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Oxidants Antioxidants And Impact Of The Oxidative Status In Male Reproduction

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Oxidants Antioxidants and Impact of the Oxidative Status in Male Reproduction

Oxidants  Antioxidants  and Impact of the Oxidative Status in Male Reproduction Book
Author : Ralf Henkel,Luna Samanta,Ashok Agarwal
Publisher : Academic Press
Release : 2018-08-23
ISBN : 0128125675
Language : En, Es, Fr & De

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Book Description :

Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners and research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The book focuses on unravelling the pathophysiology of oxidative stress mediated male infertility, recruiting top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including a new focus on reductive stress. Furthermore, the inclusion of clinical techniques to determine oxidative stress and the OMICS of reductive oxidative stress are also included. This is a must-have reference in the area of oxidative stress and male reproductive function. Offers comprehensive information on oxidative stress and its role in male reproduction, including new therapeutic approaches Deals with current approaches to oxidative stress using OMICS platform“/li> Designed for fertility practitioners, reproductive researchers, and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology

Male Infertility

Male Infertility Book
Author : Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal
Publisher : Springer Nature
Release : 2020-01-24
ISBN : 3030323005
Language : En, Es, Fr & De

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Book Description :

A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.

New Discoveries in Embryology

New Discoveries in Embryology Book
Author : Bin Wu
Publisher : BoD – Books on Demand
Release : 2015-10-21
ISBN : 9535121820
Language : En, Es, Fr & De

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Book Description :

Animal individual life begins as combination of sperm and oocyte, which results in the embryogenesis from ovum fertilization to fetal stage. Embryology has become one central discipline for many modern biotechnologies. Although this subject has been studied for more than a century, new discoveries appear continuously. This book contains some new discoveries and updates some theories and technologies in animal and human embryology. Major content include new findings in gamete biology, new theories and discoveries in embryo implantation by three-dimensional imaging technology and new concept and actual application of embryology. Thus, this book will greatly update knowledge in embryology field and provide some basic theories and technologies for animal scientists and breeders as well as embryologists and anthropologists.

Antioxidants

Antioxidants Book
Author : Viduranga Waisundara
Publisher : BoD – Books on Demand
Release : 2021-09-08
ISBN : 1839688645
Language : En, Es, Fr & De

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Book Description :

Antioxidants are one of the most sought-after biological compounds of interest to both scientific and nonscientific communities. The term gained popularity with the advent of identifying these compounds as having the ability to maintain health and wellness by combating against pathways leading to non-communicable diseases. This book covers several aspects of antioxidants—mechanisms of action, assays of measuring potency, sources, and even methods of isolation and identification. While it may seem these aspects have been covered in depth in several publications before this, this book intends to be positioned as an update, especially since the area of antioxidant research is as dynamic as ever. There are several chapters that might be of interest to health buffs, specifically those who are quite keen on maintaining health and wellness.

Oxidative Stress in Human Reproduction

Oxidative Stress in Human Reproduction Book
Author : Ashok Agarwal,Rakesh Sharma,Sajal Gupta,Avi Harlev,Gulfam Ahmad,Stefan S. du Plessis,Sandro C. Esteves,Siew May Wang,Damayanthi Durairajanayagam
Publisher : Springer
Release : 2017-05-03
ISBN : 3319484273
Language : En, Es, Fr & De

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Book Description :

This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This volume covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.

Oxidative Stress and Antioxidant Protection

Oxidative Stress and Antioxidant Protection Book
Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Release : 2016-01-14
ISBN : 111883240X
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Spermatozoa

Spermatozoa Book
Author : Rosaria Meccariello,Rosanna Chianese
Publisher : BoD – Books on Demand
Release : 2018-06-13
ISBN : 1789231701
Language : En, Es, Fr & De

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Book Description :

Spermatozoa, the haploid male gametes, are highly specialized cells capable to fertilize eggs in order to produce diploid zygote. The biogenesis of spermatozoa requires finely modulated occurrence of mitotic, meiotic, and differentiation events. Hence, the production of high-quality spermatozoa impacts fertilization with outcomes on the health of the offspring. This book provides a comprehensive overview on the biogenesis, maturation, functions and activities of spermatozoa in both physiological conditions and infertility. Particular attention has been addressed to the impact of environment on sperm quality and to the appropriate selection of high-quality spermatozoa for in vitro fertilization. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students, and offers a better understanding of spermatozoa health and disease.

Male Infertility in Reproductive Medicine

Male Infertility in Reproductive Medicine Book
Author : Botros Rizk,Ashok Agarwal,Edmund S. Sabanegh Jr.
Publisher : CRC Press
Release : 2019-10-16
ISBN : 0429940955
Language : En, Es, Fr & De

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Book Description :

This useful illustrated text summarizes for an audience of clinicians in Reproductive Medicine the practical essentials of what they need to know about diagnosis and management of the infertile male patient, whether they need to instruct or liaise with a colleague or undertake the procedures themselves.

Reactive Oxygen Species and Male Fertility

Reactive Oxygen Species and Male Fertility Book
Author : Cristian O'Flaherty
Publisher : MDPI
Release : 2020-12-02
ISBN : 3039360248
Language : En, Es, Fr & De

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Book Description :

Reactive oxygen species (ROS) are inevitable by-products of aerobic cells. A delicate balance between ROS production and antioxidant defences is essential to assure cell function. This requirement is also true for the spermatozoon, the male gamete, with the unique goal of carrying and delivering the paternal genome into the oocyte. Oxidative stress promotes damage in lipids, proteins and DNA of spermatozoa, and this oxidative damage is associated with infertility. The ROS-dependent damage could occur at different stages of the production and maturation of the sperm. On the other hand, low and controlled levels of ROS are necessary to trigger and regulate sperm function. When ejaculated, spermatozoa are incapable of fertilizing the egg. They must reside in the oviduct of the female genital tract to undergo a yet to be understood the biochemical process called capacitation. Once capacitated, the spermatozoon undergoes the exocytotic event called acrosome reaction and fertilize the oocyte. ROS regulate the different molecular mechanisms such as sperm motility, capacitation and acrosome reaction to assure fertilization. This Special Issue includes original research and reviews of literature concerning the role of reactive oxygen species in male reproduction, particularly the role of antioxidants in the regulation of male fertility as well as basic and clinical studies using antioxidant-based strategies for the treatment of male infertility.

Oxidants in Biology

Oxidants in Biology Book
Author : Giuseppe Valacchi,Paul A. Davis
Publisher : Springer Science & Business Media
Release : 2008-06-06
ISBN : 1402083998
Language : En, Es, Fr & De

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Book Description :

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Genetic Damage in Human Spermatozoa

Genetic Damage in Human Spermatozoa Book
Author : Elisabetta Baldi,Monica Muratori
Publisher : Springer Science & Business Media
Release : 2013-08-16
ISBN : 1461477832
Language : En, Es, Fr & De

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Book Description :

There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Free Radicals and Diseases

Free Radicals and Diseases Book
Author : Rizwan Ahmad
Publisher : BoD – Books on Demand
Release : 2016-10-26
ISBN : 9535127462
Language : En, Es, Fr & De

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Book Description :

The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.

Studies on Men s Health and Fertility

Studies on Men s Health and Fertility Book
Author : Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Publisher : Springer Science & Business Media
Release : 2012-03-17
ISBN : 1617797766
Language : En, Es, Fr & De

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Book Description :

Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.

Vitamin E in Health and Disease

Vitamin E in Health and Disease Book
Author : Anonim
Publisher : BoD – Books on Demand
Release : 2021-10-06
ISBN : 1839688378
Language : En, Es, Fr & De

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Book Description :

Vitamin E is a group of fat-soluble compounds found in a wide variety of foods. Daily requirements of vitamin E can be met with a balanced diet. High-dose supplementation may be hazardous rather than beneficial. Vitamin E serves as an antioxidant, participates in anti-inflammatory processes, inhibits platelet aggregation, and enhances immunity. Vitamin E supplementation can be beneficial against coronary artery disease, eye disorders, cognitive decline, cancer, and skin aging. This book will mainly focus on the diverse functions of vitamin E, importance of vitamin E status to provide a healthy lifespan, and the interaction between vitamin E and several pathological conditions. Readers will receive a general overview of the importance of vitamin E in health and different pathological conditions.

Varicocele and Male Infertility

Varicocele and Male Infertility Book
Author : Sandro C Esteves,Chak-Lam Cho,Ahmad Majzoub,Ashok Agarwal
Publisher : Springer Nature
Release : 2019-09-11
ISBN : 3319791028
Language : En, Es, Fr & De

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Book Description :

This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content. Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.

Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Oxidative Stress and Toxicity in Reproductive Biology and Medicine Book
Author : Kavindra Kumar Kesari,Shubhadeep Roychoudhury
Publisher : Springer Nature
Release : 2022-05-31
ISBN : 3030893405
Language : En, Es, Fr & De

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Book Description :

This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

A Clinician s Guide to Sperm DNA and Chromatin Damage

A Clinician s Guide to Sperm DNA and Chromatin Damage Book
Author : Armand Zini,Ashok Agarwal
Publisher : Springer
Release : 2018-03-05
ISBN : 3319718150
Language : En, Es, Fr & De

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Book Description :

This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.

Reactive Oxygen Species ROS in Living Cells

Reactive Oxygen Species  ROS  in Living Cells Book
Author : Filip Cristiana,Albu Elena
Publisher : BoD – Books on Demand
Release : 2018-05-23
ISBN : 1789231345
Language : En, Es, Fr & De

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Book Description :

Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.

Phytopharmaceuticals

Phytopharmaceuticals Book
Author : Durgesh Nandini Chauhan,Kamal Shah
Publisher : John Wiley & Sons
Release : 2021-06-29
ISBN : 111968191X
Language : En, Es, Fr & De

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Book Description :

Medicinal plants contain a variety of bioactive compounds, (also referred to as phytochemicals). in the leaves, stems, flowers and fruits. This book covers these bioactive compounds, their available sources, how the bioactive molecules are isolated from the plants, the biochemistry, structural composition and potential biological activities. Also discussed are the pharmacological aspects of medicinal plants, phytochemistry and biological activities of different natural products, ethnobotany and medicinal properties, as well as a novel dietary approach for various disease management and therapeutic potential. The importance of phytopharmaceutical of plants and potential applications in the food and pharma industries is highlighted.

Dietary Reference Intakes for Vitamin C Vitamin E Selenium and Carotenoids

Dietary Reference Intakes for Vitamin C  Vitamin E  Selenium  and Carotenoids Book
Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee on Interpretation and Uses of DRIs,Subcommittee on Upper Reference Levels of Nutrients,Panel on Dietary Antioxidants and Related Compounds
Publisher : National Academies Press
Release : 2000-08-27
ISBN : 0309069491
Language : En, Es, Fr & De

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Book Description :

This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.