antioxidants and anti-aging interventions. Key Features:Descriptions of oxidative stress reactions in plants as well as animal modelsThe role of gene expression regulation in oxidative stressDiscussion of Oxidative stress reactions in skeletal and cardiac musclesNew mechanisms for understanding positive and negative consequences of oxidative stressKeywords:Exercise;Oxidative Stress;Aging;Health;Sports;Radicals;Antioxidants;Plants and Oxidative Stress

Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress

Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress Book
Author : Blanca Hernandez-Ledesma,Cristina Martinez-Villaluenga
Publisher : Academic Press
Release : 2021-12-16
ISBN : 012822584X
Language : En, Es, Fr & De

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Book Description :

Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress presents the nutritional and technological aspects related to the development of functional foods with anti-inflammatory and antioxidant effects. Specifically, analytical approaches for the characterization of anti-inflammatory and antioxidant properties of healthy foods and functional constituents, as well as technological strategies for the extraction of compounds and fractions from raw materials to produce anti-inflammatory and antioxidant ingredients are addressed. In addition, the molecular mechanisms by which foods and their components can modulate inflammation and their oxidative stress effects on disease prevention are explored. Finally, clinical research addressing nutritional needs in pathological subjects with inflammatory diseases are considered. Covers methods of analysis and extraction of anti-inflammatory and antioxidant compounds Offers an overview of the main anti-inflammatory and antioxidant compounds in foods Provides a guide on the mechanisms of action and health benefits of anti-inflammatory and antioxidant dietary bioactives

Oxidative Damage to Plants

Oxidative Damage to Plants Book
Author : Parvaiz Ahmad
Publisher : Academic Press
Release : 2014-01-29
ISBN : 0128004606
Language : En, Es, Fr & De

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Book Description :

With contributions that review research on this topic throughout the world, Oxidative Damage to Plants covers key areas of discovery, from the generation of reactive oxygen species (ROSs), their mechanisms, quenching of these ROSs through enzymatic and non-enzymatic antioxidants, and detailed aspects of such antioxidants as SOD and CAT. Environmental stress is responsible for the generation of oxidative stress, which causes oxidative damage to biomolecules and hence reduces crop yield. To cope up with these problems, scientists have to fully understand the generation of reactive oxygen species, its impact on plants and how plants will be able to withstand these stresses. Provides invaluable information about the role of antioxidants in alleviating oxidative stress Examines both the negative effects (senescence, impaired photosynthesis and necrosis) and positive effects (crucial role that superoxide plays against invading microbes) of ROS on plants Features contributors from a variety of regions globally

Reactive Oxygen Species and Oxidative Damage in Plants Under Stress

Reactive Oxygen Species and Oxidative Damage in Plants Under Stress Book
Author : Dharmendra K. Gupta,José M. Palma,Francisco J. Corpas
Publisher : Springer
Release : 2015-09-07
ISBN : 3319204211
Language : En, Es, Fr & De

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Book Description :

This book provides detailed and comprehensive information on oxidative damage caused by stresses in plants with especial reference to the metabolism of reactive oxygen species (ROS). In plants, as in all aerobic organisms, ROS are common by-products formed by the inevitable leakage of electrons onto O2 from the electron transport activities located in chloroplasts, mitochondria, peroxisomes and in plasma membranes or as a consequence of various metabolic pathways confined in different cellular loci. Environmental stresses such as heat, cold, drought, salinity, heavy-metal toxicity, ozone and ultraviolet radiation as well as pathogens/contagion attack lead to enhanced generation of ROS in plants due to disruption of cellular homeostasis. ROS play a dual role in plants; at low concentrations they act as signaling molecules that facilitate several responses in plant cells, including those promoted by biotic and abiotic agents. In divergence, at high levels they cause damage to cellular constituents triggering oxidative stress. In either case, small antioxidant molecules and enzymes modulate the action of these ambivalent species.

Oxidative Stress

Oxidative Stress Book
Author : Canhua Huang,Yuanyuan Zhang
Publisher : Springer Nature
Release : 2021-05-27
ISBN : 981160522X
Language : En, Es, Fr & De

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Book Description :

This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.

Oxidative Stress

Oxidative Stress Book
Author : Helmut Sies
Publisher : Academic Press
Release : 2019-11-07
ISBN : 0128196963
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: A conceptual framework for studying oxidative stress. Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies. Features contributions from international leaders in oxidative stress and redox biology research.

Oxidative Stress and Redox Regulation

Oxidative Stress and Redox Regulation Book
Author : Ursula Jakob,Dana Reichmann
Publisher : Springer Science & Business Media
Release : 2013-03-15
ISBN : 9400757875
Language : En, Es, Fr & De

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Book Description :

Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Oxidative Stress Inflammation and Health

Oxidative Stress  Inflammation  and Health Book
Author : Young-Joon Surh
Publisher : CRC Press
Release : 2005-05-24
ISBN : 1420028251
Language : En, Es, Fr & De

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Book Description :

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

Modulators of Oxidative Stress

Modulators of Oxidative Stress Book
Author : Hande Gurer-Orhan,Luciano Saso,Višnja Stepanić
Publisher : MDPI
Release : 2020-11-03
ISBN : 9783039432288
Language : En, Es, Fr & De

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Book Description :

The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.

Oxidative Stress and Redox Signalling in Parkinsons Disease

Oxidative Stress and Redox Signalling in Parkinsons Disease Book
Author : Rodrigo Franco,Jonathan A Doorn,Jean-Christophe Rochet
Publisher : Royal Society of Chemistry
Release : 2017-07-21
ISBN : 1788011910
Language : En, Es, Fr & De

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Book Description :

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Oxidative Stress in Aquatic Ecosystems

Oxidative Stress in Aquatic Ecosystems Book
Author : Doris Abele,Jose Pablo Vazquez-Medina,Tania Zenteno-Savin
Publisher : John Wiley & Sons
Release : 2011-11-03
ISBN : 1444345966
Language : En, Es, Fr & De

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Book Description :

Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.

The Effects of Tert Butyl Kydroperoxide and Iron induced Oxidative Stress on Retinal Pigment Epithelium Physiology and Function

The Effects of Tert Butyl Kydroperoxide  and Iron induced Oxidative Stress on Retinal Pigment Epithelium Physiology and Function Book
Author : Ludmila Anatolievna Voloboueva
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Effects of Tert Butyl Kydroperoxide and Iron induced Oxidative Stress on Retinal Pigment Epithelium Physiology and Function book written by Ludmila Anatolievna Voloboueva, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases Book
Author : Colin R. Martin,Victor R Preedy
Publisher : Academic Press
Release : 2020-06-12
ISBN : 0128177810
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Inflammation Aging and Oxidative Stress

Inflammation  Aging  and Oxidative Stress Book
Author : Stephen C. Bondy,Arezoo Campbell
Publisher : Springer
Release : 2016-12-14
ISBN : 3319334867
Language : En, Es, Fr & De

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Book Description :

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.