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Organoids and Mini Organs

Organoids and Mini Organs Book
Author : Jamie Davies,Melanie Lawrence
Publisher : Academic Press
Release : 2018-03-09
ISBN : 012812637X
Language : En, Es, Fr & De

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Book Description :

Organs and Organoids combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved. Collects the best protocols of organoid cultures from diverse tissues Covers a wide range of organs Includes troubleshooting cases for common, but specific problems for each culture conditions Provides an entire section on the application of organoids

Organoids

Organoids Book
Author : N.A
Publisher :
Release : 2018
ISBN : 9789278417925
Language : En, Es, Fr & De

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Book Description :

Producing miniature versions of organs in a dish may sound like science-fiction, but thanks to advances in stem cell technology and bioengineering scientists are now able to artificially grow a mass of cells into organoids with similar properties to organs. Organoids represent cells grown in specific three-dimensional (3D) environments, creating mini, simplified organs that retain some physiological function. They are derived from one or a few cells, from a tissue, embryonic stem cells or induced pluripotent stem cells, which can self-organise in 3D cultures. Following the observation that cells do not behave in 2D cultures as they do in vivo, 3D cultures of organoids have emerged as promising model systems for studying tissue development and generating new therapies. With recent technological breakthroughs, 3D culture models have come to represent a more physiologically relevant approximation of the in vivo environment. Hence, researchers in the fields of the physical sciences and engineering are seeking to improve the 3D culture conditions to grow mini organs in a dish. Organoids are increasing in complexity as researchers begin probing more deeply the mechanisms behind stem cell lineage and differentiation. Models have now been grown for many organs, including brain, liver, kidney, breast, retina, and organs of the gastrointestinal tract, among others. This CORDIS Results Pack presents the first results from EU/ERC-funded research in the organoid field. It sheds light on five projects and their scientific advances in organoid technology and how they can be used as in vivo-like models. The Mini Brains project generated brain organoids to study the mechanisms of various neurological disorders and discover novel drugs to treat them. TOXANOID proved that their technology can outperform current in vitro systems and replace a significant portion of animal-based toxicology studies. The team successfully developed organoid systems for several organs including small intestine, colon and liver. ColonCan developed novel ex vivo 3D organoid cultures that replicate genetic events in colorectal cancer (CRC), the second most common cause of cancer-related deaths, and used them to test novel therapeutics. COMIET created a new cell culture platform for epithelial tissues to advance the in vitro modelling of diseases, preclinical screening for drug efficacy and toxicity, as well as the understanding of organ development. The CLOC project produced liver organoids in vitro using hepatocytes cultured on 3D scaffolds as novel models for studying liver development and disease, and potential treatment of inherited cholestatic disorders.

Tissue Engineering Strategies for Organ Regeneration

Tissue Engineering Strategies for Organ Regeneration Book
Author : Naznin Sultana,Sanchita Bandyopadhyay-Ghosh,Chin Fhong Soon
Publisher : CRC Press
Release : 2020-02-04
ISBN : 0429749627
Language : En, Es, Fr & De

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Book Description :

Tissue Engineering Strategies for Organ Regeneration addresses the existing and future trends of tissue engineering approaches for organ/tissue regeneration or repair. This book provides a comprehensive summary of the recent improvement of biomaterials used in scaffold-based tissue engineering, and the tools and different protocols needed to design tissues and organs. The chapters in this book provide the in-depth principles for many of the supporting and enabling technologies including the applications of BioMEMS devices in tissue engineering, and the combination of organoid formation and three dimensional (3D) bioprinting. The book also highlights the advances and strategies for regeneration of three-dimensional microtissues in microcapsules, tissue reconstruction techniques, and injectable composite scaffolds for bone tissue repair and augmentation. Key Features: Addresses the current obstacles to tissue engineering applications Provides the latest improvements in the field of integrated biomaterials and fabrication techniques for scaffold-based tissue engineering Shows the influence of microenvironment towards cell-biomaterials interactions Highlights significant and recent improvements of tissue engineering applications for the artificial organ and tissue generation Describes the applications of microelectronic devices in tissue engineering Describes different current bioprinting technologies

Translational Medicine

Translational Medicine Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 2018-03-13
ISBN : 3527687211
Language : En, Es, Fr & De

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Book Description :

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Multi Targeted Approach to Treatment of Cancer

Multi Targeted Approach to Treatment of Cancer Book
Author : Varsha Gandhi,Kapil Mehta,Rajesh Grover,Sen Pathak,Bharat B. Aggarwal
Publisher : Springer
Release : 2015-01-29
ISBN : 3319122533
Language : En, Es, Fr & De

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Book Description :

In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.

Developmental Biology

Developmental Biology Book
Author : Robert A. Meyers
Publisher : Wiley-Blackwell
Release : 2019-04-08
ISBN : 3527338217
Language : En, Es, Fr & De

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Book Description :

This topical volume in the respected Encyclopedia series is the first in many years to bring together all important aspects of developmental biology in one source, from morphogenesis and organogenesis, via epigenetic regulation of gene expression to evolutionary developmental biology. The editor-in-chief has assembled an outstanding team of contributors to review these topics, creating an authoritative work for many years to come. The result is a unique, top-level reference in developmental biology for researchers, students and professionals alike.

Modelling Acute Kidney Injury on IPSC Derived Organoids

Modelling Acute Kidney Injury on IPSC Derived Organoids Book
Author : Jenny Louisa May Digby
Publisher :
Release : 2019
ISBN :
Language : En, Es, Fr & De

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Book Description :

The kidneys are crucial organs for the balance of fluids and excretion of wastes. However, their excretory role renders them vulnerable to drug-induced toxicity, for example by the chemotherapeutic drug cisplatin. Nephrotoxic side effects of cisplatin manifest in acute kidney injury (AKI), an abrupt loss of kidney function. AKI is strongly associated with the progression to chronic kidney disease (CKD) and renal fibrosis, and in severe cases end stage renal disease (ESRD) requiring dialysis or kidney transplantation. Currently, no treatments for AKI or successful interventions to stop the progression of renal injury to more serious forms of impairment are available. This is in part due to the lack of clinically translatable models of cisplatin-induced AKI. In this work, I have taken advantage of the recently developed method of growing kidney organoids, 'mini kidneys' in a dish, from human induced pluripotent stem cells (iPSCs) to model cisplatin-induced AKI. Kidney organoids closely resemble human kidney tissue and can be produced in large-scale, which enabled me to assess the effects of cisplatin systematically. Organoids were treated with different regimens of cisplatin to cover a range of doses and exposure times. My results showed that cisplatin induced injury markers as well as DNA damage and apoptosis resembling the symptoms found in AKI patients, however damage specific to the proximal tubule, the primary target structure of cisplatin, was not obvious. Instead, my data suggested that cisplatin preferentially targeted proliferating cells in the organoids, thereby reflecting the anti-cancer effects of the drug. Importantly, a robust inflammatory response and evidence of fibrosis was observed, suggesting that cisplatin-treated organoids possibly recapitulate development of renal fibrosis, a hallmark of CKD. Furthermore, in a proof-of-principle approach, I demonstrated that co-treatment of cisplatin with the small molecule inhibitor JQ1 ameliorated the damage inflicted by cisplatin. Taken together, my work demonstrates that kidney organoids recapitulate acute kidney injury when exposed to cisplatin and can be used as a platform for the development of novel therapeutic interventions in AKI to CKD progression.

How to Grow a Human

How to Grow a Human Book
Author : Philip Ball
Publisher :
Release : 2019
ISBN : 022665480X
Language : En, Es, Fr & De

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Book Description :

The bestselling author of Critical Mass offers a cutting-edge examination of what it means to be human in the face of the latest technical developments and research in cell biology, tissue growth, organ regeneration, and treatments of cancer and dementia.

1995 IEEE Engineering in Medicine and Biology

1995 IEEE Engineering in Medicine and Biology Book
Author : IEEE Engineering in Medicine and Biology Society. Conference
Publisher : Institute of Electrical & Electronics Engineers(IEEE)
Release : 1997
ISBN : 9780780324756
Language : En, Es, Fr & De

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Book Description :

B A S I C

B A S I C  Book
Author : N.A
Publisher :
Release : 1965
ISBN :
Language : En, Es, Fr & De

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Book Description :

Cancer Research

Cancer Research Book
Author : N.A
Publisher :
Release : 2006-10
ISBN :
Language : En, Es, Fr & De

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Book Description :

Harrison s Principles of Internal Medicine 19 E Vol 1 Vol 2 ebook

Harrison s Principles of Internal Medicine 19 E  Vol 1   Vol 2   ebook  Book
Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2015-04-17
ISBN : 0071802169
Language : En, Es, Fr & De

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Book Description :

The landmark guide to internal medicine— updated and streamlined for today’s students and clinicians The only place you can get ALL the great content found in the two print volumes AND the acclaimed DVD in one convenient resource! Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the new Nineteenth Edition: Content is practically organized around two basic themes: education and clinical practice The teaching and learning sections cover foundational principles, cardinal manifestations of disease and approach to differential diagnosis; the content devoted to clinical practice focuses on disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, are available for easy download Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison’s patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice. Acclaim for Harrison’s: “Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. “ Doody’s Review Service reviewing the previous edition of Harrison’s

Harrison s Principles of Internal Medicine 19th Edition and Harrison s Manual of Medicine 19th Edition EBook VAL PAK

Harrison s Principles of Internal Medicine 19th Edition and Harrison s Manual of Medicine 19th Edition  EBook VAL PAK Book
Author : J. Larry Jameson,Anthony S. Fauci,Dennis L. Kasper,Stephen L. Hauser,Dan L. Longo,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2017-11-18
ISBN : 1260129071
Language : En, Es, Fr & De

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Book Description :

SPECIAL OFFER! SAVE WHEN YOU PURCHASE HARRISON’S PRINCIPLES OF INTERNAL MEDICINE, 19e ALONG WITH THE COMPANION HARRISON’S MANUAL! This dollar-saving Harrison’s bundle includes these two great resources: Harrison’s Principles of Internal Medicine, Nineteenth Edition Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the Nineteenth Edition:•Presented in two volumes: Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers disease pathogenesis and treatment•NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more•Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more.•Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever•Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more The package also includes..... Harrison’s Manual of Medicine, Nineteenth Edition Harrison’s Manual of Medicine is a concise, bedside resource derived from content found in Harrison’s Principles of Internal Medicine, Nineteenth Edition. Perfect for use at the point of care, the Manual presents clinical information covering key aspects of the diagnosis, clinical manifestations, and treatment of the major diseases that are likely to be encountered in medical practice. Presented in full color and incorporating an efficient blend of succinct text, bullet points, algorithms, and tables Harrison’s Manual of Medicine, Nineteenth Edition covers every area of clinical medicine, including:• Etiology and Epidemiology• Clinically Relevant Pathophysiology• Signs and Symptoms• Differential Diagnosis• Physical and Laboratory Findings• Therapeutics• Practice Guidelines

Harrison s Principles and Practice of Internal Medicine 19th Edition and Harrison s Principles of Internal Medicine Self Assessment and Board Review 19th Edition EBook Val Pak

Harrison s Principles and Practice of Internal Medicine 19th Edition and Harrison s Principles of Internal Medicine Self Assessment and Board Review  19th Edition  EBook Val Pak Book
Author : J. Larry Jameson,Anthony S. Fauci,Dennis L. Kasper,Stephen L. Hauser,Dan L. Longo,Joseph Loscalzo,Charles Weiner
Publisher : McGraw Hill Professional
Release : 2017-11-18
ISBN : 126012908X
Language : En, Es, Fr & De

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Book Description :

SPECIAL OFFER! SAVE WHEN YOU PURCHASE HARRISON’S PRINCIPLES OF INTERNAL MEDICINE, 19e ALONG WITH THE COMPANION BOARD REVIEW BOOK! This dollar-saving Harrison’s bundle includes two great resources: Harrison’s Principles of Internal Medicine, Nineteenth Edition Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the Nineteenth Edition:•Presented in two volumes: Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers disease pathogenesis and treatment•NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more•Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more.•Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever•Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more The package also includes..... Harrison’s Principles of Internal Medicine Self-Assessment and Board Review Based on the content of Harrison’s Principles of Internal Medicine, Nineteenth Edition, this full-color study aid is essential for Internal Medicine Board certification or recertification/maintenance of certification, or as a refresher for any internal medicine examination. Reflecting the accuracy, currency, and wide scope of Harrison’s, this complete review of internal medicine delivers more than 1,000 extremely challenging review questions, many of which utilize realistic patient scenarios, including radiographic and pathologic images. Each question is accompanied by explanations for correct and incorrect answers. These explanations -- which are derived from and cross-referenced to Harrison’s Principles of Internal Medicine, Nineteenth Edition – are one of the most effective ways to learn and teach internal medicine. They are designed to bolster your understanding of pathophysiology, epidemiology, differential diagnosis, clinical decision making, and therapeutics. You will also find a beautiful full-color atlas.

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2011 Edition

Issues in Pharmacology  Pharmacy  Drug Research  and Drug Innovation  2011 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963444
Language : En, Es, Fr & De

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Book Description :

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.