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Mitochondria and Oxidative Stress in Neurodegenerative Disorders Volume 1147

Mitochondria and Oxidative Stress in Neurodegenerative Disorders  Volume 1147 Book
Author : Gary E. Gibson,Rajiv R. Ratan,M. Flint Beal
Publisher : Wiley-Blackwell
Release : 2008-12-30
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Our understanding of how mitochondria functionally interact with other cellular organelles and the process of transcription, and how mitochondria detect oxidative modification of macromolecules has improved significantly in the past decade. Importantly, the roles of mitochondria and oxidative stress are also better defined in the pathophysiology of neurodegenerative disorders. This volume combines basic, clinical, and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders Book
Author : G. Ali Qureshi,S. Hasan Parvez
Publisher : Elsevier
Release : 2007-03-22
ISBN : 9780080489490
Language : En, Es, Fr & De

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Book Description :

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Metal Ions and Neurodegenerative Disorders

Metal Ions and Neurodegenerative Disorders Book
Author : Paolo Zatta
Publisher : World Scientific
Release : 2003
ISBN : 9789812796691
Language : En, Es, Fr & De

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Book Description :

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases

Oxidative Stress in Cancer  AIDS  and Neurodegenerative Diseases Book
Author : Luc Montagnier,Rene Olivier,Catherine Pasquier
Publisher : CRC Press
Release : 1997-10-06
ISBN : 9781420002928
Language : En, Es, Fr & De

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Book Description :

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Oxidative Stress in Vertebrates and Invertebrates

Oxidative Stress in Vertebrates and Invertebrates Book
Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Release : 2011-12-06
ISBN : 111800194X
Language : En, Es, Fr & De

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Book Description :

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Mitochondria and Oxidative Stress in Neurodegenerative Disorders

Mitochondria and Oxidative Stress in Neurodegenerative Disorders Book
Author : Gary E. Gibson,Rajiv R. Ratan,M. Flint Beal
Publisher : Wiley-Blackwell
Release : 2008-12-30
ISBN : 9781573317139
Language : En, Es, Fr & De

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Book Description :

Our understanding of how mitochondria functionally interact with other cellular organelles and the process of transcription, and how mitochondria detect oxidative modification of macromolecules has improved significantly in the past decade. Importantly, the roles of mitochondria and oxidative stress are also better defined in the pathophysiology of neurodegenerative disorders. This volume combines basic, clinical, and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Metal Ions in Neurological Systems

Metal Ions in Neurological Systems Book
Author : Wolfgang Linert,Henryk Kozlowski
Publisher : Springer Science & Business Media
Release : 2012-10-16
ISBN : 3709110017
Language : En, Es, Fr & De

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Book Description :

Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.

Advances in Neurodegenerative Disorders Alzheimer s and aging

Advances in Neurodegenerative Disorders  Alzheimer s and aging Book
Author : J. Marwah,Herman Teitelbaum
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Advances in Neurodegenerative Disorders Alzheimer s and aging book written by J. Marwah,Herman Teitelbaum, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Uday Kishore
Publisher : BoD – Books on Demand
Release : 2013-05-15
ISBN : 9535110888
Language : En, Es, Fr & De

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Book Description :

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
Release : 2012-03-12
ISBN : 1461406536
Language : En, Es, Fr & De

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Book Description :

The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Role of Oxidative Stress in Pathophysiology of Diseases

Role of Oxidative Stress in Pathophysiology of Diseases Book
Author : Pawan K. Maurya,Kamal Dua
Publisher : Springer Nature
Release : 2020
ISBN : 9811515689
Language : En, Es, Fr & De

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Book Description :

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress. --

Inflammation Aging and Oxidative Stress

Inflammation  Aging  and Oxidative Stress Book
Author : Stephen C. Bondy,Arezoo Campbell
Publisher : Springer
Release : 2016-12-14
ISBN : 3319334867
Language : En, Es, Fr & De

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Book Description :

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

DJ 1 PARK7 Protein

DJ 1 PARK7 Protein Book
Author : Hiroyoshi Ariga,Sanae M. M. Iguchi-Ariga
Publisher : Springer
Release : 2017-11-16
ISBN : 9811065837
Language : En, Es, Fr & De

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Book Description :

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.

Molecular Basis of Oxidative Stress

Molecular Basis of Oxidative Stress Book
Author : Frederick A. Villamena
Publisher : John Wiley & Sons
Release : 2013-06-06
ISBN : 1118355873
Language : En, Es, Fr & De

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Book Description :

Sets the stage for the development of better diagnostictechniques and therapeutics Featuring contributions from an international team of leadingclinicians and biomedical researchers, Molecular Basis ofOxidative Stress reviews the molecular and chemical bases ofoxidative stress, describing how oxidative stress can lead to thedevelopment of cancer and cardiovascular and neurodegenerativediseases. Moreover, it explains the potential role of free radicalsin both the diagnosis and the development of therapeutics to treatdisease. Molecular Basis of Oxidative Stress is logicallyorganized, beginning with a comprehensive discussion of thefundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage ofbiomolecules occurs Examines how these oxidative events effect cellularmetabolism Investigates the role of oxidative stress in the pathogenesisof cancer, neurodegenerative disease, cardiovascular disease, andcystic fibrosis Explores opportunities to improve the diagnosis of disease andthe design of new therapeutic agents Readers will find much novel information, including new radicalchemistries and the latest discoveries of how free radicals reactwith biomolecules. The contributors also present recent findingsthat help us better understand the initiation of oxidative stressand the mechanisms leading to the pathogenesis of variousdiseases. Throughout the book, the use of molecular structures helpsreaders better understand redox chemistry. In addition, plenty ofdetailed figures illustrate the mechanisms of oxidative stress anddisease pathogenesis. Examining everything from the basic chemistry of oxidativestress to the pathogenesis of disease, Molecular Basis ofOxidative Stress will help readers continue to explore thenature of oxidative stress and then use that knowledge to developnew approaches to prevent, detect, and treat a broad range ofdisease conditions.

Neurodegenerative Diseases and Metal Ions

Neurodegenerative Diseases and Metal Ions Book
Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Publisher : John Wiley & Sons
Release : 2006-07-11
ISBN : 0470028106
Language : En, Es, Fr & De

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Book Description :

About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Oxidative energy Metabolism in Neurodegenerative Disorders

Oxidative energy Metabolism in Neurodegenerative Disorders Book
Author : John P Blass, M.D.,Fletcher H. McDowell
Publisher : Unknown
Release : 1999
ISBN : 9781573312097
Language : En, Es, Fr & De

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Book Description :

There is solid evidence of abnormalities in oxidative / energy metabolism with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The papers contained in this book are an attempt to move studies in this area to a deeper, more mechanistic level.

Genotype Proteotype Phenotype Relationships in Neurodegenerative Diseases

Genotype   Proteotype   Phenotype Relationships in Neurodegenerative Diseases Book
Author : J. Cummings,J. Hardy,M. Poncet
Publisher : Springer Science & Business Media
Release : 2006-03-30
ISBN : 3540265228
Language : En, Es, Fr & De

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Book Description :

Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the identification of biological markers relevant to disease monitoring and to the development of new therapeutic agents capable of modifying and ameliorating basic neurodegenerative mechanisms.

Oxidative Stress Mechanisms and Disease Pathogenesis

Oxidative Stress  Mechanisms and Disease Pathogenesis Book
Author : Edwin Reynolds
Publisher : Unknown
Release : 2020-09-15
ISBN : 9781632418586
Language : En, Es, Fr & De

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Book Description :

Oxidative stress is an imbalance in the production of free radicals and the body's inability to counteract their harmful effects or detoxify. This imbalance can cause disruptions in cellular signaling. Oxidative stress implies an increased production of oxidizing species and decrease in the effectiveness of antioxidant defenses. Moderate oxidation can trigger apoptosis, while more severe cases cause necrosis. Oxidative stress is considered to be an important element in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Huntington's disease, Lou Gehrig's disease, multiple sclerosis, autism, etc. Oxidative stress has been implicated in the incidence of cardiovascular diseases, as oxidation of LDL is a precursor to plaque formation. This book elucidates the concepts and innovative models around prospective developments with respect to oxidative stress. It unravels the recent studies in the mechanisms and disease pathogenesis of oxidative stress. Coherent flow of topics, student-friendly language and extensive use of examples make this book an invaluable source of knowledge.

Inflammation and Oxidative Stress in Neurological Disorders

Inflammation and Oxidative Stress in Neurological Disorders Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2014-01-27
ISBN : 3319041118
Language : En, Es, Fr & De

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Book Description :

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.