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Osseointegration Of Orthopaedic Implants

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Osseointegration of Orthopaedic Implants

Osseointegration of Orthopaedic Implants Book
Author : Amirhossein Goharian
Publisher : Academic Press
Release : 2019-03-16
ISBN : 0128133953
Language : En, Es, Fr & De

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Book Description :

Osseointegration of Orthopaedic Implants helps product developers at orthopedic implant manufacturers enhance the effectiveness of orthopedic implants and reduce complications, particularly in patients with osteoporotic bones. The book's expert contributors provide cutting-edge information on the latest technologies and advances available. Biomaterial researchers can use the book for basic data in the further development of orthopedic implant materials with better osseointegration. Biomechanical researchers can review related challenges and concepts of osseointegration for use in the development of implants. The book is suitable for readers from academia and industry, bridging the knowledge gap between academic based researchers, industrial based engineers, and clinical based surgeons. Reviews and discusses all aspects of orthopedic implant osseointegration Provides conceptual implants for bone fracture fixation and joint replacement Offers novel ideas for the development of orthopedic implants with superior osseointegration

Surface Contaminants Inhibit the Osseointegration of Orthopaedic Implants

Surface Contaminants Inhibit the Osseointegration of Orthopaedic Implants Book
Author : Lindsay Ann Bonsignore
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The most important factor contributing to short-term and long-term success of cementless total joint arthroplasties is osseointegration. Osseointegration is the process by which a direct structural and functional connection between living bone and the surface of an implant is made. Surface contaminants may remain on orthopaedic implants after sterilization procedures and impair osseointegration. For example, specific lots of hip replacement Sulzer Inter-OPTM acetabular shells that were associated with impaired osseointegration and early failure rates were found to be contaminated with both bacterial debris and machine oil residues. However, few osseointegration studies have focused on surface contaminants and their effect on implant integration is unknown. Therefore, we developed a novel murine model that provides quantitative and reproducible measurements of osseointegration to study the effect of surface contaminants. We found that a rigorous cleaning procedure significantly enhances osseointegration compared to implants that were autoclaved. The most likely interpretation of these results is that surface contaminants on the autoclaved implants inhibit osseointegration. Using our murine model, we also found that Gram-negative bacterial derived LPS or machine oil residues on implants inhibit osseointegration. Ultrapure LPS adherent to titanium alloy discs had no detectable effect on early stages of MC3T3-E1 osteogenesis in vitro such as attachment, spreading or growth but inhibited later stages of osteogenic differentiation and mineralization. In contrast, machine oil on titanium alloy discs inhibited osteoblast attachment, spreading, growth, differentiation and mineralization in vitro. These results demonstrate that both adherent LPS and machine oil can significantly impair osseointegration through direct effects on osteoblasts; however, they do so by inhibiting distinct steps in the process. The presence of both LPS and machine oil could lead to synergistic impairment of osseointegration, which may account for the impaired osseointegration in the failed lots of Sulzer Inter-OPTM implants. These results highlight bacterial debris and machine oil as types of surface contaminants that can impair the osseointegration of orthopaedic implants. In addition, these results justify the need for the development of better detection and removal techniques for contaminants on orthopaedic implants.

Titanium Alloys

Titanium Alloys Book
Author : Jan Sieniawski,Waldemar Ziaja
Publisher : BoD – Books on Demand
Release : 2013-05-15
ISBN : 9535111108
Language : En, Es, Fr & De

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Book Description :

The book contains six chapters and covers topics dealing with biomedical applications of titanium alloys, surface treatment, relationships between microstructure and mechanical and technological properties, and the effect of radiation on the structure of the titanium alloys.

Interactions of Bone with Orthopedic Implants and Possible Failures

Interactions of Bone with Orthopedic Implants and Possible Failures Book
Author : Amirhossein Goharian,Ehsan Golkar
Publisher : Academic Press
Release : 2022-07-20
ISBN : 0323954111
Language : En, Es, Fr & De

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Book Description :

Interactions of Bone with Orthopedic Implants and Possible Failures focuses on the mechanical and biological issues that may cause failure of the implant-bone construct. The book provides discussions on the effects of the design, process, surface and other engineering parameters of implants and their interaction with bone tissue. For implant designers, it is highly crucial to know the final effects of what they are designing or aiming to design, along with performance parameters. It is also crucial for orthopedic surgeons to be familiar with the background of the design and process parameters of the implant they will insert in a patient’s body. With the understanding brought forth in this book, surgeons can have better implant options and implant designers can create and develop new implant designs. This book can also help biomechanical and mechanical engineers who are normally dealing with testing and analysis of orthopedic implants examine the biomechanical behavior of the implants and their interaction with bone tissue. Explains interactions, along with possible complications of trauma, joint and spinal implants, and failures of the implant and bone tissue Focuses on issues such as bone loss, defects and resorption at the bone and implant interface Includes case studies of implant failures and discusses the mechanical and biological reasons that would cause failure of bone and implant integration

Racing for the Surface

Racing for the Surface Book
Author : Bingyun Li,Thomas Fintan Moriarty,Thomas Webster,Malcolm Xing
Publisher : Springer Nature
Release : 2020-02-28
ISBN : 3030344711
Language : En, Es, Fr & De

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Book Description :

This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.

Bone and Metal Interface

Bone and Metal Interface Book
Author : Vitali Goriainov
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Bone and Metal Interface book written by Vitali Goriainov, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Osseoconductive Surface Engineering for Orthopedic Implants

Osseoconductive Surface Engineering for Orthopedic Implants Book
Author : Amirhossein Goharian
Publisher : Academic Press
Release : 2021-01-26
ISBN : 0128189312
Language : En, Es, Fr & De

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Book Description :

Osseoconductive Surface Engineering for Orthopedic Implants provides a comprehensive overview of the state of the art of osseointegration based on surface-mediated engineering. It offers a practical approach to the design and development of implant surface engineering, by reviewing and discussing the usability and efficacy of each processing technique. The reader can learn about the variety, characteristics, advantages, challenges, and optimum parameters for each process—enabling targeted selection of coatings and technologies to enhance long-term implant–bone integration. Practical and engineering notions in the field of osseoconductive surface engineering are reviewed and discussed using scientific principles and concepts. Engineering cases are analyzed in depth giving a thorough exploration and description of the engineering and scientific concepts for all osseoconductive surface engineering processes. Chapters integrate topics and are organised in such a way as to build on themes and practice.

The Hip Bone s Connected to the Orthopaedic Implant

The Hip Bone s Connected to the Orthopaedic Implant Book
Author : Jordan Raphel
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A vast array of implants are employed clinically to interface directly with living bone. These implants include orthopaedic prostheses, such as artificial hip and knee replacements, orthopaedic bone screws, and dental implants and are commonly made from titanium and its alloys. Over one million joint replacements and screws are implanted each year in the United States. In order for these implants to function successfully, they require strong osseointegration, the stable and functional connection between the implant and bone. Unfortunately, approximately 10% of implants fail prematurely, and many of these failures are due to poor osseointegration leading to implant loosening. Failures also occur due to microbial infection, which can be severely debilitating to the patient and may necessitate the removal of the implant. Approximately 1-3% of implants become infected, creating a large burden for the patients and the healthcare system. In this work, a versatile coating technology for bone-interfacing implants is developed to improve implant osseointegration and to provide defense from microbial infection. The coatings are derived from an engineered, elastin-like protein (ELP) that is recombinantly expressed in Escherichia coli. The ELP contains functional domains from two natural extracellular matrix proteins - elastin and fibronectin - to confer specific mechanical and biochemical properties, respectively. The elastin-like domain provides mechanical toughness and resiliency, while the fibronectin-derived RGD domain is cell-adhesive. Thin-film coatings made from ELP can be processed by a variety of methods to coat implants of any shape or size. To stabilize the coatings and adhere them to implant surfaces, a novel covalent crosslinking strategy is employed. Lysine residues are strategically substituted into the elastin-like domains to provide sites for chemical modification of the ELP through the primary amines present on the lysine side chains. A photoactive heterobifunctional crosslinker, NHS-diazirine, is conjugated through these primary amines, rendering the ELP photocrosslinkable upon exposure to ultraviolet (UV) light. The activated diazirine moiety interposes into neighboring bonds, leading to a covalently crosslinked ELP hydrogel. Furthermore, the diazirine can also covalently conjugate to common implant materials through the same UV-mediated mechanism, thereby creating a stable ELP thin-film coating with strong adhesion to implants. Good osseointegration of implants reduces the chance of aseptic loosening while poor osseointegration allows for micromotion of the implant relative to the bone, causing wear, inflammation, and implant loosening. By encouraging new bone deposition on the implant surface, osseointegration can be improved by stabilizing the bone-implant interface. The ELP coatings are able to enhance osseointegration by interacting with native osteogenic cells, including osteoblasts and mesenchymal stem cells (MSCs) through the RGD ligand. The presence of the ligand facilitates rapid cell adhesion, and the ELP coatings demonstrate the ability to improve osteogenic differentiation and bone mineral deposition in vitro, key steps for new bone formation and improved osseointegration. The coatings also improve osseointegration markers in vivo. Microbial infection is another leading cause of implant failure. Bacteria readily adhere to implant surfaces and form biofilms resistant to systemic antibiotic treatments, necessitating alternative strategies to prevent and treat implant-site infections. The antimicrobial properties of silver have long been known, and here it is employed as a localized defense against infection by incorporating silver chloride nanoparticles into the ELP coatings. These antimicrobial coatings rapidly kill over 95% of Staphylococcus aureus, the most common implant pathogen. The achievements presented in this work demonstrate significant advancements for implant coating technologies and have strong potential for clinical translation to improve implant function, lifetime, and efficacy.

Orthopedic Biomaterials

Orthopedic Biomaterials Book
Author : Bingyun Li,Thomas Webster
Publisher : Springer
Release : 2018-08-17
ISBN : 3319895427
Language : En, Es, Fr & De

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Book Description :

This book covers the latest progress in the biology and manufacturing of orthopedic biomaterials, as well as key industry perspectives. Topics covered include the development of biomaterial-based medical products for orthopedic applications, anti-infection technologies for orthopedic implants, additive manufacturing of orthopedic implants, and more. This is an ideal book for graduate students, researchers and professionals working with orthopedic biomaterials and tissue engineering. This book also: Provides an industry perspective on technologies to prevent orthopedic implant related infection Thoroughly covers how to modulate innate inflammatory reactions in the application of orthopedic biomaterials Details the state-of-the-art research on 3D printed porous bone constructs

Trauma Plating Systems

Trauma Plating Systems Book
Author : Amirhossein Goharian,Mohammed Rafiq Abdul Kadir,Mohamed Ruslan Abdullah
Publisher : Elsevier
Release : 2017-03-15
ISBN : 0128047585
Language : En, Es, Fr & De

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Book Description :

Trauma Plating Systems is the first reference and systematic book in the topic of trauma plating system in view of biomechanical, material, biological, and clinical aspects. The effects of these aspects on effectiveness of trauma plating fixation are deeply reviewed, discussed, and challenged from which promising evaluation and development concepts are explored. This book is divided into five sections: Section I covers general concepts of biomechanical, material, biological, and clinical aspects. Then it provides fundamentals of trauma plating systems, principles of biomechanical evaluation methods, and biomechanics of plating fixation in Section II. Section III reviews current metallic materials with their advantages and disadvantages in plating fixation of bone fractures and new promising materials with their potential benefits to enhance the effectiveness of plating fixation. Section IV represents currently concerned biomechanical-clinical challenges of plating fixation for various bone fractures, and Section V presents current and new development concepts of this type of trauma implants. This book as an accessible and easy usable textbook for various disciplines of audiences who are dealing with trauma plating system and fixation such as orthopedic surgeons, trauma implant manufacturers, biomechanical researchers, biomaterial researchers, and all biomedical or medical students and residents in different levels of education. Author has been diligent in both engineering and research environments in terms of research, testing, analysis, validation, verification, clinical studies, and technical writing. His main interest and effort is to integrate biomechanical, material, biological, and clinical requirements of orthopedic implants for creation of novel design conception in this industry. He has developed the website http://orthoimplant-development.com/ for further communication in development of orthopedic implants. Smooth writing style for effective following, fast reading, and easy accessibility of the content Detailed and insight reviews, discussions, and new ideas in evaluation methods and design conception Disclosing of a novel conceptual plating system (Advance Healing Fixation System—AHealFS) with advanced biomechanical and clinical benefits in various stages of healing period potential to bring an interesting science breakthrough in fixation of bone fractures

The Osseointegration Book

The Osseointegration Book Book
Author : Per-Ingvar Brånemark
Publisher : Quintessence Publishing (IL)
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Osseointegration is an area of medicine that has resulted from a greater understanding of how to unite bone and metal. In this medical handbook, Branemark (Branemark Osseointegration Center, Sweden), one of the pioneers of the field, presents 25 chapters covering the history, principles, and current state of the art of osseointegration in facial reconstruction.

Postgraduate Orthopaedics

Postgraduate Orthopaedics Book
Author : Paul A. Banaszkiewicz,Deiary F. Kader
Publisher : Cambridge University Press
Release : 2012-08-16
ISBN : 1139561332
Language : En, Es, Fr & De

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Book Description :

This book has been written specifically for candidates sitting the oral part of the FRCS (Tr & Orth) examination. It presents a selection of questions arising from common clinical scenarios along with detailed model answers. The emphasis is on current concepts, evidence-based medicine and major exam topics. Edited by the team behind the successful Candidate's Guide to the FRCS (Tr & Orth) Examination, the book is structured according to the four major sections of the examination; adult elective orthopaedics, trauma, children's/hands and upper limb and applied basic science. An introductory section gives general exam guidance and end section covers common diagrams that you may be asked to draw out. Each chapter is written by a recent (successful) examination candidate and the style of each reflects the author's experience and their opinions on the best tactics for first-time success. If you are facing the FRCS (Tr & Orth) you need this book.

Fluorapatite Coatings for the Osseointegration of Orthopaedic Implants

Fluorapatite Coatings for the Osseointegration of Orthopaedic Implants Book
Author : Jozef Adrianus Maria Clemens
Publisher : Unknown
Release : 1995
ISBN : 9789063851736
Language : En, Es, Fr & De

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Book Description :

Download Fluorapatite Coatings for the Osseointegration of Orthopaedic Implants book written by Jozef Adrianus Maria Clemens, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Orthopaedic Biomechanics

Orthopaedic Biomechanics Book
Author : Beth A. Winkelstein
Publisher : CRC Press
Release : 2012-12-18
ISBN : 1439860947
Language : En, Es, Fr & De

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Book Description :

Given the strong current attention of orthopaedic, biomechanical, and biomedical engineering research on translational capabilities for the diagnosis, prevention, and treatment of clinical disease states, the need for reviews of the state-of-art and current needs in orthopaedics is very timely. Orthopaedic Biomechanics provides an in-depth review of the current knowledge of orthopaedic biomechanics across all tissues in the musculoskeletal system, at all size scales, and with direct relevance to engineering and clinical applications. Discussing the relationship between mechanical loading, function, and biological performance, it first reviews basic structure-function relationships for most major orthopedic tissue types followed by the most-relevant structures of the body. It then addresses multiscale modeling and biologic considerations. It concludes with a look at applications of biomechanics, focusing on recent advances in theory, technology and applied engineering approaches. With contributions from leaders in the field, the book presents state-of-the-art findings, techniques, and perspectives. Much of orthopaedic, biomechanical, and biomedical engineering research is directed at the translational capabilities for the "real world". Addressing this from the perspective of diagnostics, prevention, and treatment in orthopaedic biomechanics, the book supplies novel perspectives for the interdisciplinary approaches required to translate orthopaedic biomechanics to today’s real world.

Bone Implant Interface in Orthopedic Surgery

Bone Implant Interface in Orthopedic Surgery Book
Author : Theofilos Karachalios
Publisher : Springer Science & Business Media
Release : 2013-11-19
ISBN : 1447154096
Language : En, Es, Fr & De

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Book Description :

Total joint arthroplasty is an effective surgical procedure for end-stage osteoarthritis of major joints with satisfactory long term clinical outcome. A large and growing number of arthroplasties are performed annually worldwide and a great number of orthopaedic surgeons are practicing arthroplasty surgery as their main surgical activity. The biological behavior of the bone-implant interface is crucial for the long term survival of the artificial joint. All factors which have a positive or negative effect on the interface are of great interest for those practicing arthroplasty surgery. Basic scientists and the industry are continuously searching for new implant fixation mechanisms and improved materials. There is an accumulation of a great amount of basic science data (both biological, material and mechanical) related to the incorporation or loosening of the bone-implant interface. However, basic science data does not always translate to satisfactory clinical application, and orthopaedic practitioners often wonder which piece of information is clinically useful. A further problem is that basic scientists often speak their own scientific language and may not fully appreciate common clinical practice needs. In this textbook the biological and mechanical mechanisms of implant incorporation and loosening will be presented. All new data concerning materials and methods for incorporation enhancement will be critically analyzed. Data useful for clinical application will be stressed. Orthopaedic Surgeons will find information which will improve their clinical practice and basic scientists will be helped to understand and appreciate clinical needs.

Fluorine Compounds Advances in Research and Application 2013 Edition

Fluorine Compounds   Advances in Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481675710
Language : En, Es, Fr & De

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Book Description :

Fluorine Compounds—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Fluorine Compounds—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fluorine Compounds—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Materials Sciences and Implant Orthopedic Surgery

Materials Sciences and Implant Orthopedic Surgery Book
Author : R. Kossowsky,Nir Kossovsky
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9400944748
Language : En, Es, Fr & De

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Book Description :

Combining experts from the medical and materials sciences, the Institute considered current concepts in medical and materials sciences as they relate to implantable prostheses in orthopedic surgical practice. The syllabus included theory and applications of materials properties, physiological function, and host response to metal and non-metal materials. Total hip prostheses are the most common orthopedic device implanted today involved in over 200,000 operations. Failures occur at the rate of 10~-40~ at ~ to 10 years. Failures are due to loosening, infection, fracture of femoral components, or destruction of the pe 1 vi c components .' All these, and other problems related to the implantation of the devices, the surgical procedures, and device pathology, were. discussed in light of current, as well as, emerging technologies and scientific knowledge. Repeatedly, scientists designing prostheses became aware of a lack of understanding of physiological phenomena associated with biocompatibility; the interchange among practising physicians, basic scientists, and pathologists at this Institute was appreciated. We thank all the contributors and participants for their effort. Thanks are also due to the personnel of the Scientific Affairs Division of NATO. The daily routines of running the Institute were greatly facilitated by the efforts of Pedro Cuevas, M.D, Jose Gutierrez Diaz, M.D, and Dr. Hanita Kossowsky. The devoted help of Nir Kossovsky, M.D, in setting the conference and in editing this book, is sincerely appreci ated.

Development of Osseointegrated Implants for Soldier Amputees Following Orthopaedic Extremity Trauma

Development of Osseointegrated Implants for Soldier Amputees Following Orthopaedic Extremity Trauma Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is the first year annual report of this four year research program to develop osseointegrated implants for amputees. This research will provide the basic foundations for the safe and efficacious design of implants for above the knee active amputees. These implants will allow for direct loading of the bone and have a safety release mechanism to prevent abutment and bone- implant interface failure and bone fracture. The first year of research focused on determining morphometric variations in the internal structure of the human femur as a function of gender age and ethnic background. Anthropometric studies were conducted along the length of the femur to develop sizing and design criteria. It has been a productive and challenging first year. The challenge of obtaining human cadaver specimens delayed our timeline but we will complete the task within the first quarter of the second year. We believe we have established the imaging principles for developing customized osseointegrated implants.

Bioactive Agents for Functionalization of Biomaterials for Precise Tissue Engineering

Bioactive Agents for Functionalization of Biomaterials for Precise Tissue Engineering Book
Author : Gang Wu,Rui Guo,Jenneke Klein-Nulend,Kaili Lin
Publisher : Frontiers Media SA
Release : 2023-02-28
ISBN : 2832512895
Language : En, Es, Fr & De

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Book Description :

Download Bioactive Agents for Functionalization of Biomaterials for Precise Tissue Engineering book written by Gang Wu,Rui Guo,Jenneke Klein-Nulend,Kaili Lin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Characterization and Evaluation of Submicron Femtosecond Laser Induced Periodic Surface Structures on Titanium to Improve Osseointegration of Dental and Orthopaedic Implants

Characterization and Evaluation of Submicron Femtosecond Laser Induced Periodic Surface Structures on Titanium to Improve Osseointegration of Dental and Orthopaedic Implants Book
Author : Hourieh Exir
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Surface properties such as topography and wettability play a pivotal role in controlling the cellular behavior on dental and orthopaedic implants and eventually their clinical success. The implementation of more advanced cell-targeted surface modification approaches has opened up additional possibilities for improving osseointegration to further increase the success rate of bone implants. In this thesis, the potential of employing femtosecond laser-induced periodic surface structures with submicron spatial periodicities of 300 nm, 600 nm and 760 nm on titanium to improve osseointegration of dental and orthopaedic implants was explored. Uniform submicron femtosecond laser-induced periodic surface structures with consistent periodicity, roughness and oxide thickness were generated over large areas (10 x 10 mm^2) on titanium substrates and characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), electron energy loss spectroscopy (EELS), and Auger electron microscopy (AES). In vitro experiments using osteosarcoma Saos-2 cells showed the same level of cell metabolism on the laser textured and unmodified (control) surfaces along with statistically significant alkaline phosphatase activity after 14 days of cell seeding for the laser patterned surface with periodicity of 620 nm compared to the control surface. Average circularity along with nuclear area factor of cells fixed onto the laser textured and unmodified titanium surfaces were acquired from SEM images using ImageJ. The lower circularity and higher nuclear area factor of cells was observed on all laser textured surfaces as compared to the control, and are indicative of healthier cells on the laser textured surfaces. The cells appeared to align perpendicularly to the periodic laser generated structures and showed a more elongated shape on laser patterned surfaces as compared with the control surface, with the cell's filopodia appearing to be attached to the peaks of the laser-textured pattern. In the second part of the thesis, the mechanism underlying the wettability transition from superhydrophilic to superhydrophobic on femtosecond laser generated periodic surface structures on titanium was investigated. The time-dependent wettability of the laser treated surfaces was assessed by the sessile drop method. The samples exhibited superhydrophilic behavior immediately after laser texturing and became superhydrophobic over time. Detailed surface chemical analyses by X-ray photoelectron spectroscopy revealed that the unique electronic structures of Ti2O3 and TiO2, which resulted in hydrophilic and hydrophobic hydration structures, respectively, played a crucial role in the observed wettability transition. This study demonstrates the prospect of using femtosecond laser-induced periodic surface structures as a promising surface modification strategy to potentially manipulate cellular behavior and improve dental and orthopaedic implants' clinical success rate.