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Organoids And Mini Organs

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Organoids and Mini Organs

Organoids and Mini Organs Book
Author : Jamie Davies,Melanie Lawrence
Publisher : Academic Press
Release : 2018-03-09
ISBN : 012812637X
Language : En, Es, Fr & De

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Book Description :

Organs and Organoids combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved. Collects the best protocols of organoid cultures from diverse tissues Covers a wide range of organs Includes troubleshooting cases for common, but specific problems for each culture conditions Provides an entire section on the application of organoids

Stem Cells

Stem Cells Book
Author : Christine Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers
Publisher : Academic Press
Release : 2014-05-23
ISBN : 0124115675
Language : En, Es, Fr & De

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Book Description :

The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

Tumor Organoids

Tumor Organoids Book
Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Release : 2017-10-20
ISBN : 3319605119
Language : En, Es, Fr & De

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Book Description :

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Organoids as Model Systems for Human Development Disease and Clinical Applications

Organoids as Model Systems for Human Development  Disease and Clinical Applications Book
Author : Eumorphia Remboutsika,Thimios Mitsiadis
Publisher : Frontiers Media SA
Release : 2021-11-23
ISBN : 2889716600
Language : En, Es, Fr & De

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Book Description :

Download Organoids as Model Systems for Human Development Disease and Clinical Applications book written by Eumorphia Remboutsika,Thimios Mitsiadis, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tissue Engineering Strategies for Organ Regeneration

Tissue Engineering Strategies for Organ Regeneration Book
Author : Naznin Sultana,Sanchita Bandyopadhyay-Ghosh,Chin Fhong Soon
Publisher : CRC Press
Release : 2020-02-11
ISBN : 0429749619
Language : En, Es, Fr & De

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Book Description :

Tissue Engineering Strategies for Organ Regeneration addresses the existing and future trends of tissue engineering approaches for organ/tissue regeneration or repair. This book provides a comprehensive summary of the recent improvement of biomaterials used in scaffold-based tissue engineering, and the tools and different protocols needed to design tissues and organs. The chapters in this book provide the in-depth principles for many of the supporting and enabling technologies including the applications of BioMEMS devices in tissue engineering, and the combination of organoid formation and three dimensional (3D) bioprinting. The book also highlights the advances and strategies for regeneration of three-dimensional microtissues in microcapsules, tissue reconstruction techniques, and injectable composite scaffolds for bone tissue repair and augmentation. Key Features: Addresses the current obstacles to tissue engineering applications Provides the latest improvements in the field of integrated biomaterials and fabrication techniques for scaffold-based tissue engineering Shows the influence of microenvironment towards cell-biomaterials interactions Highlights significant and recent improvements of tissue engineering applications for the artificial organ and tissue generation Describes the applications of microelectronic devices in tissue engineering Describes different current bioprinting technologies

Human Adult Stem Cells

Human Adult Stem Cells Book
Author : John Masters,Bernhard Ø Palsson
Publisher : Springer Science & Business Media
Release : 2009-05-30
ISBN : 9048122694
Language : En, Es, Fr & De

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Book Description :

The aim of volume 7 of Human Cell Culture is to provide clear and precise methods for growing primary cultures of adult stem cells from various human tissues and describe culture conditions in which these adult stem cells differentiate along their respective lineages. The book will be of value to biomedical scientists and of special interest to stem cell biologists and tissue engineers. Each chapter is written by experts actively involved in growing human adult stem cells.

Mechanisms of Morphogenesis

Mechanisms of Morphogenesis Book
Author : Jamie Davies
Publisher : Academic Press
Release : 2013-02-18
ISBN : 0124157572
Language : En, Es, Fr & De

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Book Description :

Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future Includes over 200 four-color figures Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries Covers experimental techniques as a guide to the reader Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems

Tissue Regeneration

Tissue Regeneration Book
Author : Hussein Abdelhay Essayed Kaoud
Publisher : BoD – Books on Demand
Release : 2018-06-06
ISBN : 1789232600
Language : En, Es, Fr & De

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Book Description :

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Biotechnology to Combat COVID 19

Biotechnology to Combat COVID 19 Book
Author : Megha Agrawal,Shyamasri Biswas
Publisher : BoD – Books on Demand
Release : 2022-02-23
ISBN : 183968626X
Language : En, Es, Fr & De

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Book Description :

This book provides an inclusive and comprehensive discussion of the transmission, science, biology, genome sequencing, diagnostics, and therapeutics of COVID-19. It also discusses public and government health measures and the roles of media as well as the impact of society on the ongoing efforts to combat the global pandemic. It addresses almost every topic that has been studied so far in the research on SARS-CoV-2 to gain insights into the fundamentals of the disease and mitigation strategies. This volume is a useful resource for virologists, epidemiologists, biologists, medical professionals, public health and government professionals, and all global citizens who have endured and battled against the pandemic.

SARS CoV 2 Origin and COVID 19 Pandemic Across the Globe

SARS CoV 2 Origin and COVID 19 Pandemic Across the Globe Book
Author : Vijay Kumar
Publisher : BoD – Books on Demand
Release : 2021-12-01
ISBN : 183968755X
Language : En, Es, Fr & De

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Book Description :

The current COVID-19 pandemic has infected more than 219 million people and killed more than 4.5 million people worldwide. It has also impacted the socioeconomic status of affected countries and led to the fastest development of vaccines in history. Over seven sections and seventeen chapters, this book comprehensively reviews numerous aspects of COVID-19, including epidemiology, zoonosis, drug development, telehealth, the effects of the virus on healthcare workers, the importance of architecture, and urbanism in preventing future pandemics, and much more.

Human Gastrointestinal Development

Human Gastrointestinal Development Book
Author : Emanuel Lebenthal
Publisher : Raven Press (ID)
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Human Gastrointestinal Development book written by Emanuel Lebenthal, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ethical and Legal Issues in Neurology

Ethical and Legal Issues in Neurology Book
Author : James L. Bernat,Richard Beresford
Publisher : Newnes
Release : 2014-01-09
ISBN : 0444535047
Language : En, Es, Fr & De

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Book Description :

Advances in our understanding of the brain and rapid advances in the medical practice of neurology are creating questions and concerns from an ethical and legal perspective. Ethical and Legal Issues in Neurology provides a detailed review of various general aspects of neuroethics, and contains chapters dealing with a vast array of specific issues such as the role of religion, the ethics of invasive neuroscience research, and the impact of potential misconduct in neurologic practice. The book focuses particular attention on problems related to palliative care, euthanasia, dementia, and neurogenetic disorders, and concludes with examinations of consciousness, personal identity, and the definition of death. This volume focuses on practices not only in North America but also in Europe and the developing world. It is a useful resource for all neuroscience and neurology professionals, researchers, students, scholars, practicing clinical neurologists, mental health professionals, and psychiatrists. A comprehensive introduction and reference on neuroethics Includes coverage of how best to understand the ethics and legal aspects of dementia, palliative care, euthanasia and neurogenetic disorders Brings clarity to issues regarding ethics and legal responsibilities in the age of rapidly evolving brain science and related clinical practice

The House of the Scorpion

The House of the Scorpion Book
Author : Nancy Farmer
Publisher : Simon and Schuster
Release : 2013-08-01
ISBN : 1471120384
Language : En, Es, Fr & De

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Book Description :

Matt is six years old when he discovers that he is different from other children and other people. To most, Matt isn't considered a boy at all, but a beast, dirty and disgusting. But to El Patron, lord of a country called Opium, Matt is the guarantee of eternal life. El Patron loves Matt as he loves himself - for Matt is himself. They share the exact same DNA. As Matt struggles to understand his existence and what that existence truly means, he is threatened by a host of sinister and manipulating characters, from El Patron's power-hungry family to the brain-deadened eejits and mindless slaves that toil Opium's poppy fields. Surrounded by a dangerous army of bodyguards, escape is the only chance Matt has to survive. But even escape is no guarantee of freedom… because Matt is marked by his difference in ways that he doesn't even suspect.

Medical Applications of iPS Cells

Medical Applications of iPS Cells Book
Author : Haruhisa Inoue,Yukio Nakamura
Publisher : Springer
Release : 2019-04-01
ISBN : 9811336725
Language : En, Es, Fr & De

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Book Description :

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Organogenesis of the Kidney

Organogenesis of the Kidney Book
Author : Lauri Saxen
Publisher : Cambridge University Press
Release : 1987-04-16
ISBN : 0521301521
Language : En, Es, Fr & De

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Book Description :

Although this description of a model system for cell differentation and organogenesis emphasizes the mammalian kidney, detailed coverage is also given to the development of the transient excretory organs.

Human Pluripotent Stem Cell Derived Organoid Models

Human Pluripotent Stem Cell Derived Organoid Models Book
Author : Anonim
Publisher : Academic Press
Release : 2020-06-22
ISBN : 0128215321
Language : En, Es, Fr & De

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Book Description :

Human Pluripotent Stem Cell Derived Organoid Models, Volume 159 highlights recent and emerging advances that describe organoid differentiation protocols for the different organ systems that implement organoids as tools to understand complexity and maturation, high content drug screening, disease modeling, development and evolution. Specific chapters in this new release include Pluripotent stem cell derived gastric organoids, Pluripotent stem cell derived esophageal organoids, Pluripotent stem cell derived small intestinal organoids, Pluripotent stem cell derived colonic organoids, Pluripotent stem cell intestinal organoids with an Enteric Nervous System, Pluripotent stem cell derived airway organoids, Pluripotent stem cell derived alveolar organoids, and much more. Provides the first comprehensive collection of pluripotent stem cell derived organoid protocols Includes cutting-edge methods Presents methods that generate organoids from many organ systems

Essential Current Concepts in Stem Cell Biology

Essential Current Concepts in Stem Cell Biology Book
Author : Beate Brand-Saberi
Publisher : Springer Nature
Release : 2020-01-03
ISBN : 3030339238
Language : En, Es, Fr & De

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Book Description :

This textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

The Role of Toll Like Receptor 4 in Infectious and Non Infectious Inflammation

The Role of Toll Like Receptor 4 in Infectious and Non Infectious Inflammation Book
Author : Carlo Rossetti,Francesco Peri
Publisher : Springer Nature
Release : 2020-10-30
ISBN : 3030563197
Language : En, Es, Fr & De

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Book Description :

TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.

Human Neural Stem Cells

Human Neural Stem Cells Book
Author : Leonora Buzanska
Publisher : Springer
Release : 2018-09-12
ISBN : 3319934856
Language : En, Es, Fr & De

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Book Description :

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Animal Experimentation

Animal Experimentation Book
Author : Kathrin Herrmann,Kimberley Jayne
Publisher : Human-Animal Studies
Release : 2019
ISBN : 9789004356184
Language : En, Es, Fr & De

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Book Description :

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.