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Organic Chemistry Concepts And Applications For Medicinal Chemistry

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Organic Chemistry Concepts and Applications for Medicinal Chemistry

Organic Chemistry Concepts and Applications for Medicinal Chemistry Book
Author : Joseph E. Rice
Publisher : Academic Press
Release : 2014-04-14
ISBN : 0128008326
Language : En, Es, Fr & De

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Book Description :

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material

Organic Chemistry

Organic Chemistry Book
Author : Allan D. Headley
Publisher : John Wiley & Sons
Release : 2020-01-02
ISBN : 1119504589
Language : En, Es, Fr & De

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Book Description :

Provides an in-depth study of organic compounds that bridges the gap between general and organic chemistry Organic Chemistry: Concepts and Applications presents a comprehensive review of organic compounds that is appropriate for a two-semester sophomore organic chemistry course. The text covers the fundamental concepts needed to understand organic chemistry and clearly shows how to apply the concepts of organic chemistry to problem-solving. In addition, the book highlights the relevance of organic chemistry to the environment, industry, and biological and medical sciences. The author includes multiple-choice questions similar to aptitude exams for professional schools, including the Medical College Admissions Test (MCAT) and Dental Aptitude Test (DAT) to help in the preparation for these important exams. Rather than categorize content information by functional groups, which often stresses memorization, this textbook instead divides the information into reaction types. This approach bridges the gap between general and organic chemistry and helps students develop a better understanding of the material. A manual of possible solutions for chapter problems for instructors and students is available in the supplementary websites. This important book: • Provides an in-depth study of organic compounds with division by reaction types that bridges the gap between general and organic chemistry • Covers the concepts needed to understand organic chemistry and teaches how to apply them for problem-solving • Puts a focus on the relevance of organic chemistry to the environment, industry, and biological and medical sciences • Includes multiple choice questions similar to aptitude exams for professional schools Written for students of organic chemistry, Organic Chemistry: Concepts and Applications is the comprehensive text that presents the material in clear terms and shows how to apply the concepts to problem solving.

Concepts and Applications of Organic Chemistry

Concepts and Applications of Organic Chemistry Book
Author : Saul Rowen
Publisher : Unknown
Release : 2017-05-16
ISBN : 9781632385512
Language : En, Es, Fr & De

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Book Description :

Since twentieth century, organic chemistry emerged and has been rapidly expanding throughout without deceleration in the progress of this field. Foundations of medicine and biotechnology are built on organic compounds. It is contributing to the research in medicinal chemistry, polymer chemistry, as well as several aspects of materials science. This book discusses the fundamentals and concentrates on the applications of organic chemistry. It presents the concepts and applications in a concise manner for a better understanding of the subject. Students, researchers, experts and all associated with organic chemistry will benefit alike from this book.

Medicinal Chemistry

Medicinal Chemistry Book
Author : Erica Helmer
Publisher : Unknown
Release : 2016-05-27
ISBN : 9781682860960
Language : En, Es, Fr & De

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Book Description :

Medicinal chemistry is an evolving field of science that deals with the development and design of pharmaceutical drugs. It has aided the discovery and development of new drugs for curing severe diseases. The main objective of this book is to give a general overview of different areas of synthetic organic chemistry, structural biology, chemical biology, etc. This book will prove to be beneficial for students and professionals alike.

Medicinal Chemistry Concepts and Applications

Medicinal Chemistry  Concepts and Applications Book
Author : Thomas Haldane
Publisher : Unknown
Release : 2018-02-26
ISBN : 9781632385864
Language : En, Es, Fr & De

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Book Description :

Medicinal chemistry studies the design and development of pharmaceutical drugs. It is a multi-disciplinary subject that combines pharmacology, synthetic organic chemistry, toxicology, molecular biology, etc. Discovery of newer pharmaceutical agents by studying existing drugs with pathological or biological targets is the main concern of this field. Performing clinical trials and assessing the effectiveness of drugs is another significant facet of medicinal chemistry. The topics covered in this extensive book deal with the core aspects of medicinal chemistry. It aims to equip students and experts with the advanced topics and upcoming concepts in this area.

Fundamentals of Medicinal Chemistry and Drug Metabolism

Fundamentals of Medicinal Chemistry and Drug Metabolism Book
Author : M. O. Faruk Khan,Ashok Philip
Publisher : Bentham Science Publishers
Release : 2018-06-01
ISBN : 1681086875
Language : En, Es, Fr & De

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Book Description :

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic background information about medicinal chemistry. It takes a succinct and conceptual approach to introducing important fundamental concepts required for a clear understanding of various facets of pharmacotherapeutic agents, drug metabolism and important biosynthetic pathways that are relevant to drug action. Notable topics covered in this first volume include the scope and importance of medicinal chemistry in pharmacy education, a comprehensive discussion of the organic functional groups present in drugs, and information about four major types of biomolecules (proteins, carbohydrates, lipids, nucleic acids) and key heterocyclic ring systems. The concepts of acid-base chemistry and salt formation, and their applications to the drug action and design follow thereafter. These include concepts of solubility and lipid-water partition coefficient (LWPC), isosterism, stereochemical properties, mechanisms of drug action, drug receptor interactions critical for pharmacological responses of drugs, and much more. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body.

Practical Synthetic Organic Chemistry

Practical Synthetic Organic Chemistry Book
Author : Stéphane Caron
Publisher : John Wiley & Sons
Release : 2020-01-31
ISBN : 1119448883
Language : En, Es, Fr & De

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Book Description :

This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry Book
Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Release : 2018-01-18
ISBN : 1119288584
Language : En, Es, Fr & De

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Book Description :

An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Frontiers in Computational Chemistry Volume 5

Frontiers in Computational Chemistry  Volume 5 Book
Author : Zaheer-Ul-Haq,Angela K. Wilson
Publisher : Bentham Science Publishers
Release : 2020-09-11
ISBN : 9811457778
Language : En, Es, Fr & De

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Book Description :

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The fifth volume of this series features these six chapters: - Recent Advances and Role of Computational Chemistry in Drug Designing and Development on Viral Diseases - Molecular Modeling Applied to Design of Cysteine Protease Inhibitors – A Powerful Tool for the Identification of Hit Compounds Against Neglected Tropical Diseases - Application of Systems Biology Methods in Understanding the Molecular Mechanism of Signalling Pathways in the Eukaryotic System - Implementation of the Molecular Electrostatic Potential over GPUs: Large Systems as Main Target - Molecular Electron Density Theory: A New Theoretical Outlook on Organic Chemistry - Frontier Molecular Orbital Approach to the Cycloaddition Reactions

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry Book
Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publisher : Elsevier
Release : 2015-07-01
ISBN : 012417213X
Language : En, Es, Fr & De

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Book Description :

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Stereoelectronic Effects

Stereoelectronic Effects Book
Author : Igor V. Alabugin
Publisher : John Wiley & Sons
Release : 2016-08-23
ISBN : 1118906365
Language : En, Es, Fr & De

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Book Description :

Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules An advanced textbook that provides an up-to-date overview of the field, starting from the fundamental principles Presents a large selection of modern examples of stereoelectronic effects in organic reactivity Shows practical applications of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science

Physico chemical Aspects of Textile Coloration

Physico chemical Aspects of Textile Coloration Book
Author : Stephen M. Burkinshaw,Andrew Filarowski
Publisher : John Wiley & Sons
Release : 2016-02-08
ISBN : 1118725697
Language : En, Es, Fr & De

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Book Description :

The production of textile materials comprises a very large and complex global industry that utilises a diverse range of fibre types and creates a variety of textile products. As the great majority of such products are coloured, predominantly using aqueous dyeing processes, the coloration of textiles is a large-scale global business in which complex procedures are used to apply different types of dye to the various types of textile material. The development of such dyeing processes is the result of substantial research activity, undertaken over many decades, into the physico-chemical aspects of dye adsorption and the establishment of ‘dyeing theory’, which seeks to describe the mechanism by which dyes interact with textile fibres. Physico-Chemical Aspects of Textile Coloration provides a comprehensive treatment of the physical chemistry involved in the dyeing of the major types of natural, man-made and synthetic fibres with the principal types of dye. The book covers: fundamental aspects of the physical and chemical structure of both fibres and dyes, together with the structure and properties of water, in relation to dyeing; dyeing as an area of study as well as the terminology employed in dyeing technology and science; contemporary views of intermolecular forces and the nature of the interactions that can occur between dyes and fibres at a molecular level; fundamental principles involved in dyeing theory, as represented by the thermodynamics and kinetics of dye sorption; detailed accounts of the mechanism of dyeing that applies to cotton (and other cellulosic fibres), polyester, polyamide, wool, polyacrylonitrile and silk fibres; non-aqueous dyeing, as represented by the use of air, organic solvents and supercritical CO2 fluid as alternatives to water as application medium. The up-to-date text is supported by a large number of tables, figures and illustrations as well as footnotes and widespread use of references to published work. The book is essential reading for students, teachers, researchers and professionals involved in textile coloration.

Medicinal Chemistry

Medicinal Chemistry Book
Author : Norma K. Dunlap,Donna M. Huryn
Publisher : Garland Science
Release : 2018
ISBN : 9780815345565
Language : En, Es, Fr & De

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Book Description :

Medicinal Chemistryteaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practicing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry. Pre-medical or pre-pharmacy students and professionals entering the drug discovery field will also find it a useful reference. Building on a foundation of synthetic organic chemistry and structural biology, the book interweaves therapeutics, case studies, historical context, and techniques for discovering, developing, and optimizing new drugs. Chapters are richly illustrated and include problems and annotated journal references with accompanying exercises and answers. Authored by practicing medicinal chemists--melding real-world research experience with basic concepts and up-to-date methods Flexible in presentation-- the first five chapters provide a conceptual foundation and historical understanding of the field; subsequent chapters explore the application of concepts. Chapters can be assigned in order of instructor preference and desired emphasis Presents easy-to-follow tables and descriptions of assays next to their relevance to medicinal chemistry and drug discovery, along with target values--information rarely found all in one place, but is a crucial reference Case studies and Journal Club use current literature to apply concepts from the text to real-life examples. They are also suitable for flipped classrooms and self-study

Phosphorus Ylides

Phosphorus Ylides Book
Author : Oleg I. Kolodiazhnyi
Publisher : John Wiley & Sons
Release : 2008-09-26
ISBN : 3527613919
Language : En, Es, Fr & De

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Book Description :

When Wittig first developed and described phosphorus ylides, nobody could have imagined how useful and versatile this class of compounds could be. This book provides a comprehensive and up-to-date compilation of the chemistry and applications of phosphorus ylides in organic synthesis. The ylides are discussed as reagents in the synthesis of a broad range of substances, amongst them olefins, acetylenes, cyclic and heterocyclic compounds, in such naturally occurring compounds as pheromones, steroids and carotenoids, and pharmaceutically and biologically active compounds such as antibiotics and prostaglandins. A particularly beneficial feature of this book is the 150 key experimental procedures with all the necessary data, allowing the preparation to start immediately without the need for an extremely time-consuming literature search. But should a search prove inevitable, around 2,500 references provide easy access to the primary literature. Every chemist in academia and industry working in organic, bioorganic, inorganic, and medicinal chemistry will welcome this book as an inspiration of concepts, ideas and practical syntheses.

Fundamentals of Heterocyclic Chemistry

Fundamentals of Heterocyclic Chemistry Book
Author : Louis D. Quin,John A. Tyrell
Publisher : John Wiley & Sons
Release : 2010-07-08
ISBN : 9780470626535
Language : En, Es, Fr & De

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Book Description :

Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters

Combinatorial Chemistry

Combinatorial Chemistry Book
Author : Stephen R. Wilson,Anthony W. Czarnik
Publisher : John Wiley & Sons
Release : 1997-03-28
ISBN : 9780471126874
Language : En, Es, Fr & De

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Book Description :

The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Molecular Diversity and Combinatorial Chemistry

Molecular Diversity and Combinatorial Chemistry Book
Author : Michael C. Pirrung
Publisher : Elsevier
Release : 2004-11-23
ISBN : 9780080444932
Language : En, Es, Fr & De

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Book Description :

Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Chemometric Methods in Molecular Design

Chemometric Methods in Molecular Design Book
Author : Han van de Waterbeemd
Publisher : John Wiley & Sons
Release : 2008-07-11
ISBN : 352761544X
Language : En, Es, Fr & De

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Book Description :

The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for making more rational choices in the planning of syntheses, and describes techniques for analyzing biological and chemical data. Written by the world's experts, it provides in-depth information on * molecular concepts * experimental design in the planning of syntheses * multivariate analysis of chemical and biological data * statistical validation of QSAR results An additional benefit: the book contains a critical survey of commercially available software packages both for statistical analysis as well as for special applications. Industrial and academic researches in medicinal chemistry and organic chemistry will value this book as a useful source of information for their daily work. Also available: Advanced Computer-Assisted Techniques in Drug Discovery, edited by H. van de Waterbeemd

Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs Book
Author : Marcus Vinícius Nora de Souza
Publisher : Bentham Science Publishers
Release : 2020-12-23
ISBN : 9811487545
Language : En, Es, Fr & De

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Book Description :

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development. Key Features: - Presents information about different techniques and strategies for the synthesis of organic compounds - Covers a broad range of biologically active compounds - Easy to read topical presentation - Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry - Wide range of bibliographic references for further reading and exercises presented, Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.

Chemiluminescence in Organic Chemistry

Chemiluminescence in Organic Chemistry Book
Author : Karl-Dietrich Gundermann,Frank McCapra
Publisher : Springer
Release : 2011-11-20
ISBN : 9783642716478
Language : En, Es, Fr & De

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Book Description :

The appearance of the first review in 1965 [1] and the first monograph in 1968 [2] on chemiluminescence demonstrated the extent of the phenomenon of light emission from the reaction of organic compounds in solution. Since then the num ber of chemiluminescent compounds has greatly increased, although the advan ces in theory and, more recently, applications are probably more significant. The present work is written by two authors who, together with E. H. White, helped to bring the study of chemiluminescence into the modern era. However many investigators are making contributions to the subject, even if the number of enthusiasts still remains small. It is not our intention to write an exhaustive account of chemiluminescence, still less of bioluminescence, and we have concentrated on making the landmarks in the area familiar to a readership outside the circle of specialists. The emphasis is on the range of organic compounds showing light emission with very little description of the relatively few inorganic or the more numerous biological examples which have been discovered. We hope that some of the excitement of the striking demonstrations of chemiluminescence which can be made appears in the text, albeit in the form of intellectual satisfaction and interest. We thank Prof. Dr. J. Stauff, Frankfurt for his generous advice and his critical comments. The chapter dealing with Peroxy-oxalate chemiluminescence has been commented up on critically by Dr. M. M. Rauhut, Stamford, Connecticut which we gratefully acknowledge.