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Organic Synthesis Using Biocatalysis

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Organic Synthesis Using Biocatalysis

Organic Synthesis Using Biocatalysis Book
Author : Animesh Goswami,Jon D. Stewart
Publisher : Academic Press
Release : 2015-09-06
ISBN : 012411542X
Language : En, Es, Fr & De

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Book Description :

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Biocatalysis in Organic Synthesis

Biocatalysis in Organic Synthesis Book
Author : Nicholas J. Turner,Luke Humphreys
Publisher : Royal Society of Chemistry
Release : 2018-02-08
ISBN : 1782625305
Language : En, Es, Fr & De

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Book Description :

The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Biocatalysis in Organic Synthesis

Biocatalysis in Organic Synthesis Book
Author : Nicholas J Turner,Luke Humphreys
Publisher : Royal Society of Chemistry
Release : 2018-02-15
ISBN : 1788013425
Language : En, Es, Fr & De

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Book Description :

The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Biocatalysis in Organic Synthesis Using Microorganisms and Immobilised Enzymes

Biocatalysis in Organic Synthesis Using Microorganisms and Immobilised Enzymes Book
Author : Stephanie Claudette Lemoult
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biocatalysis in Organic Synthesis Using Microorganisms and Immobilised Enzymes book written by Stephanie Claudette Lemoult, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science of Synthesis Biocatalysis in Organic Synthesis Vol 1

Science of Synthesis  Biocatalysis in Organic Synthesis Vol  1 Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2015-03-11
ISBN : 3131766115
Language : En, Es, Fr & De

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Book Description :

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" are designed to present the new possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to help start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As is the case with all of the Science of Synthesis volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including typical or general experimental procedures. The content organization of the three volumes is based on the type of reaction performed under biocatalysis. Volume 1 begins with chapters discussing the historical development of the field, sources of enzymes and appropriate selection of catalysts, and general strategies employed in biocatalysis. This is followed by reviews of the biocatalytic hydrolysis of various substrates. The volume concludes with chapters devoted to biocatalytic isomerizations, and the synthesis of glycosides.

Future Directions in Biocatalysis

Future Directions in Biocatalysis Book
Author : Tomoko Matsuda
Publisher : Elsevier
Release : 2017-08-11
ISBN : 0444637508
Language : En, Es, Fr & De

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Book Description :

Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic. This book is an indispensable tool for new researchers in the field to help identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. It provides invaluable hints and clues for conducting new research on enzymes, with final sections outlining future directions in biocatalysis further expanding the science into new applications. Gives future directions in the area of biocatalysis research Presents research topics based on their uniqueness, originality, and novelty Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists Shows that there is no boundary between organic chemistry and biochemistry

Enzyme Based Organic Synthesis

Enzyme Based Organic Synthesis Book
Author : Cheanyeh Cheng
Publisher : Wiley
Release : 2021-06-29
ISBN : 9781118027943
Language : En, Es, Fr & De

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Book Description :

The recent advances in enzyme technology, such as protein engineering, site-directed evolution, metabolic engineering, and enzyme immobilization, have made enzyme-based organic synthesis more competitive with organic synthesis derived from fossil fuels. This book discusses the methods and applications of enzymatic and microbial processes for organic synthesis, in particular asymmetric synthesis. Coverage also includes basic principles associated of enzyme specificity and catalytic abilities. The author details organic syntheses with the main classes of enzymes, illustrating their important characteristics of substrate and chemical specificity, regioselectivity, and stereoselectivity that these enzymes bring to organic synthesis. Applications for pharmaceutical and medicinal industry, food industry, cosmetics, fragrance, and health care are also described.

Biocatalysis

Biocatalysis Book
Author : W.-D. Fessner
Publisher : Springer Science & Business Media
Release : 2003-09-05
ISBN : 3540681167
Language : En, Es, Fr & De

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Book Description :

Here, leading contributors from the forefront of this exciting technology present authoritative and timely reviews on the state of the art of biocatalysis. They cover the whole spectrum from the discovery of novel enzymes - by modern screening, evolutionary or immunological approaches - through immobilization techniques for technical processes, to their use in the asymmetric synthesis of important target compounds.

Science of Synthesis Biocatalysis in Organic Synthesis Vol 2

Science of Synthesis  Biocatalysis in Organic Synthesis Vol  2 Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2015-03-11
ISBN : 3131766417
Language : En, Es, Fr & De

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Book Description :

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" are designed to present the new possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to help start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As is the case with all of the Science of Synthesis volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including typical or general experimental procedures. The content organization of the three volumes is based on the type of reaction performed under biocatalysis. Volume 2 covers reactions involving the formation of C-C bonds. Addition of carbon nucleophiles at C-O and C-N double bonds are reviewed, as are methods for the formation of C-C bonds at arenes and additions to C-C double bonds. Other chapters present transamination and reductive amination reactions, reduction of carbonyl compounds, and the chemistry of epoxides

Biocatalysts in Organic Synthesis

Biocatalysts in Organic Synthesis Book
Author : Jan Halgas,Ján Halgaš
Publisher : Elsevier Science Limited
Release : 1992
ISBN : 9780444986986
Language : En, Es, Fr & De

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Book Description :

The fundamental problem in modern organic synthesis is the selectivity of preparative organic reactions. This book reflects the recent growth of interest in the use of biocatalysts to attain high chemo-, regio- and particularly, stereoselectivity. Enantiomerically pure compounds are required as building blocks for the synthesis of many new agrochemicals, drugs, or as bioorganic models and probes. The first two chapters are devoted to a brief description of basic properties of various forms of biocatalysts: free and immobilized enzymes, free and immobilized microbial cells and other biopreparations, e.g., monoclonal antibodies. The third chapter deals with different levels of selectivity of biocatalyzed reactions. Attention is paid mainly to the differentiation of enantiomers, enantiotopic groups and faces. The remaining six chapters cover particular types of organic reactions and some 939 references from recent original papers are given. These include substitution reactions, eliminations and additions, synthesis and hydrolysis of esters and amides, oxidations and reductions.Chemists specializing in the synthesis of new biologically active compounds, such as drugs, pesticides, insecticides, insect pheromones, food and cosmetic additives, etc., will find this book of immense value. The book will also be useful as a supplementary textbook for university graduate students taking courses on organic synthesis or bioorganic chemistry.

Biocatalysis in Organic Synthesis 1 Workbench Edition

Biocatalysis in Organic Synthesis 1  Workbench Edition Book
Author : Kurt Faber
Publisher : Thieme Medical Publishers
Release : 2015
ISBN : 9783131741417
Language : En, Es, Fr & De

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Book Description :

The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 1 begins with chapters discussing the historical development of the field, sources of enzymes and appropriate selection of catalysts, and general strategies employed in biocatalysis. This is followed by reviews of the biocatalytic hydrolysis of various substrates. The volume concludes with chapters devoted to biocatalytic isomerizations, and the synthesis of glycosides.

Enzyme Catalysis in Organic Synthesis

Enzyme Catalysis in Organic Synthesis Book
Author : Karlheinz Drauz
Publisher : John Wiley & Sons
Release : 2012
ISBN : 3527325476
Language : En, Es, Fr & De

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Book Description :

Download Enzyme Catalysis in Organic Synthesis book written by Karlheinz Drauz, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biocatalysis Using Plant and Metagenomic Enzymes for Organic Synthesis

Biocatalysis Using Plant and Metagenomic Enzymes for Organic Synthesis Book
Author : Sophie Alice Newgas
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biocatalysis Using Plant and Metagenomic Enzymes for Organic Synthesis book written by Sophie Alice Newgas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science of Synthesis Biocatalysis in Organic Synthesis Vol 3

Science of Synthesis  Biocatalysis in Organic Synthesis Vol  3 Book
Author : Kurt Faber
Publisher : Georg Thieme Verlag
Release : 2015-03-11
ISBN : 3131766611
Language : En, Es, Fr & De

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Book Description :

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" present the possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As all SoS volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins by describing oxidation. A chapter on dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are also covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and the development of large-scale processes are considered. Finally, emerging trends are outlined.

Hydrolases in Organic Synthesis

Hydrolases in Organic Synthesis Book
Author : Uwe Theo Bornscheuer,Romas Joseph Kazlauskas
Publisher : John Wiley & Sons
Release : 2006-05-12
ISBN : 3527607129
Language : En, Es, Fr & De

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Book Description :

From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Inamuddin,Rajender Boddula,Mohd Imran Ahamed,Abdullah M. Asiri
Publisher : Elsevier
Release : 2020-11-20
ISBN : 0128226404
Language : En, Es, Fr & De

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Book Description :

Green Sustainable Process for Chemical and Environmental Engineering and Science: Green Solvents for Biocatalysis delivers an in-depth overview of biocatalysis in green solvents for industrial applications, also including outlines of sustainable methodologies in the area of organic chemistry, agriculture, analytical chemistry and engineering and pharmaceutical sciences. The book provides unique content in the area, making it a great source for information for undergraduate, postgraduate students, faculty, R&D professionals, production chemists, environmental engineers and industrial experts. Provides a broad overview of biocatalysis of sustainable processes Discusses the use of green alternative solvents in biocatalysis Outlines eco-friendly organic synthesis and chemical processes using biocatalysis Includes tactics on industrial product development using biocatalysis

Organic Synthesis with Enzymes in Non Aqueous Media

Organic Synthesis with Enzymes in Non Aqueous Media Book
Author : Giacomo Carrea,Sergio Riva
Publisher : John Wiley & Sons
Release : 2008-04-09
ISBN : 3527621733
Language : En, Es, Fr & De

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Book Description :

Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Selective Biocatalysis

Selective Biocatalysis Book
Author : Laszlo Poppe,Lajos Novak
Publisher : Wiley-VCH
Release : 1992-07-06
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

László Poppe, Lajos Novák Selective Biocatalysis A Synthetic Approach This stimulating monograph is a much needed response to the increasing use of biocatalysts in organic synthesis. In over 300 well-referenced pages, it reviews in detail applications and other aspects of the most widely used enzymes (e.g. hydrolases, oxidoreductases, and baker’s yeast) illustrates with examples the potential in biocatalysis of other, less frequently used enzymes and microorganisms discusses general problems of biocatalysis (e.g. stereochemistry of transformations, methods of influencing selectivity) indicates future trends in biocatalysis Researchers and students in prcparative organic chemistry. biotechnology and biochemistry will find this up-to-date monograph highly valuable in their daily work.

Enzyme Biocatalysis

Enzyme Biocatalysis Book
Author : Andrés Illanes
Publisher : Springer Science & Business Media
Release : 2008-06-19
ISBN : 1402083610
Language : En, Es, Fr & De

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Book Description :

This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Biocatalysts and Enzyme Technology

Biocatalysts and Enzyme Technology Book
Author : Klaus Buchholz,Volker Kasche,Uwe Theo Bornscheuer
Publisher : John Wiley & Sons
Release : 2012-12-21
ISBN : 3527672001
Language : En, Es, Fr & De

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Book Description :

This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.