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Overcoming Cancers Resistant To Her 2 Antibodies

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Resistance to Immunotherapeutic Antibodies in Cancer

Resistance to Immunotherapeutic Antibodies in Cancer Book
Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
Release : 2013-08-04
ISBN : 1461476542
Language : En, Es, Fr & De

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Book Description :

​​​​The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.

Cancer Chemotherapy and Biotherapy

Cancer Chemotherapy and Biotherapy Book
Author : Bruce A. Chabner,Dan L. Longo
Publisher : Lippincott Williams & Wilkins
Release : 2011-12-07
ISBN : 1451148208
Language : En, Es, Fr & De

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Book Description :

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance Book
Author : Goli Samimi,Christina Annunziata
Publisher : Academic Press
Release : 2020-11-19
ISBN : 0128198419
Language : En, Es, Fr & De

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Book Description :

Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Breast Cancer Chemosensitivity

Breast Cancer Chemosensitivity Book
Author : Dihua Yu,Mien-Chie Hung
Publisher : Springer Science & Business Media
Release : 2009-12-30
ISBN : 0387740392
Language : En, Es, Fr & De

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Book Description :

In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Advances in Cancer Research

Advances in Cancer Research Book
Author : George F. Vande Woude,George Klein
Publisher : Academic Press
Release : 2009-10-22
ISBN : 0080912265
Language : En, Es, Fr & De

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Book Description :

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papillomavirus, and modeling prostate cancer in the mouse.

Adjuvant Therapy for Breast Cancer

Adjuvant Therapy for Breast Cancer Book
Author : Monica Castiglione,Martine J. Piccart
Publisher : Springer Science & Business Media
Release : 2009-07-11
ISBN : 9780387751153
Language : En, Es, Fr & De

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Book Description :

Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Difficult Diagnoses in Breast Pathology

Difficult Diagnoses in Breast Pathology Book
Author : Juan P. Palazzo, MD
Publisher : Demos Medical Publishing
Release : 2011-06-22
ISBN : 1935281305
Language : En, Es, Fr & De

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Book Description :

Breast cancer is the second leading cause of cancer death in women in the United States. For the pathologist, almost any breast lesion may produce diagnostic difficulty, especially due to frequently small samples (core biopsy specimens) and a variety of mimics and variants seen in specific types of lesions. Additionally, the difficulty of breast lesion diagnosis has risen dramatically in recent years due to the increased emphasis on stratifying patients for appropriate therapy on an individual basis; the wider range of both local and systemic therapeutic options, and the potential for earlier diagnosis through increased mammographic breast screening leading to a higher likelihood of a favorable outcome. Difficult Diagnoses in Breast Pathology provides a highly visual presentation of the major problems and questions that a pathologist is likely to encounter in the evaluation of common and uncommon breast diseases. Coverage includes needle core biopsy interpretation, diagnosis of precursor lesions, early stage disease, and recognition of neoplastic mimics and other misleading variants. In addition, this book emphasizes particularly difficult areas including the use of newer immunohistochemical markers. Throughout, the emphasis is on an easily accessible presentation with tables and lists of key points summarizing major findings and numerous high-quality images supporting the text. Difficult Diagnoses in Breast Pathology will be a valuable reference for every pathologist who deals with the diagnosis of breast diseases. Difficult Diagnoses in Breast Pathology Features: Each chapter authored by recognized expert in the area Hundreds of high-quality images Tables and key points in each chapter summarize the most important findings Coverage based on addressing in detail the real-world diagnostic problems the pathologist will face in daily practice

Breast Cancer Management

Breast Cancer Management Book
Author : Lynda R. Wiseman
Publisher : Lippincott Williams & Wilkins
Release : 2000
ISBN :
Language : En, Es, Fr & De

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Book Description :

Cancer Research

Cancer Research Book
Author : N.A
Publisher :
Release : 2009-11
ISBN :
Language : En, Es, Fr & De

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Book Description :

Oncology

Oncology Book
Author : N.A
Publisher :
Release : 2006
ISBN :
Language : En, Es, Fr & De

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Book Description :

Goodman and Gilman s The Pharmacological Basis of Therapeutics 13th Edition

Goodman and Gilman s The Pharmacological Basis of Therapeutics  13th Edition Book
Author : Laurence Brunton,Bjorn Knollman,Randa Hilal-Dandan
Publisher : McGraw Hill Professional
Release : 2017-10-26
ISBN : 1259584747
Language : En, Es, Fr & De

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Book Description :

The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody’s Core Title for 2019! Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.

Cancer New Insights for the Healthcare Professional 2011 Edition

Cancer  New Insights for the Healthcare Professional  2011 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464900027
Language : En, Es, Fr & De

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Book Description :

Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Tumor Progression and Therapeutic Resistance

Tumor Progression and Therapeutic Resistance Book
Author : Wafik S. El-Deiry
Publisher :
Release : 2005
ISBN :
Language : En, Es, Fr & De

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Book Description :

This volume presents the entire breadth of translational cancer research and brings together members of academia and industry in the expectation of accelerating interactions and progress in the field. A variety of key topics are presented, beginning with discovery of molecular targets and pathways (oncogene, cell survival, tumor suppression, cell death), host-neoplasm interactions (cell adhesion, matrix proteases), early detection, monitoring progression, understanding tumor progression and metastasis, immune surveillance, in vivo molecular imaging, animal models, drug discovery including chemistry, high-throughput assays, mechanism determination, target validation, therapeutic window and some progress in clinical trials for more advanced agents and targets.

The Molecular Basis of Cancer

The Molecular Basis of Cancer Book
Author : John Mendelsohn,Peter M. Howley,Mark A. Israel,Lance A. Liotta,Joe W. Gray,Craig B. Thompson
Publisher : W B Saunders Company
Release : 2001
ISBN :
Language : En, Es, Fr & De

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Book Description :

The state-of-the-art 2nd Edition of this acclaimed reference explains the principles that form the scientific basis for our understanding of malignant transformation and the pathogenesis and treatment of cancer. Readers will find a broad update on the scientific principles of new diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating the latest advances and newest research, this text also gives thorough descriptions of everything from the basic mechanisms of malignant cells and molecular abnormalities in common cancers to new approaches for cancer therapy. Each chapter discusses the clinical implications for treatment. Numerous examples of the latest clinical interventions help readers understand and assess the products of the biotechnology revolution. IMPORTANT new topics, including chemo-prevention, programmed cell death (apoptosis), genetic counselling, tumour-specific vaccines, genetic abnormalities in the origin and progression of cancer, monoclonal antibody therapy, and molecular predictors of prognosis and response to treatment NEW and revised chapters, covering new basic science knowledge, new approaches to treatment and keeping all information on the cutting-edge of the specialty ABUNDANT illustrations, most of them new, to clarify and explain difficult concepts.

Proceedings of the American Association for Cancer Research

Proceedings of the American Association for Cancer Research Book
Author : American Association for Cancer Research. Meeting,American Association for Cancer Research
Publisher :
Release : 2001
ISBN :
Language : En, Es, Fr & De

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Book Description :

Contains abstracts of the scientific proceedings of the 73rd- annual meetings of the American Association for Cancer Research (1982- ).