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Overcoming Drug Resistance In Gynecologic Cancers

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Overcoming Drug Resistance in Gynecologic Cancers

Overcoming Drug Resistance in Gynecologic Cancers Book
Author : Anonim
Publisher : Elsevier
Release : 2021-09-03
ISBN : 012824299X
Language : En, Es, Fr & De

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Book Description :

Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Overcoming Drug Resistance in Gynecologic Cancers

Overcoming Drug Resistance in Gynecologic Cancers Book
Author : Anonim
Publisher : Academic Press
Release : 2021-08-11
ISBN : 0128243007
Language : En, Es, Fr & De

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Book Description :

Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Epigenetic Regulation in Overcoming Chemoresistance

Epigenetic Regulation in Overcoming Chemoresistance Book
Author : Chunfu Wu,Lihui Wang
Publisher : Academic Press
Release : 2021-06-26
ISBN : 012823685X
Language : En, Es, Fr & De

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Book Description :

Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers. Presents detailed diagrams of the mechanisms of epigenetic regulation for easy consult Encompasses multiple clinical trial summary diagrams to help readers quickly and clearly get information from clinical trials Provides future perspectives in each section to inspire readers to use epigenetic regulation to overcome chemo-resistance

Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy  Molecular Mechanisms and Innovative Reversal Strategies Book
Author : Ramasamy Paulmurugan,Tarik F. Massoud
Publisher : Academic Press
Release : 2021-06-25
ISBN : 0128215682
Language : En, Es, Fr & De

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Book Description :

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Cancer Drug Resistance Research Perspectives

Cancer Drug Resistance Research Perspectives Book
Author : Liman S. Torres
Publisher : Nova Publishers
Release : 2007
ISBN : 9781600215728
Language : En, Es, Fr & De

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Book Description :

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.

New Targeting in The Reversal of Resistant Glioblastomas

New Targeting in The Reversal of Resistant Glioblastomas Book
Author : Ali Syed Arbab
Publisher : Academic Press
Release : 2021-03-05
ISBN : 0128232765
Language : En, Es, Fr & De

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Book Description :

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field. Explains the effect of bone marrow derived cells on the development of resistance to clinically practiced therapies Provides information on the availability of alternate therapies for recurrent glioblastoma when standard practices have failed Discusses targeting tumor microenvironment using available FDA approved drugs as an alternative treatment strategy for glioblastoma

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Book
Author : Andrew Freywald,Franco Vizeacoumar
Publisher : Academic Press
Release : 2020-12-04
ISBN : 0128213116
Language : En, Es, Fr & De

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Book Description :

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Progress in Cancer Drug Resistance Research

Progress in Cancer Drug Resistance Research Book
Author : Robert A. Parsons
Publisher : Nova Publishers
Release : 2007
ISBN : 9781600218224
Language : En, Es, Fr & De

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Book Description :

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100 percent effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common.The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information on how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.

Berek and Hacker s Gynecologic Oncology

Berek and Hacker s Gynecologic Oncology Book
Author : Jonathan S. Berek,Neville F. Hacker
Publisher : Lippincott Williams & Wilkins
Release : 2010
ISBN : 0781795125
Language : En, Es, Fr & De

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Book Description :

The focus of Berek and Hacker's for four editions has been on the application of basic and clinical science to the clinical practice of gynecologic oncology. That approach has been successful and the book has been well received. The Fifth Edition follows the format of the previous editions, with the addition of color. We will also include a fully searchable companion Website that includes an image bank.

Comprehensive Gynecology E Book

Comprehensive Gynecology E Book Book
Author : Rogerio A. Lobo,David M Gershenson,Gretchen M Lentz,Fidel A Valea
Publisher : Elsevier Health Sciences
Release : 2016-06-22
ISBN : 0323430031
Language : En, Es, Fr & De

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Book Description :

The primary gynecology text for over 25 years, Comprehensive Gynecology covers all of the key issues residents, specialists, primary care doctors, and other healthcare providers encounter in everyday practice. This 7th edition has been fully updated to include a wealth of new content, including current discussions of minimally invasive surgical approaches to gynecologic care, infertility issues and treatments, effectively managing menopausal patients, and more. Written in a clear, concise and evidence-based style, it offers the practical, in-depth coverage you need to remain at the forefront of your field. Grasp key information quickly and easily through clear writing, a clinical focus, and guidance on evidence-based techniques. Access state-of-the-art information on the latest applications in diagnostic and interventional ultrasound and other essential aspects of today's practice. Prepare for the challenges you may face with a legal chapter containing factual scenarios. New videos, 20 in all, address topics such as Pap Smear Techniques; Hysteroscopic Metroplasty; Endometriosis of the Bladder; and more. Explore important issues in infertility, such as egg freezing, cancer treatment, and preimplantation genetic diagnosis. Understand the latest research in menopause, how to effectively prescribe treatments, and the consideration of using hormones for prevention. A new chapter dedicated to in vitro fertilization keeps you current with today's recent advances. Updated Preoperative Care and Quality chapter represents the ongoing 'Enhanced Recovery after Surgery' care programs.

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance Book
Author : Goli Samimi,Christina Annunziata
Publisher : Academic Press
Release : 2020-11-06
ISBN : 0128198419
Language : En, Es, Fr & De

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Book Description :

Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Carcinomas New Insights for the Healthcare Professional 2013 Edition

Carcinomas  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 148165747X
Language : En, Es, Fr & De

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Book Description :

Carcinomas: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Carcinomas: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Carcinomas: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Anticancer Agents

Anticancer Agents Book
Author : Qiao-Hong Chen
Publisher : MDPI
Release : 2021-03-02
ISBN : 3036501401
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.

Gynecologic Cancers

Gynecologic Cancers Book
Author : Samir Farghaly
Publisher : BoD – Books on Demand
Release : 2016-03-02
ISBN : 9535122541
Language : En, Es, Fr & De

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Book Description :

Gynecologic cancers include malignancies of the female genital tract involving the vulva, vagina, cervix, uterus, fallopian tubes or ovaries. In the USA, 98,280 women had gynecological cancers in 2015, and 30,440 died of these cancers. World wide, the number of women who had cancers of the female genital tract was 1,085,900, in 2012 and the number of deaths was 417,600. Cancers of the uterus, cervix and ovary are most common. Widespread screening with the Pap test has allowed physicians to find per-cancerous changes in the cervix and vagina. This has assisted in identifying some invasive cancers early. Multidisciplinary team of experts includes specialists in medical oncology, gynecologic oncology, radiology, urology, radiotherapy, and surgery who work together to determine the best treatment approach for the patient. Recent progress in the development of new surgical techniques has transformed the treatment of gynecologic cancers, resulting in greater surgical precision and fewer complications. In addition targeted adjuvant therapy has become useful in improving the oncologic outcome of patients with these cancers.

Supramolecular Metal Based Entities for Biomedical and Biological Applications

Supramolecular Metal Based Entities for Biomedical and Biological Applications Book
Author : Angela Casini,James D. Crowley
Publisher : Frontiers Media SA
Release : 2019-07-19
ISBN : 2889458997
Language : En, Es, Fr & De

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Book Description :

Research in the discovery of metal supramolecular complexes, mainly formed by the self-assembly of inorganic metal compounds with either inorganic or organic molecules via coordination (or organometallic) bonds, is a rapidly developing and newly rising highlight interdisciplinary field. This Reseach Topic is aimed at providing representative examples of supramolecular metal-based entities for different biological and biomedical applications.

Gynecologic Care

Gynecologic Care Book
Author : Martin E. Olsen,Lisa Keder
Publisher : Cambridge University Press
Release : 2018-01-31
ISBN : 1107197635
Language : En, Es, Fr & De

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Book Description :

Gynecologic Care provides comprehensive coverage for the essentials of gynecologic management. It is one in a three book series which covers the breadth of the obstetrics and gynecology specialty. The other books in the series are Obstetric Care and Office Care of Women.

Comprehensive Gynecology E Book

Comprehensive Gynecology E Book Book
Author : Gretchen M Lentz,Rogerio A. Lobo,David M Gershenson,Vern L. Katz
Publisher : Elsevier Health Sciences
Release : 2012-02-21
ISBN : 0323091318
Language : En, Es, Fr & De

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Book Description :

Comprehensive Gynecology provides you with complete, timely, and easy access to vital information on all the medical and surgical issues affecting your practice. Whether you’re a resident or practioner, you’ll get all the practical, in-depth coverage you need to stay at the forefront of your field. Now in its sixth edition, this core reference, formerly edited by Drs. Droegemueller, Stenchever, Mishell and Herbst, continues to be your primary resource for in-depth and up-to-date information. Stay up to date with the latest gynecologic advances through clear writing, a clinical focus, and a focus on evidence-based practices. Prepare for the challenges you’ll face in practice with a completely overhauled legal chapter containing factual scenarios. Stay current in your field with the most recent advances in breast care; endoscopy and hysteroscopy; menopausal bone health; legal issues affecting our practice; and much more. Access state-of-the-art guidance on the latest applications in diagnostic and interventional ultrasound - and many other essential aspects of today's practice - through detailed sections on the molecular biology of specific gynecologic malignancies and a new chapter on Fallopian Tube and Primary Peritoneal Cancer. Recognize the interactions and influences of female physiology on major disease processes with a new chapter on The Interaction of Medical Diseases and Female Physiology. Address every patient’s needs with the Emotional Issues in Gynecology chapter, now modified in partnership with a psychiatrist, and updated information on depression/anxiety treatment.

Gynecologic Oncology

Gynecologic Oncology Book
Author : Robert F. Ozols
Publisher : Springer Science & Business Media
Release : 2013-03-14
ISBN : 1461554470
Language : En, Es, Fr & De

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Book Description :

In recent years, there have been major advances in the treatment of patients with gynecologic malignancies. Perhaps the biggest advances have been in the area of ovarian cancer. Gynecologic Oncology focuses primarily upon this malignancy. This volume discusses cytoreductive surgery; screening for ovarian cancer; chemotherapy; new chemotherapeutic drugs; the controversy regarding the role of high-dose chemotherapy in gynecologic cancers; the hereditary basis for gynecologic malignancies; molecular genetics; molecular biology and new biologic therapies. Other topics covered are the treatment of all stages of cervical cancer, including radiotherapy. In addition, a chapter on advances in the pathology of gynecologic cancers is included. The advances made in the treatment of gynecologic malignancies are due, in part, to the clinical studies performed by many of the contributors to this volume. Clinical advances have been the result of multidisciplinary approaches which involve molecular biologists, pathologists, radiation therapists, surgeons and chemotherapists. Future advances will continue to rely upon collaborative interaction among these different disciplines.

Simvastatin Enhances the Anti tumoral Effect of Metronomic Cyclophosphamide Against Cancer initiating Cells CICs by Reducing ALDH1A1 Expression Both in Vitro and in Vivo an Effective Combination to Overcome Resistance and Limit the Spread of the Recurrent Disease in High grade Serous Ovarian Cancer HGSOC

Simvastatin Enhances the Anti tumoral Effect of Metronomic Cyclophosphamide Against Cancer initiating Cells  CICs  by Reducing ALDH1A1 Expression Both in Vitro and in Vivo  an Effective Combination to Overcome Resistance and Limit the Spread of the Recurrent Disease in High grade Serous Ovarian Cancer  HGSOC   Book
Author : Sumie Kato
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Introduction / Background: HGSOC is the deadliest gynecologic cancer. Most of cases end up recurring and dying from metastatic/resistant disease. Cancer-initiating cells (CICs) constitute the subpopulation responsible for the acquisition of drug resistance and the progression/recurrence of the disease. ALDH1A1 activity is commonly increased in CICs and correlates with drug resistance (by drug detoxification), metastasis and prognosis. Our grouphas demonstrated that simvastatin, a lipophilic form of statins, chemo-sensitizes ovarian cancer cells and interferes with cell plasticity of HGSOC-derived CICs reducing metastasis in a mevalonate-dependent manner. Here, we study whether the combination of simvastatin with metronomic cyclophosphamide could be effective in treating recurrent/resistant HGSOC.Methodology: CICs were isolated from HeyA8 ovarian cancer cell line and from ascites collected from chemonu00e4ive and chemoresistant recurrent advanced HGSOCs using stem cell-selecting culture conditions. CICs were treated with simvastatin (1, 2 and 5 u03bcM), mafosfamide (4,7u03bcM) or its combination (24-hour pulse, 4 days). The induction of apoptosis was measured by detection ofPARP cleavage by immunoblotting. ALDH1A1 enzyme levels were determined by q-PCR and immunoblotting. Xenograft tumors were generated by injecting CICs intraperitoneally (IP) in NSG mice. Once established xenografts, mice were treated with placebo, simvastatin (2 mg/kg/day IP), cyclophosphamide (20 mg/kg/day PO) or its combination (n=6 per group). Ascites volume, body weight, distribution of metastatic foci, and ALDH1A immunostaining atthe injection site were measured. Survival curves were also made.Results: Repeated doses of this combination significantly reduced ALDH1A1 expression and induced PARP cleavage compared with each reagent alone in vitro. More importantly, simvastatin reduced ALDH1A1 expression, and the combination diminished ascites volume, metastatic disease, and prolonged survival in vivo.Conclusion: Our findings support the effectiveness of simvastatin plus metronomic cyclophosphamide in pre-clinical models of recurrent/resistant HGSOCs. The explanatory mechanism involves a decrease in ALDH1A1 activity (an enzyme regulating the cyclophosphamide detoxification) induced by simvastatin (research support by Fondecyt 1160800)Disclosure: Nothing to disclose.

Comprehensive Gynecology

Comprehensive Gynecology Book
Author : David M Gershenson,Gretchen M Lentz,Fidel A Valea,Rogerio A. Lobo
Publisher : Elsevier Health Sciences
Release : 2021-05-08
ISBN : 032379078X
Language : En, Es, Fr & De

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Book Description :

With its trademark clear, concise writing style and evidence-based focus, Comprehensive Gynecology, 8th Edition, remains your #1 choice for practical, in-depth coverage of any women’s health issue you’re likely to encounter. It covers all key issues in gynecology, now fully updated to include new information on topics such as laparoscopy and innovations in robotic surgery, reversible contraception, and advancements in treating endometriosis. For residents, specialists, primary care doctors, and other healthcare providers, Comprehensive Gynecology is an easy-to-access source of trusted information for everyday practice. Includes helpful features such as key references and terms, key points at the end of each chapter, summary boxes for quick reference, and new bolded text to highlight the most important concepts. Features newly improved artwork; a more cohesive, easy-to-navigate design throughout; and more clinical algorithms. Contains hundreds of illustrations and tables, anatomical figures, radiographs, and photographs, as well as 20 videos that address topics such as Pap smear techniques, hysteroscopic metroplasty, and endometriosis of the bladder. Brings you up to date with the latest applications in diagnostic and interventional ultrasound, issues in infertility, the latest research in menopause, and other essential aspects of today's practice.