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Oxidative Stress And Biomaterials

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Oxidative Stress and Biomaterials

Oxidative Stress and Biomaterials Book
Author : Thomas Dziubla,D Allan Butterfield
Publisher : Academic Press
Release : 2016-05-31
ISBN : 0128032707
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Oxidative Stress on Biomaterials

Oxidative Stress on Biomaterials Book
Author : Bertrand Vileno
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Oxidative Stress on Biomaterials book written by Bertrand Vileno, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials and Wound Induced Oxidative Stress

Biomaterials and Wound Induced Oxidative Stress Book
Author : Niyas Ahamed
Publisher : Unknown
Release : 2016-12-10
ISBN : 9783659951466
Language : En, Es, Fr & De

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Book Description :

Download Biomaterials and Wound Induced Oxidative Stress book written by Niyas Ahamed, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials and Designer Functional Applications in Oral Cavity

Biomaterials and Designer Functional Applications in Oral Cavity Book
Author : Victoria Tamara Perchyonok
Publisher : Unknown
Release : 2016-04-01
ISBN : 9781634847797
Language : En, Es, Fr & De

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Book Description :

Dental biomaterials and natural products represent two growing research fields, revealing that plant-derived compounds may play a role not only as nutraceuticals in affecting oral health but also in improving physicochemical properties of biomaterials used in dentistry. Recently, the role of free radicals in healthcare has attracted tremendous interest in the field of medicine, dentistry and molecular biology. Free radicals can be either harmful or helpful to the human body. When there is an imbalance between input and output of free radicals, a condition called "oxidative stress" develops. To counteract oxidative stress, the body has protective antioxidant mechanisms, which aid in lowering the incidence of various human morbidities and mortalities. The implication of oxidative stress in the etiology of many chronic and degenerative diseases suggests that antioxidant therapy represents a promising avenue for treatment. Thus, various forms of antioxidants have been introduced as an approach to fight dental diseases and improve general gingival health. The implication of oxidative stress in the etiology of chronic and degenerative diseases as well as the body's protective antioxidant mechanisms and the role dietary antioxidants play, suggests that antioxidant therapy could act as a beneficial treatment. The aim of this book is to present all available data concerning and linking free radicals, antioxidants and bio-active scaffolds in the utilisation of vitamins, proteins and extracts rich in bio-active phytochemicals as an avenue for creating innovative dental biomaterials. These materials are capable of promoting genuine tissue/cell interface integration and gaining insight into molecular origin of the mechanism to combat oral diseases in vitro and eventually in vivo.

Engineering Biomaterials for Regenerative Medicine

Engineering Biomaterials for Regenerative Medicine Book
Author : Sujata K. Bhatia
Publisher : Springer Science & Business Media
Release : 2011-11-10
ISBN : 9781461410805
Language : En, Es, Fr & De

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Book Description :

Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

Biologically Responsive Biomaterials for Tissue Engineering

Biologically Responsive Biomaterials for Tissue Engineering Book
Author : Iulian Antoniac
Publisher : Springer Science & Business Media
Release : 2012-10-02
ISBN : 1461443288
Language : En, Es, Fr & De

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Book Description :

Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.

New and Future Developments in Catalysis

New and Future Developments in Catalysis Book
Author : Amar Nath
Publisher : Elsevier Inc. Chapters
Release : 2013-07-13
ISBN : 0128081562
Language : En, Es, Fr & De

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Book Description :

Download New and Future Developments in Catalysis book written by Amar Nath, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials Science

Biomaterials Science Book
Author : William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski
Publisher : Academic Press
Release : 2020-05-23
ISBN : 0128161388
Language : En, Es, Fr & De

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Book Description :

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for each chapter

Biomedical Application of Nanoparticles

Biomedical Application of Nanoparticles Book
Author : Bertrand Henri Rihn
Publisher : CRC Press
Release : 2017-09-05
ISBN : 1351648411
Language : En, Es, Fr & De

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Book Description :

Biomedical Application of Nanoparticles explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune system and targeted cells. Risk assessment of nanoparticles for human is described, including: cellular paradigms, transcriptomics and toxicogenomics. Finally, the applications of nanoparticles in medicine and antioxidant regenerative therapeutics are presented in several chapters with emphasis on how nanoparticles enhance transport of drugs across biological membrane barriers and therefore may enhance drug bioavailability.

Reactive Oxygen Species Lipid Peroxidation and Protein Oxidation

Reactive Oxygen Species  Lipid Peroxidation and Protein Oxidation Book
Author : Kartlos Joseph
Publisher : Nova Science Pub Incorporated
Release : 2014-11-21
ISBN : 9781633218864
Language : En, Es, Fr & De

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Book Description :

Many studies have shown that free radical damage and lipid peroxidation increase as a function of the degree of unsaturation of the fatty acids present in the phospholipids of biological membranes. Membrane phospholipids are particularly susceptible to oxidation not only because of their highly polyunsaturated fatty acid content but also because of their association in the cell membrane with non-enzymatic and enzymatic systems capable of generating pro-oxidative-free radical species. There are two broad outcomes to lipid peroxidation: structural damage to membranes and generation of secondary products. Membrane damage derives from the generation of fragmented fatty acyl chains, lipidlipid cross-links, lipidprotein cross-links and endocyclisation to produce isoprostanes and neuroprostanes. These processes combine to produce changes in the biophysical properties of membranes that can have profound effects on the activity of membrane-bound proteins. The consequence of peroxidation of unsaturated fatty acids is severe: damage of membranes function, enzymatic inactivation, toxic effects on the cellular division, etc. This new book presents and discusses current research on oxidative stress, and lipid oxidation non-inhibited and inhibited; assessment of oxidative balance in the lipo- and hydro-philic cellular environment in biological systems; mass spectrometry detection of protein modification by cross-reaction with lipid peroxidation products; diagonal gel electrophoretic analysis of protein disulfides: principles and applications. Other chapters describe: heavy metals exposure and cells oxidative damage; biodegradation of metallic biomaterials: its relation with the generation of reactive oxygen species; Oxidative modifications of proteins in the aging heart; role of reactive oxygen species as signalling molecules involved in the regulation of physiological processes of the nervous system; oxidative stress in diabetes and hypertension treated with alternative therapy of medicinal plants; impairment of redox homeostasis of tissue damage in inborn errors of metabolism with intoxication: insights from human and animal studies and finally lipid peroxidation of phospholipids in the vertebrate retina or in liposomes made of retinal lipids: similarities and differences are described.

Biomaterials in Tissue Engineering and Regenerative Medicine

Biomaterials in Tissue Engineering and Regenerative Medicine Book
Author : Birru Bhaskar
Publisher : Springer Nature
Release : 2021-10-24
ISBN : 9811600023
Language : En, Es, Fr & De

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Book Description :

Download Biomaterials in Tissue Engineering and Regenerative Medicine book written by Birru Bhaskar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biological Interactions on Materials Surfaces

Biological Interactions on Materials Surfaces Book
Author : David A. Puleo,Rena Bizios
Publisher : Springer Science & Business Media
Release : 2009-06-26
ISBN : 9780387981611
Language : En, Es, Fr & De

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Book Description :

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

Synthesis and Studies of Polymeric Biomaterials for Drug Delivery and Therapeutic Design

Synthesis and Studies of Polymeric Biomaterials for Drug Delivery and Therapeutic Design Book
Author : Melanie A.. Hutnick
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The objective of this dissertation was to develop polymeric biomaterials for a wide range of biological and biomedical aliments. Chapter 1 introduces the need to develop new therapeutic approaches to combat multidrug resistant microorganisms. Currently, the literature focuses primarily on ESKAPE pathogens, which are all bacterial infections. However, other multidrug resistant microbes, such as Candida albicans, pose an equally daunting threat to public health. In Chapter 2 we combat multidrug resistant C. albicans with photodynamic therapy (PDT) using silicon phthalocyanine Pc 4. PDT utilizes a photosensitizer, light, and cellular O2 to produce reactive oxygen species (ROS), which then induce oxidative stress resulting in apoptosis. The hydrophobic nature of Pc 4, however, poses significant formulation and delivery challenges in the use of this therapy. To mitigate these concerns, a drug delivery vehicle was synthesized to better formulate Pc 4 into a viable PDT agent for treating fungal infections. Utilizing poly(amidoamine) dendrimers as the framework for the vehicle, the amine chain ends were partially PEGylated to promote water solubility and deter non-specific adsorption. In vitro studies with C. albicans demonstrate the potency of Pc 4 was not hindered by the dendrimer vehicle. Encapsulated Pc 4 was able to effectively generate ROS and obliterate fungal pathogens upon photoactivation. Thus, we have developed a nanoparticulate delivery vehicle for Pc 4 that readily kills drug-resistant C. albicans and eliminates solvent toxicity, thereby improving formulation characteristics for the hydrophobic photosensitizer.Though we able to effectively eradicate multidrug resistant C. albicans planktonic cells, the formation of biofilms is what makes Candidal infections truly lethal. Biofilms are colonies of cells encased in a polysaccharide matrix, which acts as a reservoir of pathogens causing persistent infections. To properly obliterate these infections, the planktonic cells must be eradicated, and the polysaccharide matrix must be destroyed. In Chapter 3, the PEGylated- PAMAM Pc 4 system was further functionalized with antimicrobial peptide, KLS-W. Preliminary results indicate these particles are internalized by cells, prevent biofilm formation, and eradicate planktonic cells. In Chapter 4, an approach to inhibit the translation of the viral infection Enterovirus 71 (EV71), more commonly known as Hand, foot, and mouth disease is discussed. Enterovirus 71 (EV71) is a highly contagious disease causing widespread outbreaks. Though not often fatal, EV71 has been known to result in death. To develop a treatment, our goal is to prevent the translation of EV71 RNA. It has been shown that a very specific interaction between the RNA and a nucleic acid binding protein must occur to promote translation. By preventing this interaction, we can ultimately halt the spread of hand, foot, and mouth disease. To prevent this binding, we synthesized a screened a library of peptoids, N-substituted glycines, against the conserved domains of EV71 for potential translation factor inhibitors. Lastly, Chapter 5 discusses sustained release of proteins from hydrogels for bone tissue regeneration to mimic the physiological fracture healing model. To do so, bone morphogenetic protein-2 (BMP-2), a growth factor known to promote differentiation of progenitor cells was genetic modified to incorporate electrostatic amino acid tags the N-terminus. These proteins were to be incorporated into oppositely charged hydrogels to monitor the release kinetics of the growth factors.

Handbook of Oral Biomaterials

Handbook of Oral Biomaterials Book
Author : Jukka Pekka Matinlinna
Publisher : CRC Press
Release : 2014-07-11
ISBN : 9814463124
Language : En, Es, Fr & De

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Book Description :

The book introduces the latest advances in dental materials and biomaterials science. It contains a comprehensive introduction and covers ceramic, metallic, and polymeric oral biomaterials. The contributing authors are from all over the world and are distinguished in their disciplines. A solid primer for dental students, the book is also highly recommended for students of engineering and basic science who want to gain an insight in contemporary biomaterials science. For medical practitioners, the book offers an invaluable opportunity to learn about the latest steps in dental biomaterials.

Characterization of Biomaterials

Characterization of Biomaterials Book
Author : Ryan K. Roeder
Publisher : Elsevier Inc. Chapters
Release : 2013-03-12
ISBN : 0128070978
Language : En, Es, Fr & De

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Book Description :

The design of biomedical devices almost always involves some form of mechanical characterization of biomaterials. This chapter provides a broad overview of experimental methods and important considerations for mechanical characterization of biomaterials, with special attention to the practical needs of engineers and scientists who encounter a need to characterize the mechanical properties of a biomaterial but may not know where to begin or what the key considerations should be. Many details are necessarily omitted from this broad overview, but numerous references are provided for greater technical depth on a particular topic, standardized methodologies, and exemplary studies. Fundamental concepts are introduced, beginning with stress and strain versus force and displacement. The mechanical properties measured from a stress–strain curve, different types of stress–strain curves, and corresponding constitutive models are reviewed, including differences in material classes and anisotropy. Three primary methods of analysis for fracture mechanics are introduced, including stress concentrations, energy criteria for crack initiation and propagation (fracture toughness), and statistical methods for the probability of fracture. The mechanical characterization of biomaterials begins with selection and preparation of standardized test specimens, which are critical to obtaining accurate and reproducible measurements of material properties. Practical considerations are outlined for selection and preparation of the specimen size, geometry, surface finish, and precracking. The mechanical characterization of biomaterial test specimens always involves the application and measurement of load and deformation. Practical considerations are outlined for the selection and use of load frames, load cells, load fixtures, extensometers, and strain gauges. A number of common loading modes are introduced and compared: uniaxial tension, uniaxial compression, biaxial tension, torsion, diametral compression, three-point bending, four-point bending, and in-plane shear (including biomaterial-tissue interfacial shear strength). Strain-rate sensitivity or time-dependent behavior can profoundly influence stress–strain behavior and thus measured mechanical properties. The effects of high strain rates may be characterized by impact testing using a pendulum, drop tower, or split Hopkinson pressure bar. The effects of low strain rates may be characterized by creep deformation or creep rupture tests. The time-dependent behavior of viscoelastic materials is introduced, including creep, stress relaxation, common constitutive models, and practical considerations for testing. The frequency of loading, or cyclic loading, is another aspect of time-dependent behavior, which is critical for mechanical characterization of biomaterials, leading to fatigue deformation and failure or viscoelastic creep and stress relaxation. Practical considerations are described for selecting the waveform, frequency, cyclic stress/strain levels, loading mode, and test duration. Common methods are introduced for fatigue lifetime testing (including S-N curves, notch factors, and fatigue damage), fatigue crack propagation, and dynamic mechanical analysis (DMA). Nondestructive tests are particularly useful for sampling small volumes of a biomaterial (e.g., implant retrieval or biopsy) or characterizing spatial heterogeneity in mechanical properties. Various indentation tests and indenter geometries are introduced and compared, including classic hardness (Brinell and Rockwell), microhardness (Knoop and Vickers), and instrumented nanoindentation (Berkovich, cube corner, etc.). Methods and limitations are described for characterizing the reduced modulus, viscoelasticity, and fracture toughness using indentation. Ultrasonic wave-propagation methods are also introduced with an emphasis on methods for characterizing anisotropic elastic constants. Biomaterials are typically subjected to various sterilization methods prior to service and an aqueous physiological environment in service. Therefore, the effects of temperature, pressure, various aqueous media (water, phosphate buffered saline (PBS), media, foetal bovine serum (FBS), lipids, etc.), and irradiation on mechanical characterization of biomaterials are considered, including the degradation of mechanical properties by various mechanisms involving water uptake, hydrolysis, and oxidation. Finally, methods and guidelines are provided for data acquisition from transducers and data analysis, including an introduction to some basic statistical methods.

Surgery of the Hip E Book

Surgery of the Hip E Book Book
Author : Daniel J. Berry,Jay Lieberman
Publisher : Elsevier Health Sciences
Release : 2019-09-24
ISBN : 0323568416
Language : En, Es, Fr & De

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Book Description :

Offering authoritative, comprehensive coverage of hip surgery, the 2nd Edition of Surgery of the Hip is the definitive guide to hip replacement, other open and arthroscopic surgical procedures, and surgical and nonsurgical management of the hip across the lifespan. Modeled after Insall & Scott Surgery of the Knee, it keeps you fully up to date with the latest research, techniques, tools, and implants, enabling you to offer both adults and children the best possible outcomes. Detailed guidance from expert surgeons assists you with your toughest clinical challenges, including total hip arthroplasty, pediatric hip surgery, trauma, and hip tumor surgery. Discusses new topics such as direct anterior approach for total hip arthroplasty, hip pain in the young adult, and hip preservation surgery. Contains new coverage of minimally invasive procedures, bearing surface selection, management of complications associated with metal and metal bearing surfaces, management of bone loss associated with revision THA, and more. Provides expert, personal advice in "Author’s Preferred Technique" sections. Helps you make optimal use of the latest imaging techniques, surgical procedures, equipment, and implants available. Covers tumors of the hip, hip instability and displacement in infants and young children, traumatic injuries, degenerative joint disorders, and rehabilitation considerations—all from both a basic science and practical clinical perspective.

Polymeric Biomaterials

Polymeric Biomaterials Book
Author : Severian Dumitriu,Valentin Popa
Publisher : CRC Press
Release : 2020-03-05
ISBN : 1420094734
Language : En, Es, Fr & De

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Book Description :

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctiona

Biomedical Science Engineering and Technology

Biomedical Science  Engineering and Technology Book
Author : Dhanjoo N. Ghista
Publisher : IntechOpen
Release : 2012-01-20
ISBN : 9789533074719
Language : En, Es, Fr & De

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Book Description :

This innovative book integrates the disciplines of biomedical science, biomedical engineering, biotechnology, physiological engineering, and hospital management technology. Herein, Biomedical science covers topics on disease pathways, models and treatment mechanisms, and the roles of red palm oil and phytomedicinal plants in reducing HIV and diabetes complications by enhancing antioxidant activity. Biomedical engineering coves topics of biomaterials (biodegradable polymers and magnetic nanomaterials), coronary stents, contact lenses, modelling of flows through tubes of varying cross-section, heart rate variability analysis of diabetic neuropathy, and EEG analysis in brain function assessment. Biotechnology covers the topics of hydrophobic interaction chromatography, protein scaffolds engineering, liposomes for construction of vaccines, induced pluripotent stem cells to fix genetic diseases by regenerative approaches, polymeric drug conjugates for improving the efficacy of anticancer drugs, and genetic modification of animals for agricultural use. Physiological engineering deals with mathematical modelling of physiological (cardiac, lung ventilation, glucose regulation) systems and formulation of indices for medical assessment (such as cardiac contractility, lung disease status, and diabetes risk). Finally, Hospital management science and technology involves the application of both biomedical engineering and industrial engineering for cost-effective operation of a hospital.

Monitoring and Evaluation of Biomaterials and their Performance In Vivo

Monitoring and Evaluation of Biomaterials and their Performance In Vivo Book
Author : Roger Narayan
Publisher : Woodhead Publishing
Release : 2016-11-11
ISBN : 0081006047
Language : En, Es, Fr & De

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Book Description :

Monitoring and Evaluation of Biomaterials and Their Performance In Vivo provides essential information for scientists and researchers who need to assess and evaluate performance, monitor biological responses, gauge efficacy, and observe changes over time. Crucially, it also enables the optimization of design for future biomaterials and implants. This book presents readers with comprehensive coverage of the topic of in vivo monitoring of medical implants and biomaterials. Contains a specific focus on monitoring and evaluation of biomaterials in vivo Multi-faceted coverage of materials function and performance Focuses on a range of implants and subsequent bodily reactions